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  • Date:27ראשוןMay 201828שניMay 2018

    From Photosynthesis to Cancer Therapy

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    שעה
    08:00 - 08:00
    מיקום
    מרכז כנסים על-שם דויד לופאטי
    Kimmel Auditorium
    יושב ראש
    Lilach Agemy
    דף בית
    צרו קשר
    כנסים
  • Date:27ראשוןMay 2018

    TBA

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    שעה
    11:00
    מיקום
    בניין משפחת זוסמן
    M. Magaritz Seminar Room
    מרצה
    Michal Sela-Adler
    Department of Earth and Planetary Sciences Weizmann Institute of Science
    מארגן
    המחלקה למדעי כדור הארץ וכוכבי הלכת
    צרו קשר
    הרצאה
  • Date:27ראשוןMay 2018

    Building the pathway for motion vision

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    שעה
    12:00
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    Botnar Auditorium
    מרצה
    Prof. Claude Desplan
    NYU Biology http://www.nyu.edu/projects/desplan/
    מארגן
    המחלקה לגנטיקה מולקולרית
    Developmental Club
    צרו קשר
    הרצאה
  • Date:28שניMay 201830רביעיMay 2018

    Biological Physics Days

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    שעה
    08:00 - 08:00
    מיקום
    Institut Curie, Paris
    יושב ראש
    Efi Efrati
    מארגן
    מרכז לפיסיקה ביולוגית עש קלור
    דף בית
    צרו קשר
    כנסים
  • Date:28שניMay 2018

    "Engineering by Evolution: Bringing New Chemistry to Life"

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    שעה
    11:00 - 12:15
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצה
    Prof. Frances Arnold
    Caltech, USA
    מארגן
    הפקולטה לכימיה
    צרו קשר
    פרטים נוספיםShow full text description of Not satisfied with nature’s vast catalyst repertoire, we wan...»
    Not satisfied with nature’s vast catalyst repertoire, we want to create new protein catalysts and expand the space of genetically encoded enzyme functions. I will describe how we use the most powerful biological design process, evolution, to optimize existing enzymes and invent new ones, thereby circumventing our profound ignorance of how sequence encodes function. Using chemical intuition and mimicking nature’s evolutionary processes, we can generate whole new enzyme families that catalyze synthetically important reactions not known in biology. Recent successes include highly selective formation of C-Si and C-B bonds, anti-Markovnikov alkene oxidation, and alkyne cyclopropanation to make highly strained carbocycles, all in living cells. Extending the capabilities and uncovering the mechanisms of these new enzymes derived from natural iron-heme proteins provides a basis for discovering new biocatalysts for increasingly challenging reactions. These new capabilities increase the scope of molecules and materials we can build using synthetic biology and move us closer to fully DNA-programmed chemical synthesis.

    1. S. B. J. Kan, R. D. Lewis, K. Chen, F. H. Arnold. “Directed Evolution of Cytochrome c for Carbon–Silicon Bond Formation: Bringing Silicon to Life.” Science 354, 1048-1051 (2016).
    2. S. B. J. Kan, X. Huang, Y. Gumulya, K. Chen, F. H. Arnold. “Genetically Programmed Chiral Organoborane Synthesis.” Nature 552, 132-136 (2017). doi:10.1038/nature24996
    3. S. C. Hammer, G. Kubik, E. Watkins, S. Huang, H. Minges, F. H. Arnold, “Anti-Markovnikov Alkene Oxidation by Metal-Oxo-Mediated Enzyme Catalysis.” Science 358, 215-218 (2017).
    4. K. Chen, X. Huang, S. B. J. Kan, R. K. Zhang, F. H. Arnold, “Enzymatic Construction of Highly Strained Carbocyles.” Science, accepted for publication.
    סימפוזיונים
  • Date:28שניMay 2018

