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Date:04SundayJune 2023Lecture
Special guest seminar
More information Time All dayTitle T cell memory, metabolism and the microbiomeLocation Max and Lillian Candiotty Building
AuditoriumLecturer Professor Sammy BedouiOrganizer Department of Immunology and Regenerative BiologyContact -
Date:04SundayJune 2023Lecture
Paleoclimate reconstruction using speleothems in dry and cold regions.
More information Time 11:00 - 12:00Location Sussman Family Building for Environmental Sciences
M. Magaritz Seminar RoomLecturer Anton Vaks
GSI, IsraelOrganizer Department of Earth and Planetary SciencesContact -
Date:06TuesdayJune 2023Lecture
Chemical and Biological Physics Guest Seminar
More information Time 10:00 - 11:00Title Materials with a twist: atomically controlled interfaces for clean energyLocation Perlman Chemical Sciences Building
Room 404Lecturer Prof Magali Lingenfelder
Max Planck-EPFL Laboratory for Molecular Nanoscience and Technology, Ecole Polytechnique Federale de Lausanne (EPFL)Organizer Department of Chemical and Biological PhysicsContact Abstract Show full text abstract about Our society faces a critical challenge in shifting from a re...» Our society faces a critical challenge in shifting from a reliance on carbon-based energy to sustainable renewable sources. A key step towards achieving clean energy lies in developing efficient catalysts that can convert chemical energy into electricity or use electrons to generate chemical energy.
In our research group, we tackle these challenges by creating customized materials that draw inspiration from nature (biomimicry) and combine principles from interfacial chemistry and surface physics. For this presentation, I focus on the process of photosynthesis as inspiration for the design, characterization, and dynamic nature of functional interfaces that drive energy conversion processes such as CO2 electroreduction and water splitting.
I will also discuss the application of cutting-edge scanning probe microscopy, which allows us to visualize dynamic electrochemical processes at the nanoscale (operando imaging). Additionally, I will highlight our use of unconventional strategies that leverage chiral molecules and abundant two-dimensional materials to enhance electrocatalytic conversion processes.
(References : Nanoletters, 2021, 21, 2059; Nature Comm., 2022, 13, 3356, IJC 62, 11, 2022). -
Date:06TuesdayJune 2023Lecture
Identifying and Characterizing Biocrusts Using Spectroscopy
More information Time 11:30 - 12:30Location Nella and Leon Benoziyo Building for Biological Sciences
AuditoriumLecturer Dr. Offer Rozenstein
ARO VolcaniOrganizer Department of Plant and Environmental SciencesContact Details Show full text description of Host: Dr. David Zeevi...» Host: Dr. David Zeevi -
Date:06TuesdayJune 2023Lecture
Local and long-range inputs contributing to sequence generation in the zebra finch
More information Time 12:30 - 13:30Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Michael A. Long
NYU School of MedicineOrganizer Department of Brain SciencesContact Details Show full text description of Host: Dr. Yarden Cohen Yarden.J.Cohen@weizmann.ac.il tel: 5...» Host: Dr. Yarden Cohen Yarden.J.Cohen@weizmann.ac.il
tel: 5138
For accessibility isssues:naomi.moses@weizmann.ac.ilAbstract Show full text abstract about : A central question in neuroscience is how local processing...» : A central question in neuroscience is how local processing and long-range influences work together to create behaviorally relevant neural dynamics. We address this issue by examining the song control pathway in the zebra finch. We find sufficient synaptic information is present in a key cortical structure to enable propagation of song-related sequences. We further demonstrate that long-range inputs from the motor thalamus can engage this circuitry in the service of behavior and large-scale brain synchronization. Our findings suggest that thalamic inputs may play an important initiating role for behaviorally-relevant cortical activity across species.
