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  • Date:15SundayDecember 2024

    The Clore Center for Biological Physics

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    Time
    12:45 - 14:30
    Title
    Rationally designed functionalization of single-walled carbon nanotubes for real-time monitoring of active processes
    Location
    Nella and Leon Benoziyo Physics Library
    LecturerProf. Gili Bisker
    lunch will be reserved at 12:45
    Organizer
    Clore Center for Biological Physics
    Contact
    AbstractShow full text abstract about <p>Semiconducting single-walled carbon nanotubes (SWCN...»
    <p>Semiconducting single-walled carbon nanotubes (SWCNTs) fluoresce in the near-infrared (NIR) range, which overlaps with the transparency window of biological samples, and they do not photobleach or blink. These properties make SWCNTs uniquely suited for long-term imaging and sensing applications. Using tailored surface functionalization, SWCNTs can act as dynamic optical nanosensors, transducing biochemical changes in their environment into modulations in fluorescence intensity. Owing to their intrinsic physicochemical and optical properties, SWCNTs can provide real-time, spatiotemporal information on active processes across scales, from molecular interactions to whole organism dynamics.</p><p>Here, I will discuss different strategies for utilizing rationally designed functionalized SWCNTs to probe active biological processes. These include monitoring enzymatic activity, tracking supramolecular self-assembly and disassembly, and mapping in vivo processes. These findings showcase the potential of near-infrared fluorescent SWCNTs to provide insights into dynamic biological systems.</p><p><strong>LINK FOR STUDENTS INTERESTED MEETING PROF. GILI BISKER 14:30-15:15 &nbsp;Link</strong></p><p>&nbsp;</p><p><strong>FOR THE LATEST UPDATES AND CONTENT ON SOFT MATTER AND BIOLOGICAL PHYSICS AT THE WEIZMANN, VISIT OUR&nbsp;WEBSITE</strong>:&nbsp;https://www.biosoftweizmann.com/</p>
    Lecture
  • Date:16MondayDecember 2024

    Molecular junctions with semimetal contacts: a promising milestone on the roadmap to molecular thermoelectricity

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    Time
    11:00 - 12:15
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerProf. Yoram Selzer
    Nano Center, TAU
    Organizer
    Department of Molecular Chemistry and Materials Science
    Homepage
    Contact
    AbstractShow full text abstract about The efficiency of a thermoelectric (TE) device depends on ...»

    The efficiency of a thermoelectric (TE) device depends on the extent to which, in response to a given temperature gradient, its electron/hole transport symmetry at the Fermi level is broken. This requirement makes molecular junctions highly promising for TE applications due to their non-linear transmission properties. Yet, in the absence of an efficient method to tune the position of the Fermi level within the transmission landscape of these junctions, the Seebeck values of metal-molecules-metal junctions are typically |S|≤50μV/K, while based on their electrical and thermal conductance, it should be |S|≥1mV/K to be relevant for applications. I will describe our effort to reach this goal, which recently has culminated in molecular junctions with the semimetal Bismuth (Bi) as one of their leads and with |S| in the required mV/K range. Unlike the conventional approach to tweak the transmission properties by modifying the structure of the molecules, here the high Seebeck is a result of molecularly induced deterministic changes in the density of states within the Bi lead in the form of quantized 2D interfacial states, that in turn result in highly non-linear transport properties. I will argue that this effect is just one glimpse into the very rich and complex terra incognita of molecular layers on semimetals.
    Colloquia
  • Date:16MondayDecember 2024

    Foundations of Computer Science Seminar

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    Time
    11:15 - 12:15
    Title
    Accountability in Threshold Cryptography
    Location
    Jacob Ziskind Building
    LecturerLior Rotem
    Stanford
    Organizer
    Department of Computer Science and Applied Mathematics
    Contact
    AbstractShow full text abstract about Threshold cryptography has been fundamental to secure distri...»
    Threshold cryptography has been fundamental to secure distributed protocols for over three decades. However, it often comes at the expense of accountability: when secret information is shared among multiple parties, it can be difficult to determine who is at
    fault if this information is leaked or misused.
    In this talk, I will present a recent line of works that demonstrate that this trade-off is not inherent—we can indeed build accountable threshold cryptosystems. Most of the talk will focus on accountability in secret sharing. Suppose Alice uses a t-out-of-n secret sharing scheme to store her secret key on n servers. This guarantees that the servers learn nothing about her secret key, even if t-1 of them collude. But what happens if some servers decide to sell their shares? In this case, Alice should be able to hold them accountable; otherwise, they have a risk-free incentive to sell her shares. A secret sharing scheme that allows Alice to trace the leak back to the corrupted servers is called a traceable secret sharing scheme. I will present new definitions and practical constructions for traceable secret sharing, based on the natural and widely-used schemes of Shamir and Blakley.
    Lecture
  • Date:17TuesdayDecember 2024

