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  • Date:29ראשוןאפריל 2018

    The Israeli Electricity Market at a crossroads and its implications for renewable energies

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    שעה
    13:00 - 14:00
    כותרת
    Sustainability And Energy Research Initiative (SAERI) Seminar Series
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצה
    Ms. Nurit Gal
    VP, the Israeli Electricity Regulatory Authority (ERA)
    מארגן
    מדרשת פיינברג
    Alternative Sustainable Energy Research Initiative (AERI)
    צרו קשר
    פרטים נוספיםShow full text description of Host: Prof. Ron Milo light refreshments will be served at 1...»
    Host: Prof. Ron Milo
    light refreshments will be served at 12:40
    הרצאה
  • Date:30שניאפריל 2018

    Modeling the initiation, progression and treatment of human melanoma in the mouse

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    שעה
    14:00 - 15:00
    כותרת
    Special Guest Seminar
    מיקום
    בניין ע"ש מקס ולילאן קנדיוטי
    Auditorium
    מרצה
    Prof. Glenn Merlino
    NCL, NIH, USA
    מארגן
    המחלקה לבקרה ביולוגית
    צרו קשר
    הרצאה
  • Date:01שלישיMay 2018

    When is a Drug Price Unjust?

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    שעה
    11:00 - 12:00
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצה
    Prof. Ezekiel J. Emanuel
    Recipient of the 2018 Dan David prize for his work in Bioethics, Vice Provost of Global Initiatives Chair, Department of Medical Ethics and Health Policy Levy University Professor Perelman School of Medicine and The Wharton School University of Pennsylvania, USA
    מארגן
    מדעי החיים
    צרו קשר
    הרצאה
  • Date:01שלישיMay 2018

    Insulin action and insulin resistance in brain in control of mood and neurobehavior; CNS-dependent control of metabolism

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    שעה
    12:30 - 15:00
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    Botnar Auditorium
    מרצה
    Prof. C. Ronald Kahn & Prof. Jens Brüning
    Joslin Diabetes Center, Harvard Medical School Boston, MA, USA ; Max Planck Institute for Metabolism Research, Köln, Germany
    מארגן
    מדעי החיים
    Metabollic Research Forum
    צרו קשר
    הרצאה
  • Date:03חמישיMay 2018

    New advances in the viral vector core – expanding your research with AAV

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    שעה
    09:00
    מיקום
    בניין ע"ש מקס ולילאן קנדיוטי
    Auditorium
    מרצה
    Dr. Oded Singer
    Viral Vector Core
    מארגן
    המחלקה לתשתיות מחקר מדעי החיים
    צרו קשר
    הרצאה
  • Date:03חמישיMay 2018

    Physics Colloquium

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    שעה
    11:15 - 12:30
    מיקום
    בניין הפיסיקה ע"ש עדנה וק.ב. וייסמן
    Auditorium
    מרצה
    TBA
    מארגן
    הפקולטה לפיסיקה
    צרו קשר
    פרטים נוספיםShow full text description of 11:00 Coffee, Tea and more...»
    11:00 Coffee, Tea and more
    תקצירShow full text abstract about TBA ...»
    TBA
    סימפוזיונים
  • Date:06ראשוןMay 201807שניMay 2018

    כינוס מועצת המנהלים 2018

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    שעה
    כל היום
    מיקום
    מרכז כנסים על-שם דויד לופאטי
    Kimmel Auditorium
    צרו קשר
    מועצת המנהלים הבינלאומית
  • Date:06ראשוןMay 2018

    The role of the adipocytic lineages in the development of age-related metabolic disorders

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    שעה
    11:00 - 12:00
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    Botnar Auditorium
    מרצה
    Prof. Dr. Tim J. Schulz
    Department of Adipocyte Development and Nutrition German Institute of Human Nutrition (DIfE)Potsdam-Rehbrücke
    מארגן
    המחלקה למדעים ביומולקולריים
    צרו קשר
    פרטים נוספיםShow full text description of Obesity is a significant challenge to medical care systems w...»
    Obesity is a significant challenge to medical care systems worldwide. Thus, adequate treatment strategies are needed to counter overweight and its associated metabolic disorders. Aging exacerbates the onset and progression of many of these complications, including the development of insulin resistance and the ectopic accumulation of adipocytes in atypical anatomical sites, such as the marrow cavities of long bones. These processes are thought to contribute to the impairment of normal tissue maintenance and also to inhibit regenerative tissue repair after injury. An important goal of our current research is therefore to decipher the cellular lineages involved in regeneration. Tissue-resident adult stem and progenitor cell populations that can give rise to mature fat cells are considered to be of the mesenchymal stem cell type, and their heterogeneous composition has not been assessed in much detail. We were recently able to show that mesenchymal cells of the bone marrow cavity are functionally diverse and give rise to ectopic fat but may at the same time contribute to the regulation of regenerative processes. These findings suggest that age-dependent changes of the cellular heterogeneity of the mesenchymal lineages may negatively affect tissue regeneration and health in aged individuals.
    הרצאה
  • Date:06ראשוןMay 2018

