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Date:07SundayMarch 202109TuesdayMarch 2021Conference
Biomolecular Phase Separartion: A Student Organzied Conference
More information Time 08:00 - 08:00Location David Lopatie Conference Centre
Kimmel AuditoriumChairperson Yair HarelContact -
Date:07SundayMarch 2021Lecture
Department of Molecular Genetics department seminar
More information Time 13:00 - 13:30Title “Ambiguity resolution in the TGFb/ BMP pathways through combinatorial SMAD complex formation”Location https://weizmann.zoom.us/j/92440011671?pwd=Yk9kQUpqWkJnUmFMRUlnT0NaSlliUT09Lecturer Johannes AuthOrganizer Department of Molecular Genetics
Student and Post-Doc SeminarContact -
Date:08MondayMarch 2021Colloquia
Proteins mobility, affinity & stability for optimized function
More information Time 11:00 - 12:00Location https://weizmann.zoom.us/j/98063488104?pwd=N3VqTC9sU1A4RHVDZ1dhOGVxbU1iUT09Lecturer Prof. Koby Levy
Department of Structural BiologyOrganizer Faculty of ChemistryContact Abstract Show full text abstract about Proteins, which are at the heart of many biological processe...» Proteins, which are at the heart of many biological processes, are involved in a variety of self-assembly processes that are controlled by various chemical and physical interactions. Quantifying the driving forces that govern these processes and particularly the trade-offs between them is essential to obtaining a more complete understanding of protein dynamics and function. In my lecture, I will discuss the molecular determinants that govern linear diffusion of proteins along DNA or along microtubules. These and other cellular processes, such as protein folding, are subject to conflicting forces some of which are regulated by post-translational modifications. Understanding the trade-offs between the stability, affinity and mobility is not only essential to decipher transport processes in the cell but also for formulating concepts for their engineering. I will discuss the power of computational models in formulating fundamental biomolecular concepts and in predicting novel principles of cellular function or for its optimization. -
Date:08MondayMarch 2021Lecture
Women's Day 2021
More information Time 12:30 - 15:00Title Save the dateContact -
Date:09TuesdayMarch 2021Lecture
To be announced
More information Time 10:00 - 10:30Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Dr. Mattia Morandi
Dept. of Biomolecular Sciences-WISOrganizer Department of Biomolecular SciencesHomepage Contact -
Date:09TuesdayMarch 2021Lecture
Diatom modulation of associated bacteria
More information Time 11:30 - 12:30Title Guest Seminar via ZoomLocation https://weizmann.zoom.us/j/91943922657?pwd=QnF1eThwV0lWTk45ZWFBWnlHeGx2Zz09Password620591Lecturer Dr. Ahmed Shibl
Marine Microbial Ecology Lab - New York University Abu DhabiOrganizer Department of Plant and Environmental SciencesContact Details Show full text description of Host: Dr. Einat Segev...» Host: Dr. Einat Segev -
Date:09TuesdayMarch 2021Lecture
Dissecting the Alzheimer’s brain: from disease single cells to cellular communities
More information Time 12:30 - 13:30Lecturer Prof. Naomi Habib
Edmond & Lily Safra Center for Brain Sciences, The Hebrew University of JerusalemOrganizer Department of NeurobiologyContact Details Show full text description of Zoom link to join: https://weizmann.zoom.us/j/96608033618?p...» Zoom link to join:
https://weizmann.zoom.us/j/96608033618?pwd=SEdJUkR2ZzRBZ3laUUdGbWR1VFJTdz09
Meeting ID: 966 0803 3618
Password: 564068
Host: Dr. Rita Schmidt rita.schmidt@weizmann.ac.il tel: 9070
Abstract Show full text abstract about Alzheimer’s disease (AD) is one of the most pressing globa...»
Alzheimer’s disease (AD) is one of the most pressing global medical issues to date with no effective therapeutic strategies. Despite extensive research much remains unknown regarding the crosstalk between brain cells and the role of non-neuronal cells in the progression of Alzheimer’s disease (AD). We use single nucleus RNA-sequencing and machine learning algorithms to build detailed cellular maps of mice and human brain and to follow molecular changes in each cell type along disease progression. Our maps revealed new disease associated states in glia cells as well as unique multi-cellular communities linked to AD. Specifically, we found a link between populations of disease-associated astrocytes (DAAs), microglia, oligodendrocytes and GABAergic neurons to AD related traits in mouse models and in post-mortem human brains. Expanding the data analysis across multiple cell types, we found co-occurrences of cellular populations across individuals, which we define as multi-cellular communities. Among these communities we discovered a unique cellular community linked to cognitive decline and Alzheimer’s disease pathology. These new insights are shaping our understanding of the unique cellular environment of the Alzheimer’s disease brains.