    Global virus outbreaks: Interferons as 1st responders

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    Time
    09:30 - 10:30
    Location
    Nella and Leon Benoziyo Building for Biological Sciences
    LecturerProf. Eleanor N. Fish
    Dept. of Immunology, University of Toronto, Canada
    Organizer
    Department of Biomolecular Sciences
    Contact
    AbstractShow full text abstract about <p>Viral infections pose a major threat to human healt...»
    <p>Viral infections pose a major threat to human health. Vaccines protect from specific</p><p>infections, yet newly emerging or pandemic viral strains that exhibit genetic drift or reassortment</p><p>of genes preclude immediate responses using a vaccine strategy. Moreover, for SARS CoV-2,</p><p>although current vaccines reduce severity of disease, they do not protect from re-infection,</p><p>resulting in persistent community transmission and outbreaks. The emergence of drug resistance</p><p>also mitigates against pathogen-specific antiviral drugs. A complementary strategy focusing on</p><p>the host not the pathogen is the basis for development of broad-spectrum antivirals.</p><p>Our immediate response to any and all virus infections is the immediate production of interferon</p><p>(IFN). Data reveal that the robustness of an IFN response to respiratory infections, determines</p><p>the outcome – an aggressive or mild infection. We provide evidence that an IFN response to viral</p><p>infection, and/or IFN treatment, induces an activated phenotype in target cells that results in an</p><p>antiviral state and an optimized innate immune response, regardless of the virus. We extended</p><p>these findings to examine the therapeutic potential of IFN treatment in hospitalized individuals</p><p>infected with SARS and showed that IFN treatment accelerated viral clearance and reduced lung</p><p>abnormalities. Similarly, using human lung explants, IFN treatment cleared infection against</p><p>H5N1 avian and pandemic H1N1 influenza strains. During the Ebola virus outbreak in West</p><p>Africa, we conducted a clinical study in Guinea and provided evidence of increased survival</p><p>associated with IFN treatment. At the start of the COVID-19 pandemic we undertook a clinical</p><p>study in Wuhan, China, providing evidence that early treatment with an inhaled IFN accelerated</p><p>viral clearance, reduced inflammation and also reduced lung abnormalities. Given that limiting</p><p>transmission is the solution to shutting down any outbreak, we next conducted a clinical trial to</p><p>determine whether IFN treatment of SARS CoV-2 exposed, but uninfected individuals, would</p><p>protect from infection. We provide evidence that prophylactic treatment with IFN limits</p><p>household transmission, being most effective when the infected case in the household has a high</p><p>viral burden.</p>
    Lecture
  • Date:17TuesdayDecember 2024

    Understanding drug resistance in leukaemia with computer simulations (and some experiments)

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    Time
    14:00 - 15:00
    LecturerProf. Ran Friedman
    Organizer
    Department of Chemical and Structural Biology
    Lecture
  • Date:18WednesdayDecember 2024

    Special Guest Seminar

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    Time
    10:00 - 12:00
    Title
    Endocrine Cell Development in Human Fetal Thyroid Across Health and Disease
    Location
    Max and Lillian Candiotty Building
    LecturerDr. Hassan Massalha
    Wellcome Sanger Institute and University of Cambridge, UK
    Organizer
    Department of Immunology and Regenerative Biology
    Contact
    Lecture
  • Date:18WednesdayDecember 2024

    A Computational Perspective on Supercooled and Glassy Water

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    Time
    11:00 - 11:00
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerProf. Pablo G. Debenedetti
    Organizer
    Ben May Center for Chemical Theory and Computation
    Homepage
    Contact
    Lecture
  • Date:18WednesdayDecember 2024

    spotlight on science

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    Time
    12:30 - 14:00
    Location
    Gerhard M.J. Schmidt Lecture Hall
    Contact
    Lecture
  • Date:18WednesdayDecember 2024

