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Date:26שלישיינואר 2021הרצאה
SARS-CoV-2 suppresses IFNβ production, but not signaling, mediated by NSP1, 5, 6, 15, ORF6 and ORF7b
More information שעה 10:00 - 10:30מיקום בניין לביוכימיה על שם נלה וליאון בנוזיומרצה Dr. Maya Shemesh
Dept. of Biomolecular Sciences-WISמארגן המחלקה למדעים ביומולקולרייםצרו קשר תקציר Show full text abstract about Type I Interferons (IFN-Is) are anti-viral response cytokine...» Type I Interferons (IFN-Is) are anti-viral response cytokines, and are major candidate for treatment of SARS-CoV-2. In our study we investigated the mechanism in which SARS-CoV-2 evades early stage anti-viral response by inactivation of IFN-I production. To account for different possible cellular checkpoints in which the virus may ultimately block IFN production, we applied three cellular assays: promoter activity, IFN mRNA levels, and IFNβ secretion. SARS-CoV-2 genes NSP1, NSP5, NSP6, NSP15, ORF6 and ORF7b severely disrupted IFNβ production. Conversely, individual genes and live SARS-CoV-2 infected cells failed to block Interferon stimulated gene activation in response to added IFN-I, despite an inhibition of STAT1-phosphorylation mediated by NSP1. Our findings support a multi-gene process in which SARS-CoV-2 blocks IFN-production at early stages of infection, yet infected individuals can still benefit from the anti-viral effects of added IFN-Is. -
Date:26שלישיינואר 2021הרצאה
SARS-CoV-2 RBD in vitro evolution follows contagious mutation spread
More information שעה 10:30 - 11:00מיקום בניין לביוכימיה על שם נלה וליאון בנוזיומרצה Dr. Jiri Zahradnik
Dept. of Biomolecular Sciences-WISמארגן המחלקה למדעים ביומולקולרייםצרו קשר תקציר Show full text abstract about SARS-CoV-2 more contagious mutations are spreading rapidly. ...» SARS-CoV-2 more contagious mutations are spreading rapidly. In vitro affinity maturation of the receptor-binding domain (RBD) towards ACE2, resulted in more contagious mutations, S477N, E484K, and N501Y to be among the first selected, including the British and South African variants. Plotting the binding affinity against the incidence of different RBD mutations in the population supported correlation between the two. Further in vitro evolution provides guidelines towards potentially new evolving mutations with even higher infectivity.
For more details see Preprint: https://www.biorxiv.org/content/10.1101/2021.01.06.425392v2 -
Date:26שלישיינואר 2021הרצאה
Marine electrical imaging reveals novel freshwater transport mechanism in Hawaiʻi
More information שעה 11:00מיקום https://weizmann.zoom.us/j/7621438333?pwd=c0lpdlQzYSthellXWG9rZnM0ZDRFZz09מרצה Eric Attias
Hawaiʻi Institute of Geophysics and Planetology University of Hawaiʻiמארגן המחלקה למדעי כדור הארץ וכוכבי הלכתצרו קשר תקציר Show full text abstract about Conventional hydrogeologic models employed to compute ocean ...» Conventional hydrogeologic models employed to compute ocean island sustainable yields and aquifer storage neglect the nearshore and onshore submarine environment’s complexity. However, the onshore aquifer at the island of Hawaiʻi exhibits a significant volumetric discrepancy between high-elevation freshwater recharge and coastal discharge. This study presents a novel transport mechanism of freshwater moving from onshore to onshore via a multilayer formation of water-saturated layered basalts with interbedded low-permeability layers of ash/soil, as revealed by marine-controlled source electromagnetic (CSEM) imaging. We propose that this newly discovered transport mechanism of fresh water may be the governing mechanism in other volcanic islands. Additionally, our water column CSEM imaging detects multiple vertical freshwater plumes extending from the seafloor to the ocean surface. These findings provide valuable information to elucidate hydrogeologic and oceanographic rocesses affecting biogeochemical cycles in coastal waters worldwide. -
