Research

Time-of-Day Control of Hypoxic Liver Response via BMAL1 and HIF1α

Key transcription factors jointly regulate the liver’s response to low oxygen (hypoxia) in a time-of-day-dependent manner.

CO₂ and the Circadian Clock: Linking Gas Sensing and Lipid Metabolism

A new role for carbon dioxide (CO₂) in regulating circadian metabolism. While the impact of oxygen on circadian timing primarily through the sensor HIF1α is well characterized, how CO₂ signals to the clock remains an open question

Oxygen and Circadian Clocks

Studying the interplay between oxygen-sensing and circadian clocks has never been more exciting!

Interactions between circadian clocks and exercise physiology

Studying various aspects of exercise physiology through the lens of circadian biology.

Oscillations in metabolite levels and metabolic pathways

We employ high throughput approaches to identify oscillations in metabolite levels and metabolic pathways.

Resetting of peripheral clocks

Do all peripheral clocks respond the same, or is there tissue-specificity? Do different peripheral tissues communicate time information between each other, and how?

Unconventional Oscillations, Alternative Clocks

We are looking for a) additional clock-independent rhythms; b) potential function consequences of these rhythms on the animal’s well-being; and c) mechanistic insights into the alternative oscillator clockwork.