    Why did the RNA Cross the (Nano) Road? To Get to the Other Side

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    Time
    12:30 - 14:00
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerDr. Gil Haimovich
    Spotlight on Science lecture sponsored by the Staff Scientists Council
    Contact
    AbstractShow full text abstract about <p>All cells communicate with their neighbors. One typ...»
    <p>All cells communicate with their neighbors. One type of connection between animal cells is called Tunneling Nanotubes. These are open-ended natural tubes that allow cells to share small molecules, proteins, and even organelles.</p><p></p><p>In the Gerst lab, we mostly study the transport of messenger-RNA molecules, which carry the information needed to produce proteins inside the cell. One amazing discovery that we made was finding out that mRNAs can also be transferred between cells through these nanotubes. We still don’t know exactly how or why. But we can use it!</p><p></p><p>In this talk, I will describe the journey from the initial discovery to our plans to use it as a novel type of RNA therapeutic for rare genetic diseases.</p>
    Lecture
  • Date:18WednesdayDecember 2024

    ABC CHATS: Shira Eting

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    Time
    14:00 - 15:30
    Title
    Based on values, Delivering value
    Location
    George and Esther Sagan Students' Residence Hall
    LecturerShira Eting - Vintage Investment Partners
    Contact
    AbstractShow full text abstract about <p>During her conversation, Shira will share her perso...»
    <p>During her conversation, Shira will share her personal journey and share what has led her to each decision and what are her key learnings.</p><p>She will also share more about her position today as a Partner at Vintage, leading their investments in Healthcare and Climate.</p><p>Join our ABC CHATS, Where CEOs share their ABC’s on scientific leadership, breakthroughs and failures throughout their personal stories</p>
    Lecture
  • Date:19ThursdayDecember 2024

    Geometric Functional Analysis and Probability Seminar

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    Time
    13:30 - 14:30
    Title
    Directional expansivity in ergodic Z^d systems and its applications
    Location
    Jacob Ziskind Building
    LecturerSasha Fish
    Sydney
    Organizer
    Department of Mathematics
    Contact
    AbstractShow full text abstract about By ergodicity, any set of positive measure is expanded to a ...»
    By ergodicity, any set of positive measure is expanded to a set of full measure under all translations in Z^d. But what happens if we restrict the translations to a specific line in Z^d? In this talk, we will explore this question and, using Furstenberg’s correspondence principle, demonstrate that the set of volumes of all simplices in Z^d formed by vertices of a positive-density set always contains an infinite arithmetic progression. This talk is based on joint works with M. Björklund (Chalmers) and S. Skinner (Sydney).
    Lecture
  • Date:19ThursdayDecember 2024

    Reprogramming the Immune System: A New Avenue in Cancer Treatment

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    Time
    14:00 - 15:00
    Location
    Max and Lillian Candiotty Building
    LecturerProf. Mira Barda-Saad
    The Mina and Everard Goodman Faculty of Life Sciences
    Organizer
    Moross Integrated Cancer Center (MICC)
    Contact
    Lecture
  • Date:22SundayDecember 2024

    Making Climate Tech Work – Policies that Drive Innovation

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    Time
    13:00 - 14:00
    Location
    Nella and Leon Benoziyo Building for Plant and Environmental Sciences
    LecturerProf. Alon Tal
    Host: Prof. Ron Milo, IES Director
    Organizer
    The Institute for Environmental Sustainability , Sustainability and Energy Research Initiative (SAERI)
    Contact
    Lecture
  • Date:23MondayDecember 2024

    The Israel Rubinstein 4th Memorial Lecture -"The challenge of rechargeable batteries with very high energy density and prolonged cycle life: from basic science to practical devices"

