Publications

2017

Ramot A, Jiang Z, Tian J.B, Nahum T, Kuperman Y, Justice N, Chen A (2017). Hypothalamic Crfr1 is Essential For Hpa Axis Regulation Following Chronic Stress.  Nat. Neurosci. .

2016

Volk N, Pape J.C, Engel M, Zannas A.S, Cattane N, Cattaneo A, Binder E.B, Chen A (2016). Amygdalar Microrna-15a is Essential For Coping With Chronic Stress.  Cell Reports. 17: :1882–91.
Elliott E, Manashirov S, Zwang R, Gil S, Tsoory M, Shemesh Y, Chen A (2016). Dnmt3a in the Medial Prefrontal Cortex Regulates Anxiety-Like Behavior in Adult Mice.  Journal of Neuroscience. 36(3): :730-740.
Vaisvaser S, Modai S, Farberov L, Lin T, Sharon H, Gilam A, Volk N, Admon R, Edry L, Fruchter E, Wald I, Bar-Haim Y, Tarrasch R, Chen A, Shomron N, Hendler T (2016). Neuro-Epigenetic Indications of Acute Stress Response in Humans: the Case of Microrna-29c..  PLoS ONE. 11(1). .
Lebow M.A., Chen A (2016). Overshadowed by the Amygdala: the Bed Nucleus of the Stria Terminalis Emerges as Key to Psychiatric Disorders.  Molecular Psychiatry. 21: (4):450-463.
Kuperman, Y., Weiss, M., Dine, J., Staikin, K., Golani, O., Ramot, A., Nahum, T., Kuhne, C., Shemesh, Y., Wurst, W., Harmelin, A., Deussing, J.M., Eder, M., Chen A (2016). Crfr1 in Agrp Neurons Modulates Sympathetic Nervous System Activity to Adapt to Cold Stress and Fasting.  Cell Metab. 23: (6):1185-1199.
Amitai, M., Taler, M., Carmel, M., Michaelovsky, E., Eilat, T., Yablonski, M., Orpaz, N., Chen, A., Apter, A., Weizman, A., Fennig, S. (2016). The Relationship Between Plasma Cytokine Levels and Response to Selective Serotonin Reuptake Inhibitor Treatment in Children and Adolescents With Depression And/or Anxiety Disorders.  J Child Adolesc Psychopharmacol. 26. .
Shemesh Y, Forkosh O, Mahn M, Anpilov S, Sztainberg Y, Manashirov S, Shlapobersky T, Elliott E, Tabouy L, Ezra G, Adler Es, Ben-Efraim Yj, Gil S, Kuperman Y, Haramati S, Dine J, Eder M, Deussing Jm, Schneidman E, Yizhar O, Chen A (2016). Ucn3 and Crf-r2 in the Medial Amygdala Regulate Complex Social Dynamics.  Nat. Neurosci.. 19: (11):1489-1496.
Mjag Henckens, Y Printz, U Shamgar, J Dine, M Lebow, Y Drori, C Kuehne, A Kolarz, M Eder, Jm Deussing, Nj Justice, O Yizhar, And A Chen (2016). Crf Receptor Type 2 Neurons in the Posterior Bed Nucleus of the Stria Terminalis Critically Contribute to Stress Recovery.  Molecular Psychiatry. .
Mjag Henckens, Jm Deussing And A Chen (2016). Region-Specific Roles of the Corticotropin-Releasing Factor– Urocortin System in Stress.  Nature Reviews. 17: (10):636-651.

2015

Issler O, Chen A (2015). Determining the Role of Micrornas in Psychiatric Disorders.  Nature Reviews Neuroscience.. 16: :201–212 .

2014

Howerton Ar, Roland Av, Fluharty Jm, Marshall A, Chen A, Daniels D, Beck Sg, Bale Tl, (2014). Sex Differences in Corticotropin-Releasing Factor Receptor-1 Action Within the Dorsal Raphe Nucleus in Stress Responsivity.  Biological Psychiatry. 75: (11):873-883.
Issler O, Haramati S, Paul Ed, Maeno H, Navon I, Zwang R, Gil S, Mayberg Hs, Dunlop Bw, Menke A, Awatramani R, Binder Eb, Deneris Es, Lowry Ca, Chen A, (2014). Microrna 135 is Essential For Chronic Stress Resiliency, Antidepressant Efficacy, and Intact Serotonergic Activity.  Neuron. 83: (2):344-360.
Chen Na, Jupp B, Sztainberg Y, Lebow M, Brown Rm, Kim Jh, Chen A, Lawrence Aj, (2014). Knockdown of Crf1 Receptors in the Ventral Tegmental Area Attenuates Cue- and Acute Food Deprivation Stress-Induced Cocaine Seeking in Mice.  Journal of Neuroscience. 34: (35):11560-11570.
Lauriola M, Enuka Y, Zeisel A, D'Uva G, Roth L, Sharon-Sevilla M, Lindzen M, Sharma K, Nevo N, Feldman M, Carvalho S, Cohen-Dvashi H, Kedmi M, Ben-Chetrit N, Chen A, Solmi R, Wiemann S, Schmitt F, Domany E, Yarden Y, (2014). Diurnal Suppression of EGFR Signalling by Glucocorticoids and Implications For Tumour Progression and Treatment.  Nature Communications. 5. .
Volk N, Paul Ed, Haramati S, Eitan C, Fields Bkk, Zwang R, Gil S, Lowry Ca, Chen A, (2014). Microrna-19b Associates With Ago2 in the Amygdala Following Chronic Stress and Regulates the Adrenergic Receptor Beta 1.  Journal of Neuroscience. 34: (45):15070-15082.

