Proteomic landscape of Ewing sarcoma primary tumors and metastases
,
Gordon S., Mohan V., Shukrun R., Golani O., Metzger S., Sher O., Manisterski M., Oren R., Fellus-Alyagor L., Beck L., Addadi Y., Dekel B., Elhasid R. & Geiger T.,
,
Nature Communications,
,
17,
2026,
https://doi.org/10.1038/s41467-026-70449-5
Inhibition of Tumor Microenvironment-Driven JAK-STAT Signaling Enhances Response to Arginine Deprivation Therapy in Triple-Negative Breast Cancer
,
Tishler H., Ziman S., Cheng K., Wang K., Sanghvi N., Adler L., Stelzer G., Maniriho H., Dassa B., Bab-Dinitz E., Levi M., Galai S., Goldman O., Ariav Y., Darzi N., Ezagouri S., Nimni N., Rosenfeld N., Rotkopf R., Brandis A., Mehlman T., Oren R., Zerbib M., Kuznetsov Y., Donzelli S., Blandino G., Seger R., Ruppin E. & Erez A.,
1,
Cells,
,
15,
2026,
https://doi.org/10.3390/cells15010025
Recurrent Immunogenic Neoantigens and Their Cognate T-cell Receptors in Treatment-Resistant Metastatic Prostate Cancer
,
Gumpert N., Sagie S., Arnedo-Pac C., Babu T., Weller C., Gonzalez-Perez A., Wang Y., Todó L. M., Levy R., Chen X., Greenberg P., Dayan-Rubinov M., Yakubovich E., Wasserman-Bartov T., Zerbib M., Gong J., Rebernick R. J., Tercero A. O., Muriel L. A., Benedek G., Kedmi M., Oren R., Ben-Dor S., Levin Y., Troyanskaya O. G., Munzur A. D., Wyatt A. W., Cieslik M. P., Quigley D. A., Van Allen E. M., Anandasabapathy N., Mateo J., Yang X., Martínez-Jiménez F., Lopez-Bigas N. & Samuels Y.,
2,
Cancer Discovery,
250-269,
16,
2026,
https://doi.org/10.1158/2159-8290.cd-24-1213
Lymphodepleting chemotherapy potentiates neoantigen-directed T cell therapy by enhancing antigen presentation
,
Sagie S., Babu T., Weller C., Tabachnik C., Livneh I., Quast N. P., Gumpert N., Shomuradova A., Raybould M. I., Levy R., Malko D., Alfia A., Ben Lulu T., Alon M., Herrera F., Kutuzov M., Zerbib M., Greenberg P., Wasserman-Bartov T., Benedek G., Levin Y., Stossel C., Kamer I., Golan T., Oren R., Shmueli M., Bartok O., Bar J., Cohen J., Dushek O., Deane C. M. & Samuels Y.,
12,
Cell Reports Medicine,
,
6,
2025,
https://doi.org/10.1016/j.xcrm.2025.102506
Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
,
Shvefel S. C., Pai J. A., Cao Y., Pal L. R., Bartok O., Levy R., Zemanek M. J., Weller C., Herzog E., Yao W., Hiam-Galvez K. J., Cheng K., Yin Y., Du P. P., Raposo C. J., Gumpert N., Welti M., Martínez Gómez J. M., Sella F., Yakubovich E., Orr I., Ben-Dor S., Oren R., Fellus-Alyagor L., Golani O., Brenner O. J., Salame T. M., Zerbib M., Goliand I., Ranmar D., Savchenko I., Ketrarou N., Schäffer A. A., Dahan R., Levesque M. P., Ruppin E., Satpathy A. T. & Samuels Y.,
3,
Cancer Discovery,
553-577,
15,
2025,
https://doi.org/10.1158/2159-8290.CD-23-1422
Inhibitors of eIF1A-ribosome interaction unveil uORF-dependent regulation of translation initiation and antitumor and antiviral effects
,
Hayat D., Ogran A., Ashkenazi S., Plotnikov A., Oren R., Zerbib M., Ben-Shmuel A. & Dikstein R.,
13,
EMBO Journal,
3853-3871,
44,
2025,
https://doi.org/10.1038/s44318-025-00449-6
Translation dysregulation in cancer as a source for targetable antigens
,
