Stress Linked Psychopathologies

Lopez JP, Lücken MD, Brivio E, Karamihalev S, Kos A, De Donno C, Benjamin A, Yang H, Dick ALW, Stoffel R, Flachskamm C, Ressle A, Roeh S, Huettl RE, Parl A, Eggert C, Novak B, Yan Y, Yeoh K, Holzapfel M, Hauger B, Harbich D, Schmid B, Di Giaimo R, Turck CW, Schmidt MV, Deussing JM, Eder M, Dine J, Theis FJ, Chen A.

Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2. Neuron, doi: 10.1016/j.neuron.2022.05.001.

Amitai M, Kaffman S, Kroizer E, Lebow M, Magen I, Benaroya-Milshtein N, Fennig S, Weizman A, Apter A, Chen A.
Neutrophil to-lymphocyte and platelet-to-lymphocyte ratios as biomarkers for suicidal behavior in children and adolescents with depression or anxiety treated with selective serotonin reuptake inhibitors. Brain Behav. Immun.. doi: 10.1016/j.bbi.2022.04.018.

Benjamin A, Kuperman Y, Eren N, Rotkopf R, Amitai M, Rossman H, Shilo S, Meir T, Keshet A, Nuttman-Shwartz O, Segal E, Chen A.
Stress-related emotional and behavioural impact following the first COVID-19 outbreak peak. Mol Psychiatry. doi: 10.1038/s41380-021-01219-6.

Mevorach T, Taler M, Dar S, Lebow M, Schorr Sapir I, Rotkopf R, Apter A, Fennig S, Chen A, Weizman A, Amitai M.
The relationship between the plasma proinflammatory cytokine levels of depressed/anxious children and their parents. Sci Rep 11, Article number: 11798. doi: 10.1038/s41598-021-90971-4.

Bortolozzi A, Manashirov S, Chen A, Artigas F.
Oligonucleotides as therapeutic tools for brain disorders: Focus on major depressive disorder and Parkinson's disease. Pharmacol Ther. 2021 Apr 26;107873. doi: 10.1016/j.pharmthera.2021.107873.

Lopez JP, Brivio E, Santambrogio A, De Donno C, Kos A, Peters M, Rost N, Czamara D, Brückl TM, Roeh S, Pöhlmann ML, Engelhardt C, Ressle A, Stoffel R, Tontsch A, Villamizar JM, Reincke M, Riester A, Sbiera S, Fassnacht M, Mayberg HS, Craighead WE, Dunlop BW, Nemeroff CB, Schmidt MV, Binder EB, Theis FJ, Beuschlein F, Andoniadou CL, Chen A.
Single-cell molecular profiling of all three components of the HPA axis reveals adrenal ABCB1 as a regulator of stress adaptation. Science Advances, vol. 7, no. 5, eabe4497.

Fiori LM, Kos A, Lin R, Théroux JF, Lopez JP, Kühne C, Eggert C, Holzapfel M, Hüttl RE, Mechawar N, Belzung C, Ibrahim EC, Chen A, Turecki G.
miR-323a regulates ERBB4 and is involved in depression. Mol Psychiatry. doi: 10.1038/s41380-020-00953-7.

Amitai M, Taler M, Lebow M, Ben-Baruch R, Apter A, Fennig S, Weizman A, Chen A
An increase in IL-6 levels at 6-month follow-up visit is associated with SSRI-emergent suicidality in high-risk children and adolescents treated with fluoxetine. Eur Neuropsychopharmacol, 40, 61-69. doi: 10.1016/j.euroneuro.2020.07.007