Stress Linked Psychopathologies

Fiori LM, Kos A, Lin R, Théroux JF, Lopez JP, Kühne C, Eggert C, Holzapfel M, Hüttl RE, Mechawar N, Belzung C, Ibrahim EC, Chen A, Turecki G.
miR-323a regulates ERBB4 and is involved in depression. Mol Psychiatry. doi: 10.1038/s41380-020-00953-7.

Amitai M, Taler M, Lebow M, Ben-Baruch R, Apter A, Fennig S, Weizman A, Chen A
An increase in IL-6 levels at 6-month follow-up visit is associated with SSRI-emergent suicidality in high-risk children and adolescents treated with fluoxetine. Eur Neuropsychopharmacol, 40, 61-69. doi: 10.1016/j.euroneuro.2020.07.007

Amitai M, Taler M, Ben-Baruch R, Lebow M, Rotkopf R, Apter A, Fennig S, Weizman A, Chen A.
Increased circulatory IL-6 during 8-week fluoxetine treatment is a risk factor for suicidal behaviors in youth. Brain Behav Immun., pii: S0889-1591(19)31330-3.

Lebow MA, Schroeder M, Tsoory M, Holzman-Karniel D, Mehta D, Ben-Dor S, Gil S, Bradley B, Smith AK, Jovanovic T, Ressler KJ, Binder EB, Chen A.
Glucocorticoid-induced leucine zipper “quantifies” stressors and increases male susceptibility to PTSD. Transl. Psychiatry, volume 9, Article number: 178.

Schroeder M, Jakovcevski M, Polacheck T, Drori Y, Ben-Dor S, Röh S, Chen A.
Sex dependent impact of gestational stress on predisposition to eating disorders and metabolic disease. Mol Metab. pii: S2212-8778(18)30624-0.

Engel M, Eggert C, Kaplick PM, Eder M, Roeh S, Tietze L, Namendorf C, Arloth J, Weber P, Rex-Haffner M, Geula S, Jakovcevski M, Hanna JH, Leshkowitz D, Uhr M, Wotjak CT, Schmidt MV, Deussing JM, Binder EB, Chen A.
The Role of m6A/m-RNA Methylation in Stress Response Regulation. Neuron. 99(2):389-403.e9.

Dedic N, Kühne C, Jakovcevski M, Hartmann J, Genewsky AJ, Gomes KS, Anderzhanova E, Pöhlmann ML, Chang S, Kolarz A, Vogl AM, Dine J, Metzger MW, Schmid B, Almada RC, Ressler KJ, Wotjak CT, Grinevich V, Chen A, Schmidt MV, Wurst W, Refojo D, Deussing JM.
Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety. Nat Neurosci. 21(6):803-807.

Schroeder M, Jakovcevski M, Polacheck T, Drori Y, Luoni A, Röh S, Zaugg J, Ben-Dor S, Albrecht C, Chen A.
Placental miR-340 mediates vulnerability to activity based anorexia in mice. Nat Commun. 9(1):1596.

Engel M and Chen A.
The emerging role of mRNA methylation in normal and pathological behavior. Genes Brain Behav. 2017;e12428.