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Date:06TuesdayJune 2023Lecture
Drivers and dependencies arising during tumor evolution
More information Time 14:00 - 15:00Location Max and Lillian Candiotty Building
AuditoriumLecturer Prof. Kris Wood
Department of Pharmacology and Cancer Biology, Duke UniversityOrganizer Dwek Institute for Cancer Therapy Research
Cancer Research ClubContact Details Show full text description of Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6K...» Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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Date:06TuesdayJune 2023Lecture
Microbiome Metabolites: Syntheses and Surprises
More information Time 14:00 - 15:00Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Karl Gademann
Department of Chemistry University of ZurichOrganizer Department of Chemical and Structural BiologyContact -
Date:07WednesdayJune 202308ThursdayJune 2023Conference
Michael Sela Memorial Symposium
More information Time 08:00 - 08:00Location The David Lopatie Conference Centre
Lecture HallChairperson Ronen AlonHomepage Contact -
Date:07WednesdayJune 2023Lecture
“How atoms jiggle and wiggle in energy materials”
More information Time 10:30 - 11:30Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. David Egger
Dept. Physics, Technical University of MunichOrganizer Department of Molecular Chemistry and Materials ScienceContact Abstract Show full text abstract about Energy materials are crystalline, solid-state substances ...»
Energy materials are crystalline, solid-state substances with technological applications in energy-conversion or storage devices that include solar cells and batteries. In our work, we are particularly interested in scenarios where these systems show unusual structural dynamical effects. These effects trigger many puzzling questions in regard to updated structure-property relations and improved theoretical understandings of these solids. In my talk, I will present our recent findings regarding theoretical treatments of structural dynamics in energy materials and how we may use them to improve our understanding of their finite-temperature properties. The results will focus on halide perovskite as well as nitride semiconductors and solid-state ion conductors, which we typically investigate in tandem with experiment.
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Date:08ThursdayJune 2023Lecture
Vision and AI
More information Time 12:15 - 13:15Title Imagic: Text-Based Real Image Editing with Diffusion ModelsLocation Jacob Ziskind Building
Room 1Lecturer Shiran Zada
GoogleOrganizer Department of Computer Science and Applied Mathematics
SeminarContact Abstract Show full text abstract about Text-conditioned image editing has recently attracted consid...» Text-conditioned image editing has recently attracted considerable interest. However, most methods are currently either limited to specific editing types (e.g., object overlay, style transfer), or apply to synthetically generated images, or require multiple input images of a common object. In this paper we demonstrate, for the very first time, the ability to apply complex (e.g., non-rigid) text-guided semantic edits to a single real image. For example, we can change the posture and composition of one or multiple objects inside an image, while preserving its original characteristics. Our method can make a standing dog sit down or jump, cause a bird to spread its wings, etc. — each within its single high-resolution natural image provided by the user. Contrary to previous work, our proposed method requires only a single input image and a target text (the desired edit). It operates on real images, and does not require any additional inputs (such as image masks or additional views of the object). Our method, which we call "Imagic", leverages a pre-trained text-to-image diffusion model for this task. It produces a text embedding that aligns with both the input image and the target text, while fine-tuning the diffusion model to capture the image-specific appearance. We demonstrate the quality and versatility of our method on numerous inputs from various domains, showcasing a plethora of high quality complex semantic image edits, all within a single unified framework -
Date:11SundayJune 2023Lecture
TBA
More information Time 11:00 - 12:00Location Sussman Family Building for Environmental Sciences
M. Magaritz Seminar RoomLecturer Yael LeshnoOrganizer Department of Earth and Planetary SciencesContact -
Date:12MondayJune 2023Conference
2023 Israeli meeting on RNA Therapeutics
More information Time 08:00 - 08:00Chairperson Igor UlitskyContact -
Date:12MondayJune 2023Lecture
Systems Biology Seminar 2022-2023
More information Time 10:00 - 11:00Location Arthur and Rochelle Belfer Building for Biomedical Research
Botnar AuditoriumOrganizer Azrieli Institute for Systems BiologyContact -
Date:12MondayJune 2023Colloquia
A link between viscoelastic mechanics and biochemical function of proteins
