Publications

2024

Bispecific dendritic-T cell engager potentiates anti-tumor immunity

Shapir Itai Y., Barboy O., Salomon R., Bercovich A., Xie K., Winter E., Shami T., Porat Z., Erez N., Tanay A., Amit I. & Dahan R. (2024) Cell. Abstract

2023

Fc glycoengineering of a PD-L1 antibody harnesses Fcγ receptors for increased antitumor efficacy

Cohen Saban N., Yalin A., Landsberger T., Salomon R., Alva A., Feferman T., Amit I. & Dahan R. (2023) Science immunology. Abstract

FcγRIIB is an immune checkpoint limiting the activity of Treg-targeting antibodies in the tumor microenvironment

Knorr D. A., Blanchard L., Leidner R. S., Jensen S. M., Meng R., Jones A., Ballesteros-Merino C., Bell R. B., Baez M., Marino A., Sprott D., Bifulco C. B., Piening B., Dahan R., Osorio J. C., Fox B. A. & Ravetch J. V. (2023) Cancer immunology research. Abstract

2022

Therapeutic antibody activation of the glucocorticoid-induced TNF receptor by a clustering mechanism

He C., Maniyar R. R., Avraham Y., Zappasodi R., Rusinova R., Newman W., Heath H., Wolchok J. D., Dahan R., Merghoub T. & Meyerson J. (2022) Science advances. Abstract

Bispecific antibodies increase the therapeutic window of CD40 agonists through selective dendritic cell targeting

Salomon R., Rotem H., Katzenelenbogen Y., Weiner A., Cohen Saban N., Feferman T., Amit I. & Dahan R. (2022) Nature Cancer. Abstract

Artificial Antigen Presenting Cells for Detection and Desensitization of Autoreactive T cells Associated with Type 1 Diabetes

Artzy-Schnirman A., Abu-Shah E., Chandrawati R., Altman E., Yusuf N., Wang S., Ramos J., Hansel C. S., Haus-Cohen M., Dahan R., Arif S., Dustin M. L., Peakman M., Reiter Y. & Stevens M. M. (2022) Nano Letters. Abstract

Next Generation CD40 Agonistic Antibodies for Cancer Immunotherapy

Salomon R. & Dahan R. (2022) Frontiers in Immunology. Abstract

2021

Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis

Watson A., Li H., Ma B., Weiss R., Bendayan D., Abramovitz L., Ben-Shalom N., Mor M., Pinko E., Bar Oz M., Wang Z., Du F., Lu Y., Rybniker J., Dahan R., Huang H., Barkan D., Xiang Y., Javid B. & Freund N. T. (2021) Nature Communications. Abstract

Unified platform for genetic and serological detection of COVID-19 with single-molecule technology

Furth N., Shilo S., Cohen N., Erez N., Fedyuk V., Schrager A. M., Weinberger A., Dror A. A., Zigron A., Shehadeh M., Sela E., Srouji S., Amit S., Levy I., Segal E., Dahan R., Jones D., Douek D. C. & Shema E. (2021) PLoS ONE. Abstract

Anti-SARS-CoV-2 antibodies elicited by COVID-19mRNA vaccine exhibit a unique glycosylation pattern

Farkash I., Feferman T., Cohen-Saban N., Avraham Y., Morgenstern D., Mayuni G., Barth N., Lustig Y., Miller L., Shouval D. S., Biber A., Kirgner I., Levin Y. & Dahan R. (2021) Cell reports (Cambridge). Abstract

2020

Single-cell genomic approaches for developing the next generation of immunotherapies

Yofe I., Dahan R. & Amit I. (2020) Nature Medicine. Abstract

Testing IgG antibodies against the RBD of SARS-CoV-2 is sufficient and necessary for COVID-19 diagnosis

Indenbaum V., Koren R., Katz-Likvornik S., Yitzchaki M., Halpern O., Regev-Yochay G., Cohen C., Biber A., Feferman T., Saban N. C., Dahan R., Levin T., Gozlan Y., Weil M., Mor O., Mandelboim M., Sofer D., Mendelson E. & Lustig Y. (2020) PLoS ONE. Abstract

2019

BCR affinity differentially regulates colonization of the subepithelial dome and infiltration into germinal centers within Peyer's patches

