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  • Date:11SundayMay 2025

    Early Cancer Detection and Precision Prevention

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    Time
    08:00 - 08:00
    Title
    Early Cancer Detection and Precision Prevention
    Location
    The David Lopatie Conference Centre
    Chairperson
    Sima Lev
    Organizer
    Swiss Society Institute for Cancer Prevention Research , Moross Integrated Cancer Center (MICC)
    Contact
    Conference
  • Date:11SundayMay 2025

    The Clore Center for Biological Physics

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    Time
    13:15 - 14:30
    Title
    Second law of Thermodynamics in Living Matter
    Location
    Koffler Accelerator of the Canada Center of Nuclear Physics
    LecturerDr. Tomer Markovich
    Lunch will be served at 12:45
    Contact
    AbstractShow full text abstract about <p>Materials that are constantly driven out of thermod...»
    <p>Materials that are constantly driven out of thermodynamic equilibrium, such as active and living systems, typically violate the Einstein relation. This may arise from active contributions to particle fluctuations which are unrelated to the dissipative resistance of the surrounding medium. In this talk I will show that in these cases the widely used relation between informatic entropy production and heat dissipation does not hold. Consequently, fluctuation relations for the mechanical work, such as the Jarzynski and Crooks theorems, are invalid. The breaking of the correspondence between informatic entropy production and heat dissipation will then be related to the departure from the fluctuation-dissipation theorem. I will finally propose a temperaturelike variable that restores the correspondence between information and thermodynamics and gives rise to a generalized second law of thermodynamics. The Clausius inequality, Carnot maximum efficiency theorem, and relation between the extractable work and the change of free energy are recovered as well.</p>
    Lecture
  • Date:11SundayMay 2025

    Blow the Trumpet | The Israel Camerata Jerusalem

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    Time
    20:00 - 21:30
    Location
    Michael Sela Auditorium
    Homepage
    Contact
    Cultural Events
  • Date:12MondayMay 2025

    Seminar for PhD thesis defense

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    Time
    14:00 - 15:00
    Title
    TDP-43 pathology in ALS: from organelles to splicing, and an unexpected link to Alzheimer's Disease
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    Botnar Auditorium
    LecturerJoelle Welmoed Rachel Van Zuiden
    Academic Events
  • Date:12MondayMay 2025

    David Lerner, PhD. Defense Seminar

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    Time
    16:00 - 17:00
    Title
    The evolution and distribution of tree species across the latitudinal axis - From a global to a regional scale
    Location
    Nella and Leon Benoziyo Building for Plant and Environmental Sciences
    690
    LecturerDavid Lerner
    Department of Plant and Environmental Sciences
    Contact
    Academic Events
  • Date:14WednesdayMay 2025

    Development as a Metabolic Regulator: How Molting Controls Cholesteryl Ester Metabolism in the Somatic Stem Cells of C. elegans