Zoom link to join:
https://weizmann.zoom.us/j/96608033618?pwd=SEdJUkR2ZzRBZ3laUUdGbWR1VFJTdz09
Meeting ID: 966 0803 3618
Password: 564068
Host: Dr. Rita Schmidt rita.schmidt@weizmann.ac.il tel: 9070
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Date:10WednesdayMarch 2021Lecture
Algebraic Geometry and Representation Theory Seminar
More information Time 14:30 - 15:30Title Weyl group representations and Harish-Chandra cellsLecturer David Vogan
MITOrganizer Faculty of Mathematics and Computer Science
Algebraic Geometry and Representation Theory Seminar, Department of Computer Science and Applied Mathematics
Algebraic Geometry and Representation Theory Seminar, Department of Mathematics
Algebraic Geometry and Representation Theory SeminarHomepage Contact Abstract Show full text abstract about Suppose g is a semisimple Lie algebra with Weyl group W. Wri...» Suppose g is a semisimple Lie algebra with Weyl group W. Write L(w) for the irreducible highest weight module of highest weight -w.rho - rho. Write J (for "Joseph") for the set of primitive ideals in a semisimple enveloping algebra contained in the augmentation ideal. In a 1978 paper "W-module structure in the primitive spectrum..." Joseph attached to each primitive ideal I in J a subset
Lcell(I) = {w in W | Ann(L(w)) = I}.
He showed also how to make Lcell(I) into a basis for a representation
sigma(I) of W, in such a way that
sum_{I in J} sigma(I) = regular representation of W.
These representations sigma(I) are now called "left cell
representations," terminology that is apparently due to Joseph (see
his 1981 paper "Goldie rank in the enveloping algebra...III," page
310).
Joseph proved in a 1980 paper that each left cell representation
consists of exactly one copy of Joseph's "Goldie rank representation"
for the primitive ideal I, and some additional representations that
are not Goldie rank representations.
For the past forty years, understanding of these left cell
representations of W has been at the heart of a great deal of work on
representations of reductive groups.
Lusztig in his 1984 book gave a description of all left cells in terms of the geometry of nilpotent orbits.
Part of Lusztig's description uses Springer's parametrization of W
representations by irreducible representations of the equivariant
fundamental group A(O) for a nilpotent orbit O. I will discuss the
"opposite" part of Lusztig's description, involving conjugacy classes
in A(O).
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Date:14SundayMarch 2021Lecture
Nucleation fronts initiate frictional motion
More information Time 11:00 - 12:00Lecturer Prof. Jay FinebergOrganizer Department of Molecular Chemistry and Materials Science
Soft Matter and BiomaterialsContact Abstract Show full text abstract about Zoom LInk: https://weizmann.zoom.us/j/97917323609?pwd=OGpCV...» Zoom LInk: https://weizmann.zoom.us/j/97917323609?pwd=OGpCVzNKWGlCSS9lbTIyS0FtN1lHUT09
Recent experiments have demonstrated that rapid rupture fronts, akin to earthquakes, mediate the transition to frictional motion. Moreover, once these dynamic rupture fronts ("laboratory earthquakes" ) are created, their singular form, dynamics and arrest are well-described by fracture mechanics. Ruptures, however, need to be created within initially rough frictional interfaces, before they are able to propagate. This is the reason that ``static friction coefficients” are not well-defined; frictional ruptures can nucleate for a wide range of applied forces. A critical open question is, therefore, how the nucleation of rupture fronts actually takes place. We experimentally demonstrate that rupture front nucleation is prefaced by slow nucleation fronts. These nucleation fronts, which are self-similar, are not described by fracture mechanics. They emerge from initially rough frictional interfaces at a well-defined stress threshold, evolve at characteristic velocity and time scales governed by stress levels, and propagate within a frictional interface to form the initial rupture from which fracture mechanics take over. These results are of fundamental importance to questions ranging from earthquake nucleation and prediction to processes governing material failure. -
Date:14SundayMarch 2021Lecture
Department of Molecular Genetics departmental seminar
More information Time 13:00 - 13:30Title “Quantitative analysis by 3D MAPs reveals new cell morphogenetic behaviors which drive bone growth”Location https://weizmann.zoom.us/j/97246877306?pwd=R1FSemROR3hseTNWRDhQeVNBSExWZz09Lecturer Sarah RubinOrganizer Department of Molecular Genetics
Student and Post-Doc SeminarContact -
Date:16TuesdayMarch 2021Lecture
Cortical Layer 1 – The Memory Layer?
