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  • Date:19חמישיאוקטובר 2017

    Photoelectrochemical sensors, neuromimetic devices and reservoir computers

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    שעה
    11:00 - 12:30
    מיקום
    בניין הלן ומילטון קימלמן
    Dov Elad Room
    מרצה
    Prof. Konrad Szaciłowski
    AGH University of Science and Technology, Kraków, Poland
    מארגן
    המחלקה לכימיה אורגנית
    צרו קשר
    הרצאה
  • Date:19חמישיאוקטובר 2017

    Physics Colloquium

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    שעה
    11:15 - 12:15
    מיקום
    בניין הפיסיקה ע"ש עדנה וק.ב. וייסמן
    Auditorium
    מרצה
    Prof. Ofer Feinerman
    WIS
    מארגן
    הפקולטה לפיסיקה
    צרו קשר
    פרטים נוספיםShow full text description of 11:00 Coffee, Tea and more ...»
    11:00 Coffee, Tea and more
    תקצירShow full text abstract about TBA ...»
    TBA
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  • Date:19חמישיאוקטובר 2017

    "Image Scanning Microscopy and Metal Induced Energy Transfer: Enhancing Microscopy Resolution in All Directions"

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    שעה
    14:00
    כותרת
    Special Seminar
    מיקום
    בניין הלן ומילטון קימלמן
    Dov Elad Room
    מרצה
    Prof. Jörg Enderlein
    III. Institute of Physics – Biophysics Department of Physics Georg August University Germany
    מארגן
    המחלקה לביולוגיה מבנית
    צרו קשר
    תקצירShow full text abstract about Classical fluorescence microscopy is limited in resolution b...»
    Classical fluorescence microscopy is limited in resolution by the wavelength of light (diffraction limit) restricting lateral resolution to ca. 200 nm, and axial resolution to ca. 500 nm (at typical excitation and emission wavelengths around 500 nm). However, recent years have seen a tremendous development in high- and super-resolution techniques of fluorescence microscopy, pushing spatial resolution to its diffraction-dictated limits and much beyond. One of these techniques is Image Scanning Microscopy (ISM). In ISM, the focus of a conventional laser-scanning confocal microscope (LCSM) is scanned over the sample, but instead of recording only the total fluorescence intensity for each scan position, as done in conventional operation of an LCSM, one records a small image of the illuminated region. The result is a four-dimensional stack of data: two dimensions refer to the lateral scan position, and two dimensions to the pixel position on the chip of the image-recording camera. This set of data can then be used to obtain a super-resolved image with doubled resolution, completely analogously to what is achieved with Structured Illumination Microscopy. However, ISM is conceptually and technically much simpler, suffers less from sample imperfections like refractive index variations, and can easily be implemented into any existing LSCM. I will also present recent results of combining ISM with two-photon excitation, which is important for deep-tissue imaging of e.g. neuronal tissue, and for performing non-linear coherent microscopy such as second-harmonic generation.

    A second method which I will present is concerned with achieving nanometer resolution along the optical axis. It is called Metal Induced Energy Transfer or MIET and is based on the fact that, when placing a fluorescent molecule close to a metal, its fluorescence properties change dramatically. In particular, one observes a strongly modified lifetime of its excited state (Purcell effect). This coupling between an excited emitter and a metal film is strongly dependent on the emitter’s distance from the metal. We have used this effect for mapping the basal membrane of live cells with an axial accuracy of ~3 nm. The method is easy to implement and does not require any change to a conventional fluorescence lifetime microscope; it can be applied to any biological system of interest, and is compatible with most other super-resolution microscopy techniques which enhance the lateral resolution of imaging. Moreover, it is even applicable to localizing individual molecules, thus offering the prospect of three-dimensional single-molecule localization microscopy with nanometer isotropic resolution for structural biology.
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  • Date:22ראשוןאוקטובר 2017

    "A stress-Induced Hidden Secret of the Genetic Code"

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    שעה
    10:00
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    Botnar Auditorium
    מרצה
    Prof. Hanna Engelberg-Kulka
    Hadassah Medical School, The Hebrew University
    מארגן
    המחלקה לגנטיקה מולקולרית
    הרצאה
  • Date:22ראשוןאוקטובר 2017

    Evolution and Engineering of Allosteric Regulation in Protein Kinases

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    שעה
    10:00 - 11:00
    מיקום
    בניין לביוכימיה על שם נלה וליאון בנוזיו
    Auditorium
    מרצה
    Dr. Orna Resnekov
    מארגן
    המחלקה למדעים ביומולקולריים
    צרו קשר
    תקצירShow full text abstract about Allosteric regulation - the control of protein function by s...»
    Allosteric regulation - the control of protein function by sites far from the active
    site, is a common feature that enables dynamic cellular responses. Reversible post-translational
    modifications (such as phosphorylation) appear to be well suited to mediate dynamic cellular responses - yet
    how new allosteric regulation evolves is not understood.
    We mutationally scanned the surface of a prototypical kinase to identify readily evolvable phosphorylation
    sites. Our data reveal spatially distributed "hotspots" on the surface of the protein that coevolve with the
    active site and preferentially modulate kinase activity. By engineering simple consensus phosphorylation
    sites at these hotspots, we successfully re-wired in vivo cell signaling.
    Our results demonstrate a general strategy for engineering new cell signaling pathways, suggest cryptic sites for developing
    small molecule allosteric kinase inhibitors and also provide a context for interpreting kinase mutations involved in disease.
    הרצאה
  • Date:22ראשוןאוקטובר 2017