    From dragons’ sleep to sliders’ sight: reexamination of reptilian model systems

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    שעה
    12:30
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצה
    Dr. Mark Shein-Idelson
    Dept of Neurobiology Faculty of Life Sciences Sagol School for Neuroscience Tel Aviv University
    מארגן
    המחלקה לנוירוביולוגיה
    צרו קשר
    פרטים נוספיםShow full text description of Host: Prof. Ilan Lampl ilan.lampl@weizmann.ac.il tel: 3179...»
    Host: Prof. Ilan Lampl ilan.lampl@weizmann.ac.il tel: 3179
    For assistance with accessibility issues, please contact naomi.moses@weizmann.ac.il
    תקצירShow full text abstract about Throughout the history of neuroscience, a large set of model...»
    Throughout the history of neuroscience, a large set of model systems has been used for studying a large variety of questions. These model systems were frequently chosen for their unique experimental advantages, but studying them also provided a wider perspective on basic questions: By examining the manifestation of a given biological phenomenon across different species, one could separate the salient or fundamental from the transient or variable. In my talk I will focus on two of our studies in reptiles: sleep in bearded dragons and visual processing in red eared sliders. I will show how we can use turtles for understanding structure function relations in neural circuits and how we can use lizards for exploring the organization of collective activity during sleep. In addition, I will show that such studies provide a new u! nderstanding of the evolution of brain dynamics.

    הרצאה
  • Date:28שניMay 2018

    Foundations of Computer Science Seminar

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    שעה
    14:30 - 16:00
    מיקום
    בניין יעקב זיסקינד
    Room 155
    מרצה
    Kevin Leyton-Brown
    University of British Columbia
    מארגן
    המחלקה למדעי המחשב ומתמטיקה שימושית
    Faculty of Mathematical Sciences Seminar
    צרו קשר
    הרצאה
  • Date:28שניMay 2018

    Foundations of Computer Science Seminar

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    שעה
    14:30 - 16:00
    כותרת
    Learning as a Tool for Algorithm Design and Beyond-Worst-Case Analysis
    מיקום
    בניין יעקב זיסקינד
    Room 155
    מרצה
    Kevin Leyton-Brown
    University of British Columbia
    מארגן
    המחלקה למדעי המחשב ומתמטיקה שימושית
    Faculty of Mathematical Sciences Seminar
    צרו קשר
    הרצאה
  • Date:29שלישיMay 2018

    IVS-MRS 2018 Student Conference

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    שעה
    08:00 - 08:00
    מיקום
    מרכז כנסים על-שם דויד לופאטי
    Kimmel Auditorium
    יושב ראש
    Olga Kraynis
    צרו קשר
    כנסים
  • Date:29שלישיMay 2018

    Pancreatic Cancer Biology & Medicine

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    שעה
    09:30
    מיקום
    בניין ע"ש מקס ולילאן קנדיוטי
    Auditorium
    מרצה
    Dr. David Tuveson
    MD, PhD Cold Spring Harbor Laboratory
    מארגן
    המחלקה לביולוגיה מולקולרית של התא
    צרו קשר
    הרצאה
  • Date:29שלישיMay 2018

    How Malaria Parasite Tricks the Immune System

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    שעה
    10:00 - 10:30
    מיקום
    בניין לביוכימיה על שם נלה וליאון בנוזיו
    Auditorium
    מרצה
    Dr. Yifat Ofir-Birin
    Dept. of Biomolecular Sciences-WIS
    מארגן
    המחלקה למדעים ביומולקולריים
    צרו קשר
    תקצירShow full text abstract about Our ability to cure infectious diseases is greatly limited b...»
    Our ability to cure infectious diseases is greatly limited by a lack of understanding of the way many pathogens evade the human innate immune system. This is indeed the case when it comes to the parasite Plasmodium falciparum (P. falciparum), the leading infectious agent of Malaria, one of the most devastating infectious diseases in humans.
    We show that while growing within human red blood cells, the parasites secrete extracellular vesicles containing genomic DNA, RNA and proteins. These vesicles are taken up by human monocytes, the DNA species are then released within the host cytosol leading to cytosolic STING-dependent DNA sensing. Additionally, we provide the evidence that internalization of late stage (trophozoite) P. falciparum-derived vesicles by monocytes prompts the activation of a known master regulator transcription factor, NF-kB. The activated NF-kB is then translocated to the nucleus to induce transcription of a target gene. Our finding opens a new line of investigation concerning the function of the vesicle DNA and RNA cargo components. This newly discovered crosstalk mechanism strongly supports the existence of a 'manipulation strategy' of the host immune environment by the deadly pathogen, P. falciparum parasite.
    הרצאה
  • Date:29שלישיMay 2018

