All events

Firing Rate Homeostasis in Neural Circuits: From basic principles to malfunctions

Lecture
Date:
Tuesday, November 9, 2021
Hour: 12:30
Location:
Gerhard M.J. Schmidt Lecture Hall
Prof. Inna Slutsky
|
Head, Dept of Physiology and Pharmacology Sackler Faculty of Medicine, Tel Aviv University

Maintaining average activity level within a set-point range constitutes a fundamental property of central neural circuits. Accumulated evidence suggests that firing rate distributions and their means represent physiological variables regulated by homeostatic systems. Utilizing basic concepts of control theory, we developed a theoretical and experimental framework for identifying the core members of homeostatic machinery. I will describe an integrative approach to study the relationships between ongoing spiking activity of individual neurons and neuronal populations in local microcircuits, synaptic transmission and plasticity, sleep and memory functions. I will show our new data on a state-dependent regulation of firing rate set-points, their dysregulation at the presymptomatic stage of Alzheimer’s disease, and the role of mitochondria in these processes.

To be announced

Lecture
Date:
Tuesday, November 23, 2021
Hour: 12:30
Location:
Gerhard M.J. Schmidt Lecture Hall
Prof. Michal Irani
|
Dept of Computer Science and Applied Mathematics, WIS

To be announced

Lecture
Date:
Tuesday, November 30, 2021
Hour: 14:00
Location:
Catherine Dulac
|
Harvard

To be announced

Lecture
Date:
Tuesday, December 7, 2021
Hour: 12:30
Location:
Bernhard Staresina
|
Birmingham University

To be announced

Lecture
Date:
Tuesday, December 14, 2021
Hour: 12:30
Location:
Gerhard M.J. Schmidt Lecture Hall
Boaz Barak
|
TAU

To be announced

Lecture
Date:
Tuesday, December 28, 2021
Hour: 12:30
Location:
Gerhard M.J. Schmidt Lecture Hall
Shai Sabah
|
HUJI

Sleep-related memory consolidation in humans: beyond single, isolated memories

Lecture
Date:
Wednesday, December 29, 2021
Hour: 14:00 - 15:00
Location:
Gerhard M.J. Schmidt Lecture Hall
Dr. Eitan Schechtman
|
Northwestern University, Evanston, Illinois

Sleep is critical for the stabilization of memories. This process is thought to be supported by the reactivation of memories, thereby strengthening the neural infrastructure supporting them. Theoretical accounts of this consolidation process focus on the process through which memories are independently strengthened, but in natural settings individual memories never exist in a vacuum. In this talk, I will present a series of studies exploring the extent of memory reactivation during sleep in humans, how interactions between memories impact the consolidation process, and the role of encoding context in memory processing during sleep. The main technique used to explore memory reactivation in these studies is targeted memory reactivation, a behavioral manipulation that can selectively bias consolidation during sleep. The results demonstrate that multiple semantically related memories can be simultaneously consolidated during sleep. Additionally, they show that memory reactivation during sleep may involve contextual reinstatement, thereby impacting multiple contextually linked memories. These data suggest that reactivation during sleep is not limited to single memory items, and can occur at the network or brain-state level. Relatedly, we show that reactivating a suppression state during sleep can be used to selectively weaken memories. Taken together, these results inform our current understanding regarding memory consolidation processes and open new avenues for translatable research to alleviate memory-related symptoms in patients suffering from psychiatric disorders.

To be announced

Lecture
Date:
Tuesday, January 11, 2022
Hour: 15:30
Location:
Naoshige Uchida
|
Harvard

To be announced

Lecture
Date:
Tuesday, January 25, 2022
Hour: 12:30
Location:
Gerhard M.J. Schmidt Lecture Hall
Alex Borst
|
Max Planck

To be announced

Lecture
Date:
Tuesday, February 1, 2022
Hour: 12:30
Location:
Claudia Clopath
|
Imperial College

To be announced

Lecture
Date:
Tuesday, March 1, 2022
Hour: 12:30
Location:
Gerhard M.J. Schmidt Lecture Hall
Alex L. Kolodkin
|
JHU

Brain plasticity: Regulation and Modulation

Conference
Date:
Monday, May 16, 2022
Hour: 08:00 - 18:00
Location:
David Lopatie Conference Centre

