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תוצאות חיפוש לאירועים
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Date:22ראשוןמאי 202226חמישימאי 2022כנסים
18th International p53 Workshop
More information שעה 08:00 - 08:00מיקום אודיטוריום מיכאל סלעיושב ראש Varda Rotterדף בית צרו קשר -
Date:22ראשוןמאי 2022הרצאה
Chemical and Biological Physics Guest Seminar
More information שעה 11:00 - 12:00כותרת Electron Transfer and Spin Selectivity in Biomoleculesמיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof Dave Waldeck
University of Pittsburghמארגן המחלקה לפיסיקה כימית וביולוגיתצרו קשר -
Date:22ראשוןמאי 2022הרצאה
Chemical and Biological Physics Guest Seminar
More information שעה 11:00 - 12:00כותרת Electron Transfer and Spin Selectivity in Biomoleculesמיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Terryמארגן המחלקה לפיסיקה כימית וביולוגיתצרו קשר -
Date:22ראשוןמאי 2022הרצאה
The cap-binding protein, 4EHP/eIF4E2 mediates miRNA suppression of mRNA translation.
More information שעה 11:00 - 12:00מיקום בניין לביוכימיה על שם נלה וליאון בנוזיו
Auditoriumמרצה Prof. Nahum Sonenberg
Gilman Cheney Professor McGill University, Department of Biochemistry Goodman Cancer Research Center Montreal, Quebec, Canadaמארגן המחלקה למדעים ביומולקולרייםצרו קשר תקציר Show full text abstract about The eIF4E Homolog Protein (4EHP, eIF4E2) is a mRNA cap-bindi...» The eIF4E Homolog Protein (4EHP, eIF4E2) is a mRNA cap-binding protein that in contrast to eIF4E cannot interact with eIF4G and acts as a translation repressor. The CCR4-NOT complex functions in miRNA-mediated mRNA silencing through its recruitment by the RISC (RNA-induced silencing complex). The CCR4-NOT complex recruits the helicase DDX6, which binds 4E-T (eIF4E-Transporter), which in turn binds 4EHP resulting in inhibition of cap-dependent translation (Proc. Natl. Acad. Sci. 2017). 4EHP suppresses IFN-production by promoting the miR-34a-induced translational silencing of Ifnb1 mRNA. (Mol. Cell, 2021). The SARS-CoV2 encoded Non-Structural Protein 2 (NSP2), directly interacts with the cellular GIGYF2 protein and enhances the binding of GIGYF2 to 4EHP and thereby enhances translational repression of Ifnb-1 mRNA. Depletion of 4EHP or GIGYF2 resulted in enhanced IFN-ß expression accompanied by a significant reduction of SARS-CoV-2 replication.
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Date:23שנימאי 2022סימפוזיונים
Israel Physics Colloquium
More information כותרת Quantum gas in a boxמיקום https://weizmann.zoom.us/j/94885314520?pwd=Q2pra0dyS284VENiUVVhWGVTTjJFQT09מרצה Prof. Zoran Hadzibabic
Cambridge Universityמארגן הפקולטה לפיסיקהצרו קשר פרטים נוספים Show full text description of Meeting ID: 948 8531 4520 Password: 192379 ...» Meeting ID: 948 8531 4520
Password: 192379
תקציר Show full text abstract about For nearly three decades, ultracold atomic gases have been u...» For nearly three decades, ultracold atomic gases have been used with great success to study fundamental many-body phenomena such as Bose-Einstein condensation and superfluidity. While traditionally they were produced in harmonic electromagnetic traps and thus had inhomogeneous densities, it is now also possible to create homogeneous samples in the uniform potential of an optical box trap. Box trapping simplifies the interpretation of experimental results, provides more direct connections with theory and, in some cases, allows qualitatively new, hitherto impossible experiments. I will give an overview of our recent experiments with box-trapped three- and two-dimensional Bose gases, focusing on a series of related experiments on non-equilibrium phenomena, including phase-transition dynamics, turbulence, and equilibration of closed quantum systems -
Date:23שנימאי 2022סימפוזיונים
Covalent Binders: From Discovery to Function
More information שעה 11:00 - 12:15מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Dr. Nir London
Department of Chemical & Structural Biology, WISמארגן הפקולטה לכימיהצרו קשר תקציר Show full text abstract about Small molecule inhibitors and drugs that are able to form a ...» Small molecule inhibitors and drugs that are able to form a covalent bond with
their protein target have several advantages over traditional binders. While they were
avoided for a long time due to concerns of specificity, in recent years they are attracting
significant interest as underscored by FDA approvals of rationally designed covalent
