Stress Linked Psychopathologies

Issler O and Chen A.
Determining the role of microRNAs in psychiatric disorders. Nat Rev Neurosci. 16:201-212. [20]

Volk N, Paul ED, Haramati S, Eitan C, Fields BK, Zwang R, Gil S, Lowry CA, Chen A.
MicroRNA-19b associates with Ago2 in the amygdala following chronic stress and regulates the adrenergic receptor beta 1. J Neurosci. 34:15070-15082. [10]

Chen NA, Jupp B, Sztainberg Y, Lebow M, Brown RM, Kim JH, Chen A, Lawrence AJ.
Knockdown of CRF1 receptors in the ventral tegmental area attenuates cue- and acute food deprivation stress-induced cocaine seeking in mice. J Neurosci. 34:11560-11570. [5]

Issler O, Haramati S, Paul ED, Maeno H, Navon I, Zwang R, Gil S, Mayberg HS, Dunlop BW, Menke A, Awatramani R, Binder EB, Deneris ES, Lowry CA, Chen A.
MicroRNA 135 is essential for chronic stress resiliency, antidepressant efficacy, and intact serotonergic activity. Neuron 83:344-360. [75]

Lucas M, Chen A, Richter-Levin G.
Hypothalamic corticotropin-releasing factor is centrally involved in learning under moderate stress. Neuropsychopharmacology 38:1825-1832.

Neufeld-Cohen A, Kelly PA, Paul ED, Carter RN, Skinner E, Olverman HJ, Vaughan JM, Issler O, Kuperman Y, Lowry CA, Vale WW, Seckl JR, Chen A, Jamieson PM.
Chronic activation of corticotropin-releasing factor type 2 receptors reveals a key role for 5-HT1A receptor responsiveness in mediating behavioral and serotonergic responses to stressful challenge. Biol Psychiatry 72:437-447. [17]

Bale TL, Chen A.
Minireview: CRF and Wylie Vale: A Story of 41 Amino Acids and a Texan with Grit. Endocrinology 153:2556-2561. [11]

Lebow M, Neufeld-Cohen A, Kuperman Y, Gil S and Chen A.
Susceptibility to PTSD is mediated by CRF receptor type 2 levels in the bed nucleus of the stria terminalis. J Neurosci. 32:6906-6916. [33]

Regev R, Tsoory M, Gil S, Chen A.
Site-specific genetic manipulation of amygdala CRF reveals its imperative role in mediating behavioral response to challenge. Biol Psychiatry 71:317-326. [41]

Amir-Zilberstein L, Blechman J, Sztainberg Y, Norton WHJ, Reuveny A, Borodovsky N, Tahor M, Bonkowsky JL, Chen A, Levkowitz G.
Homeodomain Protein Otp and Activity-Dependent Splicing Modulate Neuronal Adaptation to Stress. Neuron 73:279-291. [28]