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תוצאות חיפוש לאירועים

  • Date:22ראשוןמאי 202226חמישימאי 2022

    18th International p53 Workshop

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    שעה
    08:00 - 08:00
    מיקום
    אודיטוריום מיכאל סלע
    יושב ראש
    Varda Rotter
    דף בית
    צרו קשר
    כנסים
  • Date:22ראשוןמאי 2022

    Chemical and Biological Physics Guest Seminar

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    שעה
    11:00 - 12:00
    כותרת
    Electron Transfer and Spin Selectivity in Biomolecules
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצה
    Prof Dave Waldeck
    University of Pittsburgh
    מארגן
    המחלקה לפיסיקה כימית וביולוגית
    צרו קשר
    הרצאה
  • Date:22ראשוןמאי 2022

    Chemical and Biological Physics Guest Seminar

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    שעה
    11:00 - 12:00
    כותרת
    Electron Transfer and Spin Selectivity in Biomolecules
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצה
    Terry
    מארגן
    המחלקה לפיסיקה כימית וביולוגית
    צרו קשר
    הרצאה
  • Date:22ראשוןמאי 2022

    The cap-binding protein, 4EHP/eIF4E2 mediates miRNA suppression of mRNA translation.

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    שעה
    11:00 - 12:00
    מיקום
    בניין לביוכימיה על שם נלה וליאון בנוזיו
    Auditorium
    מרצה
    Prof. Nahum Sonenberg
    Gilman Cheney Professor McGill University, Department of Biochemistry Goodman Cancer Research Center Montreal, Quebec, Canada
    מארגן
    המחלקה למדעים ביומולקולריים
    צרו קשר
    תקצירShow full text abstract about The eIF4E Homolog Protein (4EHP, eIF4E2) is a mRNA cap-bindi...»
    The eIF4E Homolog Protein (4EHP, eIF4E2) is a mRNA cap-binding protein that in contrast to eIF4E cannot interact with eIF4G and acts as a translation repressor. The CCR4-NOT complex functions in miRNA-mediated mRNA silencing through its recruitment by the RISC (RNA-induced silencing complex). The CCR4-NOT complex recruits the helicase DDX6, which binds 4E-T (eIF4E-Transporter), which in turn binds 4EHP resulting in inhibition of cap-dependent translation (Proc. Natl. Acad. Sci. 2017). 4EHP suppresses IFN-production by promoting the miR-34a-induced translational silencing of Ifnb1 mRNA. (Mol. Cell, 2021). The SARS-CoV2 encoded Non-Structural Protein 2 (NSP2), directly interacts with the cellular GIGYF2 protein and enhances the binding of GIGYF2 to 4EHP and thereby enhances translational repression of Ifnb-1 mRNA. Depletion of 4EHP or GIGYF2 resulted in enhanced IFN-ß expression accompanied by a significant reduction of SARS-CoV-2 replication.

    הרצאה
  • Date:23שנימאי 2022

    Israel Physics Colloquium

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    כותרת
    Quantum gas in a box
    מיקום
    https://weizmann.zoom.us/j/94885314520?pwd=Q2pra0dyS284VENiUVVhWGVTTjJFQT09
    מרצה
    Prof.  Zoran Hadzibabic
    Cambridge University
    מארגן
    הפקולטה לפיסיקה
    צרו קשר
    פרטים נוספיםShow full text description of Meeting ID: 948 8531 4520 Password: 192379 ...»
    Meeting ID: 948 8531 4520
    Password: 192379
    תקצירShow full text abstract about For nearly three decades, ultracold atomic gases have been u...»
    For nearly three decades, ultracold atomic gases have been used with great success to study fundamental many-body phenomena such as Bose-Einstein condensation and superfluidity. While traditionally they were produced in harmonic electromagnetic traps and thus had inhomogeneous densities, it is now also possible to create homogeneous samples in the uniform potential of an optical box trap. Box trapping simplifies the interpretation of experimental results, provides more direct connections with theory and, in some cases, allows qualitatively new, hitherto impossible experiments. I will give an overview of our recent experiments with box-trapped three- and two-dimensional Bose gases, focusing on a series of related experiments on non-equilibrium phenomena, including phase-transition dynamics, turbulence, and equilibration of closed quantum systems
    סימפוזיונים
  • Date:23שנימאי 2022

