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Shechter R, London A, Kuperman Y, Ronen A, Rolls A, Chen A, Schwartz M. (2013). Hypothalamic neuronal toll-like receptor 2 protects against age-induced obesity. Sci. Rep. |
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Shapiro H, Pecht T, Shaco-Levy R, Harman-Boehm I, Kirshtein B, Kuperman Y, Chen A, Blüher M, Shai I, Rudich A. (2013). Adipose Tissue Foam Cells Are Present in Human Obesity. J Clin Endocrin Metab. |
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Taliaz D, Nagaraj V, Haramati S, Chen A, Zangen A. (2012) Altered Brain-Derived Neurotrophic Factor Expression in the Ventral Tegmental Area, but not in the Hippocampus, Is Essential for Antidepressant-Like Effects of Electroconvulsive Therapy. Biol Psychiatry. |
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Ryabinin AE, Tsoory MM, Kozicz T, Thiele TE, Neufeld-Cohen A, Chen A, Lowery-Gionta EG, Giardino WJ, Kaur S. (2012). Urocortins: CRF’s siblings and their potential role in anxiety, depression and alcohol drinking behavior. Alcohol 46:349-57. |
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Neufeld-Cohen A, Kelly PAT, Paul ED, Carter RN, Skinner E, Olverman HJ, Vaughan JM, Issler O, Kuperman Y, Lowry CA, Vale WW, Seckl JR, Chen A and Jamieson PM. (2012). Chronic Activation of Corticotropin-Releasing Factor Type 2 Receptors Reveals a Key Role for 5-HT1A Receptor Responsiveness in Mediating Behavioral and Serotonergic Responses to Stressful Challenge. Biol Psychiatry. |
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Lebow M, Neufeld-Cohen A, Kuperman Y, Tsoory M, Gil S and Chen A. (2012). Susceptibility to PTSD-Like Behavior Is Mediated by Corticotropin-Releasing Factor Receptor Type 2 Levels in the Bed Nucleus of the Stria Terminalis. J Neurosci 32:6906-16. |
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Amir-Zilberstein L, Blechman J, Sztainberg Y, Norton WHJ, Reuveny A, Borodovsky N, Tahor M, Bonkowsky JL, Bally-Cuif L, Chen A and Levkowitz G. (2012). Homeodomain Protein Otp and Activity-Dependent Splicing Modulate Neuronal Adaptation to Stress. Neuron 73:279-91. |
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Riester A, Spyroglou A, Neufeld-Cohen A, Chen A and Beuschlein F. (2012) Urocortin dependent effects on adrenal morphology, growth and expression of steroidogenic enzymes in vivo. JME. |
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Cooper A, Grigoryan G, Guy-David L, Tsoory MM, Chen A and Reuveny E. (2012) Trisomy of the G protein-coupled K+ channel gene,Kcnj6, affects reward mechanisms, cognitive functions, and synaptic plasticity in mice. PNAS 109:2642-7. |
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Riester A, Issler O, Spyroglou A, Haramati Rodrig S, Chen A and Beuschlein F. (2012) ACTH-Dependent Regulation of microRNA As Endogenous Modulators of Glucocorticoid Receptor Expression in the Adrenal. Endocrinology 153(1). |
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Sztainberg Y, Chen A. (2011) Neuropeptide Regulation of Stres- Induced Behavior: Insights from the CRF/Urocortin Family. In: Fink G, Pfaff DW, Levine JE, eds. Handbook of Neuroendocrinology. London, Waltham, San Diego: Academic press, Elsevier; 2012:355-76. |
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Sztainberg Y, Kuperman Y, Justice N and Chen A. (2011) An Anxiolytic Role for CRF Receptor Type 1 in the Globus Pallidus. J Neurosci. 31(48):17416 –24. |
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Haramati S, Navon I, Issler O, Ezra-Nevo G, Gil S, Zwang R, Horenstein E and Chen A. (2011) microRNA as Repressors of Stress-Induced Anxiety: The Case of Amygdalar miR-34. J Neurosci. 31:14191-203. |
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Regev L, Tsoory M, Gil S and Chen A. (2011) Site-specific genetic manipulation of amygdala CRF reveals its imperative role in mediating behavioral response to challenge. Biological Psychiatry In Press. |
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Shema, R., Haramati, S., Ron, S., Hazvi, S., Chen, A., Sacktor, TC., and Dudai. Y. (2011) Enhancement of consolidated long-term memory by overexpression of protein kinase Mzeta in the neocortex. Science. 331:1207-10. |
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Jamieson, P.M., Cleasby, M.E., Kuperman, Y., Morton, N.M., Kelly, P.A., Brownstein, D.G., Mustard, K.J., Vaughan, J.M., Carter, R.N., Hahn, C.N., Hardie, D.G., Seckl, J.R., Chen, A., and Vale, W.W. (2011) Urocortin 3 transgenic mice exhibit a metabolically favourable phenotype resisting obesity and hyperglycaemia on a high-fat diet. Diabetologia. 54:2392-2403. |
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Rousso-Noori, L., Knobler, H., Levy-Apter, E., Kuperman, Y., Neufeld-Cohen, A., Keshet, Y., Akepati, VR., Klinghoffer, RA., Chen, A., and Elson, A. (2011) Protein tyrosine phosphatase epsilon affects body weight by downregulating leptin signaling in a phosphorylation-dependent manner. Cell Metab. 13:562-72. |
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Taliaz, D., Loya, A., Gersner, R., Haramati, S., Chen, A., and Zangen, A. (2011) Resilience to chronic stress is mediated by hippocampal brain-derived neurotrophic factor. J Neurosci. 31:4475-83. |