    Defining the microglia contributions to lysosomal storage disorders

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    שעה
    10:30 - 11:00
    מיקום
    בניין לביוכימיה על שם נלה וליאון בנוזיו
    Auditorium
    מרצה
    Dr. Soo-Min Cho
    Members - Dept. of Biomolecular Sciences-WIS
    מארגן
    המחלקה למדעים ביומולקולריים
    צרו קשר
    תקצירShow full text abstract about Lysosomal storage disorders (LSD), such as Gaucher disease (...»
    Lysosomal storage disorders (LSD), such as Gaucher disease (GD) and Niemann–Pick type C (NPC) disease, display neuronal degeneration accompanied by neuroinflammation. In the brain, innate immunity is maintained by microglia, the major myeloid cell population in the CNS. FACS analysis of end stage LSD models showed minor monocyte infiltration indicating that CNS-resident microglia are the major myeloid player in these pathologies. I will further discuss the functional contribution of microglia to LSD pathophysiology based on RNAseq analysis of microglia from various LSD animal models.

    הרצאה
  • Date:29שלישיMay 2018

    Live demonstration of Redcap – a new system for working with secure clinical online questionnaires

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    שעה
    11:00 - 12:00
    מיקום
    בניין ע"ש מקס ולילאן קנדיוטי
    Auditorium
    מרצה
    Dr. Ron Rotkopf
    Bioinformatics unit, Life Sciences Core Facilities
    מארגן
    המחלקה לתשתיות מחקר מדעי החיים
    צרו קשר
    תקצירShow full text abstract about Redcap – a new system for working with clinical online quest...»
    Redcap – a new system for working with clinical online questionnaires
    Hello all,
    We would like to bring to your attention that we have recently installed REDCap at
    the Weizmann Institute. REDCap is a secure web application for building and
    managing online surveys and databases, used by thousands of academic institutions
    and hospitals around the world.
    Using REDCap, you can easily create online questionnaires or surveys, and collect
    responses from your collaborators anywhere, or even from survey participants who
    are not logged in. This is particularly useful for clinical projects, but can be used for
    any project that requires collecting data from multiple collaborators.
    The REDCap interface is user-friendly, and no coding experience is needed to start a
    new project and create your own questionnaires.
    After the data is collected, it can be exported easily to Excel or any common statistical
    packages (e.g. SPSS, SAS, Stata, R).
    You can read more about REDCap at https://www.project-redcap.org/
    The Weizmann installation of REDCap is at https://redcap.weizmann.ac.il/
    If you just want to check it out without registering, a demo version is available (only
    from within the institute) at http://demohealth.weizmann.ac.il/.
    Do not enter any important/confidential data in the demo version!
    If you have any questions, or would like to register to REDCap, please contact
    Ron Rotkopf (ron.rotkopf@weizmann.ac.il) at the LSCF Bioinformatics unit.
    The demonstration will be held at Candiotty auditorium on Tuesday, May 29th, at 11:00.
    Registration is not required, but if you plan to come, please take a minute to answer this
    anonymous survey:
    http://j.mp/2rtn7a6
    The survey was created in Redcap, and we will use it as an example of creating a
    questionnaire and collecting data.
    הרצאה
  • Date:29שלישיMay 2018

    Algebraic Geometry and Representation Theory Seminar

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    שעה
    11:15 - 12:30
    כותרת
    Branching laws for non-generic representations
    מיקום
    בניין יעקב זיסקינד
    Room 155
    מרצה
    Max Gurevich
    Singapore
    מארגן
    המחלקה למדעי המחשב ומתמטיקה שימושית
    Faculty of Mathematical Sciences Seminar
    צרו קשר
    הרצאה
  • Date:29שלישיMay 2018

