DAP5 and cap-independent translation

We wish to understand how non-canonical protein translation regulates cell fate decisions involving cell death and differentiation, specifically by studying the cap-independent translation factor DAP5.

Applying PPI platforms and whole-genome siRNA screens for novel pathway discovery

We have generated PCD-specific platforms that monitor protein-protein interactions in cells to discover novel interactions among the PCD proteins. We are applying whole genome siRNA screens to uncover novel pathways mediating inter-modular cross-talk and alternative death pathways. The physiological implications of the various mechanisms are being investigated in early embryonic differentiation.

Harnessing the PCD network for cancer studies

We have applied our new insights into the PCD network to understand cancer progression, response to standard treatment, and to develop precision therapy based on the integrity of the PCD network and its composite nodes in individual tumors.