Date:26שלישיינואר 2021הרצאה
Viral impacts in the marine world: from single-cells to planktonic ecosystems
More information שעה 11:30 - 12:30כותרת Dept. Seminar via Zoomמיקום https://weizmann.zoom.us/j/92760289710?pwd=SEROejJMWUtBQU5PMGZ5Ri9Ud0hNZz09 Password: 740144מרצה Dr. Flora Vincent
Prof. Assaf Vardi's lab., Dept. of Plant and Environmental Sciencesמארגן המחלקה למדעי הצמח והסביבהצרו קשר פרטים נוספים Show full text description of Host: Prof. Assaf Vardi ...» Host: Prof. Assaf Vardi
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Date:26שלישיינואר 2021הרצאה
Layers of primary visual cortex as a window into internal models about predicted and simulated environments
More information שעה 12:30 - 13:30מרצה Prof. Lars Muckli
Visual and Cognitive Neurosciences, Director of fMRI at the Centre for Cognitive Neuroimaging, Glasgow, Scotlandמארגן המחלקה לנוירוביולוגיהצרו קשר פרטים נוספים Show full text description of Zoom link to join: https://weizmann.zoom.us/j/96608033618?p...» Zoom link to join:
https://weizmann.zoom.us/j/96608033618?pwd=SEdJUkR2ZzRBZ3laUUdGbWR1VFJTdz09
Meeting ID: 966 0803 3618
Password: 564068
Host: Dr. Rita Schmidt rita.schmidt@weizmann.ac.il tel: 9070
תקציר Show full text abstract about Normal brain function involves the interaction of internal p...» Normal brain function involves the interaction of internal processes with incoming sensory stimuli. We have created a series of brain imaging experiments (using 7T fMRI) that sample internal models and feedback mechanisms in early visual cortex. Primary visual cortex (V1) is the entry-stage for cortical processing of visual information. We can show that there are 3 information counter-streams concerned with: (1) retinotopic visual input, (2) top-down predictions of internal models generated by the brain, and (3) top-down imagery acting independently of the perception and prediction loop. Internal models amplify and disamplify incoming information, but there is also mental imagery not interfering with visual perception. Our results speak to the conceptual framework of predictive coding. Healthy brain function will strike a balance between the precision of prediction and prediction update based on prediction error. Our results incorporate state of the art, layer-specific ultra-high field fMRI and other imaging techniques. We argue that fMRI with its capability of measuring dendritic energy consumption is sensitive to activity in different parts of layer spanning neurons, enriching our computational understanding of counter stream brain mechanisms.
Zoom link to join:
https://weizmann.zoom.us/j/96608033618?pwd=SEdJUkR2ZzRBZ3laUUdGbWR1VFJTdz09
Meeting ID: 966 0803 3618
Password: 564068
Host: Dr. Rita Schmidt rita.schmidt@weizmann.ac.il tel: 9070
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Date:26שלישיינואר 2021הרצאה
Faculty Seminar
More information שעה 16:00 - 17:30כותרת Towards Reliable Data-Driven Computationsמרצה Yuval Moskovitch
University of Michiganמארגן הפקולטה למתמטיקה ומדעי המחשב
Faculty of Mathematical Sciences Seminarצרו קשר פרטים נוספים Show full text description of Data-driven methods are increasingly being used in domains s...» Data-driven methods are increasingly being used in domains such as fraud and risk detection, where data-driven algorithmic decision making may affect human life.
The growing impact of data and data-driven systems on society makes it important that people be able to trust analytical results obtained from data-driven computations.