    Enzyme rates in the omics era

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    שעה
    11:30
    כותרת
    From global characterization to a pivotal case study
    מיקום
    בניין לביוכימיה על שם נלה וליאון בנוזיו
    Auditorium
    מרצה
    Dan Davidi
    Prof. Ron Milo’s lab., Dept. of Plant and Environmental Sciences, Weizmann Institute of Science
    מארגן
    המחלקה למדעי הצמח והסביבה
    צרו קשר
    תקצירShow full text abstract about Enzymes determine the rate of most biological processes. Dec...»
    Enzymes determine the rate of most biological processes. Decades of biochemistry have demonstrated how enzymes vary by orders of magnitude in their kinetic properties. Why are some enzymes faster than others and how are enzyme capacities related to physiological demands? I will talk about the interplay between enzyme kinetics and different evolutionary driving forces in an attempt to unravel which factors constrain and sculpt enzymatic rates. I will then move to examine the relevance of in-vitro kinetics to living systems, asking whether the rates of enzymes are similar between test-tubes and cells, and if not, why this is the case.
    Lastly, I will focus on one particular enzyme with lousy kinetics. This enzyme is called Rubisco - the key carboxylating enzyme on the planet, and therefore the gateway into the organic world.
    Instead of trying to improve Rubisco by directed evolution approaches, which have largely failed so far, I will describe our ongoing journey to find the best Rubisco Nature has to offer...
    הרצאה
  • Date:29שלישיMay 2018

    Synaptic and extrasynaptic neuron-glia interactions

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    שעה
    12:30 - 13:30
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצה
    Prof. Alexey Semyanov
    Institute of Neuroscience University of Nizhny Novgorod, Russia
    מארגן
    המחלקה לנוירוביולוגיה
    צרו קשר
    פרטים נוספיםShow full text description of Host: Prof. Menahem Segal Menahem.segal@weizmann.ac.il tel:...»
    Host: Prof. Menahem Segal Menahem.segal@weizmann.ac.il tel: 2553
    For assistance with accessibility issues, please contact naomi.moses@weizmann.ac.il
    תקצירShow full text abstract about Brain is often viewed as large neuronal connectome where the...»
    Brain is often viewed as large neuronal connectome where the information is encoded in the patterns of action potentials and stored in the changes of synaptic strength or appearance of new wiring routes. However, recent studies have demonstrated that astrocytes also possess complex patterns of calcium signals influenced by neuronal activity. Astrocytic calcium signals regulate various functions of these cells including release of gliotransmitters and morphological changes in the astrocytic processes (Tanaka et al., 2013). It has been tempting to suggest that information in astrocytes is encoded in the frequency of calcium events, similar to patters of neuronal action potentials. Synaptically released neurotransmitters thought to trigger new calcium events in perisynaptic astrocytic processes (PAPs) though activation of metabotropic glutamate receptors (mGluRs). In contrast, our recent findings suggest that PAPs are devoid of calcium stores that are required for mGluR-mediated calcium signaling (Patrushev et al., 2013). This makes unlikely any significant role of mGluRs in triggering calcium events in PAPs. Instead, we show that activation of ‘extrasynaptic’ astrocytic mGluRs increases proportion of spatially extended calcium events in the power-law based distribution of calcium event sizes (Wu et al., 2014). This effect takes place without any significant increase in the frequency of calcium events. These findings suggest that astrocytic response to surrounding neuronal activity is rather encoded in spatial characteristics of their calcium events and fundamentally different from temporal information coding in neurons (e.g. coincidence detection, action potentials sequences etc). Nevertheless, we cannot exclude local ionic changes in PAPs in response to synaptic activity. For example, potassium ions accumulate in the synaptic cleft of glutamatergic synapses during repetitive activity. We have demonstrated that the bulk of these ions is contributed by potassium efflux through postsynaptic NMDA receptors (Shih et al., 2013). Potassium mediated depolarization of presynaptic terminal increases glutamate release probability. Now we have found that accumulation of intracleft potassium during repetitive synaptic activity could also inhibit astrocytic glutamate uptake by depolarizing PAPs. This extends glutamate dwell-time in the synaptic cleft and boosts glutamate spillover effects.
    הרצאה
  • Date:29שלישיMay 2018