All events

Firing Rate Homeostasis in Neural Circuits: From basic principles to malfunctions

Lecture
Date:
Tuesday, November 9, 2021
Hour: 12:30
Location:
Gerhard M.J. Schmidt Lecture Hall
Prof. Inna Slutsky
|
Head, Dept of Physiology and Pharmacology Sackler Faculty of Medicine, Tel Aviv University

Maintaining average activity level within a set-point range constitutes a fundamental property of central neural circuits. Accumulated evidence suggests that firing rate distributions and their means represent physiological variables regulated by homeostatic systems. Utilizing basic concepts of control theory, we developed a theoretical and experimental framework for identifying the core members of homeostatic machinery. I will describe an integrative approach to study the relationships between ongoing spiking activity of individual neurons and neuronal populations in local microcircuits, synaptic transmission and plasticity, sleep and memory functions. I will show our new data on a state-dependent regulation of firing rate set-points, their dysregulation at the presymptomatic stage of Alzheimer’s disease, and the role of mitochondria in these processes.

To be announced

Lecture
Date:
Tuesday, November 23, 2021
Hour: 12:30
Location:
Gerhard M.J. Schmidt Lecture Hall
Prof. Michal Irani
|
Dept of Computer Science and Applied Mathematics, WIS

To be announced

Lecture
Date:
Tuesday, November 30, 2021
Hour: 14:00
Location:
Catherine Dulac
|
Harvard

To be announced

Lecture
Date:
Tuesday, December 7, 2021
Hour: 12:30
Location:
Bernhard Staresina
|
Birmingham University

To be announced

Lecture
Date:
Tuesday, December 14, 2021
Hour: 12:30
Location:
Gerhard M.J. Schmidt Lecture Hall
Boaz Barak
|
TAU

To be announced

Lecture
Date:
Tuesday, December 28, 2021
Hour: 12:30
Location:
Gerhard M.J. Schmidt Lecture Hall
Shai Sabah
|
HUJI

Sleep-related memory consolidation in humans: beyond single, isolated memories

Lecture
Date:
Wednesday, December 29, 2021
Hour: 14:00 - 15:00
Location:
Gerhard M.J. Schmidt Lecture Hall
Dr. Eitan Schechtman
|
Northwestern University, Evanston, Illinois

Sleep is critical for the stabilization of memories. This process is thought to be supported by the reactivation of memories, thereby strengthening the neural infrastructure supporting them. Theoretical accounts of this consolidation process focus on the process through which memories are independently strengthened, but in natural settings individual memories never exist in a vacuum. In this talk, I will present a series of studies exploring the extent of memory reactivation during sleep in humans, how interactions between memories impact the consolidation process, and the role of encoding context in memory processing during sleep. The main technique used to explore memory reactivation in these studies is targeted memory reactivation, a behavioral manipulation that can selectively bias consolidation during sleep. The results demonstrate that multiple semantically related memories can be simultaneously consolidated during sleep. Additionally, they show that memory reactivation during sleep may involve contextual reinstatement, thereby impacting multiple contextually linked memories. These data suggest that reactivation during sleep is not limited to single memory items, and can occur at the network or brain-state level. Relatedly, we show that reactivating a suppression state during sleep can be used to selectively weaken memories. Taken together, these results inform our current understanding regarding memory consolidation processes and open new avenues for translatable research to alleviate memory-related symptoms in patients suffering from psychiatric disorders.

To be announced

Lecture
Date:
Tuesday, January 11, 2022
Hour: 15:30
Location:
Naoshige Uchida
|
Harvard

To be announced

Lecture
Date:
Tuesday, January 25, 2022
Hour: 12:30
Location:
Gerhard M.J. Schmidt Lecture Hall
Alex Borst
|
Max Planck

To be announced

Lecture
Date:
Tuesday, February 1, 2022
Hour: 12:30
Location:
Claudia Clopath
|
Imperial College

To be announced

Lecture
Date:
Tuesday, March 1, 2022
Hour: 12:30
Location:
Gerhard M.J. Schmidt Lecture Hall
Alex L. Kolodkin
|
JHU

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All events

Brain plasticity: Regulation and Modulation

Conference
Date:
Monday, May 16, 2022
Hour: 08:00 - 18:00
Location:
David Lopatie Conference Centre