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  • Date:25שלישיספטמבר 2018

    “From “Crowdoxidation” to Organoselenide C-E Bond Cleavage: Enlisting the help of Chalcogens in Analysis of Biological Systems Trough Novel Probe Design”

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    שעה
    11:00 - 12:00
    מיקום
    בניין הלן ומילטון קימלמן
    Dov Elad Room
    מרצה
    Prof. David G. Churchill
    Department of Chemistry, KAIST
    מארגן
    המחלקה לכימיה אורגנית
    צרו קשר
    תקצירShow full text abstract about Our laboratory is studying small molecule selenium-containin...»
    Our laboratory is studying small molecule selenium-containing organic and organometallic systems for their potential selective fluorescence imaging properties; our goal is to eventually probing aspects of neurodegenerative disease and disease models in a more precise way based on the present state of the art. Like some transition metals, heavier chalcogens also have capacity for redox with common changes in their valence state from 2 to 4 and from 4 to 6 being possible. Also, reduced heavier chalcogenide centers such as selenium have the ability for metal chelation. The optical characteristics are sometimes profoundly changed by an additional 2+ oxidation state at e.g. a selenium atom when the Se is in an aromatic ring or as a direct aryl substituent to a fluorogenic framework. While the atom which can become chemically oxidized may be contained within an aromatic ring, or present as a substituent, there is also the possibility for C-E bond rupture; C-Se bond c! leavage was studied with selective biothiol detection in mind and therefore, the extent of Se-C rupture possible is a design parameter in these small fluorogenic molecules and its study is ongoing. Sulfur chemistry in biology is dynamic and diverse; therefore, we are hereby exploring the extent of versatility available for selenium in small synthetic molecules in the context of biology, and specifically, towards better understanding and addressing aging and neurodegenerative disease research.
    הרצאה
  • Date:27חמישיספטמבר 2018

    Special Physics Colloquium-

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    שעה
    11:15 - 12:15
    מיקום
    בניין הפיסיקה ע"ש עדנה וק.ב. וייסמן
    Auditorium
    מרצה
    Gerhard Rempe
    Max Planck Institute of Quantum Optics, Germany
    מארגן
    הפקולטה לפיסיקה
    Special Seminar
    צרו קשר
    פרטים נוספיםShow full text description of 11:00 – coffee, tea, and more...»
    11:00 – coffee, tea, and more
    תקצירShow full text abstract about Quantum physics allows for applications not possible within ...»
    Quantum physics allows for applications not possible within classical physics. A prominent example is the quantum computer that, once realized, needs a quantum communication environment – a quantum internet. With this in mind, the talk will discuss a unique toolbox for distributed quantum computation and quantum communication by means of photonic qubits that propagate between atomic quantum memories localized in optical resonators as quantum interfaces.
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  • Date:07ראשוןאוקטובר 201811חמישיאוקטובר 2018

    WIS Summer School: Introduction to Biological Physics for Students of Science and Engineering

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    שעה
    08:00 - 08:00
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    יושב ראש
    Samuel Safran
    מארגן
    מזכיר אקדמי מדרשת פיינברג , המחלקה לפיסיקה כימית וביולוגית
    צרו קשר
    כנסים
  • Date:07ראשוןאוקטובר 2018

    “Macrocycle-based Adventures in Self-Assembly”

