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תוצאות חיפוש לאירועים
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Date:11ראשוןמאי 2025כנסים
Early Cancer Detection and Precision Prevention
More information שעה 08:00 - 08:00כותרת Early Cancer Detection and Precision Preventionמיקום מרכז כנסים על-שם דויד לופאטייושב ראש Sima Levמארגן המכון לחקר מניעת סרטן עש אגודת ידידי מכון ויצמן בשווייץ , מרכז הבינתחומי לחקר סרטן עש מורוסצרו קשר -
Date:11ראשוןמאי 2025הרצאה
The Clore Center for Biological Physics
More information שעה 13:15 - 14:30כותרת Second law of Thermodynamics in Living Matterמיקום המאיץ ע"ש קופלר במרכז קנדה לפיסיקה גרעיניתמרצה Dr. Tomer Markovich
Lunch will be served at 12:45צרו קשר תקציר Show full text abstract about <p>Materials that are constantly driven out of thermod...» <p>Materials that are constantly driven out of thermodynamic equilibrium, such as active and living systems, typically violate the Einstein relation. This may arise from active contributions to particle fluctuations which are unrelated to the dissipative resistance of the surrounding medium. In this talk I will show that in these cases the widely used relation between informatic entropy production and heat dissipation does not hold. Consequently, fluctuation relations for the mechanical work, such as the Jarzynski and Crooks theorems, are invalid. The breaking of the correspondence between informatic entropy production and heat dissipation will then be related to the departure from the fluctuation-dissipation theorem. I will finally propose a temperaturelike variable that restores the correspondence between information and thermodynamics and gives rise to a generalized second law of thermodynamics. The Clausius inequality, Carnot maximum efficiency theorem, and relation between the extractable work and the change of free energy are recovered as well.</p> -
Date:11ראשוןמאי 2025אירועי תרבות
תקעו חצוצרה ברמה | הקאמרטה הישראלית ירושלים
More information שעה 20:00 - 21:30מיקום אודיטוריום מיכאל סלעדף בית צרו קשר -
Date:12שנימאי 2025אירועים אקדמיים
Seminar for PhD thesis defense
More information שעה 14:00 - 15:00כותרת TDP-43 pathology in ALS: from organelles to splicing, and an unexpected link to Alzheimer's Diseaseמיקום בניין ארתור ורושל בלפר למחקר ביורפואי
Botnar Auditoriumמרצה Joelle Welmoed Rachel Van Zuiden -
Date:12שנימאי 2025אירועים אקדמיים
David Lerner, PhD. Defense Seminar
More information שעה 16:00 - 17:00כותרת The evolution and distribution of tree species across the latitudinal axis - From a global to a regional scaleמיקום בניין לביוכימיה על שם נלה וליאון בנוזיו למדעי הצמח
690מרצה David Lerner
Department of Plant and Environmental Sciencesצרו קשר -
Date:14רביעימאי 2025הרצאה
Development as a Metabolic Regulator: How Molting Controls Cholesteryl Ester Metabolism in the Somatic Stem Cells of C. elegans
More information שעה 10:00 - 11:00מיקום בניין ארתור ורושל בלפר למחקר ביורפואי
Botnar Auditoriumמרצה Dr. Amir Sapir צרו קשר תקציר Show full text abstract about <p>Development as a Metabolic Regulator: How Molting C...» <p>Development as a Metabolic Regulator: How Molting Controls Cholesteryl Ester Metabolism in the Somatic Stem Cells of <em>C. elegans</em></p><p> </p><p>Raj Rani1, Or Ben-Hemo1, Benjamin Trabelcy1, Agam Bar1, Hans-Joachim Knölker2, Yoram Gerchman1,3,4, and Amir Sapir1*</p><p>1Department of Biology and the Environment, Faculty of Natural Sciences, University of Haifa, Oranim, Tivon, 36006 Israel</p><p>2 Fakultät Chemie, Technische Universität Dresden, Bergstrasse 66, 01069 Dresden, Germany</p><p>3Institute of Evolution, Faculty of Natural Sciences, University of Haifa, Haifa, Israel</p><p>4Oranim Academic College, Kiryat Tivon, Israel</p><p> </p><p>The metabolism of steroids, such as cholesterol, is critical for mammalian physiology and human health, yet its function in invertebrates remains poorly understood. Using <em>Caenorhabditis elegans</em>, we constructed the first comprehensive homology-based enzymatic atlas of steroid metabolism in invertebrates, identifying 159 candidate genes. We performed a two-dimensional genetic and