More information Time 11:00 - 12:15Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Tsvi Tlusty
Department of Physics, National University in Ulsan, South KoreaOrganizer Faculty of ChemistryHomepage Contact Abstract Show full text abstract about Our starting point is the idea that specific regions in the ...» Our starting point is the idea that specific regions in the protein evolve to
become flexible viscoelastic elements facilitating conformational changes
associated with function, especially allostery. Simple theories show how
these regions can emerge through evolution and indicate that they are
easily identified by amino acid rearrangement upon binding (i.e., shear
motion). Surprisingly, AlphaFold can also identify such regions by
computing the shear induced by a single or a few mutations. With these
methods, we have tested the concept of shear and its functional relevance
in a variety of proteins. I will present recent results from an experimental
study of the enzyme guanylate kinase linking shear, large scale motions,
and catalytic function. Altogether, the present findings paint a physical
picture of proteins as viscoelastic machines with sequence encoded
specifications, and we will discuss its general implications for
understanding proteins and designing new ones. -
Date:13TuesdayJune 2023Lecture
Mechanisms of sperm-egg fusion in mammals
More information Time 10:00 - 11:00Location Nella and Leon Benoziyo Building for Biological Sciences
AuditoriumLecturer Dr. Nico Brukman
Faculty of Biology Technion - Israel Inst. of TechnologyOrganizer Department of Biomolecular SciencesContact Details Show full text description of Faculty of Biology Technion - Israel Inst. of Technology ...» Faculty of Biology Technion - Israel Inst. of Technology -
Date:13TuesdayJune 2023Lecture
Joint Chemical and Biological Physics and Molecular Chemistry and Materials Science Guest Seminar
More information Time 10:00 - 11:00Title Tunneling and Zero-Point Energy Effects in Multidimensional Hydrogen Transfer ReactionsLocation Gerhard M.J. Schmidt Lecture HallLecturer Dr Yair Litman
University of CambridgeOrganizer Department of Chemical and Biological PhysicsContact Abstract Show full text abstract about ydrogen transfer reactions play a prominent role in nature a...» ydrogen transfer reactions play a prominent role in nature and many technological applications. Despite appearing to be simple reactions, they constitute complex processes where nuclear quantum effects (NQE) such as zero-point energy and nuclear tunneling play a decisive role even at ambient temperature. In this talk, I will show how state-of-the-art methodologies based on the path integral formulation of quantum mechanics in combination with the density functional approximation provide the unique possibility to theoretically address these effects in complex environments. The first part of the talk will focus on the porphycene molecule in the gas phase and adsorbed on metallic surfaces. The porphycene molecule constitutes a paradigmatic example of a molecular switch and has recently received great attention due to its intriguing hydrogen dynamics. I will demonstrate how a correct treatment of NQE, as well as the inclusion of multidimensional anharmonic couplings, are essential to obtain qualitatively correct results regarding the non-trivial temperature dependence of the hydrogen transfer rates and vibrational spectra [1-3]. Finally, I shall also mention some of our recent results for hydrogen diffusion on metals for which non-adiabatic effects, in addition to NQE, play a significant role and can lead to “quantum localization” [4-6].
[1] Y. Litman, J. O. Richardson, T. Kumagai, and M. Rossi, J. Am. Chem. Soc. 141, 2526 (2019)
[2] Y. Litman, J. Behler, and M. Rossi, Faraday Discuss. 221, 526 (2020)
[3] Y. Litman and M. Rossi, Phys. Rev. Lett. 125, 216001 (2020)
[4] Y. Litman, E. S. Pos. C. L. Box, R. Martinazzo, R. J. Maurer, and M. Rossi, J. Chem. Phys. 156, 194106 (2022)
[5] Y. Litman, E. S. Pos. C. L. Box, R. Martinazzo, R. J. Maurer, and M. Rossi , J. Chem. Phys. 156, 194107 (2022)
[6] O. Bridge, R. Martinazzo, S. C. Althorpe, Y. Litman, in preparation (2023)
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Date:13TuesdayJune 2023Lecture
Translational Chemical Biology
More information Time 14:00 - 15:00Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Xiaoguang Lei
Peking UniversityOrganizer Department of Chemical and Structural BiologyContact -
Date:15ThursdayJune 2023Lecture
“Parahydrogen Enhanced Magnetic Resonance - a tale of spin physics, materials and catalysis”
More information Time All dayLocation Gerhard M.J. Schmidt Lecture HallLecturer Dr. Stefan Glogger
Max Plank Institute for Multidisciplinary Sciences, GottingenOrganizer Clore Institute for High-Field Magnetic Resonance Imaging and SpectroscopyContact Abstract Show full text abstract about Catalysts are essential in increasing reaction rates of ch...»