2013

Greenman Y, Kuperman Y, Drori Y, Asa Sl, Navon I, Forkosh O, Gil S, Stern N, Chen A, (2013). Postnatal Ablation of Pomc Neurons Induces an Obese Phenotype Characterized by Decreased Food Intake and Enhanced Anxiety-Like Behavior.  Molecular Endocrinology. 27: (7):1091-1102.
Taliaz D, Nagaraj V, Haramati S, Chen A, Zangen A, (2013). Altered Brain-Derived Neurotrophic Factor Expression in the Ventral Tegmental Area, But Not in the Hippocampus, is Essential For Antidepressant-Like Effects of Electroconvulsive Therapy.  Biological Psychiatry. 74: (4):305-312.
Shechter R, London A, Kuperman Y, Ronen A, Rolls A, Chen A, Schwartz M, (2013). Hypothalamic Neuronal Toll-Like Receptor 2 Protects Against Age-Induced Obesity.  Scientific Reports. 3. .
Shapiro H, Pecht T, Shaco-Levy R, Harman-Boehm I, Kirshtein B, Kuperman Y, Chen A, Bluher M, Shai I, Rudich A, (2013). Adipose Tissue Foam Cells Are Present in Human Obesity.  Journal of Clinical Endocrinology & Metabolism. 98: (3):1173-1181.
Lucas M, Chen A, Richter-Levin G, (2013). Hypothalamic Corticotropin-Releasing Factor is Centrally Involved in Learning Under Moderate Stress.  Neuropsychopharmacology. 38: (9):1825-1832.
Kollet O, Vagima Y, D'Uva G, Golan K, Canaani J, Itkin T, Gur-Cohen S, Kalinkovich A, Caglio G, Medaglia C, Ludin A, Lapid K, Shezen E, Neufeld-Cohen A, Varol D, Chen A, Lapidot T, (2013). Physiologic Corticosterone Oscillations Regulate Murine Hematopoietic Stem/Progenitor Cell Proliferation and Cxcl12 Expression by Bone Marrow Stromal Progenitors.  Leukemia. 27: (10):2006-2015.
Elharrar E, Warhaftig G, Issler O, Sztainberg Y, Dikshtein Y, Zahut R, Redlus L, Chen A, Yadid G, (2013). Overexpression of Corticotropin-Releasing Factor Receptor Type 2 in the Bed Nucleus of Stria Terminalis Improves Posttraumatic Stress Disorder-Like Symptoms in a Model of Incubation of Fear.  Biological Psychiatry. 74: (11):827-836.
Shemesh Y, Sztainberg Y, Forkosh O, Shlapobersky T, Chen A, Schneidman E, (2013). High-Order Social Interactions in Groups of Mice.  Elife. 2. .

2012

Riester A, Spyroglou A, Neufeld-Cohen A, Chen A, Beuschlein F, (2012). Urocortin-Dependent Effects on Adrenal Morphology, Growth, and Expression of Steroidogenic Enzymes in Vivo.  Journal of Molecular Endocrinology. 48: (2):159-167.
Bale Tl, Chen A (2012). Minireview: Crf and Wylie Vale: a Story of 41 Amino Acids and a Texan With Grit.  Endocrinology. 153: (6):2556-2561.
Lebow M, Neufeld-Cohen A, Kuperman Y, Tsoory M, Gil S, Chen A, (2012). Susceptibility to Ptsd-Like Behavior is Mediated by Corticotropin-Releasing Factor Receptor Type 2 Levels in the Bed Nucleus of the Stria Terminalis.  Journal of Neuroscience. 32: (20):6906-6916.
Ryabinin Ae, Tsoory Mm, Kozicz T, Thiele Te, Neufeld-Cohen A, Chen A, Lowery-Gionta Eg, Giardino Wj, Kaur S, (2012). Urocortins: Crf's Siblings and Their Potential Role in Anxiety, Depression and Alcohol Drinking Behavior.  Alcohol. 46: (4):349-357.
Neufeld-Cohen A, Kelly Pat, Paul Ed, Carter Rn, Skinner E, Olverman Hj, Vaughan Jm, Issler O, Kuperman Y, Lowry Ca, Vale Ww, Seckl Jr, Chen A, Jamieson Pm (2012). Chronic Activation of Corticotropin-Releasing Factor Type 2 Receptors Reveals a Key Role For 5-Ht1a Receptor Responsiveness in Mediating Behavioral and Serotonergic Responses to Stressful Challenge.  Biological Psychiatry. 72: (6):437-447.
Sztainberg Y, Chen A, (2012). Neuropeptide Regulation of Stress-Induced Behavior: Insights from the Crf/Urocortin Family.  Handbook of Neuroendocrinology. :355-375.
Cooper A, Grigoryan G, Guy-David L, Tsoory Mm, Chen A, Reuveny E, (2012). Trisomy of the g Protein-Coupled k+ Channel Gene, Kcnj6, Affects Reward Mechanisms, Cognitive Functions, and Synaptic Plasticity in Mice.  Proceedings of the National Academy of Sciences of the United States of America. 109: (7):2642-2647.
Regev L, Tsoory M, Gil S, Chen A, (2012). Site-Specific Genetic Manipulation of Amygdala Corticotropin-Releasing Factor Reveals Its Imperative Role in Mediating Behavioral Response to Challenge.  Biological Psychiatry. 71: (4):317-326.
Amir-Zilberstein L, Blechman J, Sztainberg Y, Norton Wnj, Reuveny A, Borodovsky N, Tahor M, Bonkowsky Jl, Bally-Cuif L, Chen A, Levkowitz G, (2012). Homeodomain Protein Otp and Activity-Dependent Splicing Modulate Neuronal Adaptation to Stress.  Neuron. 73: (2):279-291.
Riester A, Issler O, Spyroglou A, Rodrig Sh, Chen A, Beuschlein F, (2012). Acth-Dependent Regulation of Microrna as Endogenous Modulators of Glucocorticoid Receptor Expression in the Adrenal Gland.  Endocrinology. 153: (1):212-222.