metabolic screen, knocking down the atlas genes under varying cholesterol conditions to identify those functioning in steroid metabolism. Among the screen hits, we focused on <em>mboa-1</em>, an ortholog of mammalian SOAT1/2 enzymes that synthesize cholesteryl esters from sterols and fatty acids. Surprisingly, <em>mboa-1</em> knockdown and knockout disrupt hypodermis and cuticle integrity. Consistent with its predicted enzymatic function, bacterially expressed <em>C. elegans</em> MBOA-1 generates cholesteryl esters when supplemented with the steroid 4,3-cholesta and fatty acids. Moreover, 4,3-cholesta—but not steroid hormones—rescued the <em>mboa-1</em> RNAi phenotype, suggesting a new branch of steroid metabolism in <em>C. elegans</em>. <em>mboa-1</em> is expressed specifically in the somatic stem cells of <em>C. elegans</em>, the seam cells, which contribute to the hypodermis and cuticle. Expression begins in mid-embryogenesis, persists throughout larval development, but declines sharply in adults. Underscoring its role in cuticle dynamics, <em>mboa-1</em> expression oscillates with the molting cycle and is regulated by <em>lin-29</em>–mediated heterochronic control during the larval-to-adult transition, a stage when seam cells terminally differentiate. Our functional studies in Clade IV and V nematodes, along with insect expression data, suggest that during evolution, <em>mboa-1</em> regulation was rewired to support a structural role for cholesteryl esters in cuticle formation, diverging from their primarily metabolic functions in mammals and insects. Our findings reveal how, during evolution, steroid metabolism was repurposed for a novel function in nematodes through the mechanistic reconfiguring of developmental regulation and stem cell biology.</p> -
Date:14רביעימאי 2025הרצאה
Machine Learning and Statistics Seminar
More information שעה 11:15 - 12:15כותרת Sample Compression and Topological Radon Theoremמיקום בניין יעקב זיסקינד
Room 1 - 1 חדרמרצה Bogdan Chornomaz
Technionמארגן המחלקה למדעי המחשב ומתמטיקה שימושיתצרו קשר תקציר Show full text abstract about If asked, what mathematical tools are mostly used in machine...» If asked, what mathematical tools are mostly used in machine learning, one would probably name statistics, probability, or combinatorics. So it is especially pleasing when some other tools, considered rather exotic in this area, find natural applications to ML problems. In this talk, I will speak about an application of (a variant of) topological Radon theorem to an old open problem in theoretical machine learning regarding the existence of the so-called sample compression schemes.
The talk is based on the joint work with Zachary Chase, Steve Hanneke, Shay Moran, and Amir Yehudayoff. -
Date:14רביעימאי 2025הרצאה
Targeting leukemia cell vulnerabilities with our experimental new drug
More information שעה 14:00 - 15:00מיקום בניין ע"ש מקס ולילאן קנדיוטי
Auditoriumמרצה Prof. Yinon Ben-Neriah מארגן המכון לחקר הטיפול בסרטן עש דואק -
Date:14רביעימאי 2025הרצאה
ABC CHATS: Assaf Kacen
More information שעה 14:00 - 15:00כותרת From Academia to Industry: The PromiseBio Journeyמיקום בניין על-שם גרשון ואסתר סאגאן
Loungeתקציר Show full text abstract about <p>Join our ABC CHATS, Where CEOs share their ABC’s on...» <p>Join our ABC CHATS, Where CEOs share their ABC’s on scientific leadership, breakthroughs and failures throughout their personal stories</p> -
Date:14רביעימאי 2025הרצאה
Special Guest Seminar
More information שעה 14:00 - 15:00כותרת Understanding evolutionary paths to virus virulence and the rational design of live-attenuated viral vaccinesמיקום בניין ארתור ורושל בלפר למחקר ביורפואי
Botnar Auditoriumמרצה Prof. Raul Andino -
Date:15חמישימאי 2025אירועים אקדמיים
Scientific Council Meeting
More information שעה 10:00 - 12:00מיקום LOP
KIMELצרו קשר -
Date:15חמישימאי 2025אירועים אקדמיים
PhD Thesis Defense- Aviva Rotter(Strassman's lab)
More information שעה 14:30 - 16:30כותרת Bacteria Mediated resistance to ALKi in EML4-ALK fusion NSCLCמיקום בניין אולמן למדעי החיים
201צרו קשר -
Date:15חמישימאי 2025הרצאה
How to Enhance Sex Determination?
