Crystalline materials in nature

  • Biomineralization-formation of crystals and other aggregated phases in organisms
  • Crystallization in and from cell membranes
  • Cell interactions at interfaces
  • Antibody-Crystal interactions

High-throughput protein-DNA biophysics

  • The impact of DNA structure and sequence on transcription factors binding
  • The biophysical mechanism of mutagenesis
  • The effect of mechanical perturbations in the genome on DNA biochemistry

Protein interactions by NMR

  • The interaction of HIV-1 envelope glycoprotein with the HIV-1 co-receptor CCR5
  • The interaction of chemokines with CCR5
  • The use of transferred NOE to study intermolecular interactions in large protein complexes
  • Vladimir Kost

    PI: Prof. Jacob Anglister

    Phone: +972-8-934-3531

    Location: Helen and Milton A. Kimmelman Building, 550

  • Dr. Adi Moseri

    PI: Prof. Jacob Anglister

    Location: Helen and Milton A. Kimmelman Building, 506


Structural virology & immunology - elucidating the molecular mechanisms of host / pathogen interactions

  • Structural basis for virus cell entry
  • Structural aspects of host immune response against pathogens
  • Novel therapeutic approaches inspired by structural information

Integrated structural enzymology

  • Structures, mechanisms, and regulation of enzymes that catalyze disulfide bond formation
  • Novel structural techniques for studying extracellular matrix assembly
  • Development of potential cancer therapeutics targeting the cell microenvironment
  • Physiological functions of disulfide catalysts in the formation of complex biomaterials

Molecular systems biophysics

  • Single-molecule spectroscopy
  • Protein interactions and dynamics
  • Bio-molecular networks

Cooperativity in protein structure, folding and function

  • Allostery in chaperonins
  • Mechanisms of action of chaperonins
  • Development of methods to study allostery
  • Correlated mutation analysis

Structural systems biology - protein-protein interactions from atoms to cells

  • Proteins self-assembly and self-organization in cells
  • Evolution of the cellular protein machinery
  • Design and engineering of large protein assemblies

Computational molecular biophysics - quantifying the self-assembly mechanisms of biomolecules

  • Understanding the mechanism of DNA search by proteins
  • Deciphering the effect of post-translational modifications on protein biophysics
  • Investigation of folding of multi-domain proteins


Biology - study of large protein complexes through nuclear magnetic resonance

  • Molecular chaperones combating neurodegenerative diseases
  • Protein folding and disaggregation
  • Structure, dynamics, and function of supramolecular complexes
  • Advanced Nuclear Magnetic Resonance techniques

Structural biology – structure-function studies of transcription factors and of enzymes from pathogenic bacteria

  • The tumor-suppressor protein p53 and its interaction with DNA
  • Cancer-related p53 mutants and their rescue by suppressor mutations and by small molecules
  • Fatty-acid synthesis enzymes from Mycobacterium tuberculosis as potential drug targets

Structural Biology - Study of macromolecules through cryo-EM

> Structure and function of membrane proteins and their signaling pathways

> Specialized translation

> Single particle cryo-EM


Structure/Function studies of Biomacromolecules

  • Proteins from the nervous system, including Acetylcholinesterase
  • Bioinformatic tools, including Proteopedia, FoldIndex and Dipole Moment Server
  • Proteins involved in decontamination of deadly poisons
  • Dr. Jacob Grunwald

    PI: Prof. Joel Sussman

    Location: Nella and Leon Benoziyo Building for Brain Research, 124

  • Dr. Michal Harel

    PI: Prof. Joel Sussman

    Phone: +972-8-934-2647

    Location: Nella and Leon Benoziyo Building for Biological Sciences, 124


  • Dr. Joshua Milgram

    PI: Prof. Stephen Weiner

    Location: Helen and Milton A. Kimmelman Building

  • Noy Shaked

    PI: Prof. Stephen Weiner, Prof. Lia Addadi

    Phone: +972-8-934-3514

    Location: Helen and Milton A. Kimmelman Building, 568


Translation of the genetic code: protein biosynthesis

  • Mechanisms of decoding and peptide bond formation
  • Antibiotics action and resistance
  • New generation of environmental friendly, species specific antibiotics
  • Origin of life