2011

Sztainberg Y, Kuperman Y, Chen A (2011). An Anxiolytic Role For Crf Receptor Type 1 in the Globus Pallidus..  J Neurosci. 31: (48):17416 –24.
Kuperman Y, Issler O, Vaughan J, Bilezikjian L, Vale W, Chen A, (2011). Expression and Regulation of Corticotropin-Releasing Factor Receptor Type 2 Beta in Developing and Mature Mouse Skeletal Muscle.  Molecular Endocrinology. 25: (1):157-169.
Shema R, Haramati S, Ron S, Hazvi S, Chen A, Sacktor Tc, Dudai Y, (2011). Enhancement of Consolidated Long-Term Memory by Overexpression of Protein Kinase m Zeta in the Neocortex.  Science. 331: (6021):1207-1210.
Taliaz D, Loya A, Gersner R, Haramati S, Chen A, Zangen A, (2011). Resilience to Chronic Stress is Mediated by Hippocampal Brain-Derived Neurotrophic Factor.  Journal of Neuroscience. 31: (12):4475-4483.
Lukkes Jl, Staub Dr, Dietrich A, Truitt W, Neufeld-Cohen A, Chen A, Johnson Pl, Shekhar A, Lowry Ca, (2011). Topographical Distribution of Corticotropin-Releasing Factor Type 2 Receptor-Like Immunoreactivity in the Rat Dorsal Raphe Nucleus: co-Localization With Tryptophan Hydroxylase.  Neuroscience. 183: :47-63.
Rousso-Noori L, Knobler H, Levy-Apter E, Kuperman Y, Neufeld-Cohen A, Keshet Y, Akepati Vr, Klinghoffer Ra, Chen A, Elson A, (2011). Protein Tyrosine Phosphatase Epsilon Affects Body Weight by Downregulating Leptin Signaling in a Phosphorylation-Dependent Manner.  Cell Metabolism. 13: (5):562-572.
Regev L, Neufeld-Cohen A, Tsoory M, Kuperman Y, Getselter D, Gil S, Chen A, (2011). Prolonged and Site-Specific Over-Expression of Corticotropin-Releasing Factor Reveals Differential Roles For Extended Amygdala Nuclei in Emotional Regulation.  Molecular Psychiatry. 16: (7):714-728.
Jamieson Pm, Cleasby Me, Kuperman Y, Morton Nm, Kelly Pat, Brownstein Dg, Mustard Kj, Vaughan Jm, Carter Rn, Hahn Cn, Hardie Dg, Seckl Jr, Chen A, Vale Ww, (2011). Urocortin 3 Transgenic Mice Exhibit a Metabolically Favourable Phenotype Resisting Obesity and Hyperglycaemia on a High-Fat Diet.  Diabetologia. 54: (9):2392-2403.
Haramati S, Navon I, Issler O, Ezra-Nevo G, Gil S, Zwang R, Hornstein E, Chen A, (2011). Microrna as Repressors of Stress-Induced Anxiety: the Case of Amygdalar Mir-34.  Journal of Neuroscience. 31: (40):14191-14203.
Sterrenburg L, Gaszner B, Boerrigter J, Santbergen L, Bramini M, Elliott E, Chen A, Peeters Bwmm, Roubos Ew, Kozicz T, (2011). Chronic Stress Induces Sex-Specific Alterations in Methylation and Expression of Corticotropin-Releasing Factor Gene in the Rat.  PLoS ONE. 6: (11).

2010

Neufeld-Cohen A, Evans Ak, Getselter D, Spyroglou A, Hill A, Gil S, Tsoory M, Beuschlein F, Lowry Ca, Vale W, Chen A, (2010). Urocortin-1 And-2 Double-Deficient Mice Show Robust Anxiolytic Phenotype and Modified Serotonergic Activity in Anxiety Circuits.  Molecular Psychiatry. 15: (4):426-441.
Regev L, Ezrielev E, Gershon E, Gil S, Chen A, (2010). Genetic Approach For Intracerebroventricular Delivery.  Proceedings of the National Academy of Sciences of the United States of America. 107: (9):4424-4429.
Neufeld-Cohen A, Tsoory Mm, Evans Ak, Getselter D, Gil S, Lowry Ca, Vale Ww, Chen A, (2010). A Triple Urocortin Knockout Mouse Model Reveals an Essential Role For Urocortins in Stress Recovery.  Proceedings of the National Academy of Sciences of the United States of America. 107: (44):19020-19025.
Kuperman Y, Issler O, Regev L, Musseri I, Navon I, Neufeld-Cohen A, Gil S, Chen A, (2010). Perifornical Urocortin-3 Mediates the Link Between Stress-Induced Anxiety and Energy Homeostasis.  Proceedings of the National Academy of Sciences of the United States of America. 107: (18):8393-8398.
Haramati S, Chapnik E, Sztainberg Y, Eilam R, Zwang R, Gershoni N, Mcglinn E, Heiser Pw, Wills Am, Wirguin I, Rubin Ll, Misawa H, Tabin Cj, Brown R, Chen A, Hornstein E, (2010). Mirna Malfunction Causes Spinal Motor Neuron Disease.  Proceedings of the National Academy of Sciences of the United States of America. 107: (29):13111-13116.
Sztainberg Y, Chen A, (2010). An Environmental Enrichment Model For Mice.  Nature Protocols. 5: (9):1535-1539.
Elliott E, Ezra-Nevo G, Regev L, Neufeld-Cohen A, Chen A, (2010). Resilience to Social Stress Coincides With Functional DNA Methylation of the Crf Gene in Adult Mice.  Nature Neuroscience. 13: (11):1351-1353.
Sztainberg Y, Kuperman Y, Tsoory M, Lebow M, Chen A, (2010). The Anxiolytic Effect of Environmental Enrichment is Mediated Via Amygdalar Crf Receptor Type 1.  Molecular Psychiatry. 15: (9):905-917.

