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February 01-28, 2017
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Date:01WednesdayFebruary 2017Lecture
Cardiovascular Lineage Plasticity During Embryogenesis
More information Time 10:00Location Arthur and Rochelle Belfer Building for Biomedical Research
Botnar AuditoriumLecturer Eldad Tzahor
Dept. of Molecular Cell Biology, WISOrganizer Life SciencesContact -
Date:01WednesdayFebruary 2017Lecture
Theory Excellence Center Seminar
More information Time 11:00 - 12:00Title Solving the Problem of Anharmonic Densities of StatesLocation Gerhard M.J. Schmidt Lecture HallLecturer Prof. Julius Jellinek
Chemical Sciences and Engineering Division Argonne National Laboratory, USAOrganizer Department of Chemical and Biological PhysicsContact Abstract Show full text abstract about Solving the Problem of Anharmonic Densities of States* Ju...» Solving the Problem of Anharmonic Densities of States*
Julius Jellinek
Chemical Sciences and Engineering Division
Argonne National Laboratory, Argonne, IL 60439, USA
Density of states (DOS) is a fundamental characteristic of systems that lies in the very foundation of statistical mechanics and all the theoretical constructs that derive from them (e.g., kinetic rate theories, phase diagrams, etc.). Knowledge of DOS is central for calculation of entropy, partition function, free energy, reaction rate constants, and other important characteristics. The accuracy of all these depends on the accuracy with which the DOS is defined. Even though virtually all real systems are anharmonic, the current practice in the computation of vibrational DOSs is largely based on the harmonic approximation. The reason is that despite major efforts over about eight decades a general and exact, yet practical in applications, solution to the problem of anharmonic DOSs stubbornly resisted resolution. The alternatives introduced are mostly limited to cases of weak anharmonicity and/or suffer from other shortcomings.
In a recent development, we formulated a general and exact solution to this long-standing problem, which is applicable to arbitrary degree of anharmonicity (i.e., any system) and that is practical and efficient in applications. The solution and its algorithmic implementations are developed within the frameworks of both classical and quantum mechanics. The quantum implementation involves generalization and significant enhancement in the efficiency of the celebrated Beyer-Swinehart counting scheme, which is the fastest to date algorithm used in the computation of the quantum harmonic DOSs. Our solution is based on simulating the actual dynamical behavior of systems on the time scale of interest, short or long, as defined by the experiment and/or the nature of the process or phenomenon at hand. As a consequence, the resulting anharmonic DOSs are fully dynamically informed and, in general, time-dependent. As such, they lay the foundation for formulation of new statistical mechanical frameworks that incorporate time and reproduce exactly the actual time-averaged dynamical behavior of systems on the temporal scale of interest irrespective of whether this behavior is statistical or not in the traditional sense.
Work has been initiated on extending this development to the general case of rotational(ro)-vibrational DOSs for systems with arbitrary degree of anharmonicity and arbitrarily strong ro-vibrational coupling.
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* This work was supported by the Office of Basic Energy Sciences, Division of Chemical Sciences, Geosciences and Biosciences, U.S. Department of Energy under Contract No. DE-AC02-06CH11357.
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Date:01WednesdayFebruary 2017Lecture
(β)Arrestin Prostate Cancer Progression
More information Time 14:00Title Special Guest SeminarLocation Max and Lillian Candiotty Building
Seminar RoomLecturer Prof. Yehia Daaka
University of FloridaOrganizer Department of Immunology and Regenerative BiologyContact -
Date:02ThursdayFebruary 2017Colloquia
One day in the life of Anabaena, A one-dimensional developing organism that exhibits Turing-like patterns
More information Time 11:15 - 12:30Location Edna and K.B. Weissman Building of Physical Sciences
AuditoriumLecturer Joel Stavans
WISOrganizer Faculty of PhysicsContact Details Show full text description of 11:00 – coffee, tea, and more...» 11:00 – coffee, tea, and moreAbstract Show full text abstract about Within the last two decades it has become clear that cells h...» Within the last two decades it has become clear that cells having the same genetic information can behave very differently, due to inevitable stochastic fluctuations in gene expression, known as noise. How do cells in multicellular organisms achieve high precision in their developmental fate in the presence of noise, in order to reap the benefits of division of labor? We address this fundamental question from Systems Biology and Statistical Physics perspectives, with Anabaena cyanobacterial filaments as a model system, one of the earliest examples of multicellular organisms in nature. These filaments can form one-dimensional, nearly-regular patterns of cells of two types. The developmental program uses tightly regulated, non-linear processes that include activation, inhibition, and transport, in order to create spatial and temporal patterns of gene expression that we can follow in real time, at the level of individual cells. We study cellular decisions, properties of the genetic network behind pattern formation, and establish the spatial extent to which gene expression is correlated along filaments. Motivated by our experimental results, I will show that pattern formation in Anabaena can be described theoretically by a minimal, three-component model that exhibits a deterministic, diffusion-driven Turing instability. Furthermore, I will discuss how noise can enhance considerably the robustness of the developmental program, by promoting the formation of stochastic patterns in regions of parameter space for which deterministic patterns do not form, suggesting a novel mechanism for pattern formation in this and other systems.
