We study the mitochondria, and are especially passionate about their most ancient and conserved pathway- iron-sulfur cluster biosynthesis

Illuminating antigen presenters and their cross-talk with T cells to execute inflammatory and peaceful immune responses.

We study morphogenesis, cell biology and function of hypothalamic neurons, which regulate appetite, stress and social behavior

Interactions between bacteria and the viruses that infect them

Death without caspases and caspases without death in development

We study the functional roles of epigenetics during cell-fate decisions

Mechanisms of leukocyte migration across distinct blood vessels during infections using genetically manipulated immune competent mice and state of the art imaging approaches. Imaging cancer cell crossing of blood vessels during metastatic processes.

Deciphering the intrinsic and extrinsic mechanisms of neuronal wiring

The interplay between viruses and their hosts

We study the molecular foundations and applied potential of mammalian pluripotent stem cells in early organ development, germ cell formation and whole synthetic embryo generation ex utero

Our studies proceed along three major lines: (1) Microbial population dynamics under stress, (2) Understanding drought resistance and engineering drought-resistant nutritious plants (3) The plant microbiome and its dynamics

The synaptic basis for sexual dimorphism in the nervous system

Mechanisms of axon growth, destruction and refinement during developmental neuronal remodeling

Studying cell-cell communication mechanisms of malaria parasites within a population and with their hosts

Combining data analysis and experimental methods for understanding tissue function from single cells

An integrative approach for the exploration of melanoma genetic and immunological interactions

Understanding epithelial, stem and immune cell interactions in the gut

How human RNA viruses interact with their host cells and transform them into viral factories

Functional genomics and systematic screens to uncover new protein functions

How diverse posttranscriptional modifications regulate the fate of mRNA

Intracellular and intercellular trafficking of mRNA and its role in protein localization and cell physiology