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    Time
    10:00 - 11:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    Botnar Auditorium
    LecturerDr. Amir Sapir
    Contact
    AbstractShow full text abstract about <p>Development as a Metabolic Regulator: How Molting C...»
    <p>Development as a Metabolic Regulator: How Molting Controls Cholesteryl Ester Metabolism in the Somatic Stem Cells of <em>C. elegans</em></p><p>&nbsp;</p><p>Raj Rani1, Or Ben-Hemo1, Benjamin Trabelcy1, Agam Bar1, Hans-Joachim Knölker2, Yoram Gerchman1,3,4, and Amir Sapir1*</p><p>1Department of Biology and the Environment, Faculty of Natural Sciences, University of Haifa, Oranim, Tivon, 36006 Israel</p><p>2 Fakultät Chemie, Technische Universität Dresden, Bergstrasse 66, 01069 Dresden, Germany</p><p>3Institute of Evolution, Faculty of Natural Sciences, University of Haifa, Haifa, Israel</p><p>4Oranim Academic College, Kiryat Tivon, Israel</p><p>&nbsp;</p><p>The metabolism of steroids, such as cholesterol, is critical for mammalian physiology and human health, yet its function in invertebrates remains poorly understood. Using <em>Caenorhabditis elegans</em>, we constructed the first comprehensive homology-based enzymatic atlas of steroid metabolism in invertebrates, identifying 159 candidate genes. We performed a two-dimensional genetic and metabolic screen, knocking down the atlas genes under varying cholesterol conditions to identify those functioning in steroid metabolism. Among the screen hits, we focused on <em>mboa-1</em>, an ortholog of mammalian SOAT1/2 enzymes that synthesize cholesteryl esters from sterols and fatty acids. Surprisingly, <em>mboa-1</em> knockdown and knockout disrupt hypodermis and cuticle integrity. Consistent with its predicted enzymatic function, bacterially expressed <em>C. elegans</em> MBOA-1 generates cholesteryl esters when supplemented with the steroid 4,3-cholesta and fatty acids. Moreover, 4,3-cholesta—but not steroid hormones—rescued the <em>mboa-1</em> RNAi phenotype, suggesting a new branch of steroid metabolism in <em>C. elegans</em>. <em>mboa-1</em> is expressed specifically in the somatic stem cells of <em>C. elegans</em>, the seam cells, which contribute to the hypodermis and cuticle. Expression begins in mid-embryogenesis, persists throughout larval development, but declines sharply in adults. Underscoring its role in cuticle dynamics, <em>mboa-1</em> expression oscillates with the molting cycle and is regulated by <em>lin-29</em>–mediated heterochronic control during the larval-to-adult transition, a stage when seam cells terminally differentiate. Our functional studies in Clade IV and V nematodes, along with insect expression data, suggest that during evolution, <em>mboa-1</em> regulation was rewired to support a structural role for cholesteryl esters in cuticle formation, diverging from their primarily metabolic functions in mammals and insects. Our findings reveal how, during evolution, steroid metabolism was repurposed for a novel function in nematodes through the mechanistic reconfiguring of developmental regulation and stem cell biology.</p>
    Lecture
  • Date:14WednesdayMay 2025

    Machine Learning and Statistics Seminar

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    Time
    11:15 - 12:15
    Title
    Sample Compression and Topological Radon Theorem
    Location
    Jacob Ziskind Building
    Room 1 - 1 חדר
    LecturerBogdan Chornomaz
    Technion
    Organizer
    Department of Computer Science and Applied Mathematics
    Contact
    AbstractShow full text abstract about If asked, what mathematical tools are mostly used in machine...»
    If asked, what mathematical tools are mostly used in machine learning, one would probably name statistics, probability, or combinatorics. So it is especially pleasing when some other tools, considered rather exotic in this area, find natural applications to ML problems. In this talk, I will speak about an application of (a variant of) topological Radon theorem to an old open problem in theoretical machine learning regarding the existence of the so-called sample compression schemes.

    The talk is based on the joint work with Zachary Chase, Steve Hanneke, Shay Moran, and Amir Yehudayoff.
    Lecture
  • Date:14WednesdayMay 2025

    Targeting leukemia cell vulnerabilities with our experimental new drug

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    Time
    14:00 - 15:00
    Location
    Max and Lillian Candiotty Building
    Auditorium
    LecturerProf. Yinon Ben-Neriah
    Organizer
    Dwek Institute for Cancer Therapy Research
    Lecture
  • Date:14WednesdayMay 2025

    ABC CHATS: Assaf Kacen

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    Time
    14:00 - 15:00
    Title
    From Academia to Industry: The PromiseBio Journey
    Location
    George and Esther Sagan Students' Residence Hall
    Lounge
    AbstractShow full text abstract about <p>Join our ABC CHATS, Where CEOs share their ABC’s on...»
    <p>Join our ABC CHATS, Where CEOs share their ABC’s on scientific leadership, breakthroughs and failures throughout their personal stories</p>
    Lecture
  • Date:14WednesdayMay 2025

    Special Guest Seminar

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    Time
    14:00 - 15:00
    Title
    Understanding evolutionary paths to virus virulence and the rational design of live-attenuated viral vaccines
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    Botnar Auditorium
    LecturerProf. Raul Andino
    Lecture
  • Date:15ThursdayMay 2025