drugs, such as Ibrutinib and Afatinib. In the past few years my research team has been
focused on technology development for the field of Covalent Ligand Discovery. These
include: covalent virtual screening, empirical covalent fragment screening, the first
reported reversible covalent targeted degraders (PROTACs), and most recently the
discovery of new chemistry that enables the design of superior covalent binders. These
technologies enabled the discovery of novel, potent inhibitors for several challenging
targets. These inhibitors, in turn, have shed new light on the target’s biological function
and represent potential therapeutic leads. I will describe our journey from the original goal
of mere ‘discovery’ of covalent binders to the current challenge of functionalizing covalent
binders for various applications. -
Date:23שנימאי 2022הרצאה
Foundations of Computer Science Seminar
More information שעה 11:15 - 12:45כותרת Proving as Fast as Computing: Succinct Arguments with Constant Prover Overheadמיקום בניין יעקב זיסקינד
Room 155מרצה Ron Rothblum
The Technionמארגן הפקולטה למתמטיקה ומדעי המחשב
Seminarצרו קשר תקציר Show full text abstract about Succinct arguments are proof systems that allow a powerful, ...» Succinct arguments are proof systems that allow a powerful, but untrusted, prover to convince a weak verifier that an input x belongs to a language L in NP, with communication that is much shorter than the NP witness. Such arguments, which grew out of the theory literature, are now drawing immense interest also in practice, where a key bottleneck that has arisen is the high computational cost of proving correctness.
In this work we address this problem by constructing succinct arguments for general computations, expressed as Boolean circuits (of bounded fan-in), with a strictly linear size prover. The soundness error of the protocol is an arbitrarily small constant. Prior to this work, succinct arguments were known with a quasi-linear size prover for general Boolean circuits or with linear-size only for arithmetic circuits, defined over large finite fields.
Joint work Noga Ron-Zewi.
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Date:24שלישימאי 2022הרצאה
Mitochondrial behavior
More information שעה 10:00 - 11:00מיקום בניין לביוכימיה על שם נלה וליאון בנוזיו
Auditoriumמרצה Prof. Jodi Nunnari
Department of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davisמארגן המחלקה למדעים ביומולקולרייםצרו קשר תקציר Show full text abstract about Jodi Nunnari is a pioneer in the field of mitochondrial biol...» Jodi Nunnari is a pioneer in the field of mitochondrial biology. She was the first to describe the organelle as a dynamic network in homeostatic balance and decipher the mechanisms of the machines responsible for mitochondrial division and fusion, which are critical determinants of overall mitochondrial shape and distribution. Nunnari’s laboratory at UC Davis is using system-based approaches to address how mitochondrial behavior is physiologically regulated within cells to shed light onto how mitochondrial dysfunction contributes to human disease. -
Date:24שלישימאי 2022הרצאה
Real-time monitoring of replication fork progression in single live cells
More information שעה 14:00 - 15:00מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof. Amir Aharoni
Dept. of Life Sciences Ben-Gurion Universityמארגן המחלקה לביולוגיה מבנית וכימיתצרו קשר -
Date:25רביעימאי 202226חמישימאי 2022הרצאה
THEORY AVANT GARDE, A Workshop in Honor of Moni Naor
More information מיקום אולם ע"ש דולפי ולולה אבנרמארגן הפקולטה למתמטיקה ומדעי המחשבדף בית צרו קשר פרטים נוספים Show full text description of Organizing Committee: Cynthia Dwork, Harvard University Am...» Organizing Committee:
Cynthia Dwork, Harvard University
Amos Fiat, Tel Aviv University
Seffi Naor, Technion
Omer Reingold, Stanford University
Guy Rothblum, Weizmann Insititute of Science
Alon Rosen, Bocconi University
Sponsors
The Chorafas Institute for Scientific Exchange -
Date:25רביעימאי 2022הרצאה
Special guest semianr with Prof. Jin Billy Li
More information שעה 13:15כותרת RNA Editing and Innate Immunityמיקום בניין ארתור ורושל בלפר למחקר ביורפואי
Botnar Auditoriumמרצה Jin Billy Li
Department of Genetics, Standford Universityמארגן המחלקה לגנטיקה מולקולריתצרו קשר -
Date:26חמישימאי 2022הרצאה
New solid-state NMR methods for exciting and separating anisotropic interactions of spin I = 1 nuclei
More information שעה 09:30 - 10:30מיקום בניין פרלמן למדעי הכימיה