Weller C., Bartok O., McGinnis C. S., Palashati H., Chang T. G., Malko D., Shmueli M. D., Nagao A., Hayoun D., Murayama A., Sakaguchi Y., Poulis P., Khatib A., Erlanger Avigdor B., Gordon S., Cohen Shvefel S., Zemanek M. J., Nielsen M. M., Boura-Halfon S., Sagie S., Gumpert N., Yang W., Alexeev D., Kyriakidou P., Yao W., Zerbib M., Greenberg P., Benedek G., Litchfield K., Petrovich-Kopitman E., Nagler A., Oren R., Ben-Dor S., Levin Y., Pilpel Y., Rodnina M., Cox J., Merbl Y., Satpathy A. T., Carmi Y., Erhard F., Suzuki T., Buskirk A. R., Olweus J., Ruppin E., Schlosser A. & Samuels Y.,
5,
Cancer Cell,
823-840.e18,
43,
2025,
https://doi.org/10.1016/j.ccell.2025.03.003
Establishing a Mouse Genotyping Core Facility Based on Automation, High-resolution Melting Analysis, and Purpose-developed MATLAB Applications for Sample Tracking, Data Analysis, and Report Generation
,
Dafni H., Levi K., Eldad M. C., Shaul M., Oren R., Alyagor L., Stettner N., Harmelin A. & Haffner-Krausz R.,
4,
Comparative Medicine,
263-273,
74,
2024,
https://doi.org/10.30802/AALAS-CM-24-000014
Efficacy of an AAV vector encoding a thermostable form of glucocerebrosidase in alleviating symptoms in a Gaucher disease mouse model
,
Milenkovic I., Blumenreich S., Hochfelder A., Azulay A., Biton I. E., Zerbib M., Oren R., Tsoory M., Joseph T., Fleishman S. J. & Futerman A. H.,
9-10,
Gene Therapy,
439-444,
31,
2024,
https://doi.org/10.1038/s41434-024-00476-8
A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib
,
Simoni-Nieves A., Lindzen M., Giri S., Gupta N., Chatterjee R., Selvadurai B. R., Van Daele M., Love D., Haga Y., Romaniello D., Salame T. M., Zerbib M., Oren R., Tsutsumi Y., Lauriola M., Marrocco I. & Yarden Y.,
9,
Cell Reports Medicine,
,
5,
2024,
https://doi.org/10.1016/j.xcrm.2024.101703
Dual targeting of histone deacetylases and myc as potential treatment strategy for h3- k27m pediatric gliomas
,
Algranati D., Oren R., Dassa B., Fellus-Alyagor L., Plotnikov A., Barr H., Harmelin A., London N., Ron G., Furth N. & Shema E.,
,
eLife,
,
13,
2024,
https://doi.org/10.7554/eLife.96257
Depleting the 19S proteasome regulatory PSMD1 subunit as a cancer therapy strategy
,
Adler J., Oren R. & Shaul Y.,
9,
Cancer Medicine,
10781-10790,
12,
2023,
https://doi.org/10.1002/cam4.5775
Chemically programmable bacterial probes for the recognition of cell surface proteins
,
Prasad P. K., Eizenshtadt N., Goliand I., Fellus-Alyagor L., Oren R., Golani O., Motiei L. & Margulies D.,
,
Materials Today Bio,
,
20,
2023,
https://doi.org/10.1016/j.mtbio.2023.100669
L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
,
Marrocco I., Giri S., Simoni-Nieves A., Gupta N., Rudnitsky A., Haga Y., Romaniello D., Sekar A., Zerbib M., Oren R., Lindzen M., Fard D., Tsutsumi Y., Lauriola M., Tamagnone L. & Yarden Y.,
8,
Cell Reports Medicine,
,
4,
2023,
https://doi.org/10.1016/j.xcrm.2023.101142
Early Infiltration of Innate Immune Cells to the Liver Depletes HNF4α and Promotes Extrahepatic Carcinogenesis
,
Goldman O., Adler L. N., Hajaj E., Croese T., Darzi N., Galai S., Tishler H., Ariav Y., Lavie D., Fellus-Alyagor L., Oren R., Kuznetsov Y., David E., Jaschek R., Stossel C., Singer O., Malitsky S., Barak R., Seger R., Erez N., Amit I., Tanay A., Saada A., Golan T., Rubinek T., Sang Lee J., Ben-Shachar S., Wolf I. & Erez A.,
7,
Cancer Discovery,
1616-1635,
13,
2023,
https://doi.org/10.1158/2159-8290.CD-22-1062
Sulfamate Acetamides as Self-Immolative Electrophiles for Covalent Ligand-Directed Release Chemistry
,