    Contrary to Dogma: Tau is not a stabilizer of microtubules in the axon

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    שעה
    13:00
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    Botnar Auditorium
    מרצה
    Prof. Peter W. Baas
    Professor, Department of Neurobiology and Anatomy Director, Graduate Program in Neuroscience Drexel University College of Medicine, Philadelphia, USA http://drexel.edu/medicine/About/Departments/Neurobiology-Anatomy/Research/Baas-Lab/
    מארגן
    המחלקה לגנטיקה מולקולרית
    צרו קשר
    הרצאה
  • Date:29שלישיMay 2018

    Molecular Neuroscience Forum Seminar

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    שעה
    15:00 - 16:00
    כותרת
    Molecular mechanisms for synaptic control of gene transcription
    מיקום
    בניין לביוכימיה על שם נלה וליאון בנוזיו
    Auditorium
    מרצה
    Michael R. Kreutz
    Leibniz Institute for Neurobiology, Magdeburg and Center for Molecular Neurobiology, ZMNH, Hamburg
    מארגן
    המחלקה למדעים ביומולקולריים
    דף בית
    צרו קשר
    הרצאה
  • Date:30רביעיMay 2018

    Nano safety and Education

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    שעה
    11:00 - 12:00
    מיקום
    בניין פרלמן למדעי הכימיה
    Room 404
    מרצה
    Prof. Martin Himly
    Dept. Of Bio-sciences, University of Salzburg
    מארגן
    המחלקה לחומרים ופני שטח
    צרו קשר
    תקצירShow full text abstract about Nanotechnology has reached every-day life. A high number o...»

    Nanotechnology has reached every-day life. A high number of all-day products either contain nanomaterials (NMs) or have been processed by nanotechnological work flows. New interactions with other all-day products, i.e. an every-growing number of modern lifestyle products (MLPs), become more and more likely. Moreover, the new generation has a high degree of creativity in using MLPs in different ways potentially resulting in not foreseen interactions of NMs with MLPs during the marketing process. Therefore, an interdisciplinary research project termed Nan-O-Style has been established investigating interactions between NMs in consumer products with substances from daily life with a special focus on MLPs used by adolescents. Furthermore, Nan-O-Style aims at the compilation of an education initiative about nanotechnology including teaching resources and international peer-teaching.
    In order to achieve a high variety of perspectives, students from different types of Austrian higher schools (technical/scientific vs. economic vs. artistic) work in close contact with scientists from academia. Due to the within Nan-O-Style acquired competences and the established network between academic scientists, students and educational institutions, the students develop new models for interdisciplinary teaching in mathematical/scientific/technical (MINT) subjects and apply them as best practice examples. We particularly focus on schools with an economic or fashion background which typically have a higher share of girls. A number of pre-scientific projects in nano-technological, nano-biological or nano-educational topics are carried out.
    This approach towards interdisciplinary MINT education thus strengthens the profile formation of the Paris Lodron University of Salzburg and further extends to the education of teachers. Previously, the educational EU framework projects www.NanoTOES.eu and www.NanoEIS.eu had been coordinated by Prof. Duschl and his group. Nan-O-Style is based on this background and therefore internationally connected to educational partners in Israel (ORT Moshinsky R&D Center, Tel Aviv, http://en.ort.org.il/), Spain (Nanoeduca, Barcelona, http://nanoeduca.cat/es/inicio/), and Germany (cc-NanoBioNet e.V, Saarbrücken, http://www.nanobionet.de/).
    The Duschl group furthermore conducts nanosafety research involving advanced in vitro models of the human lung barrier, including air-liquid interface cultures (1), addressing potential modulations of the immune response towards NMs (2, 3). As allergens may be inhaled simultaneously to nanoparticles they can become part of the protein corona. The group investigates whether this poses a risk for people with an existing allergic condition (4).

    הרצאה
  • Date:31חמישיMay 2018

    Annual Meeting of the Israeli Statistical Association

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    שעה
    08:00 - 08:00
    מיקום
    מרכז כנסים על-שם דויד לופאטי
    יושב ראש
    Boaz Nadler
    דף בית
    צרו קשר
    כנסים

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