In our research we focused on the design of functional crystalline supra molecular architectures such as single crystals, crystalline domains at the air/water interface, racemic beta-sheets in aqueous solutions. Consequently, we exploited their unique properties, such as symmetry, chirality, crystalline polarity, for the performance of specific experiments in different sub-fields of science. Those architectures contributed for the understanding the mechanisms of photoreaction performed within inclusion crystals, the ability to perform absolute asymmetric synthesis, to assign the absolute configuration of chiral molecules from crystal morphology, to control crystal polymorphism etc. In particular we are taking advantage of the unique electric properties of polar crystals, such as pyroelectricity and piezo electricity for the unraveling the chemical mechanism of electrofreezing.