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Positions
Scientist | Description |
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Prof. Gad Asher | 4 Years Phone:+972-8-934-6949 |
<p>Our lab has a longstanding interest in circadian clock resetting. We previously have identified and characterized novel resetting cues such as hypoxia and CO2. Recently, we have developed a new method to study resetting agents in vitro in an efficient and high-throughput manner, dubbed <a href="https://www.nature.com/articles/s41467-021-26210-1">Circa-SCOPE</a>. The method allows screening of multiple drugs in parallel to identify which affects the clock and how. |
Prof. Gad Asher | 4 Years Phone:+972-8-934-6949 |
<p>Circadian clocks are key regulators of daily physiology and metabolism in mammals. Our understanding of the role of the circadian clock and specific clock proteins in controlling exercise capacity is rudimentary. Consequently, there is growing interest in exercise biology in general, specifically in its interaction with other processes that govern whole-body physiology and metabolism. |
Prof. Gad Asher | 4 Years Phone:+972-8-934-6949 |
<p>We demonstrated that low-amplitude oxygen cycles, which mimic the daily physiological cycles in oxygen levels observed in rodents, can reset the clock in a HIF-1a-dependent manner (<a href="https://www.weizmann.ac.il/Biomolecular_Sciences/Asher/publications" style="color: rgb(30, 121, 159); text-transform: none; text-indent: 0px; letter-spacing: normal; font-family: "Proxima Nova"; font-size: 15px; font-style: normal; font-weight: 400; word-spacing: 0px; white-space: normal; orphans: 2; widows: 2; font-variant-ligatures: normal; font-variant-caps: n |
| 5 Years Phone:+972-8-934- |
<p>Size matters, especially in neurons. Differentiated cells in higher eukaryotes exhibit a wide variety of shapes and sizes, while maintaining defined size ranges within cell subtypes. How do they do that? Genome expression must be matched to different cell sizes, with rapidly growing cells likely requiring higher transcriptional and translational output than cells in slow growth or maintenance phase. |
Dr. Nir Fluman | 4.5 Years Phone:+972-8-934-6456 |
Membrane proteins make up a quarter of the proteome of every living organism and participate in nearly every biological process. We are interested in the fascinating process of how these proteins get produced, fold, and assemble in cells. The questions we address are: How do proteins fold in the membranes of living cells? How do the dynamic features of unfolded proteins assist in this process? How do cellular factors recognize membrane proteins that failed to fold and need to be cleared? The lab combines biochemical, cell biology, genetic and computational tools. |
Prof. Neta Regev-Rudzki | 5 Years Phone:+972-8-934-3160 |
<p><strong>Applicants with a strong research background at the intersection of molecular biology, biochemistry, imaging and/or biophysics are encouraged to apply. |
Prof. Eitan Reuveny | 5 Years Phone:+972-8-934-3243 |
<p>G protein-coupled receptors (GPCRs) are the largest gene family in the human genome. Their role is to translate chemical information into cellular responses, like olfactory processing, neuronal activity modulation, and hormone actions or regulating blood pressure among many. Their cellular effectors can range from various enzymes to ion channels. Interestingly, nature has designed the GPCR as a major target for many natural compounds and the pharmaceutical industry has focused its attention on designing various agonists and antagonists to treat various illnesses. |