    Covalent Binders: From Discovery to Function

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    שעה
    11:00 - 12:15
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצה
    Dr. Nir London
    Department of Chemical & Structural Biology, WIS
    מארגן
    הפקולטה לכימיה
    צרו קשר
    תקצירShow full text abstract about Small molecule inhibitors and drugs that are able to form a ...»
    Small molecule inhibitors and drugs that are able to form a covalent bond with
    their protein target have several advantages over traditional binders. While they were
    avoided for a long time due to concerns of specificity, in recent years they are attracting
    significant interest as underscored by FDA approvals of rationally designed covalent
    drugs, such as Ibrutinib and Afatinib. In the past few years my research team has been
    focused on technology development for the field of Covalent Ligand Discovery. These
    include: covalent virtual screening, empirical covalent fragment screening, the first
    reported reversible covalent targeted degraders (PROTACs), and most recently the
    discovery of new chemistry that enables the design of superior covalent binders. These
    technologies enabled the discovery of novel, potent inhibitors for several challenging
    targets. These inhibitors, in turn, have shed new light on the target’s biological function
    and represent potential therapeutic leads. I will describe our journey from the original goal
    of mere ‘discovery’ of covalent binders to the current challenge of functionalizing covalent
    binders for various applications.
    סימפוזיונים
  • Date:23שנימאי 2022

    Foundations of Computer Science Seminar

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    שעה
    11:15 - 12:45
    כותרת
    Proving as Fast as Computing: Succinct Arguments with Constant Prover Overhead
    מיקום
    בניין יעקב זיסקינד
    Room 155
    מרצה
    Ron Rothblum
    The Technion
    מארגן
    הפקולטה למתמטיקה ומדעי המחשב
    Seminar
    צרו קשר
    תקצירShow full text abstract about Succinct arguments are proof systems that allow a powerful, ...»
    Succinct arguments are proof systems that allow a powerful, but untrusted, prover to convince a weak verifier that an input x belongs to a language L in NP, with communication that is much shorter than the NP witness. Such arguments, which grew out of the theory literature, are now drawing immense interest also in practice, where a key bottleneck that has arisen is the high computational cost of proving correctness.

    In this work we address this problem by constructing succinct arguments for general computations, expressed as Boolean circuits (of bounded fan-in), with a strictly linear size prover. The soundness error of the protocol is an arbitrarily small constant. Prior to this work, succinct arguments were known with a quasi-linear size prover for general Boolean circuits or with linear-size only for arithmetic circuits, defined over large finite fields.

    Joint work Noga Ron-Zewi.
    הרצאה
  • Date:24שלישימאי 2022

    Mitochondrial behavior

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    שעה
    10:00 - 11:00
    מיקום
    בניין לביוכימיה על שם נלה וליאון בנוזיו
    Auditorium
    מרצה
    Prof. Jodi Nunnari
    Department of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis
    מארגן
    המחלקה למדעים ביומולקולריים
    צרו קשר
    תקצירShow full text abstract about Jodi Nunnari is a pioneer in the field of mitochondrial biol...»
    Jodi Nunnari is a pioneer in the field of mitochondrial biology. She was the first to describe the organelle as a dynamic network in homeostatic balance and decipher the mechanisms of the machines responsible for mitochondrial division and fusion, which are critical determinants of overall mitochondrial shape and distribution. Nunnari’s laboratory at UC Davis is using system-based approaches to address how mitochondrial behavior is physiologically regulated within cells to shed light onto how mitochondrial dysfunction contributes to human disease.
    הרצאה
  • Date:24שלישימאי 2022

    Real-time monitoring of replication fork progression in single live cells

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    שעה
    14:00 - 15:00
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצה
    Prof. Amir Aharoni
    Dept. of Life Sciences Ben-Gurion University
    מארגן
    המחלקה לביולוגיה מבנית וכימית
    צרו קשר
    הרצאה
  • Date:25רביעימאי 202226חמישימאי 2022

    THEORY AVANT GARDE, A Workshop in Honor of Moni Naor

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    מיקום
    אולם ע"ש דולפי ולולה אבנר
    מארגן
    הפקולטה למתמטיקה ומדעי המחשב
    דף בית
    צרו קשר
    פרטים נוספיםShow full text description of Organizing Committee: Cynthia Dwork, Harvard University Am...»
    Organizing Committee:
    Cynthia Dwork, Harvard University
    Amos Fiat, Tel Aviv University
    Seffi Naor, Technion
    Omer Reingold, Stanford University
    Guy Rothblum, Weizmann Insititute of Science
    Alon Rosen, Bocconi University

    Sponsors
    The Chorafas Institute for Scientific Exchange
    הרצאה
  • Date:25רביעימאי 2022

    Special guest semianr with Prof. Jin Billy Li

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    שעה
    13:15
    כותרת
    RNA Editing and Innate Immunity
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    Botnar Auditorium
    מרצה
    Jin Billy Li
    Department of Genetics, Standford University
    מארגן
    המחלקה לגנטיקה מולקולרית
    צרו קשר
    הרצאה
  • Date:26חמישימאי 2022