2003-2009

Lapter S, Marom A, Meshorer A, Elmann A, Sharabi A, Vadai E, Neufeld A, Sztainberg Y, Gil S, Getselter D, Chen A, Mozes E, (2009). Amelioration of Brain Pathology and Behavioral Dysfunction in Mice With Lupus Following Treatment With a Tolerogenic Peptide.  Arthritis and Rheumatism. 60: (12):3744-3754.
Sztainberg Y, Kuperman Y, Issler O, Gil S, Vaughan J, Rivier J, Vale W, Chen A (2009). A Novel Corticotropin-Releasing Factor Receptor Splice Variant Exhibits Dominant Negative Activity: a Putative Link to Stress-Induced Heart Disease.  Faseb Journal. 23: (7):2186-2196.
Kuperman Y, Chen A, (2008). Urocortins: Emerging Metabolic and Energy Homeostasis Perspectives.  Trends in Endocrinology and Metabolism. 19: (4):122-129.
Chen A, Zorrilla E, Smith S, Rousso D, Levy C, Vaughan J, Donaldson C, Roberts A, Lee Kf, Vale W. (2006). Urocortin 2-Deficient Mice Exhibit Gender-Specific Alterations in Circadian Hypothalamus-Pituitary-Adrenal Axis and Depressive-Like Behavior..  J Neurosci. 2006 May 17;. 26: (20):5500-10.
Chen A, Brar B, Choi Cs, Rousso D, Vaughan J, Kuperman Y, Kim Sn, Donaldson C, Smith Sm, Jamieson P, Li C, Nagy Tr, Shulman Gi, Lee Kf, Vale W, (2006). Urocortin 2 Modulates Glucose Utilization and Insulin Sensitivity in Skeletal Muscle.  Proceedings of the National Academy of Sciences of the United States of America. 103: (44):16580-16585.
Chen A, Perrin M, Brar B, Li C, Jamieson P, Digruccio M, Lewis K, Vale W. (2005). Mouse Corticotropin-Releasing Factor Receptor Type 2alpha Gene: Isolation, Distribution, Pharmacological Characterization and Regulation by Stress and Glucocorticoids..  Mol Endocrinol.. 19: (2):441-58.
Chen A, Perrin Mh, Digruccio Mr, Vaughan Jm, Brar Bk, Arias Cm, Lewis Ka, Rivier Je, Sawchenko Pe, Vale Ww. (2005). A Soluble Mouse Brain Splice Variant of Type 2alpha Corticotropin-Releasing Factor (Crf) Receptor Binds Ligands and Modulates Their Activity..  Proc Natl Acad Sci u s a. 2005 Feb 15. 102: (7):2620-5.
Chen A, Blount A, Vaughan J, Brar B, Vale W. (2004). Urocortin II Gene is Highly Expressed in Mouse Skin and Skeletal Muscle Tissues: Localization, Basal Expression in Corticotropin-Releasing Factor Receptor (Crfr) 1- and Crfr2-Null Mice, and Regulation by Glucocorticoids..  Endocrinology. 2004 May. 145: (5):2445-57.
Rahimipour S, Ben-Aroya N, Ziv K, Chen A, Fridkin M, Koch Y (2003). Receptor-Mediated Targeting of a Photosensitizer by Its Conjugation to Gonadotropin-Releasing Hormone Analogues.  Journal of Medicinal Chemistry. 46: ( 19):3965-3974.
Chen A, Vaughan J, Vale Ww. (2003). Glucocorticoids Regulate the Expression of the Mouse Urocortin II Gene: a Putative Connection Between the Corticotropin-Releasing Factor Receptor Pathways..  Mol Endocrinol.. 17: (8):1622-39.

2015

Issler O, Chen A (2015). Determining the Role of Micrornas in Psychiatric Disorders.  Nature Reviews Neuroscience.. 16: :201–212 .

2014

Issler O, Haramati S, Paul Ed, Maeno H, Navon I, Zwang R, Gil S, Mayberg Hs, Dunlop Bw, Menke A, Awatramani R, Binder Eb, Deneris Es, Lowry Ca, Chen A, (2014). Microrna 135 is Essential For Chronic Stress Resiliency, Antidepressant Efficacy, and Intact Serotonergic Activity.  Neuron. 83: (2):344-360.
Chen Na, Jupp B, Sztainberg Y, Lebow M, Brown Rm, Kim Jh, Chen A, Lawrence Aj, (2014). Knockdown of Crf1 Receptors in the Ventral Tegmental Area Attenuates Cue- and Acute Food Deprivation Stress-Induced Cocaine Seeking in Mice.  Journal of Neuroscience. 34: (35):11560-11570.
Volk N, Paul Ed, Haramati S, Eitan C, Fields Bkk, Zwang R, Gil S, Lowry Ca, Chen A, (2014). Microrna-19b Associates With Ago2 in the Amygdala Following Chronic Stress and Regulates the Adrenergic Receptor Beta 1.  Journal of Neuroscience. 34: (45):15070-15082.

2013

Shemesh Y, Sztainberg Y, Forkosh O, Shlapobersky T, Chen A, Schneidman E, (2013). High-Order Social Interactions in Groups of Mice.  Elife. 2. .

2012

Regev L, Tsoory M, Gil S, Chen A, (2012). Site-Specific Genetic Manipulation of Amygdala Corticotropin-Releasing Factor Reveals Its Imperative Role in Mediating Behavioral Response to Challenge.  Biological Psychiatry. 71: (4):317-326.
Lebow M, Neufeld-Cohen A, Kuperman Y, Tsoory M, Gil S, Chen A, (2012). Susceptibility to Ptsd-Like Behavior is Mediated by Corticotropin-Releasing Factor Receptor Type 2 Levels in the Bed Nucleus of the Stria Terminalis.  Journal of Neuroscience. 32: (20):6906-6916.

2011

Sztainberg Y, Kuperman Y, Chen A (2011). An Anxiolytic Role For Crf Receptor Type 1 in the Globus Pallidus..  J Neurosci. 31: (48):17416 –24.
Regev L, Neufeld-Cohen A, Tsoory M, Kuperman Y, Getselter D, Gil S, Chen A, (2011). Prolonged and Site-Specific Over-Expression of Corticotropin-Releasing Factor Reveals Differential Roles For Extended Amygdala Nuclei in Emotional Regulation.  Molecular Psychiatry. 16: (7):714-728.
Haramati S, Navon I, Issler O, Ezra-Nevo G, Gil S, Zwang R, Hornstein E, Chen A, (2011). Microrna as Repressors of Stress-Induced Anxiety: the Case of Amygdalar Mir-34.  Journal of Neuroscience. 31: (40):14191-14203.