More information Time 12:30Lecturer Dr. Guy Doron
Humboldt University of Berlin Neurocure Cluster of Excellence, BerlinOrganizer Department of NeurobiologyContact Details Show full text description of Zoom link to join: https://weizmann.zoom.us/j/96608033618?p...» Zoom link to join:
https://weizmann.zoom.us/j/96608033618?pwd=SEdJUkR2ZzRBZ3laUUdGbWR1VFJTdz09
Meeting ID: 966 0803 3618
Password: 564068
Host: Dr. Rita Schmidt rita.schmidt@weizmann.ac.il tel: 9070
Abstract Show full text abstract about The hippocampus and related medial temporal lobe structures ...» The hippocampus and related medial temporal lobe structures (entorhinal cortex, perirhinal cortex, etc.) play a vital role in transforming experience into long-term memories that are then stored in the cortex, however the cellular mechanisms which designate single neurons to be part of a memory trace remain unknown. Part of the difficulty in addressing the mechanisms of transformation of short-term to long-term memories is the distributed nature of the resulting “engram” at synapses throughout the cortex. We therefore used a behavioral paradigm dependent on both the hippocampus and neocortex that enabled us to generate memory traces rapidly and reliably in a specific cortical location, by training rodents to associate the direct electrical microstimulation of the primary sensory neocortex with a reward. We found that medial-temporal input to neocortical Layer 1 (L1) gated the emergence of specific firing responses in subpopulations of Layer 5 pyramidal neurons marked by increased burstiness related to apical dendritic activity. Following learning and during memory retrieval, these neocortical responses became independent of the medial-temporal influence but continued to evoke behaviour with single bursts sufficient to elicit a correct response. These findings suggest that L1 is the locus for hippocampal-dependent associative learning in the neocortex, where memory engrams are established in subsets of pyramidal neurons by enhancing the sensitivity of tuft dendrites to contextual inputs and driving burst firing.
Zoom link to join- https://weizmann.zoom.us/j/96608033618?pwd=SEdJUkR2ZzRBZ3laUUdGbWR1VFJTdz09
Meeting ID: 966 0803 3618
Password: 564068
Host: Dr. Rita Schmidt rita.schmidt@weizmann.ac.il tel: 9070
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Date:16TuesdayMarch 2021Lecture
Ecosystem ecology to inform global biodiversity restoration
More information Time 13:00 - 14:00Title SAERI - Sustainability and Energy Research Initiative seminar seriesLocation via zoomLecturer Prof. Thomas Crowther
Department of Environmental Systems Science, ETH Zurich, SwitzerlandOrganizer Feinberg Graduate School
Alternative Sustainable Energy Research Initiative (AERI)Contact Details Show full text description of Host: Prof. Ron Milo https://weizmann.zoom.us/j/939128959...» Host: Prof. Ron Milo
https://weizmann.zoom.us/j/93912895903?pwd=VFZtMHFCK244MTBrMUJoNmY1dEhCQT09
Meeting ID: 939 1289 5903
Password: 12345
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Date:17WednesdayMarch 2021Lecture
Algebraic Geometry and Representation Theory Seminar
More information Time 16:30 - 17:30Title The orbit method, microlocal analysis and applications to L-functionsLecturer Paul Nelson
ETH ZurichOrganizer Faculty of Mathematics and Computer Science
Algebraic Geometry and Representation Theory Seminar, Department of Computer Science and Applied Mathematics
Algebraic Geometry and Representation Theory Seminar, Department of Mathematics
Algebraic Geometry and Representation Theory SeminarContact Abstract Show full text abstract about I will describe how the orbit method can be developed in a q...» I will describe how the orbit method can be developed in a quantitative form, along the lines of microlocal analysis, and applied to local problems in representation theory and global problems concerning automorphic forms. The local applications include asymptotic expansions of relative characters. The global applications include moment estimates and subconvex bounds for L-functions. These results are the subject of two papers, the first joint with Akshay Venkatesh:
https://arxiv.org/abs/1805.07750
https://arxiv.org/abs/2012.0218
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Date:18ThursdayMarch 2021Lecture
RNA Therapeutics: From Gene Silencing to Gene Editing
More information Time 14:00 - 15:00Lecturer Dan Peer, PhD
Director, Laboratory of Precision NanoMedicine Tel Aviv UniversityOrganizer Dwek Institute for Cancer Therapy Research
Cancer Research ClubContact Details Show full text description of https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2...» https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09 -
Date:21SundayMarch 2021Lecture
Department of Molecular Genetics departmental seminar
More information Time 13:00 - 13:30Title “Watching translocation as it occurs: A new approach to study protein targeting”Location https://weizmann.zoom.us/j/96948336875?pwd=Q3Bva1hldHdWVk85a2JZeDIxMUZBdz09Lecturer Nir CohenOrganizer Department of Molecular GeneticsContact -
Date:22MondayMarch 2021Colloquia
Computational protein design: basic research and applications
More information Time 11:00 - 12:00Location https://weizmann.zoom.us/j/98063488104?pwd=N3VqTC9sU1A4RHVDZ1dhOGVxbU1iUT09Lecturer Prof. Sarel Fleishman
Department of Biomolecular Sciences, WISOrganizer Faculty of ChemistryContact Abstract Show full text abstract about Until very recently, the accuracy of protein-design calculat...» Until very recently, the accuracy of protein-design calculations was considered too low to enable the design of large proteins of complex fold. As a result, enzyme and binder optimization has relied on random or semi-rational mutagenesis and high-throughput screening. Our lab is developing a unique approach that combines structural bioinformatics analyses with atomistic design calculations to dramatically increase the accuracy of design calculations. Using this strategy, we have developed several general and completely automated methods for optimizing protein stability and activity. I will briefly discuss the fundamentals of this strategy and show case studies of large and complex proteins that we and our collaborators have optimized. Our lab’s long-term and still-unmet research goal is to enable the completely automated design of any biomolecular activity, and I will focus on our current research directions including the design of new enzymes and binders. -
Date:05MondayApril 2021Colloquia
Chemistry colloquium
More information Time 11:00 - 12:00Location https://weizmann.zoom.us/j/98063488104?pwd=N3VqTC9sU1A4RHVDZ1dhOGVxbU1iUT09Lecturer Prof. Rafal Klajn
Department of Organic Chemistry, WISOrganizer Faculty of ChemistryContact -
Date:06TuesdayApril 2021Lecture
To be announced
More information Time 12:30Lecturer Guy Doron
Interdisciplinary Center, HerzliyaOrganizer Department of NeurobiologyContact Details Show full text description of Zoom link to join-https://weizmann.zoom.us/j/96608033618?pwd...» Zoom link to join-https://weizmann.zoom.us/j/96608033618?pwd=SEdJUkR2ZzRBZ3laUUdGbWR1VFJTdz09
Meeting ID: 966 0803 3618
Password: 564068
Host: Dr. Rita Schmidt rita.schmidt@weizmann.ac.il tel: 9070
Abstract Show full text abstract about zoom link to join-https://weizmann.zoom.us/j/96608033618?pwd...» zoom link to join-https://weizmann.zoom.us/j/96608033618?pwd=SEdJUkR2ZzRBZ3laUUdGbWR1VFJTdz09
Meeting ID: 966 0803 3618
Password: 564068
Host: Dr. Rita Schmidt rita.schmidt@weizmann.ac.il tel: 9070 -
Date:07WednesdayApril 2021Academic Events
Scientific Council meeting
More information Time 14:00 - 16:00Contact -
Date:08ThursdayApril 2021Lecture
Inactivation of DNA repair and high dose Vitamin C boost cancer immunotherapy
More information Time 14:00 - 15:00Lecturer Prof. Alberto Bardelli
University of Turin, Dept. of Oncology and Candiolo Cancer Institute, FPO-IRCCSOrganizer Dwek Institute for Cancer Therapy Research
Cancer Research ClubContact Details Show full text description of https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2...» https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09