This can be done in two complementary ways: by providing result explanations so that the user understands the computation and the basis for the observed results -
Date:27רביעיינואר 2021הרצאה
"The use of animals in drug development: challenges and opportunities"
More information שעה 11:00כותרת Zoom link: https://weizmann.zoom.us/j/99576968476?pwd=aVNtc0Q1N0ZYUk1rU3N2VlJhZ3IvQT09מרצה Dr. Moran Grossman
Nonclinical Safety Project Leader, Teva Pharmaceuticals.צרו קשר -
Date:27רביעיינואר 2021הרצאה
Machine Learning and Statistics Seminar
More information שעה 14:00 - 15:30כותרת Deep Learning on Structured and Geometric Dataמרצה Haggai Maron
NVIDIA Researchמארגן הפקולטה למתמטיקה ומדעי המחשב
Faculty of Mathematical Sciences Seminarצרו קשר פרטים נוספים Show full text description of Deep Learning of structured and geometric data, such as sets...» Deep Learning of structured and geometric data, such as sets, graphs, and surfaces, is a prominent research direction that has received considerable attention in the last few years. Given a learning task that involves structured data, the main challenge is identifying suitable neural network architectures and understanding their theoretical and practical tradeoffs.
This talk will focus on a popular learning setup where the learning task is invariant to a group of transformations of the input data. This setup is relevant to many popular learning tasks and data types. In the first part of the talk, I will present a general framework for designing neural network architectures based on layers that respect these transformations. In particular, I will show that these layers can be implemented using parameter-sharing schemes induced by the group. In the second part of the talk, I will demonstrate the framework’s applicability by presenting novel neural network architectures for two widely used data types: graphs and sets. I will also show that these architectures have desirable theoretical properties and that they perform well in practice.
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Date:27רביעיינואר 2021הרצאה
Superalgebra Theory and Representations Seminar
More information שעה 18:30 - 19:45כותרת Bigrassmannian permutations and Verma modulesמרצה Volodymyr Mazorchuk
Uppsala Universityמארגן הפקולטה למתמטיקה ומדעי המחשב
Faculty of Mathematical Sciences Seminarצרו קשר פרטים נוספים Show full text description of In this talk I will describe how bigrassmannian permutations...» In this talk I will describe how bigrassmannian permutations control the socle of the cokernel of
embeddings of Verma modules for sl_n. An application of this is a description of the socle of the cokernel of homomorphisms between Verma modules for the periplective Lie superalgebra. This is based on two joint works: one with Hankyung Ko and Rafael Mrden and another one with Chih-Whi Chen.
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Date:28חמישיינואר 2021הרצאה
“Low-field MRI: new perspectives”
More information שעה 09:30 - 10:30מרצה Prof. Najat Salamehמארגן המחלקה לחומרים ופני שטח
The Helen and Martin Kimmel Institute for Magnetic Resonanceצרו קשר תקציר Show full text abstract about Zoom: Link: https://weizmann.zoom.us/j/98957854014?pwd=ZTEya...» Zoom: Link: https://weizmann.zoom.us/j/98957854014?pwd=ZTEyazd6cThxUE90L3ZJbkdkbkFWQT09
passcode: 159170
Magnetic Resonance Imaging (MRI) is a non-ionizing, non-invasive imaging modality that has become key in modern medicine. Its high value resides in a broad range of soft tissue contrasts or biomarkers that can be tuned to enable the identification and follow-up of many pathophysiological or metabolic processes. Such developments were made possible thanks to almost forty years of hardware and software development, yet access to MRI nowadays remains exclusive, bound to radiology suites in hospitals, and restricted to less than half of the world population. This limited accessibility is mostly due to its one-fits-all design and its prerequisites for intense magnetic field strength that impact cost, siting infrastructure, and clinical compatibility. One way to improve accessibility in MRI is to lower the magnetic field strength that will naturally influence cost, siting, and compatibility. Further, lowering the field strength can translate in smaller footprint designs which geometry and contrast could purposely be tuned to certain targeted applications. Indeed, relaxation mechanisms are known to change with the surrounding magnetic field, with larger T1 dispersion at low field that have for the most part been unexplored.