Reddi R. N., Rogel A., Gabizon R., Rawale D. G., Harish B., Marom S., Tivon B., Arbel Y. S., Gurwicz N., Oren R., David K., Liu J., Duberstein S., Itkin M., Malitsky S., Barr H., Katz B., Herishanu Y., Shachar I., Shulman Z. & London N.,
6,
Journal of the American Chemical Society,
3346-3360,
145,
2023,
https://doi.org/10.1021/jacs.2c08853
Single-cell epigenetic analysis reveals principles of chromatin states in H3.3-K27M gliomas
,
Harpaz N., Mittelman T., Beresh O., Griess O., Furth N., Salame T., Oren R., Fellus-Alyagor L., Harmelin A., Alexandrescu S., Marques J. G., Filbin M. G., Ron G. & Shema E.,
14,
Molecular Cell,
2696-2713+,
82,
2022,
https://doi.org/10.1016/j.molcel.2022.05.023
Pediatric glioblastoma cells are sensitive to drugs that inhibit eIF2α dephosphorylation and its phosphomimetic S51D variant
,
Eytan K., Versano Z., Oren R., Jacob-Hirsch J., Leitner M., Harmelin A., Rechavi G., Toren A., Paglin S. & Yalon M.,
,
Frontiers in Oncology,
,
12,
2022,
https://doi.org/10.3389/fonc.2022.959133
Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo
,
Dubiella C., Pinch B. J., Koikawa K., Zaidman D., Poon E., Manz T. D., Nabet B., He S., Resnick E., Rogel A., Langer E. M., Daniel C. J., Seo H., Chen Y., Adelmant G., Sharifzadeh S., Ficarro S. B., Martins da Costa B., Jamin Y., Zimmerman M. W., Lian X., Kibe S., Kozono S., Doctor Z. M., Browne C. M., Yang A., Stoler-Barak L., Shah R. B., Vangos N. E., Geffken E. A., Oren R., Koide E., Sidi S., Shulman Z., Wang C., Marto J. A., Dhe-Paganon S., Look T., Zhou X. Z., Lu K. P., Sears R. C., Chesler L., Gray N. S. & London N.,
9,
Nature Chemical Biology,
954-963,
17,
2021,
https://doi.org/10.1038/s41589-021-00786-7
Upfront admixing antibodies and EGFR inhibitors preempts sequential treatments in lung cancer models
,
Marrocco I., Romaniello D., Vaknin I., Drago-Garcia D., Oren R., Uribe M. L., Belugali Nataraj N., Ghosh S., Eilam R., Salame T. M., Lindzen M. & Yarden Y.,
4,
EMBO Molecular Medicine,
,
13,
2021,
https://doi.org/10.15252/emmm.202013144
Targeting her3, a catalytically defective receptor tyrosine kinase, prevents resistance of lung cancer to a third-generation egfr kinase inhibitor
,
Romaniello D., Marrocco I., Nataraj N. B., Ferrer I., Drago-Garcia D., Vaknin I., Oren R., Lindzen M., Ghosh S., Kreitman M., Kittel J. C., Gaborit N., Baez G. B., Sanchez B., Eilam R., Pikarsky E., Paz-Ares L. & Yarden Y.,
9,
Cancers,
1-20,
12,
2020,
https://doi.org/10.3390/cancers12092394
Predicting and affecting response to cancer therapy based on pathway-level biomarkers
,
Ben-Hamo R., Jacob Berger A., Gavert N., Miller M., Pines G., Oren R., Pikarsky E., Benes C. H., Neuman T., Zwang Y., Efroni S., Getz G. & Straussman R.,
1,
Nature Communications,
,
11,
2020,
https://doi.org/10.1038/s41467-020-17090-y
Targeting purine synthesis in ASS1-expressing tumors enhances the response to immune checkpoint inhibitors
,
Keshet R., Lee J. S., Adler L., Iraqi M., Ariav Y., Lim L. Q. J., Lerner S., Rabinovich S., Oren R., Katzir R., Tishler H. W., Stettner N., Goldman O., Landesman H., Galai S., Kuperman Y., Kuznetsov Y., Brandis A., Mehlman T., Malitsky S., Itkin M., Koehler S. E., Zhao Y., Talsania K., Shen T., Peled N., Ulitsky I., Porgador A., Ruppin E. & Erez A.,
9,
Nature Reviews Cancer,
894-908,
1,
2020,
https://doi.org/10.1038/s43018-020-0106-7