    Scientific Council Meeting

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    Time
    10:00 - 12:00
    Location
    LOP
    KIMEL
    Contact
    Academic Events
  • Date:15ThursdayMay 2025

    PhD Thesis Defense- Aviva Rotter(Strassman's lab)

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    Time
    14:30 - 16:30
    Title
    Bacteria Mediated resistance to ALKi in EML4-ALK fusion NSCLC
    Location
    Ullmann Building of Life Sciences
    201
    Contact
    Academic Events
  • Date:15ThursdayMay 2025

    How to Enhance Sex Determination?

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    Time
    15:00 - 16:00
    Location
    Nella and Leon Benoziyo Building for Biological Sciences
    Auditorium Rm.191
    LecturerDr. Nitzan Gonen
    Faculty of Life Sciences and the Nanotechnology Institute, Bar Ilan University
    AbstractShow full text abstract about <p>Sex determination is the process through which an o...»
    <p>Sex determination is the process through which an organism will develop as male or female. This process is extremely delicate, relying on mutual antagonistic pathways of pro-male and pro-female factors. Nowadays, more than 50% of individuals with Differences of Sex Development (DSD) fail to receive genetic diagnosis following exome sequencing, suggesting that many variants fall within the non-coding genome. We have identified many regulatory elements, disruptions in which lead to sex reversal in mice with clinical relevance to DSD patients. We also aim to generate an <em>in vitro</em> system to model the gonads using the creation of testis organoids generated from primary tissues and gonadal cells differentiated from stem cells.</p>
    Lecture
  • Date:15ThursdayMay 2025

    Shabat in Brazil | Joca Perpignan, Marcelo Nami & Lea Shabat

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    Time
    21:00 - 22:30
    Location
    Michael Sela Auditorium
    Homepage
    Contact
    Cultural Events
  • Date:18SundayMay 2025

    Photonic seismology

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    Time
    11:00 - 12:00
    Location
    Sussman Family Building for Environmental Sciences
    M. Magaritz seminar room
    LecturerAriel Lellouch
    Contact
    AbstractShow full text abstract about <p>Distributed Fiber Optic Sensing (DFOS) is revolutio...»
    <p>Distributed Fiber Optic Sensing (DFOS) is revolutionizing seismology thanks to dense measurements at an unprecedented scale. In this talk, I will describe the main principles behind the technology, as well as multiple scientific and practical questions that we could answer with fiber-optic sensing: vehicle tracking in urban environments, microearthquake location and fault plane reconstruction, an inversion approach to jointly resolve subsurface and structural parameters, and finally – a recent experiment in which we deployed a joint fiber-accelerometer in an abandoned well near the Kinneret, targeting local undetected earthquakes.</p>
    Lecture
  • Date:18SundayMay 2025

    The Age of Plastic: A Blessing or A Curse?

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    Time
    13:00 - 14:00
    Title
    IES- Institute For Environmental Sustainability seminar series 2025-2026
    Location
    Nella and Leon Benoziyo Building for Biological Sciences
    690
    LecturerDr. Shira Haber
    Ben-Gurion University , The Department of Chemistry
    Organizer
    The Institute for Environmental Sustainability
    Lecture
  • Date:19MondayMay 2025

    Chemistry Colloquium

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    Time
    11:00 - 12:15
    Title
    title tbd
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerProf. Michael Neidig
    Homepage
    Colloquia
  • Date:19MondayMay 2025