2010

Regev L, Ezrielev E, Gershon E, Gil S, Chen A, (2010). Genetic Approach For Intracerebroventricular Delivery.  Proceedings of the National Academy of Sciences of the United States of America. 107: (9):4424-4429.
Neufeld-Cohen A, Evans Ak, Getselter D, Spyroglou A, Hill A, Gil S, Tsoory M, Beuschlein F, Lowry Ca, Vale W, Chen A, (2010). Urocortin-1 And-2 Double-Deficient Mice Show Robust Anxiolytic Phenotype and Modified Serotonergic Activity in Anxiety Circuits.  Molecular Psychiatry. 15: (4):426-441.
Kuperman Y, Issler O, Regev L, Musseri I, Navon I, Neufeld-Cohen A, Gil S, Chen A, (2010). Perifornical Urocortin-3 Mediates the Link Between Stress-Induced Anxiety and Energy Homeostasis.  Proceedings of the National Academy of Sciences of the United States of America. 107: (18):8393-8398.
Haramati S, Chapnik E, Sztainberg Y, Eilam R, Zwang R, Gershoni N, Mcglinn E, Heiser Pw, Wills Am, Wirguin I, Rubin Ll, Misawa H, Tabin Cj, Brown R, Chen A, Hornstein E, (2010). Mirna Malfunction Causes Spinal Motor Neuron Disease.  Proceedings of the National Academy of Sciences of the United States of America. 107: (29):13111-13116.
Sztainberg Y, Kuperman Y, Tsoory M, Lebow M, Chen A, (2010). The Anxiolytic Effect of Environmental Enrichment is Mediated Via Amygdalar Crf Receptor Type 1.  Molecular Psychiatry. 15: (9):905-917.
Neufeld-Cohen A, Tsoory Mm, Evans Ak, Getselter D, Gil S, Lowry Ca, Vale Ww, Chen A, (2010). A Triple Urocortin Knockout Mouse Model Reveals an Essential Role For Urocortins in Stress Recovery.  Proceedings of the National Academy of Sciences of the United States of America. 107: (44):19020-19025.
Elliott E, Ezra-Nevo G, Regev L, Neufeld-Cohen A, Chen A, (2010). Resilience to Social Stress Coincides With Functional DNA Methylation of the Crf Gene in Adult Mice.  Nature Neuroscience. 13: (11):1351-1353.
Ramot A, Jiang Z, Tian J.B, Nahum T, Kuperman Y, Justice N, Chen A (2017). Hypothalamic Crfr1 is Essential For Hpa Axis Regulation Following Chronic Stress.  Nat. Neurosci. .
Volk N, Pape J.C, Engel M, Zannas A.S, Cattane N, Cattaneo A, Binder E.B, Chen A (2016). Amygdalar Microrna-15a is Essential For Coping With Chronic Stress.  Cell Reports. 17: :1882–91.
Elliott E, Manashirov S, Zwang R, Gil S, Tsoory M, Shemesh Y, Chen A (2016). Dnmt3a in the Medial Prefrontal Cortex Regulates Anxiety-Like Behavior in Adult Mice.  Journal of Neuroscience. 36(3): :730-740.
Vaisvaser S, Modai S, Farberov L, Lin T, Sharon H, Gilam A, Volk N, Admon R, Edry L, Fruchter E, Wald I, Bar-Haim Y, Tarrasch R, Chen A, Shomron N, Hendler T (2016). Neuro-Epigenetic Indications of Acute Stress Response in Humans: the Case of Microrna-29c..  PLoS ONE. 11(1). .
Lebow M.A., Chen A (2016). Overshadowed by the Amygdala: the Bed Nucleus of the Stria Terminalis Emerges as Key to Psychiatric Disorders.  Molecular Psychiatry. 21: (4):450-463.
Kuperman, Y., Weiss, M., Dine, J., Staikin, K., Golani, O., Ramot, A., Nahum, T., Kuhne, C., Shemesh, Y., Wurst, W., Harmelin, A., Deussing, J.M., Eder, M., Chen A (2016). Crfr1 in Agrp Neurons Modulates Sympathetic Nervous System Activity to Adapt to Cold Stress and Fasting.  Cell Metab. 23: (6):1185-1199.
Amitai, M., Taler, M., Carmel, M., Michaelovsky, E., Eilat, T., Yablonski, M., Orpaz, N., Chen, A., Apter, A., Weizman, A., Fennig, S. (2016). The Relationship Between Plasma Cytokine Levels and Response to Selective Serotonin Reuptake Inhibitor Treatment in Children and Adolescents With Depression And/or Anxiety Disorders.  J Child Adolesc Psychopharmacol. 26. .
Shemesh Y, Forkosh O, Mahn M, Anpilov S, Sztainberg Y, Manashirov S, Shlapobersky T, Elliott E, Tabouy L, Ezra G, Adler Es, Ben-Efraim Yj, Gil S, Kuperman Y, Haramati S, Dine J, Eder M, Deussing Jm, Schneidman E, Yizhar O, Chen A (2016). Ucn3 and Crf-r2 in the Medial Amygdala Regulate Complex Social Dynamics.  Nat. Neurosci.. 19: (11):1489-1496.
Mjag Henckens, Y Printz, U Shamgar, J Dine, M Lebow, Y Drori, C Kuehne, A Kolarz, M Eder, Jm Deussing, Nj Justice, O Yizhar, And A Chen (2016). Crf Receptor Type 2 Neurons in the Posterior Bed Nucleus of the Stria Terminalis Critically Contribute to Stress Recovery.  Molecular Psychiatry. .
Mjag Henckens, Jm Deussing And A Chen (2016). Region-Specific Roles of the Corticotropin-Releasing Factor– Urocortin System in Stress.  Nature Reviews. 17: (10):636-651.
Issler O, Chen A (2015). Determining the Role of Micrornas in Psychiatric Disorders.  Nature Reviews Neuroscience.. 16: :201–212 .
