Positions

<p>The relevant projects address the influence of circadian clocks on exercise performance, and training efficiency, as well as the effect of chronotype, feeding, and hypoxia on exercise capacity.</p>&#xD;
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<p>Circadian clocks are key regulators of daily physiology and metabolism in mammals. Our understanding of the role of the circadian clock and specific clock proteins in controlling exercise capacity is rudimentary.

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<li><strong>Clocks resetting |</strong><em>&nbsp;</em>Recently, we have developed a new method to study resetting agents in vitro in an efficient and high-throughput manner, dubbed Circa-SCOPE (<a href="https://www.weizmann.ac.il/Biomolecular_Sciences/Asher/publications">Man... al</em>.,&nbsp;<em>Nature Communication</em>&nbsp;2021)</a>. This methodology opens the door to a wide range of applications, in both basic and translational research.

<p>Regulation of gene expression at the transcriptional and translational levels is fundamental to all biological activities and is frequently altered in disease states. Our broad research interests are (i) to elucidate how the transcription and translation processes control the cellular response to environmental stimuli, (ii) to reveal the connections between the transcription and translation processes, and (iii) to develop tools to manipulate these processes for the potential treatment of cancer, chronic inflammation, and neurodegenerative diseases.</p>&#xD;

<p>How does a neuron grow? Genome expression must be matched to different cell sizes, with rapidly growing cells likely requiring higher transcriptional and translational output than cells in slow growth or maintenance phase. Neurons exhibit the greatest size differences of any class of cells, with process lengths ranging from a few microns in central interneurons to a meter in human peripheral neurons, and even longer in larger mammals.

Membrane proteins make up a quarter of the proteome of every living organism and participate in nearly every biological process. We are interested in the fascinating process of how these proteins get produced, fold, and assemble in cells. The questions we address are: How do proteins fold in the membranes of living cells? How do the dynamic features of unfolded proteins assist in this process? How do cellular factors recognize membrane proteins that failed to fold and need to be cleared? The lab combines biochemical, cell biology, genetic and computational tools.

<p>Applicants with a strong research background at the intersection of molecular biology, biochemistry, imaging and/or biophysics are encouraged to apply. Experience in microbiology, molecular genetics (including CRISPR/Cas9), advanced imaging platforms (including image analysis) or advanced protein chemistry is advantageous. This is a full-time position available from October 2023 for a period of two years with a possibility of a further extension subject to funding availability. Candidate should send a cover letter and CV (includes a publication list) to Dr. Neta Regev-Rudzki.

<p>Applicants with a strong research background at the intersection of molecular biology, biochemistry, imaging and/or biophysics are encouraged to apply. Experience in microbiology, molecular genetics (including CRISPR/Cas9), advanced imaging platforms or advanced protein chemistry is advantageous. This is a full-time position available for a period of three years with a possibility of a further extension subject to funding availability. Candidate should send a cover letter and CV (includes a publication list) to Prof. Neta Regev-Rudzki.

<p><strong>We have open positions for Ph.D. candidates or Postdoc candidates interested in mechanisms of channels function, GPCRs regulation of Cellular processes emphasizing on ion channel regulation and the interaction between animal toxins and ion channels.</strong></p>&#xD;
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