More information שעה 15:00 - 16:00מיקום בניין לביוכימיה על שם נלה וליאון בנוזיו
Auditorium Rm.191מרצה Dr. Nitzan Gonen
Faculty of Life Sciences and the Nanotechnology Institute, Bar Ilan Universityתקציר Show full text abstract about <p>Sex determination is the process through which an o...» <p>Sex determination is the process through which an organism will develop as male or female. This process is extremely delicate, relying on mutual antagonistic pathways of pro-male and pro-female factors. Nowadays, more than 50% of individuals with Differences of Sex Development (DSD) fail to receive genetic diagnosis following exome sequencing, suggesting that many variants fall within the non-coding genome. We have identified many regulatory elements, disruptions in which lead to sex reversal in mice with clinical relevance to DSD patients. We also aim to generate an <em>in vitro</em> system to model the gonads using the creation of testis organoids generated from primary tissues and gonadal cells differentiated from stem cells.</p> -
Date:15חמישימאי 2025אירועי תרבות
שבת בברזיל | ז'וקה פרפיניאן ומרסלו נמי, מארחים את לאה שבת
More information שעה 21:00 - 22:30מיקום אודיטוריום מיכאל סלעדף בית צרו קשר -
Date:18ראשוןמאי 2025הרצאה
Photonic seismology
More information שעה 11:00 - 12:00מיקום בניין משפחת זוסמן
M. Magaritz seminar roomמרצה Ariel Lellouch צרו קשר תקציר Show full text abstract about <p>Distributed Fiber Optic Sensing (DFOS) is revolutio...» <p>Distributed Fiber Optic Sensing (DFOS) is revolutionizing seismology thanks to dense measurements at an unprecedented scale. In this talk, I will describe the main principles behind the technology, as well as multiple scientific and practical questions that we could answer with fiber-optic sensing: vehicle tracking in urban environments, microearthquake location and fault plane reconstruction, an inversion approach to jointly resolve subsurface and structural parameters, and finally – a recent experiment in which we deployed a joint fiber-accelerometer in an abandoned well near the Kinneret, targeting local undetected earthquakes.</p> -
Date:18ראשוןמאי 2025הרצאה
The Age of Plastic: A Blessing or A Curse?