Howerton Ar, Roland Av, Fluharty Jm, Marshall A, Chen A, Daniels D, Beck Sg, Bale Tl, (2014). Sex Differences in Corticotropin-Releasing Factor Receptor-1 Action Within the Dorsal Raphe Nucleus in Stress Responsivity.  Biological Psychiatry. 75: (11):873-883.
Issler O, Haramati S, Paul Ed, Maeno H, Navon I, Zwang R, Gil S, Mayberg Hs, Dunlop Bw, Menke A, Awatramani R, Binder Eb, Deneris Es, Lowry Ca, Chen A, (2014). Microrna 135 is Essential For Chronic Stress Resiliency, Antidepressant Efficacy, and Intact Serotonergic Activity.  Neuron. 83: (2):344-360.
Chen Na, Jupp B, Sztainberg Y, Lebow M, Brown Rm, Kim Jh, Chen A, Lawrence Aj, (2014). Knockdown of Crf1 Receptors in the Ventral Tegmental Area Attenuates Cue- and Acute Food Deprivation Stress-Induced Cocaine Seeking in Mice.  Journal of Neuroscience. 34: (35):11560-11570.
Lauriola M, Enuka Y, Zeisel A, D'Uva G, Roth L, Sharon-Sevilla M, Lindzen M, Sharma K, Nevo N, Feldman M, Carvalho S, Cohen-Dvashi H, Kedmi M, Ben-Chetrit N, Chen A, Solmi R, Wiemann S, Schmitt F, Domany E, Yarden Y, (2014). Diurnal Suppression of EGFR Signalling by Glucocorticoids and Implications For Tumour Progression and Treatment.  Nature Communications. 5. .
Volk N, Paul Ed, Haramati S, Eitan C, Fields Bkk, Zwang R, Gil S, Lowry Ca, Chen A, (2014). Microrna-19b Associates With Ago2 in the Amygdala Following Chronic Stress and Regulates the Adrenergic Receptor Beta 1.  Journal of Neuroscience. 34: (45):15070-15082.
Greenman Y, Kuperman Y, Drori Y, Asa Sl, Navon I, Forkosh O, Gil S, Stern N, Chen A, (2013). Postnatal Ablation of Pomc Neurons Induces an Obese Phenotype Characterized by Decreased Food Intake and Enhanced Anxiety-Like Behavior.  Molecular Endocrinology. 27: (7):1091-1102.
Taliaz D, Nagaraj V, Haramati S, Chen A, Zangen A, (2013). Altered Brain-Derived Neurotrophic Factor Expression in the Ventral Tegmental Area, But Not in the Hippocampus, is Essential For Antidepressant-Like Effects of Electroconvulsive Therapy.  Biological Psychiatry. 74: (4):305-312.
Shechter R, London A, Kuperman Y, Ronen A, Rolls A, Chen A, Schwartz M, (2013). Hypothalamic Neuronal Toll-Like Receptor 2 Protects Against Age-Induced Obesity.  Scientific Reports. 3. .
Shapiro H, Pecht T, Shaco-Levy R, Harman-Boehm I, Kirshtein B, Kuperman Y, Chen A, Bluher M, Shai I, Rudich A, (2013). Adipose Tissue Foam Cells Are Present in Human Obesity.  Journal of Clinical Endocrinology & Metabolism. 98: (3):1173-1181.
Lucas M, Chen A, Richter-Levin G, (2013). Hypothalamic Corticotropin-Releasing Factor is Centrally Involved in Learning Under Moderate Stress.  Neuropsychopharmacology. 38: (9):1825-1832.
Kollet O, Vagima Y, D'Uva G, Golan K, Canaani J, Itkin T, Gur-Cohen S, Kalinkovich A, Caglio G, Medaglia C, Ludin A, Lapid K, Shezen E, Neufeld-Cohen A, Varol D, Chen A, Lapidot T, (2013). Physiologic Corticosterone Oscillations Regulate Murine Hematopoietic Stem/Progenitor Cell Proliferation and Cxcl12 Expression by Bone Marrow Stromal Progenitors.  Leukemia. 27: (10):2006-2015.
Elharrar E, Warhaftig G, Issler O, Sztainberg Y, Dikshtein Y, Zahut R, Redlus L, Chen A, Yadid G, (2013). Overexpression of Corticotropin-Releasing Factor Receptor Type 2 in the Bed Nucleus of Stria Terminalis Improves Posttraumatic Stress Disorder-Like Symptoms in a Model of Incubation of Fear.  Biological Psychiatry. 74: (11):827-836.
Shemesh Y, Sztainberg Y, Forkosh O, Shlapobersky T, Chen A, Schneidman E, (2013). High-Order Social Interactions in Groups of Mice.  Elife. 2. .
Riester A, Spyroglou A, Neufeld-Cohen A, Chen A, Beuschlein F, (2012). Urocortin-Dependent Effects on Adrenal Morphology, Growth, and Expression of Steroidogenic Enzymes in Vivo.  Journal of Molecular Endocrinology. 48: (2):159-167.
Bale Tl, Chen A (2012). Minireview: Crf and Wylie Vale: a Story of 41 Amino Acids and a Texan With Grit.  Endocrinology. 153: (6):2556-2561.
Lebow M, Neufeld-Cohen A, Kuperman Y, Tsoory M, Gil S, Chen A, (2012). Susceptibility to Ptsd-Like Behavior is Mediated by Corticotropin-Releasing Factor Receptor Type 2 Levels in the Bed Nucleus of the Stria Terminalis.  Journal of Neuroscience. 32: (20):6906-6916.
Ryabinin Ae, Tsoory Mm, Kozicz T, Thiele Te, Neufeld-Cohen A, Chen A, Lowery-Gionta Eg, Giardino Wj, Kaur S, (2012). Urocortins: Crf's Siblings and Their Potential Role in Anxiety, Depression and Alcohol Drinking Behavior.  Alcohol. 46: (4):349-357.