Although very promising, many challenges arise linked to the lower intrinsic nuclear spin polarization inherent to low field technologies, calling for original and innovative approaches to reach clinical relevance. During this seminar, Prof. Najat Salameh will describe those challenges and possible solutions by presenting the current landscape of low field imaging and recent progress made at the Center for Adaptable MRI Technology, Basel University.
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Date:28חמישיינואר 2021הרצאה
Studying resistance in cancer
More information שעה 14:00 - 15:00מרצה Prof. Getz Gad
Broad Institute, MGH Cancer Centerמארגן המכון לחקר הטיפול בסרטן על-שם דואק
Cancer Research Clubצרו קשר פרטים נוספים Show full text description of https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2...» https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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Date:31ראשוןינואר 202104חמישיפברואר 2021כנסים
Induced topological states and phases in quantum matter
More information שעה 08:00 - 08:00מיקום מרכז כנסים על-שם דויד לופאטייושב ראש Haim Beidenkopfצרו קשר -
Date:31ראשוןינואר 2021הרצאה
Live imaging of chromatin distribution reveals novel principles of nuclear architecture and chromatin compartmentalization”.
More information שעה 11:00 - 12:00מרצה Prof. Talila Volk
Dept. Molecular Genetics, WISמארגן המחלקה לחומרים ופני שטח
Soft Matter and Biomaterialsצרו קשר תקציר Show full text abstract about Zoom Link: https://weizmann.zoom.us/j/91657907719?pwd=M2...» Zoom Link:
https://weizmann.zoom.us/j/91657907719?pwd=M2F2WlRKWGRuUHlxN0tNWFhZVUVzZz09
The genetic material of live organisms is packed and stored within the nucleus. It contains DNA wrapped around the nucleosomes, which then organized into chromatin fibers that partition into distinct compartments, which eventually fill the entire nucleus. Chromatin three dimensional topology is essential for proper accessibility of transcription factors, which control tissue-specific gene expression programs. Whereas chromatin partition into specific domains has been described in cells in culture conditions, information regarding chromatin 3 dimensional distribution in tissues within live organisms is still missing. We have imaged the chromatin in muscle fibers of live, intact Drosophila larvae, and revealed its 3 dimensional structure. Our results demonstrate novel 3 dimensional architecture of the chromatin which is evolutionary conserved, and has important implications on the regulation of gene expression. -
Date:31ראשוןינואר 2021הרצאה
Simulating Chemistry from Atoms to Devices: Next-Generation Reactive Molecular Dynamics
More information שעה 14:00 - 15:00מרצה Dr. David Furman
Dept. Chemistry, University of Cambridgeמארגן המחלקה לחומרים ופני שטחצרו קשר תקציר Show full text abstract about Zoom Link: https://weizmann.zoom.us/j/97142508810?pwd=S2...» Zoom Link:
https://weizmann.zoom.us/j/97142508810?pwd=S2Voc3BMYnh6RmFTYUxLbUFjQXRGZz09
Until recently, computational studies of chemical reactivity were exclusively dealt with using quantum mechanical approaches, which severely limited the system's size and accessible time scales for simulation.
To bypass the need to solve Schrodinger's equation, and facilitate large-scale simulations for up to millions of atoms, both accurate and efficient models of the chemical bond have to be constructed.
I will present recent advances in the field of modeling chemical reactions in large-scale, complex systems (i.e. "dirty chemistry"), with a particular focus on ReaxFF reactive molecular dynamics.
Prominent applications from recent years will be highlighted, including: (a) discovery of the underlying operation principles of a novel laser-based mass-spectrometry technique,
and (b) prediction of the surprising chemistry that leads to the formation of several key precursors to biomolecules of life upon the collapse of a "primordial bubble".
Finally, I will present a new ReaxFF formulation that opens exciting new avenues for orders of magnitude more accurate simulations for long time scales.