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    שעה
    11:00 - 12:00
    מיקום
    בניין הלן ומילטון קימלמן
    Dov Elad Room
    מרצה
    Prof. Jonathan L. Sessler
    The University of Texas at Austin
    מארגן
    המחלקה לכימיה אורגנית
    צרו קשר
    תקצירShow full text abstract about We are working on new strategies for self-assembly. Systems ...»
    We are working on new strategies for self-assembly. Systems whose study is relatively advanced are the so-called cyclo[m]pyridine[n]pyrroles. These systems permit self-assembly via anion recognition. They also display substrate-dependent responsive features. This has made them of interest as sensor systems and functional materials whose ground and excited state properties may be “switched” through modulation of solvent, pH, and exposure to ionic and neutral analytes.
    Complementing work on charged building blocks is the use of electron rich calix[4]pyrroles. Here, anion binding serves to switch the fundamental conformation of the core receptor so as to control self-assembly. This allows the production of monomers, capsules, and oligomers via the judicious choice of calix[4]pyrrole, anion, cation, solvent, and targeted substrate. It also permits control over charge transfer interactions and the construction of multi-state molecular logic devices. One of these has permitted inters-species "chemical communication".
    Finally, a set of "Texas-size" box-like receptors has been created. These are permitting the chemistry of self-assembly and information storage to be extended into the realm of soft materials. Applications in the realm of water purification are also being explored.
    This work was made possible by the dedicated efforts of many coworkers and collaborators who will be thanked during the presentation. Support from the U.S. National Science Foundation, US National Institutes of Health, the US Department of Energy, and the Robert A. Welch Foundation is acknowledged. Funding has also come from Shanghai University.
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  • Date:07ראשוןאוקטובר 2018

    "What is it like to be a bat?" - A pathway to the answer from the Integrated Information Theory

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    שעה
    12:30 - 13:30
    מיקום
    בניין לחקר המוח על-שם נלה וליאון בנוזיו
    מרצה
    Dr. Naotsugu Tsuchiya
    School of Psychological Sciences, Monash Institute of Cognitive & Clinical Neuroscience Monash University, Australia
    מארגן
    המחלקה לנוירוביולוגיה
    צרו קשר
    פרטים נוספיםShow full text description of Benoziyo Brain Research Building Room 113 Host: Prof. Raf...»
    Benoziyo Brain Research Building Room 113

    Host: Prof. Rafi Malach rafi.malach@weizmann.ac.il tel: 2758
    For assistance with accessibility issues, please contact naomi.moses@weizmann.ac.il
    תקצירShow full text abstract about What does it feel like to be a bat? Is conscious experience ...»
    What does it feel like to be a bat? Is conscious experience of echolocation closer to that of vision or audition? Or, echolocation is non-conscious processing and it doesn't feel anything? This famous question of bats' experience, posed by a philosopher Thomas Nagel in 1974, clarifies the difficult nature of the mind-body problem. Why a particular sense, such as vision, has to feel like vision, but not like audition, is puzzling. This is especially so given that any conscious experience is supported by neuronal activity. Activity of a single neuron appears fairly uniform across modalities, and even similar to those for non-conscious processing. Without any explanation on why a particular sense has to feel as the way it does, researchers even cannot approach the question of the bats' experience. Is there any theory that gives us a hope for such explanation? Currently, probably none, except for one. Integrated Information Theory (IIT), proposed by Tononi in 2004 has a potential to offer a plausible explanation. IIT essentially claims that any system that is composed of causally interacting mechanisms can have conscious experience. And precisely how the system feels like is determined by the way the mechanisms influence each other in a holistic way. In this talk, I will give a brief explanation of the essence of IIT and provide initial empirical partial tests of the theory, proposing a potential scientific pathway to approach bats' conscious experience. If IIT, or its improved or related versions, is validated enough, it will gain credibility to accept its prediction on rough nature of bats' experience. If we can gain a sophisticated insight as to whether bats' experience is closer to vision or audition, it is already a tremendously big step in consciousness science, which is just a first yet critical one, possibly a similar level of the breakthrough in cosmology in precisely estimating the age of the universe.
    References:
    0) talk slide: https://www.slideshare.net/NaoNaotsuguTsuchiya/17-june-20-empirical-test-of-iit-dresden
    1) Andrew M. Haun, Masafumi Oizumi, Christopher K. Kovach, Hiroto Kawasaki, Hiroyuki Oya, Matthew A. Howard, Ralph Adolphs, Naotsugu Tsuchiya, (2017, accepted) “Conscious perception as integrated information patterns in human electrocorticography” eNeuro link
    2) Tsuchiya “"What is it like to be a bat?" - a pathway to the answer from the Integrated Information Theory ” Philosophy Compass (2017) link
    3) Oizumi M, Tsuchiya N, Amari S, “Unified framework for quantifying causality and integrated information in a dynamical system” (2016) PNAS link
    הרצאה
  • Date:08שניאוקטובר 201810רביעיאוקטובר 2018