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Date:02ThursdayFebruary 2017Lecture
Cellular substrates for network information processing in hippocampal CA1
More information Time 12:30Location Gerhard M.J. Schmidt Lecture HallLecturer Dr. Alessio Attardo
Dept of Stress Neurobiology and Neurogenetics Max Planck Institute of Psychiatry, MunichOrganizer Department of Brain SciencesContact Details Show full text description of Host: Dr.Yaniv Ziv yaniv.ziv@weizmann.ac.il tel: 4275 For a...» Host: Dr.Yaniv Ziv yaniv.ziv@weizmann.ac.il tel: 4275
For assistance with accessibility issues,
please contact naomi.moses@weizmann.ac.il
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Date:02ThursdayFebruary 2017Cultural Events
Lihi Lapid - New date 2/2/17 instead of 26/1/17
More information Time 20:30Location Michael and Anna Wix AuditoriumContact Details Show full text description of Lihi Lapid, who deal with contemporary women's issues. ...» Lihi Lapid, who deal with contemporary women's issues.
In this lecture we will stop a minute and think how can we be good to ourselves -
Date:05SundayFebruary 2017Lecture
Flow Cytometry and Single Cell Heterogeneity in the Mammalian Liver
More information Time 09:00 - 10:00Location Arthur and Rochelle Belfer Building for Biomedical Research
Botnar AuditoriumLecturer Dr. Ayala Sharp and Dr. Shalev ItzkovitzOrganizer Department of Life Sciences Core Facilities
SeminarContact -
Date:05SundayFebruary 2017Lecture
The elusive nature of Earth magnetic field : paleomagnetic research from nano to global scale
More information Time 11:00Location Sussman Family Building for Environmental Sciences
M. Magaritz Seminar RoomLecturer Ron Shaar
Hebrew University of JerusalemOrganizer Department of Earth and Planetary SciencesContact -
Date:05SundayFebruary 2017Lecture
The role of FABP4 in ER stress-triggered cell death
More information Time 13:00Location Arthur and Rochelle Belfer Building for Biomedical Research
Botnar AuditoriumLecturer Rinat Livne
Menachem Rubinstein's group, Dept. of Molecular Genetics, WISOrganizer Department of Molecular GeneticsContact -
Date:06MondayFebruary 2017Colloquia
"Imaging wave function of few body systems: He dimers, trimers and the Efimov state of He3"
More information Time 11:00 - 12:15Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Reinhard Doerner
Institute for Nuclear Physics, Goethe University, FrankfurtOrganizer Faculty of ChemistryContact Abstract Show full text abstract about Two and three Helium atoms form very unusual and extreme qua...» Two and three Helium atoms form very unusual and extreme quantum systems. Their typical extend is ten to hundred times bigger than radius of the atoms, the wavefunction lives almost completely in the classically forbidden tunneling region and the binding energy of these systems is about 8 orders of magnitude smaller than that of a normal molecule.
We will show how coincidence detection of charged fragments and super strong laser fields can be used to image the wave functions of these Helium quantum giants and will show the first experimental images of an Efimov state. -
Date:06MondayFebruary 2017Lecture
Personalized Cancer Nano-Medicines
More information Time 14:00 - 15:00Title Special Guest SeminarLocation Max and Lillian Candiotty Building
Seminar RoomLecturer Prof. Avi Schroeder
Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Chemical Engineering Technion - Israel Institute of Technology, HaifaOrganizer Department of Immunology and Regenerative BiologyContact Abstract Show full text abstract about The field of medicine is taking its first steps towards pati...» The field of medicine is taking its first steps towards patient-specific care. Our research is aimed at tailoring treatments to address each person’s individualized needs and unique disease presentation. Specifically, we are developing nanoparticles that target disease sites, where they perform a programmed therapeutic task. These systems utilize molecular-machines and cellular recognition to improve efficacy and reduce side effects.
Nanoparticles have many potential benefits for treating cancer, including the ability to transport complex molecular cargoes, as well as targeting to specific cell populations.