Neufeld-Cohen A, Kelly Pat, Paul Ed, Carter Rn, Skinner E, Olverman Hj, Vaughan Jm, Issler O, Kuperman Y, Lowry Ca, Vale Ww, Seckl Jr, Chen A, Jamieson Pm (2012). Chronic Activation of Corticotropin-Releasing Factor Type 2 Receptors Reveals a Key Role For 5-Ht1a Receptor Responsiveness in Mediating Behavioral and Serotonergic Responses to Stressful Challenge.  Biological Psychiatry. 72: (6):437-447.
Sztainberg Y, Chen A, (2012). Neuropeptide Regulation of Stress-Induced Behavior: Insights from the Crf/Urocortin Family.  Handbook of Neuroendocrinology. :355-375.
Cooper A, Grigoryan G, Guy-David L, Tsoory Mm, Chen A, Reuveny E, (2012). Trisomy of the g Protein-Coupled k+ Channel Gene, Kcnj6, Affects Reward Mechanisms, Cognitive Functions, and Synaptic Plasticity in Mice.  Proceedings of the National Academy of Sciences of the United States of America. 109: (7):2642-2647.
Regev L, Tsoory M, Gil S, Chen A, (2012). Site-Specific Genetic Manipulation of Amygdala Corticotropin-Releasing Factor Reveals Its Imperative Role in Mediating Behavioral Response to Challenge.  Biological Psychiatry. 71: (4):317-326.
Amir-Zilberstein L, Blechman J, Sztainberg Y, Norton Wnj, Reuveny A, Borodovsky N, Tahor M, Bonkowsky Jl, Bally-Cuif L, Chen A, Levkowitz G, (2012). Homeodomain Protein Otp and Activity-Dependent Splicing Modulate Neuronal Adaptation to Stress.  Neuron. 73: (2):279-291.
Riester A, Issler O, Spyroglou A, Rodrig Sh, Chen A, Beuschlein F, (2012). Acth-Dependent Regulation of Microrna as Endogenous Modulators of Glucocorticoid Receptor Expression in the Adrenal Gland.  Endocrinology. 153: (1):212-222.
Sztainberg Y, Kuperman Y, Chen A (2011). An Anxiolytic Role For Crf Receptor Type 1 in the Globus Pallidus..  J Neurosci. 31: (48):17416 –24.
Kuperman Y, Issler O, Vaughan J, Bilezikjian L, Vale W, Chen A, (2011). Expression and Regulation of Corticotropin-Releasing Factor Receptor Type 2 Beta in Developing and Mature Mouse Skeletal Muscle.  Molecular Endocrinology. 25: (1):157-169.
Shema R, Haramati S, Ron S, Hazvi S, Chen A, Sacktor Tc, Dudai Y, (2011). Enhancement of Consolidated Long-Term Memory by Overexpression of Protein Kinase m Zeta in the Neocortex.  Science. 331: (6021):1207-1210.
Taliaz D, Loya A, Gersner R, Haramati S, Chen A, Zangen A, (2011). Resilience to Chronic Stress is Mediated by Hippocampal Brain-Derived Neurotrophic Factor.  Journal of Neuroscience. 31: (12):4475-4483.
Lukkes Jl, Staub Dr, Dietrich A, Truitt W, Neufeld-Cohen A, Chen A, Johnson Pl, Shekhar A, Lowry Ca, (2011). Topographical Distribution of Corticotropin-Releasing Factor Type 2 Receptor-Like Immunoreactivity in the Rat Dorsal Raphe Nucleus: co-Localization With Tryptophan Hydroxylase.  Neuroscience. 183: :47-63.
Rousso-Noori L, Knobler H, Levy-Apter E, Kuperman Y, Neufeld-Cohen A, Keshet Y, Akepati Vr, Klinghoffer Ra, Chen A, Elson A, (2011). Protein Tyrosine Phosphatase Epsilon Affects Body Weight by Downregulating Leptin Signaling in a Phosphorylation-Dependent Manner.  Cell Metabolism. 13: (5):562-572.
Regev L, Neufeld-Cohen A, Tsoory M, Kuperman Y, Getselter D, Gil S, Chen A, (2011). Prolonged and Site-Specific Over-Expression of Corticotropin-Releasing Factor Reveals Differential Roles For Extended Amygdala Nuclei in Emotional Regulation.  Molecular Psychiatry. 16: (7):714-728.
Jamieson Pm, Cleasby Me, Kuperman Y, Morton Nm, Kelly Pat, Brownstein Dg, Mustard Kj, Vaughan Jm, Carter Rn, Hahn Cn, Hardie Dg, Seckl Jr, Chen A, Vale Ww, (2011). Urocortin 3 Transgenic Mice Exhibit a Metabolically Favourable Phenotype Resisting Obesity and Hyperglycaemia on a High-Fat Diet.  Diabetologia. 54: (9):2392-2403.
Haramati S, Navon I, Issler O, Ezra-Nevo G, Gil S, Zwang R, Hornstein E, Chen A, (2011). Microrna as Repressors of Stress-Induced Anxiety: the Case of Amygdalar Mir-34.  Journal of Neuroscience. 31: (40):14191-14203.
Sterrenburg L, Gaszner B, Boerrigter J, Santbergen L, Bramini M, Elliott E, Chen A, Peeters Bwmm, Roubos Ew, Kozicz T, (2011). Chronic Stress Induces Sex-Specific Alterations in Methylation and Expression of Corticotropin-Releasing Factor Gene in the Rat.  PLoS ONE. 6: (11).
Neufeld-Cohen A, Evans Ak, Getselter D, Spyroglou A, Hill A, Gil S, Tsoory M, Beuschlein F, Lowry Ca, Vale W, Chen A, (2010). Urocortin-1 And-2 Double-Deficient Mice Show Robust Anxiolytic Phenotype and Modified Serotonergic Activity in Anxiety Circuits.  Molecular Psychiatry. 15: (4):426-441.