    Minerva Annual Meeting 2018

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    שעה
    כל היום
    כותרת
    Minerva Committee interviews of scientists who submitted full proposals in all faculties
    דף בית
    צרו קשר
    תקצירShow full text abstract about If you require further information, please contact Chaya Moy...»
    If you require further information, please contact Chaya Moykopf (4048)
    אירועים אקדמיים
  • Date:08שניאוקטובר 2018

    "Materials by Design: Three-Dimensional (3D) Nano-Architected Metamaterials"

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    שעה
    11:00 - 12:15
    כותרת
    Annual G.M.J. Schmidt Memorial Lecture
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצה
    Prof. Julia R. Greer
    Caltech
    מארגן
    הפקולטה לכימיה
    צרו קשר
    סימפוזיונים
  • Date:08שניאוקטובר 2018

    Unraveling novel protease activity mechanisms at the tumor microenvironment of pancreas cancers

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    שעה
    14:00 - 15:00
    כותרת
    Cancer Research Club
    מיקום
    בניין ע"ש מקס ולילאן קנדיוטי
    Auditorium
    מרצה
    Prof. Irit Sagi
    Dept. of Biological Regulation Weizmann Institute
    מארגן
    המחלקה לבקרה ביולוגית
    דף בית
    צרו קשר
    הרצאה
  • Date:11חמישיאוקטובר 2018

    Seminar for thesis defense

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    שעה
    12:00 - 13:00
    כותרת
    “Creating and utilizing a novel yeast library to systematically characterize the yeast proteome”
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    מרצה
    Uri Weill
    מארגן
    המחלקה לגנטיקה מולקולרית
    Seminar
    צרו קשר
    הרצאה
  • Date:11חמישיאוקטובר 2018

    Understanding the crosstalk between RNA processing and signal transduction

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    שעה
    14:00 - 15:00
    כותרת
    Special Guest Seminar
    מיקום
    בניין ע"ש מקס ולילאן קנדיוטי
    Auditorium
    מרצה
    Prof. Jingyi Hui
    Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China
    מארגן
    המחלקה לבקרה ביולוגית
    צרו קשר
    הרצאה
  • Date:14ראשוןאוקטובר 201819שישיאוקטובר 2018

    Mol Med of Sphingolipids conference 2018

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    שעה
    08:00 - 08:00
    יושב ראש
    Anthony H. Futerman
    מארגן
    מרכז לאסטרופיסיקה עש נלה וליאון בנוזיו
    דף בית
    צרו קשר
    כנסים
  • Date:14ראשוןאוקטובר 2018

    TBA

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    שעה
    11:00
    מיקום
    בניין משפחת זוסמן
    M. Magaritz Seminar Room
    מרצה
    Udi Strobach
    NASA GSFC
    מארגן
    המחלקה למדעי כדור הארץ וכוכבי הלכת
    צרו קשר
    הרצאה
  • Date:15שניאוקטובר 2018

    Life Science Colloquium

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    שעה
    11:00 - 12:00
    כותרת
    TBD
    מיקום
    אולם ע"ש דולפי ולולה אבנר
    מרצה
    Prof. Jan van Deursen
    Mayo Clinic, Minnesota
    מארגן
    מדעי החיים
    צרו קשר
    סימפוזיונים
  • Date:15שניאוקטובר 2018

    "Jupiter’s deep atmosphere revealed by Juno"

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    שעה
    11:00 - 12:15
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצה
    Prof. Yohai Kaspi
    Earth and Planetary Sciences, WIS
    מארגן
    הפקולטה לכימיה
    צרו קשר
    סימפוזיונים
  • Date:15שניאוקטובר 2018