    New solid-state NMR methods for exciting and separating anisotropic interactions of spin I = 1 nuclei

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    שעה
    09:30 - 10:30
    מיקום
    בניין פרלמן למדעי הכימיה
    Shlomo Alexander Science Lounge
    מרצה
    Dr. Rihard Aleksis
    Department of Materials and Environmental Chemistry, Stockholm University
    מארגן
    מכון קלור לדימות וספקטרוסקופיה של תהונה מגנטית בעוצמות גבוהות
    צרו קשר
    תקצירShow full text abstract about Solid-state NMR has become an essential tool for structural ...»
    Solid-state NMR has become an essential tool for structural characterisation of materials,
    in particular systems with poor crystallinity and structural disorder. In recent years, a surge of
    interest has been observed for the study of paramagnetic systems, in which the interaction between
    nuclei and unpaired electrons allows to probe the electronic structure and properties of materials
    more directly. However, simultaneously this interaction leads to very broad resonances, which are
    dicult to acquire and interpret. While signi cant advancements in both NMR instrumentation
    and methodology have paved the way for the study of spin I = 1=2 nuclei in these systems, still
    many issues remain to be resolved for routine investigation of quadrupolar nuclei I > 1=2. Here we
    focus on improving both the excitation of the broad resonances and the resolution in the spectra
    of spin I = 1 nuclei. The latter problem is addressed by developing methods for separation of the
    shift and the quadrupolar interactions. We introduce two new methods under static conditions,
    which have the advantage over previous experiments of both suppressing spectral artefacts and
    exhibiting a broader excitation bandwidth. Furthermore, we demonstrate for the rst time an
    approach for separation of the anisotropic parts of the shift and quadrupolar interaction under
    magic-angle spinning. Secondly, to achieve broadband excitation we develop a new theoretical
    formalism for phase-modulated pulse sequences in rotating solids, which are applicable to nuclear
    spins with anisotropic interactions substantially larger than the spinning frequency, under conditions
    where the radio-frequency amplitude is smaller than or comparable to the spinning frequency. We
    apply the framework to the excitation of double-quantum spectra of 14N and design new pulse
    schemes with
    -encoded properties. Finally, we employ the new sequences together with density
    functional theory calculations to elucidate the electron and hydride ion conduction mechanisms in
    barium titanium oxyhydride.
    הרצאה
  • Date:26חמישימאי 2022

    BRD4 in Transcription Programming and Cancer Therapy

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    שעה
    10:30 - 11:30
    מיקום
    בניין לביוכימיה על שם נלה וליאון בנוזיו
    Cafeteria
    מרצה
    Prof. Cheng-Ming Chiang
    Simmons Comprehensive Cancer Center, Department of Biochemistry and Department of Pharmacology, University of Texas Southwestern Medical Center, UT Southwestern Medical Center U.S.A.
    מארגן
    המחלקה למדעים ביומולקולריים
    צרו קשר
    תקצירShow full text abstract about Bromodomain-containing protein 4 (BRD4) is an epigenetic reg...»
    Bromodomain-containing protein 4 (BRD4) is an epigenetic regulator and transcription cofactor whose phosphorylation by casein kinase II (CK2) and dephosphorylation by protein phosphatase 2A (PP2A) modulates its function in gene-specific targeting and recruitment of transcriptional regulators and chromatin modifiers. BRD4 has emerged as an important cancer therapeutic target due to widely available small compound inhibitors, such as JQ1 and I-BET, targeting the bromodomain and extra-terminal (BET) family members. Besides transcriptional regulation, BRD4 also plays crucial roles in regulating diverse cellular processes, including cell cycle progression, DNA damage response, chromatin structure maintenance, stem cell reprogramming, cell lineage differentiation, and viral latency and reactivation. While BET inhibitors and degraders show promising anticancer effects, issues related to drug resistance upon prolonged treatment remain a challenge in BET-targeted therapeutics development. Recently, we identified specific small compound inhibitors targeting phosphorylation-dependent BRD4 interaction with distinct transcription/replication components and DNA damage response (DDR) factors, including p53, c-Myc, AP-1, and cancer-associated human papillomavirus E2 proteins. Some of these compounds effectively block cancer cell growth and migration and specifically inhibit p53 interaction with BRD4. These new types of protein-protein interaction (PPI) inhibitors highlight molecular action distinct from the widely used BET bromodomain inhibitors.