Regev L, Ezrielev E, Gershon E, Gil S, Chen A, (2010). Genetic Approach For Intracerebroventricular Delivery.  Proceedings of the National Academy of Sciences of the United States of America. 107: (9):4424-4429.
Neufeld-Cohen A, Tsoory Mm, Evans Ak, Getselter D, Gil S, Lowry Ca, Vale Ww, Chen A, (2010). A Triple Urocortin Knockout Mouse Model Reveals an Essential Role For Urocortins in Stress Recovery.  Proceedings of the National Academy of Sciences of the United States of America. 107: (44):19020-19025.
Kuperman Y, Issler O, Regev L, Musseri I, Navon I, Neufeld-Cohen A, Gil S, Chen A, (2010). Perifornical Urocortin-3 Mediates the Link Between Stress-Induced Anxiety and Energy Homeostasis.  Proceedings of the National Academy of Sciences of the United States of America. 107: (18):8393-8398.
Haramati S, Chapnik E, Sztainberg Y, Eilam R, Zwang R, Gershoni N, Mcglinn E, Heiser Pw, Wills Am, Wirguin I, Rubin Ll, Misawa H, Tabin Cj, Brown R, Chen A, Hornstein E, (2010). Mirna Malfunction Causes Spinal Motor Neuron Disease.  Proceedings of the National Academy of Sciences of the United States of America. 107: (29):13111-13116.
Sztainberg Y, Chen A, (2010). An Environmental Enrichment Model For Mice.  Nature Protocols. 5: (9):1535-1539.
Elliott E, Ezra-Nevo G, Regev L, Neufeld-Cohen A, Chen A, (2010). Resilience to Social Stress Coincides With Functional DNA Methylation of the Crf Gene in Adult Mice.  Nature Neuroscience. 13: (11):1351-1353.
Sztainberg Y, Kuperman Y, Tsoory M, Lebow M, Chen A, (2010). The Anxiolytic Effect of Environmental Enrichment is Mediated Via Amygdalar Crf Receptor Type 1.  Molecular Psychiatry. 15: (9):905-917.
Lapter S, Marom A, Meshorer A, Elmann A, Sharabi A, Vadai E, Neufeld A, Sztainberg Y, Gil S, Getselter D, Chen A, Mozes E, (2009). Amelioration of Brain Pathology and Behavioral Dysfunction in Mice With Lupus Following Treatment With a Tolerogenic Peptide.  Arthritis and Rheumatism. 60: (12):3744-3754.
Sztainberg Y, Kuperman Y, Issler O, Gil S, Vaughan J, Rivier J, Vale W, Chen A (2009). A Novel Corticotropin-Releasing Factor Receptor Splice Variant Exhibits Dominant Negative Activity: a Putative Link to Stress-Induced Heart Disease.  Faseb Journal. 23: (7):2186-2196.
Kuperman Y, Chen A, (2008). Urocortins: Emerging Metabolic and Energy Homeostasis Perspectives.  Trends in Endocrinology and Metabolism. 19: (4):122-129.
Chen A, Zorrilla E, Smith S, Rousso D, Levy C, Vaughan J, Donaldson C, Roberts A, Lee Kf, Vale W. (2006). Urocortin 2-Deficient Mice Exhibit Gender-Specific Alterations in Circadian Hypothalamus-Pituitary-Adrenal Axis and Depressive-Like Behavior..  J Neurosci. 2006 May 17;. 26: (20):5500-10.
Chen A, Brar B, Choi Cs, Rousso D, Vaughan J, Kuperman Y, Kim Sn, Donaldson C, Smith Sm, Jamieson P, Li C, Nagy Tr, Shulman Gi, Lee Kf, Vale W, (2006). Urocortin 2 Modulates Glucose Utilization and Insulin Sensitivity in Skeletal Muscle.  Proceedings of the National Academy of Sciences of the United States of America. 103: (44):16580-16585.
Chen A, Perrin M, Brar B, Li C, Jamieson P, Digruccio M, Lewis K, Vale W. (2005). Mouse Corticotropin-Releasing Factor Receptor Type 2alpha Gene: Isolation, Distribution, Pharmacological Characterization and Regulation by Stress and Glucocorticoids..  Mol Endocrinol.. 19: (2):441-58.
Chen A, Perrin Mh, Digruccio Mr, Vaughan Jm, Brar Bk, Arias Cm, Lewis Ka, Rivier Je, Sawchenko Pe, Vale Ww. (2005). A Soluble Mouse Brain Splice Variant of Type 2alpha Corticotropin-Releasing Factor (Crf) Receptor Binds Ligands and Modulates Their Activity..  Proc Natl Acad Sci u s a. 2005 Feb 15. 102: (7):2620-5.
Chen A, Blount A, Vaughan J, Brar B, Vale W. (2004). Urocortin II Gene is Highly Expressed in Mouse Skin and Skeletal Muscle Tissues: Localization, Basal Expression in Corticotropin-Releasing Factor Receptor (Crfr) 1- and Crfr2-Null Mice, and Regulation by Glucocorticoids..  Endocrinology. 2004 May. 145: (5):2445-57.
Rahimipour S, Ben-Aroya N, Ziv K, Chen A, Fridkin M, Koch Y (2003). Receptor-Mediated Targeting of a Photosensitizer by Its Conjugation to Gonadotropin-Releasing Hormone Analogues.  Journal of Medicinal Chemistry. 46: ( 19):3965-3974.
Chen A, Vaughan J, Vale Ww. (2003). Glucocorticoids Regulate the Expression of the Mouse Urocortin II Gene: a Putative Connection Between the Corticotropin-Releasing Factor Receptor Pathways..  Mol Endocrinol.. 17: (8):1622-39.