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Kuperman, Y., Issler, O., Vaughan, J., Bilezikjian, L., Vale, W., and Chen, A. (2011) Expression and regulation of corticotropin-releasing factor receptor type 2β in developing and mature mouse skeletal muscle. Mol Endocrinol. 25:157-69. |
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Regev L, Neufeld-Cohen A, Tsoory M, Kuperman Y, Getselter D, Gil S, Chen A. (2011) Prolonged and site-specific over-expression of corticotropin-releasing factor reveals differential roles for extended amygdala nuclei in emotional regulation. Mol Psychiatry. 16:714-728. |
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Neufeld-Cohen, A., Tsoory, MM., Evans, AK., Getselter, D., Gil, S., Lowry, CA., Vale, WW., and Chen, A. (2010) A triple urocortin knockout mouse model reveals an essential role for urocortins in stress recovery. Proc Natl Acad Sci U S A. 107,19020-5. |
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Elliott, E., Ezra-Nevo G., Regev L., Neufeld-Cohen, A. and Chen A. (2010) Resilience to social stress coincides with functional DNA methylation of the CRF gene in adult mice. Nat. Neuroscience 13, 1351–1353. |
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Sztainberg, Y. and Chen, A. (2010) An environmental enrichment model for mice, Nature Protocols 15, 1535-9. |
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Sztainberg, Y., Kuperman, Y., Tsoory, M., Lebow, M., and Chen, A. (2010) The anxiolytic effect of environmental enrichment is mediated via amygdalar CRF receptor type 1. Molecular Psychiatry. |
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Kuperman, Y., Issler, O., Regev, L., Musseri, I., Navon, I., Neufeld-Cohen, A., Gil, S., and Chen, A. (2010) Perifornical Urocortin-3 mediates the link between stress-induced anxiety and energy homeostasis. Proc Natl Acad Sci U S A 107, 8393-8. |
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Haramati, S., Chapnik, E., Sztainberg, Y., Eilam, R., Zwang R.,Gershoni, N., McGlinn, E., Heiser, P., Wills, A., Wirguin, I., Rubin, L., Misawa, H., Tabin, C., Brown, R. Jr., Chen, A. and Hornstein, E. (2010) miRNA malfunction causes spinal motor neuron disease. Proc Natl Acad Sci U S A 107, 13111-6. |
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Regev, L., Ezrielev, E., Gershon, E., Gil, S., and Chen, A. (2010) Genetic approach for intracerebroventricular delivery, Proc Natl Acad Sci U S A 107, 4424-9. |
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Neufeld-Cohen, A., Evans, AK., Getselter, D., Spyroglou, A., Hill, A., Gil, S., Tsoory, M., Beuschlein, F., Lowry, CA., Vale, W. and Chen, A. (2010) Urocortin-1 and -2 double-deficient mice show robust anxiolytic phenotype and modified serotonergic activity in anxiety circuits, Molecular Psychiatry 15, 426-41, 339. |
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Lapter, S., Marom, A., Meshorer, A., Elmann, A., Sharabi, A., Vadai, E., Neufeld, A., Sztainberg, Y., Gil, S., Getselter, D., Chen, A., Mozes, E. (2009) Amelioration of brain pathology and behavioral dysfunction in mice with lupus following treatment with a tolerogenic peptide. Arthritis Rheum. 60:3744-54. |
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Sztainberg, Y., Kuperman, Y., Issler, O., Gil, S., Vaughan, J., Rivier, J., Vale, W., and Chen, A. (2009) A novel corticotropin-releasing factor receptor splice variant exhibits dominant negative activity: a putative link to stress-induced heart disease. FASEB J 23, 2186-96. |
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Kuperman, Y., and Chen, A., (2008) Urocortins: Emerging metabolic and energy homeostasis perspectives. Trends Endocrinol Metab. 19, 122-129. |
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Chen, A., Brar, B., Choi, C.S., Rousso, D., Vaughan, J., Kuperman, Y., Kim, S.N., Donaldson, C., Smith, S.M., Jamieson, P., Li, C., Nagy, T., Shulman, G., Lee, K.F., and Vale, W. (2006) Urocortin 2 modulates glucose utilization and insulin sensitivity in skeletal muscle. Proc Natl Acad Sci U S A 103, 16580-16585. |
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Chen, A., Zorrilla, E., Smith, S., Rousso, D., Levy, C., Vaughan, J., Donaldson, C., Roberts, A., Lee, K.F., and Vale, W. (2006) Urocortin 2-deficient mice exhibit gender-specific alterations in circadian hypothalamus-pituitary-adrenal axis and depressive-like behavior. J Neurosci. 26, 5500-5510. |
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Chen, A., Perrin, M., Brar, B., Li, C., Jamieson, P., Digruccio, M., Lewis, K., and Vale, W. (2005) Mouse corticotropin releasing factor receptor type 2{alpha} gene: isolation, distribution, pharmacological characterization and regulation by stress and glucocorticoids. Mol Endocrinol. 19, 441-458. |
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Chen, A., Perrin, M., DiGruccio, M., Vaughan, J., Brar, B., Arias, C., Lewis, K., Rivier, J., Sawchenko, P., and Vale, W. (2005) A soluble mouse brain splice variant of type 2a corticotropin-releasing factor (CRF) receptor binds ligands and modulates their activity. Proc Natl Acad Sci U S A. 102, 2620-2625. |
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Chen, A., Vaughan, J., and Vale, W.W. (2003) Glucocorticoids regulate the expression of the mouse Urocortin II Gene: a putative connection between the corticotropin-releasing factor receptor pathways. Mol Endocrinol. 17, 1622-1639. |
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