Shlomo Alexander Science Loungeמרצה Dr. Rihard Aleksis
Department of Materials and Environmental Chemistry, Stockholm Universityמארגן מכון קלור לדימות וספקטרוסקופיה של תהונה מגנטית בעוצמות גבוהותצרו קשר תקציר Show full text abstract about Solid-state NMR has become an essential tool for structural ...» Solid-state NMR has become an essential tool for structural characterisation of materials,
in particular systems with poor crystallinity and structural disorder. In recent years, a surge of
interest has been observed for the study of paramagnetic systems, in which the interaction between
nuclei and unpaired electrons allows to probe the electronic structure and properties of materials
more directly. However, simultaneously this interaction leads to very broad resonances, which are
dicult to acquire and interpret. While signicant advancements in both NMR instrumentation
and methodology have paved the way for the study of spin I = 1=2 nuclei in these systems, still
many issues remain to be resolved for routine investigation of quadrupolar nuclei I > 1=2. Here we
focus on improving both the excitation of the broad resonances and the resolution in the spectra
of spin I = 1 nuclei. The latter problem is addressed by developing methods for separation of the
shift and the quadrupolar interactions. We introduce two new methods under static conditions,
which have the advantage over previous experiments of both suppressing spectral artefacts and
exhibiting a broader excitation bandwidth. Furthermore, we demonstrate for the rst time an
approach for separation of the anisotropic parts of the shift and quadrupolar interaction under
magic-angle spinning. Secondly, to achieve broadband excitation we develop a new theoretical
formalism for phase-modulated pulse sequences in rotating solids, which are applicable to nuclear
spins with anisotropic interactions substantially larger than the spinning frequency, under conditions
where the radio-frequency amplitude is smaller than or comparable to the spinning frequency. We
apply the framework to the excitation of double-quantum spectra of 14N and design new pulse
schemes with
-encoded properties. Finally, we employ the new sequences together with density
functional theory calculations to elucidate the electron and hydride ion conduction mechanisms in
barium titanium oxyhydride. -
Date:26חמישימאי 2022הרצאה
BRD4 in Transcription Programming and Cancer Therapy
More information שעה 10:30 - 11:30מיקום בניין לביוכימיה על שם נלה וליאון בנוזיו
Cafeteriaמרצה Prof. Cheng-Ming Chiang
Simmons Comprehensive Cancer Center, Department of Biochemistry and Department of Pharmacology, University of Texas Southwestern Medical Center, UT Southwestern Medical Center U.S.A.מארגן המחלקה למדעים ביומולקולרייםצרו קשר תקציר Show full text abstract about Bromodomain-containing protein 4 (BRD4) is an epigenetic reg...» Bromodomain-containing protein 4 (BRD4) is an epigenetic regulator and transcription cofactor whose phosphorylation by casein kinase II (CK2) and dephosphorylation by protein phosphatase 2A (PP2A) modulates its function in gene-specific targeting and recruitment of transcriptional regulators and chromatin modifiers. BRD4 has emerged as an important cancer therapeutic target due to widely available small compound inhibitors, such as JQ1 and I-BET, targeting the bromodomain and extra-terminal (BET) family members. Besides transcriptional regulation, BRD4 also plays crucial roles in regulating diverse cellular processes, including cell cycle progression, DNA damage response, chromatin structure maintenance, stem cell reprogramming, cell lineage differentiation, and viral latency and reactivation. While BET inhibitors and degraders show promising anticancer effects, issues related to drug resistance upon prolonged treatment remain a challenge in BET-targeted therapeutics development. Recently, we identified specific small compound inhibitors targeting phosphorylation-dependent BRD4 interaction with distinct transcription/replication components and DNA damage response (DDR) factors, including p53, c-Myc, AP-1, and cancer-associated human papillomavirus E2 proteins. Some of these compounds effectively block cancer cell growth and migration and specifically inhibit p53 interaction with BRD4. These new types of protein-protein interaction (PPI) inhibitors highlight molecular action distinct from the widely used BET bromodomain inhibitors.