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Date:02שלישיפברואר 2021הרצאה
Adventures in the Critical Zone: from carbon fluxes to wildfires
More information שעה 10:00מיקום https://weizmann.zoom.us/j/7621438333?pwd=c0lpdlQzYSthellXWG9rZnM0ZDRFZz09מרצה Antonello Provenzale
מארגן המחלקה למדעי כדור הארץ וכוכבי הלכתצרו קשר תקציר Show full text abstract about The Hadley circulation is a key element of the climate syste...» The Hadley circulation is a key element of the climate system. It is traditionally defined as the zonally averaged meridional circulation in the tropics, therefore treated as a zonally symmetric phenomenon. However, differences in temperature between land and sea cause zonal asymmetries on Earth, dramatically affecting the circulation. This longitudinal dependence of the meridional circulation evokes questions about where and when the actual large scale tropical circulation occurs. Here, we look into the connection between the longitudinally dependent meridional circulation, and the actual large scale transport of air in the tropics using a coupled Eulerian and Lagrangian approach. Decomposing the velocity field into rotational and divergent components, we identify how each component affects the actual circulation. We propose an alternative definition for the circulation, that describes the actual path of air parcels in the tropics, as a tropical atmospheric conveyor belt. We further investigate this definition, analyzing the circulation under climate change and its effect on precipitation changes. We show that in order to predict future climate, the regionality and three-dimensionality of the large-scale tropical circulation must be taken into account. We find that the changes in the circulation vary significantly over longitude, and are overlooked when analyzing the zonally averaged meridional circulation. The circulation is strengthening and expanding in the center of the Pacific, a region where the circulation barely existed in past. On the other hand, the circulation is weakening in the Indo-Pacific region, where it was the most significant in the past. These differences appear as a shift in the region of ascent of the conveyor belt, that is revealed when analyzing the decomposed vertical wind. The pattern of weakening of the ascent in the Indo-Pacific and strengthening in the center of the Pacific explains the projected changes in precipitation. The Indo-Pacific region is drying, while the precipitation in the center of the Pacific is intensifying. -
Date:02שלישיפברואר 2021הרצאה
Dust as a nutrient source to the globally important cyanobacterium Trichodesmium
More information שעה 11:30 - 12:30כותרת Guest Seminar via zoomמיקום https://weizmann.zoom.us/j/95618583887?pwd=VDdCaWlLTkFjR1JYNmxmUVJoU0JtZz09 Password: 239905מרצה Prof. Yeala Shaked
Department of Earth Sciences, Hebrew University of Jerusalem & The Interuniversity Institute for Marine Sciences, Eilat.מארגן המחלקה למדעי הצמח והסביבהצרו קשר פרטים נוספים Show full text description of Host: Dr. Assaf Gal...» Host: Dr. Assaf Gal -
Date:04חמישיפברואר 2021הרצאה
Multiome and More: Next Generation Genomic Technologies in Weizmann Core Facilities
More information שעה 09:00 - 10:00מיקום ZOOMמרצה Dr. Hadas Keren-Shaul
Genomics Unitמארגן המחלקה לתשתיות מחקר מדעי החייםדף בית צרו קשר -
Date:04חמישיפברואר 2021הרצאה
Targeted protein degradation for the treatment of cancer
More information שעה 14:00 - 15:00מרצה Benjamin Ebert, MD, PhD
Chair for the Department of Medical Oncology at Dana-Farber Cancer Institute, Boston.מארגן המכון לחקר הטיפול בסרטן על-שם דואק
Cancer Research Clubצרו קשר פרטים נוספים Show full text description of https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2...» https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09
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Date:07ראשוןפברואר 202111חמישיפברואר 2021כנסים
Noncoding RNA in Embryonic Development and Cell Differentiation
More information שעה 08:00 - 08:00מיקום מרכז כנסים על-שם דויד לופאטייושב ראש Igor Ulitskyצרו קשר -
Date:07ראשוןפברואר 202111חמישיפברואר 2021כנסים
FRISNO 16
More information שעה 08:00 - 08:00מיקום Ein Gediיושב ראש Dan Oronדף בית צרו קשר