    הרצאה
  • Date:26חמישימאי 2022

    “Modeling Photo and Bias Induced Electron transfer and transport. An ab-initio perspective on kinetics”

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    שעה
    11:00 - 12:00
    מיקום
    בניין פרלמן למדעי הכימיה
    Room 404
    מרצה
    Prof. Barry Dunietz
    Dept. Chemistry and Biochemistry, Kent State University, OH
    מארגן
    המחלקה לכימיה מולקולרית ולמדע חומרים
    צרו קשר
    תקצירShow full text abstract about Charge transfer and transport processes through molecular in...»
    Charge transfer and transport processes through molecular interfaces are ubiquitous and of a crucial role in determining functionality of biological systems and in enabling energy conversion applications. We study computationally such processes to understand structure-function relationships at the molecular level.

    We will discuss studies in the following two primary fields: (1) Photovoltaic and charge transfer properties of organic semiconductors materials. (2) Charge transport through voltage-biased molecular scale bridges. Importantly we establish predictive computational scheme that addresses key challenges. Our studies are employed in conjunction with experimental efforts to design materials and applications that control and tune relevant physical properties
    הרצאה
  • Date:26חמישימאי 2022

    Chaperoning protein aggregation diseases

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    שעה
    11:30 - 12:30
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    Botnar Auditorium
    מרצה
    Prof. Stefan Rudiger
    Bijvoet Center for Biomolecular Research Utrecht University
    מארגן
    המחלקה לביולוגיה מבנית וכימית
    צרו קשר
    הרצאה
  • Date:26חמישימאי 2022

    Vision and AI

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    שעה
    12:15 - 13:30
    כותרת
    Image Denoising - Not What You Think
    מיקום
    בניין יעקב זיסקינד
    Room 1
    מרצה
    Miki Elad
    Technion
    מארגן
    הפקולטה למתמטיקה ומדעי המחשב , המחלקה למדעי המחשב ומתמטיקה שימושית , המחלקה למתמטיקה
    צרו קשר
    פרטים נוספיםShow full text description of Image denoising - removal of white additive Gaussian noise f...»
    Image denoising - removal of white additive Gaussian noise from an image - is one of the oldest and most studied problems in image processing. An extensive work over several decades has led to thousands of papers on this subject, and to many well-performing algorithms for this task. As expected, the era of deep learning has brought yet another revolution to this subfield, and took the lead in today's ability for noise suppression in images. All this progress has led some researchers to believe that "denoising is dead", in the sense that all that can be achieved is already done.
    הרצאה
  • Date:26חמישימאי 2022

    Targeting metabolic vulnerabilities in cancer

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    שעה
    14:00 - 15:00
    מיקום
    בניין ע"ש מקס ולילאן קנדיוטי
    Auditorium
    מרצה
    Prof. Tomer Shlomi
    The faculties of Computer Science and Biology, Technion
    מארגן
    המכון לחקר הטיפול בסרטן עש דואק
    Cancer Research Club
    צרו קשר
    פרטים נוספיםShow full text description of Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6K...»
    Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    הרצאה
  • Date:29ראשוןמאי 2022

    The Summer STARS 2022 workshop

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    מארגן
    הפקולטה למתמטיקה ומדעי המחשב
    דף בית
    צרו קשר
    פרטים נוספיםShow full text description of Summer STARS Workshop 2022 May 29, June 1-2, 2022 WEBPAGE ...»
    Summer STARS Workshop 2022
    May 29, June 1-2, 2022
    WEBPAGE https://sites.google.com/view/summerstars2022/home
    הרצאה
  • Date:29ראשוןמאי 2022

    TBA

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    שעה
    11:00
    מיקום
    https://weizmann.zoom.us/j/7621438333?pwd=c0lpdlQzYSthellXWG9rZnM0ZDRFZz09
    מרצה
    Nadav Lensky
    Geological survey of Israel
    מארגן
    המחלקה למדעי כדור הארץ וכוכבי הלכת
    צרו קשר
    הרצאה
  • Date:29ראשוןמאי 2022

    Conservation outside protected areas: Designing multifunctional landscapes for the mutual benefit of people and biodiversity

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    שעה
    13:00 - 14:00
    כותרת
    SAERI ZOOM Lecture- Sustainability and Energy Research Initiative lecture series
    מיקום
    via Zoom
    מרצה
    Prof. Assaf Shwartz
    Faculty of Architecture and Town Planning Technion - Israel Institute of Technology
    מארגן
    מדרשת פיינברג
    Alternative Sustainable Energy Research Initiative (AERI)
    צרו קשר
    פרטים נוספיםShow full text description of Host: Prof. Ron Milo, SAERI Scientific Director The lect...»

    Host: Prof. Ron Milo, SAERI Scientific Director
    The lecture will take place via zoom:https://weizmann.zoom.us/j/91824811393?pwd=ZUF2ekNkd21RRWNMcmN0MzFtcUhhUT09
    Meeting ID: 918 2481 1393
    Password: 12345
    הרצאה

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