    Mechanisms of axonal degeneration following traumatic brain injury

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    Time
    11:00 - 12:30
    Location
    Benoziyo Bldg. for Biological Sciences
    Seminar Rm. 290 -Floor 2
    LecturerProf. Wilma Friedman
    Special Guest Joint Seminar Dept. of Biomolecular Sciences & Dept. of  Molecular Neuroscience
    AbstractShow full text abstract about <p>Traumatic brain injury to the cortex elicits the lo...»
    <p>Traumatic brain injury to the cortex elicits the loss of neurons at the site of damage, but also evokes changes in the tissue environment of axon terminals that project to the site of injury from distal locations.&nbsp; We previously demonstrated that basal forebrain cholinergic neurons (BFCNs) undergo retrograde degeneration following cortical TBI that is mediated by the p75 neurotrophin receptor (p75NTR).&nbsp; We have investigated mechanisms governing p75NTR-mediated retrograde degeneration as well as the behavioral consequences of the loss of BFCNs following TBI. &nbsp;Mice lacking the p75NTR in cholinergic neurons showed sparing of these neurons following TBI, and preservation of cognitive function.</p>
    Lecture
  • Date:19MondayMay 2025

    Foundations of Computer Science Seminar

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    Time
    11:15 - 12:15
    Title
    Tree PCPs
    Location
    Jacob Ziskind Building
    Room 1 - 1 חדר
    LecturerTamer Mour
    Bocconi University
    Organizer
    Department of Computer Science and Applied Mathematics
    Contact
    AbstractShow full text abstract about Probabilistically checkable proofs (PCPs) allow encoding a c...»
    Probabilistically checkable proofs (PCPs) allow encoding a computation so that it can be quickly verified by only reading a few symbols. Inspired by tree codes (Schulman, STOC'93), we propose tree PCPs; these are PCPs that evolve as the computation progresses so that a proof for time t is obtained by appending a short string to the end of the tree PCP proof for time t-1. At any given time step t, a verifier can make a small number of queries to the entire tree PCP string (constructed thus far) to verify the correctness of the entire computation.

     

    We construct tree PCPs for non-deterministic space-s computation, where at time step t, the proof only grows by an additional poly(s,log(t)) bits, and the number of queries made by the verifier to the overall proof is poly(s)*t^epsilon, for an arbitrary constant epsilon > 0.
     

    Tree PCPs are well-suited to proving correctness of ongoing computation that unfolds over time.  They may be thought of as an information-theoretic analog of the cryptographic notion of incrementally verifiable computation (Valiant, TCC'08). We show that, in the random oracle model, tree PCPs can be compiled to realize a variant of incrementally verifiable computation where the prover is allowed a small number of queries to a large evolving state. This yields the first construction of (a natural variant of) IVC in the random oracle model.

    This is a joint work with Alon Rosen and Ron D. Rothblum.
    Lecture
  • Date:20TuesdayMay 2025

    Trauma Under Psychedelics: How trauma during altered states of consciousness impacts cognitive, physiological, neural, and clinical outcomes

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    Time
    12:30 - 13:30
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerProf. Roy Salomon
    Organizer
    Department of Brain Sciences
    Contact
    AbstractShow full text abstract about <p>Abstract: Recent research has focused on how psyche...»
    <p>Abstract: Recent research has focused on how psychedelics and empathogens may assist in the treatment of PTSD and depression following trauma. However, there is almost no knowledge regarding how psychoactive substances may impact the processing of Traumatic Events (TE) in real time. The large-scale terror attack by Hamas on October 7th 2023 on the 4000 attendees of the Supernova music festival has provided a tragic opportunity to study these two phenomena in conjunction. The attack took place shortly after sunrise, when many attendees were under the influence of mind-altering substances, mostly MDMA, LSD, ketamine and, as well as cannabis. This is an unprecedented mass trauma event that many of its victims experienced while in altered states of consciousness. We have begun a large-scale, longitudinal study with these survivors regarding the processing of trauma under the influence of psychedelics in the peritraumatic and post traumatic periods. Our results indicate that approximately 65% of the participants were exposed to severe trauma while under the influence of mind-altering substances. In this talk I will show preliminary results from this unique cohort including clinical (n = 1400), physiological (n = 300), cognitive (n = 900) and neural (fMRI) measures (n = 140) and how they relate to trauma and psychedelic use. The data and experiences of the courageous survivors of the festival provide novel insights into how trauma processing is impacted by psychoactive substances revealing unique interactions between cognitive, pharmacological and clinical factors.</p>
    Lecture

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