Catalysts are essential in increasing reaction rates of chemical reactions. They have not only shaped our modern world but are also used by nature in many biochemical reactions. Understanding catalytic mechanisms and developing new catalysts holds promise to e.g. solve energy challenges of our society.
Before this background, I am developing new methodologies based on magnetic resonance to unravel processes in catalysis and work towards nano-materials in which nuclear spin states can be controlled
during reactions. Thereby, I am making use of the technique of parahydrogen induced polarization, which is an enhancement technology in NMR, boosting signals by four orders of magnitude. This approach uses parahydrogen, a spin isomer of normal hydrogen gas that interacts with a catalyst and undergoes a chemical reaction. During this process, the spin order of parahydrogen is converted into largely enhanced magnetic resonance signals and acts as a spy molecule for the catalytic process.
In recent years my group has pioneered the use of parahydrogen to study metalloenzymes and more in specific hydrogenases. Hydrogenases are considered nature's blueprint for efficient hydrogen activation catalysts. Although they represent an important class of enzymes, the catalytic mechanisms leading to hydrogen activation are not fully understood. My developed tools allowed for new insights that no other analytical technology could provide and thereby refined details of the catalytic mechanisms.
Additionally, my group has been researching the development of nano-catalysts that can allow for maintaining the para-hydrogen spin order on surfaces. This promises on one side to develop new enhancement strategies in particular to boost the signal of mobile protons that can e.g. exchange with proteins or small molecules leading to their further enhancements in solution. On the other side, a precise control of nuclear spin states during chemical reactions in solution can allow for the future production of
large quantities of spin-controlled chemicals such as para-water or formaldehyde in the para-state. These are chemicals found in e.g. interstellar clouds showing different ratios between ortho (triplet) and para (singlet) states as compared to earth and are thought to display different reactivities. Understanding the effect of nuclear spin states on reactions could lead to new application in chemical reactions and catalysis
in the future.
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Date:15ThursdayJune 2023Lecture
Chemical and Biological Physics Guest Seminar
More information Time 11:00Title Ratchet based ion pumpsLocation Gerhard M.J. Schmidt Lecture HallLecturer Dr Gideon Segev
School of Electrical Engineering, Tel Aviv UniversityOrganizer Department of Chemical and Biological PhysicsContact Abstract Show full text abstract about Even though highly selective ion pumps can be found in every...» Even though highly selective ion pumps can be found in every living cell membrane, artificial, membrane-based ion selective separation is a longstanding unmet challenge in science and engineering. The development of a membrane-based ion separation technology can drive a dramatic progress in a wide range of applications such as: water treatment, bio-medical devices, extraction of precious metals from sea water, chemical sensors, solar fuels and more. In this seminar I will discuss our theoretical and experimental demonstration of ion pumps based on an electronic flashing ratchet mechanism.
Electronic flashing ratchets are devices that utilize modulation in a spatially varying electric field to drive steady state current. Like peristaltic pumps, where the pump mechanism is not in direct contact with the pumped fluid, electronic ratchets induce net current with no direct charge transport between the power source and the pumped charge carriers. Thus, electronic ratchets can be used to pump ions in steady state with no electrochemical reactions between the power source and the pumped ions resulting in an “all electric” ion pump.
Ratchet-based ion pumps (RBIPs) were fabricated by coating the two surfaces of nano-porous alumina wafers with gold forming nano-porous capacitor-like devices. The electric field within the nano-pores is modulated by oscillating the capacitors voltage. Thus, when immersed in solution, ions within the pores experience a modulating electric field resulting in ratchet-based ion pumping. The RBIPs performance was studied for various input signals, geometries, and solutions. RBIPs were shown to drive ionic current densities of several μA/cm2 even when opposed by an electrostatic force. A significant ratchet action was observed with input signal amplitudes as low as 0.1V thus demonstrating that RBIPs can drive an ionic current with no associated redox reactions. Simulations show that frequency dependent flux inversions in ratchet systems may pave the way towards ion selective RBIPs. -
Date:15ThursdayJune 2023Lecture
Vision and AI
More information Time 12:00 - 13:30Title TBALocation Jacob Ziskind Building
Room 1Lecturer Daniel Soudry
TechnionOrganizer Department of Computer Science and Applied Mathematics
SeminarContact Abstract Show full text abstract about TBA ...» TBA