The talk will describe principles for developing lipid nanoparticles that can be remotely triggered to release their payload in disease sites.
Two examples will be described: the first involves a nanoscale theranostic system for predicting the therapeutic potency of cancer medications. The system provides patient-specific drug activity data with single-cell resolution. The system makes use of barcoded nanoparticles to predict the therapeutic effect different drugs will have on the tumor microenvironment.
The second system makes use of enzymes, loaded into a biodegradable chip, to perform a programed therapeutic task – surgery with molecular precision. Collagenase is an enzyme that cleaves collagen, but not other tissues. This enzyme was loaded into the biodegradable chip and placed in the periodontal pocket. Once the collagenase releases from the chip, collagen fibers that connect between the teeth and the underlying bone are relaxed, thereby enabling enhanced orthodontic corrective motion and reducing pain. This new field is termed BioSurgery.
The clinical implications of these approaches will be discussed. -
Date:06MondayFebruary 2017Cultural Events
Trofoti - Children's Theater
More information Time 17:30Location Michael and Anna Wix AuditoriumContact -
Date:07TuesdayFebruary 2017Lecture
Breaking the dimer: NF-kB dimerization emerges as an excellent drug target
More information Time 10:00 - 10:30Location Wolfson Building for Biological Research
AuditoriumLecturer Shaked Ashkenazi
Members - Dept. of Biomolecular Sciences-WISOrganizer Department of Biomolecular SciencesContact -
Date:07TuesdayFebruary 2017Lecture
QUANTUM FIELD THEORIES OF (N-1)-DIMENSIONAL EXTENDED OBJECTS IN 2N-DIMENSIONAL SPACE-TIME MANIFOLDS AS 2D QUANTUM FIELD THEORIES ON ``QUASI RIEMANN SURFACES'' OF INTEGRAL (N-1)-CURRENTS.
More information Time 10:00Location Newe ShalomLecturer DANIEL FRIEDAN
REUTGERSOrganizer Department of Particle Physics and Astrophysics
Joint SeminarContact Details Show full text description of 09:50 Gathering and coffee ...» 09:50 Gathering and coffee
Abstract Show full text abstract about Abstract: In my talk I will discuss some new features of ...»
Abstract: In my talk I will discuss some new features of conformal anomaly and entanglement entropy in the presence of boundaries. The talk is based on recent papers.This is a project to develop a wide expanse of new quantum field theories in 2n-dimensional space-time manifolds. For each 2d qft, there is to be a qft of extended objects in every 2n-dimensional space-time manifold M. The quantum fields live on ``quasi Riemann surfaces'', which are certain spaces of integral (n-1)-currents in M. The notion of integral current comes from Geometric Measure Theory. The quasi Riemann surfaces are complete metric spaces with analytic properties strictly analogous to Riemann surfaces. The new qfts are to be constructed on the quasi Riemann surfaces just as 2d qfts are constructed on ordinary Riemann surfaces. Local fields in space-time are obtained by restricting to small extended objects.
arXiv:1510.04566, arXiv:1601.06418 and arXiv:1604.07571
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Date:07TuesdayFebruary 2017Lecture
Antimicrobial Peptides: Mechanisms of Bacterial Biofilms Neutralization.
More information Time 10:30 - 11:00Location Wolfson Building for Biological Research
AuditoriumLecturer Liav Tia Segev Zarko
Members - Dept. of Biomolecular Sciences-WISOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about Multidrug resistant bacteria are a growing phenomenon that c...» Multidrug resistant bacteria are a growing phenomenon that concerns the scientific community worldwide. Two extensively studied resistance mechanisms are biofilm colonization and bacterial outer membrane remodeling. An attractive alternative to conventional antibiotics are antimicrobial peptides (AMPs), innate immune system molecules serving as a first line of defense in fighting invading pathogens. We show that AMPs can either inhibit or reduce biofilm formation and degrade established ones via several bactericidal and non- bactericidal mechanisms. Alternatively, AMPs can promote bacterial lipopolysaccharide (LPS) remodeling and potentially affect biofilm colonization. Our findings suggest that bacteria that are unable to remodel LPS compensate for it by adopting a biofilm lifestyle.