    TBA

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    שעה
    11:00
    מיקום
    בניין משפחת זוסמן
    M. Magaritz Seminar Room
    מרצה
    The Hebrew University of Jerusalem
    מארגן
    המחלקה למדעי כדור הארץ וכוכבי הלכת
    צרו קשר
    הרצאה
  • Date:06ראשוןMay 2018

    TBA

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    שעה
    11:00
    מיקום
    בניין משפחת זוסמן
    M. Magaritz Seminar Room
    מרצה
    Michal Sela-Adler (WIS)
    Department of Earth and Planetary Science Weizmann Institute of Science
    מארגן
    המחלקה למדעי כדור הארץ וכוכבי הלכת
    צרו קשר
    הרצאה
  • Date:06ראשוןMay 2018

    From large image datasets to meaningful representations in developmental biology

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    שעה
    15:00
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    Botnar Auditorium
    מרצה
    Paul Villoutreix
    Zelzer Lab Department of Molecular Genetics
    מארגן
    המחלקה לתשתיות מחקר מדעי החיים
    צרו קשר
    הרצאה
  • Date:07שניMay 2018

    "Getting the (mechanical) message across cell membranes"

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    שעה
    11:00 - 12:15
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצה
    Prof. Deborah E. Leckband
    Department of Chemistry University of Illinois at Urbana-Champaign
    מארגן
    הפקולטה לכימיה
    צרו קשר
    סימפוזיונים
  • Date:07שניMay 2018

    MYC, the “undruggable” target

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    שעה
    14:00
    מיקום
    בניין ע"ש מקס ולילאן קנדיוטי
    Auditorium
    מרצה
    Professor Peter Vogt
    Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA
    מארגן
    המחלקה לביולוגיה מולקולרית של התא
    צרו קשר
    הרצאה
  • Date:07שניMay 2018

    Foundations of Computer Science Seminar

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    שעה
    14:30 - 16:00
    כותרת
    Detecting Correlations with Little Memory and Communication
    מיקום
    בניין יעקב זיסקינד
    Room 155
    מרצה
    Yuval Dagan
    Weizmann
    מארגן
    הפקולטה למתמטיקה ומדעי המחשב
    Faculty of Mathematical Sciences Seminar, המחלקה למדעי המחשב ומתמטיקה שימושית
    Faculty of Mathematical Sciences Seminar, המחלקה למתמטיקה
    Faculty of Mathematical Sciences Seminar
    צרו קשר
    הרצאה
  • Date:08שלישיMay 2018

    Students Seminar

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    שעה
    11:15 - 12:30
    מיקום
    בניין וולפסון למחקר ביולוגי
    Auditorium
    מארגן
    המחלקה לביולוגיה מולקולרית של התא
    צרו קשר
    הרצאה
  • Date:08שלישיMay 2018

    Students Seminar

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    שעה
    11:15 - 12:30
    מיקום
    בניין וולפסון למחקר ביולוגי
    Auditorium
    מרצה
    Prof. Valery Krizhanovsky lab
    מארגן
    המחלקה לביולוגיה מולקולרית של התא
    צרו קשר
    הרצאה
  • Date:08שלישיMay 2018

    Students Seminar

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    שעה
    11:15 - 12:30
    מיקום
    בניין וולפסון למחקר ביולוגי
    Auditorium
    מרצה
    Prof. Valery Krizhanovsky lab
    מארגן
    המחלקה לביולוגיה מולקולרית של התא
    צרו קשר
    הרצאה
  • Date:08שלישיMay 2018

    "Sculpted by self-replication"

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    שעה
    14:00 - 15:00
    מיקום
    בניין הלן ומילטון קימלמן
    Dov Elad Room
    מרצה
    Dr. Shlomi Reuveni
    TAU
    מארגן
    המחלקה לביולוגיה מבנית
    צרו קשר
    תקצירShow full text abstract about Many fine-scale features of ribosomes have been explained in...»
    Many fine-scale features of ribosomes have been explained in terms of function, revealing a molecular machine that is optimized for error-correction, speed and control. In this talk, I will demonstrate mathematically that much less understood, larger-scale features of ribosomes—such as why RNA dominates the ribosome mass and why the ribosomal protein content is divided into 55–80 small and similarly sized segments—could all be explained by optimization for self-replication.
    הרצאה
  • Date:08שלישיMay 2018

    Atlases of structure-function relationships in small motifs: the limits of modularity