    TBA

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    שעה
    14:00 - 15:00
    כותרת
    Special Guest
    מיקום
    בניין ע"ש מקס ולילאן קנדיוטי
    Auditorium
    מרצה
    Dr. Maik Dahlhoff
    Institute of Molecular Animal Breeding and Biotechnology, LMU Muenchen, Germany
    מארגן
    המחלקה לבקרה ביולוגית
    צרו קשר
    הרצאה
  • Date:15שניאוקטובר 2018

    Building your Personal Brand: LinkedIn insights

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    שעה
    15:00 - 16:00
    מיקום
    אולם ע"ש דולפי ולולה אבנר
    מרצה
    Tamir Huberman
    IDC Herzlia
    מארגן
    מדרשת פיינברג
    צרו קשר
    הרצאה
  • Date:16שלישיאוקטובר 2018

    Expeditious Synthesis of Bacterial Glycoconjugates

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    שעה
    11:00 - 12:00
    מיקום
    בניין הלן ומילטון קימלמן
    Dov Elad Room
    מרצה
    Prof. Suvarn S. Kulkarni
    Indian Institute of Technology Bombay
    מארגן
    המחלקה לכימיה אורגנית
    צרו קשר
    תקצירShow full text abstract about Expeditious Synthesis of Bacterial Glycoconjugates Suvarn ...»
    Expeditious Synthesis of Bacterial Glycoconjugates
    Suvarn S. Kulkarni
    Department of Chemistry, IIT Bombay, Powai, Mumbai-400076
    Bacterial glycoconjugates are comprised of rare D and L deoxy amino sugars, which are not present on the human cell surface. This peculiar structural difference allows discrimination between the pathogen and the host cell and offers avenues for target-specific drug discovery and carbohydrate-based vaccine development. However, they cannot be isolated with sufficient purity in acceptable amounts, and therefore chemical synthesis is a crucial step toward the development of these products.1 We recently established short and convenient methodologies for the synthesis of orthogonally protected bacterial D and L-deoxy amino hexopyranoside and glycosamine building blocks starting from cheaply available D-mannose and L-rhamnose.2-4 The one-pot protocols rely on highly regioselective nucleophilic displacements of triflates. These procedures have been applied to the synthesis of various bacterial glycoconjugates2-8 (Figure 1) as well as metabolic oligosaccharide engineering.7


    1) Emmadi, M.; Kulkarni, S. S. Nat. Prod. Rep. 2014, 31, 870-879. 2) Emmadi, M.; Kulkarni, S. S. Nature Protocols 2013, 8, 1870-1889. 3) Sanapala, S. R.; Kulkarni S. S. J. Am. Chem. Soc. 2016, 138, 4938−4947. 4) Sanapala, S. R.; Kulkarni S. S. Org. Lett. 2016, 18, 3790–3793. 5) Podilapu, A. R.; Kulkarni, S. S. Org. Lett. 2014, 16, 4336-4339. 6) Sanapala, S. R.; Kulkarni, S. S., Chem. Eur. J. 2014, 20, 3578-3583. 7) Clark, E.; I.; Emmadi, M.; Krupp, K. L.; Podilapu, A. R.; Helble, J. D.; Kulkarni, S. S.; Dube, D. H. ACS Chem Biol 2016, 11, 3365-3373. 8) Podilapu, A. R.; Kulkarni, S. S. Org. Lett. 2017, 19, 5466-5469.
    הרצאה
  • Date:16שלישיאוקטובר 2018

    “Beauty and Benefits of cryo-EM; Resolving the 3D structure of the Type VII secretion system in Mycobacterium tuberculosis”

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    שעה
    14:00 - 15:00
    מיקום
    בניין הלן ומילטון קימלמן
    Dov Elad Room
    מרצה
    Prof. Peter Peters
    Maastricht Multimodal Molecular Imaging institute (M4I).
    מארגן
    המחלקה לביולוגיה מבנית
    צרו קשר
    הרצאה
  • Date:17רביעיאוקטובר 2018