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    Time
    11:00 - 12:00
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerProf. Doron Aurbach
    Bar Ilan University, Department of Chemistry
    Organizer
    Department of Molecular Chemistry and Materials Science
    Contact
    AbstractShow full text abstract about The development of high energy density, long running recharg...»
    The development of high energy density, long running rechargeable batteries like
    Li ion batteries, that power so successfully all mobile electronic devices, can be
    considered as the greatest success of modern electrochemistry.
    However, the basis for this success was the capability of exploring most complex
    electrodes, electrolyte solutions and reactive interfaces by most sophisticated
    electroanalytical tools in conjunction with advanced spectroscopic and microscopic
    was a first-rate leader in electroanalytical ז"ל techniques. Professor Israel Rubinstein
    chemistry. I learned a lot from him.
    The main theme of this presentation is to examine what is the true horizons for advanced
    high energy density batteries that can promote the electro-mobility revolution. The
    limiting factor in Li-ion batteries in terms of energy density, cost, potential, durability
    and cycling efficiency are the cathode materials used. We will examine most energetic
    cathode materials and novel approaches we developed for their stabilization. We
    describe in this lecture which electrode materials can be relevant, methodologies
    of their stabilization by doping, coating, and affecting electrodes surface chemistry
    by the use of active additives. Most important cathode materials are comprising the
    5 elements Li,Ni,Co,Mn,O at different stoichiometries that determine voltage and
    specific capacities. We will explain how the stoichiometry dictates basic cathodes
    properties.1,2 We will discuss the renaissance of Li metal-based rechargeable batteries.3
    We have learned how the stabilize Li metal anodes in rechargeable batteries using
    reactive electrolyte solutions that induce excellent passivation through controlled
    surface reactions. The emphasis is on fluorinated co-solvents that open the door for a
    very rich surface chemistry that forms passivating surface films that behave as ideal
    solid electrolyte interphase on both anodes and cathodes in advanced secondary Li
    batteries. This field provides fascinating examples how systematic basic scientific
    work leads to development of most practical devices for energy storage & conversion.
    Lecture
  • Date:24TuesdayDecember 2024

    Winter STAR Workshop

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    Time
    10:00 - 18:00
    Location
    Jacob Ziskind Building
    Lecture
  • Date:24TuesdayDecember 2024

    Anterior-Posterior Insula Circuit Mediates Retrieval of a Conditioned Immune Response in Mice

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    Time
    12:30 - 13:30
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerPnina Hadad
    Organizer
    Department of Brain Sciences
    Contact
    AbstractShow full text abstract about <p>The brain can form associations between sensory inf...»
    <p>The brain can form associations between sensory information of inner and/or outer world (e.g. Pavlovian conditioning) but also between sensory information and the immune system. The phenomenon which was described in the last century is termed conditioned immune response (CIR) but very little is known about neuronal mechanisms subserving it.&nbsp; The conditioned stimulus can be a given taste and the unconditioned stimulus is an agent that induces or reduces a specific immune response.&nbsp; Over the last years, we and others revealed molecular and cellular mechanisms underlying taste valance representation in the anterior insular cortex (aIC). Recently, a circuit in the posterior insular cortex (pIC) encoding the internal representation of a given immune response was identified. Together, it allowed us to hypothesize and prove that the internal reciprocal connections between the anterior and posterior insula encode CIR.&nbsp; One can look at CIR as a noon declarative form of Nocebo effect and thus we demonstrate for the first time a detailed circuit mechanism for Placebo/Nocebo effect in the cortex.</p>
    Lecture
  • Date:25WednesdayDecember 2024

    Winter STAR Workshop

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    Time
    10:00 - 18:00
    Location
    Jacob Ziskind Building
    Lecture
  • Date:25WednesdayDecember 2024

    Machine Learning and Statistics Seminar

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    Time
    11:15 - 12:15
    Title
    Communal AI - Open, Collaborative & Accessible LLMs
    Location
    Jacob Ziskind Building
    LecturerLeshem Choshen
    MIT
    Organizer
    Department of Computer Science and Applied Mathematics
    Contact
    AbstractShow full text abstract about Developing better Language Models would benefit a myriad of ...»
    Developing better Language Models would benefit a myriad of communities. However, it is prohibitively costly. The talk would describe collaborative approaches to pretraining, such as model merging, which allows the combining of several specialized models into one. Then, it would introduce efficient evaluation to reduce overheads and touch on other accessible and collaborative aspects that best harness the expertise and diversity in Academia.
    Lecture
  • Date:26ThursdayDecember 2024

    An intimate meeting with the families of the hostages Tal Shoham and Yagev Buchshtab

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    Time
    09:45 - 11:15
    Location
    Nella and Leon Benoziyo Building for Biological Sciences
    Organizer
    Department of Molecular Cell Biology
    Contact
    Cultural Events
  • Date:26ThursdayDecember 2024

    Winter STAR Workshop

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    Time
    10:00 - 18:00
    Location
    Jacob Ziskind Building
    Lecture

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