Circadian rhythmicity is a fundamental property present in almost all light-sensitive organisms, from cyanobacteria, through plants, flies to humans. As earth completes each rotation every 24 hours, such an endogenous clock assists organisms to predict and adapt to daily environmental changes. These diurnal rhythms in physiology and behavior have been studied for centuries, but only recently a tremendous leap has been made in our understanding of these key processes.

The mammalian circadian timing system consists of a central pacemaker in the brain that synchronizes subsidiary oscillators in virtually all cells of the body. All these oscillators were found to share a similar molecular makeup, and are maintained through interconnected transcriptional-translational feedback loops of core clock genes. While the brain’s master clock is entrained by daily light-dark cycles, feeding time appears to be the dominant timing cue for peripheral clocks.

Compelling evidence points toward a tight intertwining between circadian rhythms and metabolism. Circadian clocks play a major role in orchestrating daily metabolism and their disruption can lead to metabolic diseases such as diabetes and obesity. Concomitantly, clocks are tightly coupled to cellular metabolism and respond to feeding cycles. Our overarching goal is to uncover molecular mechanism within the core clock circuitry in respect to cellular metabolism and identify metabolic cycles in mammals

News & Announcements

2 Jan 2023
QUADRIVIUM: music and science coming together

A culmination of a year-long project in musical and scientific creativity.

Final meeting:   January 22, 2023, 19:00 Clairmont concert hall, Buchmann-Mehta School of Music, Tel Aviv University

25 Oct 2022
Congratulations to Gal Manella on a new publication!
13 Feb 2022
Quadrivium: Music and Science coming together

Second meeting: June 6, 2022, 14:00-16:30. Wolfson Auditorium, Weizmann Institute of Science. Click here for details

2 Jan 2022
New paper for a great ending of 2021, congratulations!
congratulations to Gal Manella!
21 Oct 2021

We report here the development of an efficient and high throughput assay, dubbed Circadian Single-Cell Oscillators PTC Extraction (CircaSCOPE), for generating high-resolution PTCs. 

13 Dec 2020
Like clockwork

Two research students confronted the metaphor underlying the scientific thinking in their field



9 Feb 2020

Circadian rhythms at the highest city in the world, La Rinconada, Peru

9 Dec 2018

Our student organized meeting Timeline in Biology 2018: From a Solo Recital to a Full Orchestra