More information שעה 13:00 - 14:00כותרת IES- Institute For Environmental Sustainability seminar series 2025-2026מיקום בניין לביוכימיה על שם נלה וליאון בנוזיו
690מרצה Dr. Shira Haber
Ben-Gurion University , The Department of Chemistryמארגן המכון לסביבה וקיימות -
Date:19שנימאי 2025סימפוזיונים
Chemistry Colloquium
More information שעה 11:00 - 12:15כותרת title tbdמיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof. Michael Neidig דף בית -
Date:19שנימאי 2025הרצאה
Mechanisms of axonal degeneration following traumatic brain injury
More information שעה 11:00 - 12:30מיקום Benoziyo Bldg. for Biological Sciences
Seminar Rm. 290 -Floor 2מרצה Prof. Wilma Friedman
Special Guest Joint Seminar Dept. of Biomolecular Sciences & Dept. of Molecular Neuroscienceתקציר Show full text abstract about <p>Traumatic brain injury to the cortex elicits the lo...» <p>Traumatic brain injury to the cortex elicits the loss of neurons at the site of damage, but also evokes changes in the tissue environment of axon terminals that project to the site of injury from distal locations. We previously demonstrated that basal forebrain cholinergic neurons (BFCNs) undergo retrograde degeneration following cortical TBI that is mediated by the p75 neurotrophin receptor (p75NTR). We have investigated mechanisms governing p75NTR-mediated retrograde degeneration as well as the behavioral consequences of the loss of BFCNs following TBI. Mice lacking the p75NTR in cholinergic neurons showed sparing of these neurons following TBI, and preservation of cognitive function.</p> -
Date:19שנימאי 2025הרצאה
Foundations of Computer Science Seminar
More information שעה 11:15 - 12:15כותרת Tree PCPsמיקום בניין יעקב זיסקינד
Room 1 - 1 חדרמרצה Tamer Mour
Bocconi Universityמארגן המחלקה למדעי המחשב ומתמטיקה שימושיתצרו קשר תקציר Show full text abstract about Probabilistically checkable proofs (PCPs) allow encoding a c...» Probabilistically checkable proofs (PCPs) allow encoding a computation so that it can be quickly verified by only reading a few symbols. Inspired by tree codes (Schulman, STOC'93), we propose tree PCPs; these are PCPs that evolve as the computation progresses so that a proof for time t is obtained by appending a short string to the end of the tree PCP proof for time t-1. At any given time step t, a verifier can make a small number of queries to the entire tree PCP string (constructed thus far) to verify the correctness of the entire computation.
We construct tree PCPs for non-deterministic space-s computation, where at time step t, the proof only grows by an additional poly(s,log(t)) bits, and the number of queries made by the verifier to the overall proof is poly(s)*t^epsilon, for an arbitrary constant epsilon > 0.
Tree PCPs are well-suited to proving correctness of ongoing computation that unfolds over time. They may be thought of as an information-theoretic analog of the cryptographic notion of incrementally verifiable computation (Valiant, TCC'08). We show that, in the random oracle model, tree PCPs can be compiled to realize a variant of incrementally verifiable computation where the prover is allowed a small number of queries to a large evolving state. This yields the first construction of (a natural variant of) IVC in the random oracle model.
This is a joint work with Alon Rosen and Ron D. Rothblum. -
Date:20שלישימאי 2025הרצאה
Trauma Under Psychedelics: How trauma during altered states of consciousness impacts cognitive, physiological, neural, and clinical outcomes
More information שעה 12:30 - 13:30מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof. Roy Salomon מארגן המחלקה למדעי המוחצרו קשר תקציר Show full text abstract about <p>Abstract: Recent research has focused on how psyche...» <p>Abstract: Recent research has focused on how psychedelics and empathogens may assist in the treatment of PTSD and depression following trauma. However, there is almost no knowledge regarding how psychoactive substances may impact the processing of Traumatic Events (TE) in real time. The large-scale terror attack by Hamas on October 7th 2023 on the 4000 attendees of the Supernova music festival has provided a tragic opportunity to study these two phenomena in conjunction. The attack took place shortly after sunrise, when many attendees were under the influence of mind-altering substances, mostly MDMA, LSD, ketamine and, as well as cannabis. This is an unprecedented mass trauma event that many of its victims experienced while in altered states of consciousness. We have begun a large-scale, longitudinal study with these survivors regarding the processing of trauma under the influence of psychedelics in the peritraumatic and post traumatic periods. Our results indicate that approximately 65% of the participants were exposed to severe trauma while under the influence of mind-altering substances. In this talk I will show preliminary results from this unique cohort including clinical (n = 1400), physiological (n = 300), cognitive (n = 900) and neural (fMRI) measures (n = 140) and how they relate to trauma and psychedelic use. The data and experiences of the courageous survivors of the festival provide novel insights into how trauma processing is impacted by psychoactive substances revealing unique interactions between cognitive, pharmacological and clinical factors.</p>