Immunoproteasome expression is associated with better prognosis and response to checkpoint therapies in melanoma
,
Kalaora S., Lee J. S., Barnea E., Levy R., Greenberg P., Alon M., Yagel G., Bar Eli G., Oren R., Peri A., Patkar S., Bitton L., Rosenberg S. A., Lotem M., Levin Y., Admon A., Ruppin E. & Samuels Y.,
1,
Nature Communications,
,
11,
2020,
https://doi.org/10.1038/s41467-020-14639-9
BACH family members regulate angiogenesis and lymphangiogenesis by modulating VEGFC expression
,
Cohen B., Tempelhof H., Raz T., Oren R., Nicenboim J., Bochner F., Even R., Jelinski A., Eilam R., Ben-Dor S., Adaddi Y., Golani O., Lazar S., Yaniv K. & Neeman M.,
4,
Life Science Alliance,
,
3,
2020,
https://doi.org/10.26508/lsa.202000666
The Likelihood of Misidentifying Rodent Pasteurellaceae by Using Results from a Single PCR Assay
,
Dafni H., Greenfeld L., Oren R. & Harmelin A.,
2,
Journal of the American Association for Laboratory Animal Science,
201-207,
58,
2019,
https://doi.org/10.30802/AALAS-JAALAS-18-000049
Whole Organ Blood and Lymphatic Vessels Imaging (WOBLI)
,
Oren R., Fellus-Alyagor L., Addadi Y., Bochner F., Gutman H., Blumenreich S., Dafni H., Dekel N., Neeman M. & Lazar S.,
1,
Scientific Reports,
,
8,
2018,
https://doi.org/10.1038/s41598-018-19663-w
Genetic manipulation of iron biomineralization enhances MR relaxivity in a ferritin-M6A chimeric complex
,
Radoul M., Lewin L., Cohen B., Oren R., Popov S., Davidov G., Vandsburger M. H., Harmelin A., Bitton R., Greneche J. M., Neeman M. & Zarivach R.,
,
Scientific Reports,
,
6,
2016,
https://doi.org/10.1038/srep26550
Fibroblast recruitment as a tool for ovarian cancer detection and targeted therapy
,
Oren R., Addadi Y., Haziza L. N., Dafni H., Rotkopf R., Meir G., Fishman A. & Neeman M.,
8,
International Journal of Cancer,
1788-1798,
139,
2016,
https://doi.org/10.1002/ijc.30209
Cardio-chemical exchange saturation transfer magnetic resonance imaging reveals molecular signatures of endogenous fibrosis and exogenous contrast media
,
Vandsburger M., Vandoorne K., Oren R., Leftin A., Mpofu S., Castelli D. D., Aime S. & Neeman M.,
1,
Circulation-Cardiovascular Imaging,
,
8,
2014,
https://doi.org/10.1161/CIRCIMAGING.114.002180
Imaging aspects of the tumor stroma with therapeutic implications
,
Narunsky L., Oren R., Bochner F. & Neeman M.,
2,
Pharmacology and Therapeutics,
192-208,
141,
2014,
https://doi.org/10.1016/j.pharmthera.2013.10.003
Dysregulation of Dicer1 in beta cells impairs islet architecture and glucose metabolism
,
Mandelbaum A. D., Melkman-Zehavi T., Oren R., Kredo-Russo S., Nir T., Dor Y. & Hornstein E.,
,
Experimental Diabetes Research,
,
2012,
2012,
https://doi.org/10.1155/2012/470302
MiRNAs control insulin content in pancreatic β 2-cells via downregulation of transcriptional repressors
,
Melkman-Zehavi T., Oren R., Kredo-Russo S., Shapira T., Mandelbaum A. D., Rivkin N., Nir T., Lennox K. A., Behlke M. A., Dor Y. & Hornstein E.,
5,
EMBO Journal,
835-845,
30,
2011,
https://doi.org/10.1038/emboj.2010.361
Systemic antitumor protection by vascular-targeted photodynamic therapy involves cellular and humoral immunity
,
Preise D., Oren R., Glinert I., Kalchenko V., Jung S., Scherz A. & Salomon Y.,
1,
Cancer Immunology, Immunotherapy,
71-84,
58,
2009,
https://doi.org/10.1007/s00262-008-0527-0