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Date:07TuesdayFebruary 2017Lecture
Controls and functions of non-structural carbon reserves in trees
More information Time 11:00 - 11:45Location Ullmann Building of Life Sciences
Aharon Katzir HallLecturer Dr. Guenter Hoch
Department of Environmental Sciences - Botany, University of Basel, SwitzerlandOrganizer Department of Plant and Environmental SciencesContact Details Show full text description of homepage: https://botanik.unibas.ch/hoch/ ...» homepage: https://botanik.unibas.ch/hoch/
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Date:07TuesdayFebruary 2017Lecture
TACHYONIC ANTIBRANES AND THE LANDSCAPE
More information Time 11:15Location Newe ShalomLecturer IOSIF BENA
SACLAYOrganizer Department of Particle Physics and Astrophysics
High Energy Theory Joint SeminarContact Abstract Show full text abstract about Abstract:: ntibranes in backgrounds that have charge dissolv...» Abstract:: ntibranes in backgrounds that have charge dissolved in fluxes are a key ingredient in constructing a landscape (Multiverse) of deSitter vacua in String Theory, and also of constructing microstate solutions corresponding to non-supersymmetric near-extremal black holes. There are several regimes of parameters in which one can study the physics of these antibranes, and I will show that in the regime of parameters where their gravitational backreaction is important, antibranes have a naked singularity that cannot be resolved either by brane polarization or by cloaking with a black hole horizon, and that signals a tachyonic instability. I will also present recent evidence that the theory on the wordvolume of anti-D3 branes is finite to all loops. I will conclude by discussing the implications of these results for the Multiverse paradigm and for the Fuzzball proposal. -
Date:07TuesdayFebruary 2017Lecture
Store it, use it or lose it; Carbon reserve dynamics in stressed trees
More information Time 12:15 - 13:00Location Ullmann Building of Life Sciences
Aharon Katzir HallLecturer Prof. Simon Landhausser
Department of Renewable Resources, University of Alberta, Edmonton, CanadaOrganizer Department of Plant and Environmental SciencesContact Details Show full text description of Website: http://www.rr.ualberta.ca/ and http://landhausser.u...» Website: http://www.rr.ualberta.ca/ and http://landhausser.ualberta.ca/
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Date:07TuesdayFebruary 2017Lecture
S-DUALITY IN MATHCAL{N} = 1 ORIENTIFOLD SCFTS
More information Time 12:30Location Newe ShalomLecturer INAKI GARCIA-ETXEBARRIA
MPIOrganizer Department of Particle Physics and Astrophysics
High Energy Theory Joint SeminarContact Abstract Show full text abstract about Abstract: I will present a general solution to the problem o...» Abstract: I will present a general solution to the problem of determining all S-dual descriptions for a specific (but very rich) class of N=1 SCFTs. These SCFTs are indexed by decorated toric diagrams, and can be engineered in string theory by probing orientifolds of isolated toric singularities with D3 branes. The S-dual phases are described by quiver gauge theories coupled to specific types of conformal matter which I will describe explicitly. -
Date:07TuesdayFebruary 2017Lecture
Why Sensory Deprivation and High Plasticity may lead to Hallucinations and Synaesthesia:A Computational Perspective
More information Time 12:30Location Gerhard M.J. Schmidt Lecture HallLecturer Dr. Oren Shriki
Dept of Cognitive and Brain Sciences Ben-Gurion UniversityOrganizer Department of Brain SciencesContact Details Show full text description of Host: Dr.Yaniv Ziv yaniv.ziv@weizmann.ac.il tel: 4275 For a...» Host: Dr.Yaniv Ziv yaniv.ziv@weizmann.ac.il tel: 4275
For assistance with accessibility issues, please contact naomi.moses@weizmann.ac.il
Abstract Show full text abstract about Recurrent connections are abundant in cortical circuitry but...» Recurrent connections are abundant in cortical circuitry but their functional role has been the subject of intense debates. The talk will present a computational approach to investigate the role of recurrent connections in the context of sensory processing. Specifically, I will describe a neural network model in which the recurrent connections evolve according to concrete learning rules that optimize the information representation of the network. Interestingly, these networks tend to operate near a "critical" point in their dynamics, namely close to a phase of "hallucinations", in which non-trivial spontaneous patterns of activity evolve even without structured input. Various scenarios, such as attenuation of the external inputs or increased plasticity, can lead the network to cross the border into the hallucinatory phase. The theory will be illustrated through applications to a model of a visual hypercolumn, a model of tinnitus and a model of synaesthesia.
References:
Shriki O. and Yellin D., Optimal Information Representation and Criticality in an Adaptive Sensory Recurrent Neural Network. PLoS Computational Biology 12(2): e1004698. doi:10.1371/journal.pcbi.1004698, 2016
Shriki O., Sadeh Y. and Ward J., The Emergence of Synaesthesia in a Neuronal Network Model via Changes in Perceptual Sensitivity and Plasticity. PLoS Computational Biology 12(7): e1004959. doi:10.1371/journal.pcbi.1004959, 2016.