    G-INCPM-Special Seminar - Prof. Rony Seger, Department of Biological Regulation, Weizmann Institute - "Targeting the nuclear translocation of MAPKs as a novel anti-inflammatory and anti cancer therapy"

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    שעה
    11:00 - 12:15
    מיקום
    המרכז הישראלי הלאומי לרפואה מותאמת אישית על-שם ננסי וסטיבן גרנד
    Auditorium
    מארגן
    המחלקה למדעים ביומולקולריים
    צרו קשר
    תקצירShow full text abstract about A hallmark of MAPK signaling is their nuclear translocation ...»
    A hallmark of MAPK signaling is their nuclear translocation upon stimulation, which is necessary for their physiological/pathological functions. We have identified two novel, distinct, regulated nuclear translocation mechanisms for ERK1/2 and JNK/p38, of which we made use of as a promising therapeutic approach. We developed a myristoylated, NTS-derived phosphomimetic peptide (EPE peptide), which blocked ERK1/2 nuclear translocation. In culture, the EPE peptide induced apoptosis of melanoma cells, inhibited the proliferation of other cancer cells but had no effect on immortalized cells. Combination of the EPE peptide and the MEK inhibitor had synergistic antitumor activity in mutated NRAS, BRAF and NF1 melanoma and Kras pancreatic cells. In xenograft models, the peptide was significantly more effective than BRAF inhibitors in preventing tumor recurrence of treatment-eradicated melanoma xenografts. We also developed p38-derived myristoylated peptide, termed PERY peptide, which inhibited the importin interaction with JNK1/2 and p38α/β and prevented their nuclear translocation. This peptide affected viability of several breast cancer-derived cell lines, and significantly reduced inflammation and intestinal damage in a mouse model of colitis. Moreover, the peptide inhibited inflammation-induced colorectal cancer in a AOM/DSS mouse model. Taken together, both the cancer and inflammatory models support the use of nuclear translocation of MAPKs as a novel drug target for signaling-related diseases.
    הרצאה
  • Date:17רביעיאוקטובר 2018

    G-INCPM-Special Seminar - Prof. Rony Seger, Department of Biological Regulation, Weizmann Institute - "Targeting the nuclear translocation of MAPKs as a novel anti-inflammatory and anti cancer therapy"

    More information
    שעה
    11:00 - 12:15
    מיקום
    המרכז הישראלי הלאומי לרפואה מותאמת אישית על-שם ננסי וסטיבן גרנד
    Auditorium
    מארגן
    המחלקה למדעים ביומולקולריים
    צרו קשר
    תקצירShow full text abstract about A hallmark of MAPK signaling is their nuclear translocation ...»
    A hallmark of MAPK signaling is their nuclear translocation upon stimulation, which is necessary for their physiological/pathological functions. We have identified two novel, distinct, regulated nuclear translocation mechanisms for ERK1/2 and JNK/p38, of which we made use of as a promising therapeutic approach. We developed a myristoylated, NTS-derived phosphomimetic peptide (EPE peptide), which blocked ERK1/2 nuclear translocation. In culture, the EPE peptide induced apoptosis of melanoma cells, inhibited the proliferation of other cancer cells but had no effect on immortalized cells. Combination of the EPE peptide and the MEK inhibitor had synergistic antitumor activity in mutated NRAS, BRAF and NF1 melanoma and Kras pancreatic cells. In xenograft models, the peptide was significantly more effective than BRAF inhibitors in preventing tumor recurrence of treatment-eradicated melanoma xenografts. We also developed p38-derived myristoylated peptide, termed PERY peptide, which inhibited the importin interaction with JNK1/2 and p38α/β and prevented their nuclear translocation. This peptide affected viability of several breast cancer-derived cell lines, and significantly reduced inflammation and intestinal damage in a mouse model of colitis. Moreover, the peptide inhibited inflammation-induced colorectal cancer in a AOM/DSS mouse model. Taken together, both the cancer and inflammatory models support the use of nuclear translocation of MAPKs as a novel drug target for signaling-related diseases.
    הרצאה

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