Biram A., Stromberg A., Winter E., Stoler-Barak L., Salomon R., Addadi Y., Dahan R., Yaari G., Bemark M. & Shulman Z. (2019) Nature Immunology. Abstract

2018

Toxicity of an Fc-engineered anti-CD40 antibody is abrogated by intratumoral injection and results in durable antitumor immunity

Knorr D. A., Dahan R. & Ravetch J. (2018) Proceedings Of The National Academy Of Sciences Of The United States Of America-Physical Sciences. Abstract

2017

Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors

Vargas F. A., Furness A. J. S., Solomon I., Joshi K., Mekkaoui L., Lesko M. H., Rota E. M., Dahan R., Georgiou A., Sledzinska A., Ben Aissa A. A., Franz D., Sunderland M. W., Wong Y. N. S., Henry J. Y., O'Brien T., Nicol D., Challacombe B., Beers S. A., Turajlic S., Gore M., Larkin J., Swanton C., Chester K. A., Pule M., Ravetch J. V., Marafioti T., Peggs K. S. & Quezada S. A. (2017) Immunity.

Signaling by Antibodies: Recent Progress

Bournazos S., Wang T. T., Dahan R., Maamary J. & Ravetch J. V. (2017) ANNUAL REVIEW OF IMMUNOLOGY.

2016

Therapeutic Activity of Agonistic, Human Anti-CD40 Monoclonal Antibodies Requires Selective Fc gamma R Engagement

Dahan R., Barnhart B. C., Li F., Yamniuk A. P., Korman A. J. & Ravetch J. V. (2016) Cancer Cell.

Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis

Georgoudaki A., Prokopec K. E., Boura V. F., Hellqvist E., Sohn S., Ostling J., Dahan R., Harris R. A., Rantalainen M., Klevebring D., Sund M., Brage S. E., Fuxe J., Rolny C., Li F., Ravetch J. V. & Karlsson M. C. I. (2016) Cell Reports.

2015

2014

Type I and type II Fc receptors regulate innate and adaptive immunity

Pincetic A., Bournazos S., DiLillo D. J., Maamary J., Wang T. T., Dahan R., Fiebiger B. & Ravetch J. V. (2014) Nature Immunology.

HLA-DR alpha 1 Constructs Block CD74 Expression and MIF Effects in Experimental Autoimmune Encephalomyelitis

Meza-Romero R., Benedek G., Yu X., Mooney J. L., Dahan R., Duvshani N., Bucala R., Offner H., Reiter Y., Burrows G. G. & Vandenbark A. A. (2014) Journal of Immunology.

2013

Antigen-specific immunomodulation for type 1 diabetes by novel recombinant antibodies directed against diabetes-associates auto-reactive T cell epitope

Dahan R., Gebe J. A., Preisinger A., James E. A., Tendler M., Nepom G. T. & Reiter Y. (2013) Journal of Autoimmunity.

A novel regulatory pathway for autoimmune disease: Binding of partial MHC class II constructs to monocytes reduces CD74 expression and induces both specific and bystander T-cell tolerance

Vandenbark A. A., Meza-Romero R., Benedek G., Andrew S., Huan J., Chou Y. K., Buenafe A. C., Dahan R., Reiter Y., Mooney J. L., Offner H. & Burrows G. G. (2013) Journal of Autoimmunity.

2012

T-cell-receptor-like antibodies - generation, function and applications

Dahan R. & Reiter Y. (2012) Expert Reviews in Molecular Medicine.

2011

TCR-like antibodies distinguish conformational and functional differences in two- versus four-domain auto reactive MHC class II-peptide complexes

Dahan R., Tabul M., Chou Y. K., Meza-Romero R., Andrew S., Ferro A. J., Burrows G. G., Offner H., Vandenbark A. A. & Reiter Y. (2011) European Journal of Immunology.

2008

Analysis of strand transfer and template switching mechanisms of DNA gap repair by homologous recombination in Escherichia coli: Predominance of strand transfer

Izhar L., Goldsmith M., Dahan R., Geacintov N., Lloyd R. G. & Livneh Z. (2008) Journal of Molecular Biology. Abstract

2007

2004

HLA-DRB1*1501 risk association in multiple sclerosis may not be related to presentation of myelin epitopes

Finn T., Jones R., Rich C., Dahan R., Link J., David C., Chou Y., Offner H. & Vandenbark A. (2004) Journal of Neuroscience Research.