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    שעה
    14:00
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    Botnar Auditorium
    מרצה
    Dr. James Sharpe
    EMBL Barcelona, Spain Head of Barcelona outstation on Tissue Biology and Disease Modelling
    מארגן
    מכון עזריאלי למערכות ביולוגיות
    System Biology
    צרו קשר
    תקצירShow full text abstract about Abstract: I will discuss our work on visualizing “topology ...»
    Abstract:
    I will discuss our work on visualizing “topology atlases” which act as a map of possible circuit designs for small 3-node regulatory motifs. These can help in understanding the relationship between a circuit's structure and its function, but how is this relationship affected if the circuit must perform multiple distinct functions within the same organism? In particular, to what extent do multi‐functional circuits contain modules which reflect the different functions? We computationally surveyed a range of bi‐functional circuits which show no simple structural modularity: They can switch between two qualitatively distinct functions, while both functions depend on all genes of the circuit. Our analysis revealed two distinct classes: hybrid circuits which overlay two simpler mono‐functional sub‐circuits within their circuitry, and emergent circuits, which do not. In this second class, the bi‐functionality emerges from more complex designs which are not fully decomposable into distinct modules and are consequently less intuitive to predict or understand. These non‐intuitive emergent circuits are just as robust as their hybrid counterparts, and we therefore suggest that the common bias toward studying modular systems may hinder our understanding of real biological circuits.

    Relevant papers:
    1. A spectrum of modularity in multi-functional gene circuits.
    Jiménez A, Cotterell J, Munteanu A, Sharpe J. (2017)
    Mol Syst Biol 13(4):925. doi: 10.15252/msb.20167347
    http://msb.embopress.org/content/13/4/925
    2. An atlas of gene regulatory networks reveals multiple three-gene mechanisms for interpreting morphogen gradients.
    Cotterell J, Sharpe J. (2010)
    Mol Syst Biol 6:425. doi: 10.1038/msb.2010.74
    http://msb.embopress.org/content/6/1/425

    Bio:
    James Sharpe was originally captivated by computer programming, but upon learning about the digital nature of the genetic code, chose to study Biology for his undergraduate degree at Oxford University (1988-1991). He then did his PhD on the genetic control of embryo development at NIMR, London (1992-1997) and in parallel started writing computer simulations of multicellular development. During his post-doc in Edinburgh, he began modelling the dynamics of limb development, and also invented a new optical imaging technology called Optical Projection Tomography (OPT), which is dedicated to imaging specimens too large for microscopy - tissues and organs. In 2006 he moved to Barcelona, becoming a senior group leader at the Centre for Genomic Regulation, and focusing on a systems biology approach to modelling limb development – combining experimentation with computer modelling. In this way the group demonstrated that the signalling proteins which pattern the fingers during embryogenesis, act as a Turing reaction-diffusion system. In 2011 he became the coordinator of the Systems Biology Program, and in 2017 was recruited to EMBL as Head of the new Barcelona outstation on Tissue Biology and Disease Modelling.
    הרצאה
  • Date:09רביעיMay 2018

    Developmental Club Series 2017-2018

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    שעה
    10:00
    כותרת
    Spanning the Scales: Computer modelling of growth and form in the developing limb bud
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    Botnar Auditorium
    מרצה
    Dr. James Sharpe
    Head of Outstation and Senior Scientist at EMBL, Barcelona, Spain
    מארגן
    המחלקה לגנטיקה מולקולרית
    Developmental Club
    צרו קשר
    פרטים נוספיםShow full text description of James Sharpe was originally captivated by computer programmi...»
    James Sharpe was originally captivated by computer programming, but upon learning about the digital nature of the genetic code, chose to study Biology for his undergraduate degree at Oxford University (1988-1991). He then did his PhD on the genetic control of embryo development at NIMR, London (1992-1997) and in parallel started writing computer simulations of multicellular development. During his post-doc in Edinburgh, he began modelling the dynamics of limb development, and also invented a new optical imaging technology called Optical Projection Tomography (OPT), which is dedicated to imaging specimens too large for microscopy - tissues and organs. In 2006 he moved to Barcelona, becoming a senior group leader at the Centre for Genomic Regulation, and focusing on a systems biology approach to modelling limb development – combining experimentation with computer modelling. In this way the group demonstrated that the signalling proteins which pattern the fingers during embryogenesis, act as a Turing reaction-diffusion system. In 2011 he became the coordinator of the Systems Biology Program, and in 2017 was recruited to EMBL as Head of the new Barcelona outstation on Tissue Biology and Disease Modelling.
    תקצירShow full text abstract about The vertebrate limb bud is a classical model system for deve...»
    The vertebrate limb bud is a classical model system for developmental biology – with the advantage of having been studied for many decades. Despite this, and despite its relatively simple shape, a consensus model of its physical morphogenesis has not been reached. I will introduce our own hypothesis on limb bud morphogenesis – convergent-extension coupled with tissue growth – and contrast it to previous ideas. I will introduce a 3D dynamical model which captures this hypothesis (a Cellular Potts Model) and also discuss our ongoing improvements to these simulations.
    הרצאה

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