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Date:26חמישימאי 2022הרצאה
“Modeling Photo and Bias Induced Electron transfer and transport. An ab-initio perspective on kinetics”
More information שעה 11:00 - 12:00מיקום בניין פרלמן למדעי הכימיה
Room 404מרצה Prof. Barry Dunietz
Dept. Chemistry and Biochemistry, Kent State University, OHמארגן המחלקה לכימיה מולקולרית ולמדע חומריםצרו קשר תקציר Show full text abstract about Charge transfer and transport processes through molecular in...» Charge transfer and transport processes through molecular interfaces are ubiquitous and of a crucial role in determining functionality of biological systems and in enabling energy conversion applications. We study computationally such processes to understand structure-function relationships at the molecular level.
We will discuss studies in the following two primary fields: (1) Photovoltaic and charge transfer properties of organic semiconductors materials. (2) Charge transport through voltage-biased molecular scale bridges. Importantly we establish predictive computational scheme that addresses key challenges. Our studies are employed in conjunction with experimental efforts to design materials and applications that control and tune relevant physical properties -
Date:26חמישימאי 2022הרצאה
Chaperoning protein aggregation diseases
More information שעה 11:30 - 12:30מיקום אולם הרצאות ע"ש גרהרד שמידט
Botnar Auditoriumמרצה Prof. Stefan Rudiger
Bijvoet Center for Biomolecular Research Utrecht Universityמארגן המחלקה לביולוגיה מבנית וכימיתצרו קשר -
Date:26חמישימאי 2022הרצאה
Vision and AI
More information שעה 12:15 - 13:30כותרת Image Denoising - Not What You Thinkמיקום בניין יעקב זיסקינד
Room 1מרצה Miki Elad
Technionמארגן הפקולטה למתמטיקה ומדעי המחשב , המחלקה למדעי המחשב ומתמטיקה שימושית , המחלקה למתמטיקהצרו קשר פרטים נוספים Show full text description of Image denoising - removal of white additive Gaussian noise f...» Image denoising - removal of white additive Gaussian noise from an image - is one of the oldest and most studied problems in image processing. An extensive work over several decades has led to thousands of papers on this subject, and to many well-performing algorithms for this task. As expected, the era of deep learning has brought yet another revolution to this subfield, and took the lead in today's ability for noise suppression in images. All this progress has led some researchers to believe that "denoising is dead", in the sense that all that can be achieved is already done.
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Date:26חמישימאי 2022הרצאה
Targeting metabolic vulnerabilities in cancer
More information שעה 14:00 - 15:00מיקום בניין ע"ש מקס ולילאן קנדיוטי
Auditoriumמרצה Prof. Tomer Shlomi
The faculties of Computer Science and Biology, Technionמארגן המכון לחקר הטיפול בסרטן עש דואק
Cancer Research Clubצרו קשר פרטים נוספים Show full text description of Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6K...» Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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Date:29ראשוןמאי 2022הרצאה
The Summer STARS 2022 workshop
More information מארגן הפקולטה למתמטיקה ומדעי המחשבדף בית צרו קשר פרטים נוספים Show full text description of Summer STARS Workshop 2022 May 29, June 1-2, 2022 WEBPAGE ...» Summer STARS Workshop 2022
May 29, June 1-2, 2022
WEBPAGE https://sites.google.com/view/summerstars2022/home -
Date:29ראשוןמאי 2022הרצאה
TBA
More information שעה 11:00מיקום https://weizmann.zoom.us/j/7621438333?pwd=c0lpdlQzYSthellXWG9rZnM0ZDRFZz09מרצה Nadav Lensky
Geological survey of Israelמארגן המחלקה למדעי כדור הארץ וכוכבי הלכתצרו קשר -
Date:29ראשוןמאי 2022הרצאה
Conservation outside protected areas: Designing multifunctional landscapes for the mutual benefit of people and biodiversity
More information שעה 13:00 - 14:00כותרת SAERI ZOOM Lecture- Sustainability and Energy Research Initiative lecture seriesמיקום via Zoomמרצה Prof. Assaf Shwartz
Faculty of Architecture and Town Planning Technion - Israel Institute of Technologyמארגן מדרשת פיינברג
Alternative Sustainable Energy Research Initiative (AERI)צרו קשר פרטים נוספים Show full text description of Host: Prof. Ron Milo, SAERI Scientific Director The lect...»
Host: Prof. Ron Milo, SAERI Scientific Director
The lecture will take place via zoom:https://weizmann.zoom.us/j/91824811393?pwd=ZUF2ekNkd21RRWNMcmN0MzFtcUhhUT09
Meeting ID: 918 2481 1393
Password: 12345