    2017 Weizmann Memorial Lecture

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    שעה
    15:00 - 16:30
    מיקום
    מרכז כנסים על-שם דויד לופאטי
    Kimmel Auditorium
    מרצה
    Prof. Gero Miesenböck
    Optogenetics: Lighting Up the Brain
    צרו קשר
    אירועים אקדמיים
  • Date:23שניאוקטובר 2017

    IMM Guest Seminar: Prof. Smita Krishnaswamy, from Yale school of Medicine, will lecture on "Manifold-Learning Frameworks for Extracting Structure from High-throughput Single-Cell Datasets", Monday Oct 23rd, 2017

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    שעה
    10:00
    מיקום
    בניין וולפסון למחקר ביולוגי
    Auditorium
    מרצה
    Prof. Smita Krishnaswamy
    Assistant Professor of Genetics and of Computer Science, Yale school of Medicine
    מארגן
    המחלקה לאימונולוגיה
    צרו קשר
    תקצירShow full text abstract about Recent advances in single-cell technologies enable deep insi...»
    Recent advances in single-cell technologies enable deep insights into cellular development, gene regulation, and phenotypic diversity by measuring gene expression and epigenetics for thousands of single cells in a single experiment. While these technologies hold great potential for improving our understanding of cellular states and progression, they also pose new challenges in terms of scale, complexity, noise and measurement artifact which require advanced mathematical and algorithmic tools to extract underlying biological signals. In this talk, I cover one of most promising techniques to tackle these problems: manifold learning, and the related manifold assumption in data analysis. Manifold learning provides a powerful structure for algorithmic approaches to naturally process and the data, visualize the data and understand progressions as well as to find phenotypic diversity as well and infer patterns in it. I will cover two alternative approaches to manifold learning, diffusion-based and deep learning-based and show results in several projects including:1) MAGIC (Markov Affinity-based Graph Imputation of Cells): an algorithm for denoising and transcript recover of single cells applied to single-cell RNA sequencing data from the epithelial-to-mesenchymal transition in breast cancer, 2) PHATE (Potential of Heat-diffusion Affinity-based Transition Embedding): a visualization technique that offers an alternative to tSNE in that it emphasizes progressions and branching structures rather than cluster separations shown on several datasets including a newly generated embryoid body differentiation dataset, and 3) SAUCIE (Sparse AutoEncoders for Clustering Imputation and Embedding): a novel auto encoder architecture that performs denoising, batch normalization, clustering and visualization simultaneously for massive single-cell data sets from multi-patient cohorts shown on mass cytometry data from Dengue patients.
    הרצאה
  • Date:23שניאוקטובר 2017

    Life Science Colloquium

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    שעה
    11:00 - 12:00
    כותרת
    Organizational principles of nervous system specification
    מיקום
    אולם ע"ש דולפי ולולה אבנר
    מרצה
    Prof. Oliver Hobert
    Professor, Department of Biochemistry and Molecular Biophysics Investigator, Howard Hughes Medical Institute
    מארגן
    מדעי החיים
    צרו קשר
    סימפוזיונים
  • Date:23שניאוקטובר 2017

    2017 Weizmann Memorial Lecture

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    שעה
    15:00 - 16:30
    מיקום
    מרכז כנסים על-שם דויד לופאטי
    Kimmel Auditorium
    מרצה
    Prof. Gero Miesenböck
    Time to Decide
    אירועים אקדמיים
  • Date:24שלישיאוקטובר 2017

    HESTPV Solar ERAnet October 2017 meeting

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    שעה
    08:00 - 08:00
    מיקום
    אולם ע"ש מיכאל וחנה ויקס
    Jean Goldwurm 3D Visualization Theater
    יושב ראש
    David Cahen
    דף בית
    צרו קשר
    כנסים
  • Date:24שלישיאוקטובר 2017

    Sewing the Original “Smart Fabrics”: Catalysts of Extracellular Matrix Assembly

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    שעה
    10:00 - 11:00
    מיקום
    בניין לביוכימיה על שם נלה וליאון בנוזיו
    Auditorium
    מרצה
    Prof. Deborah Fass
    Dept. of Structural Biology
    מארגן
    המחלקה למדעים ביומולקולריים
    צרו קשר
    תקצירShow full text abstract about Abstract: Disulfide bonds are covalent cross-links that sta...»
    Abstract:
    Disulfide bonds are covalent cross-links that stabilize and regulate proteins. Disulfides are typically introduced into proteins as they fold in the endoplasmic reticulum (ER), and a great number of enzymes are present in the ER to help with this process. Despite the predominance of the ER as the site of disulfide cross-linking, an additional disulfide catalyst, called Quiescin Sulfhydryl Oxidase (QSOX), is found in the Golgi apparatus. We have investigated the function of QSOX in cultured cells and animals and have found that it participates in the formation of extracellular “smart fabrics” such as fibrous matrices and mucus. The structural and compositional complexity of these materials makes studying them on the biomolecular level a great challenge, but their enormous importance to cell and organismal biology inspire us to seek novel approaches.
    Bio:
    Deborah Fass received her scientific training at Harvard and MIT and came to Israel in 1998 to join the Department of Structural Biology. She has a background in molecular virology and protein folding. She became interested in disulfide bond formation by studying how virus envelope proteins manipulate endoplasmic reticulum chaperones to acquire “spring-loaded” conformations that prime them to penetrate new target cells. Over the past two decades, she has been continually surprised at how many interesting and unexpected biological processes are controlled by disulfide bond formation.
    הרצאה
  • Date:24שלישיאוקטובר 2017

    Identification of a unique cell cycle regulator in Streptococcus pneumoniae by en masse GFP localization, Tn-seq and CRISPRi phenotyping

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    שעה
    11:00 - 12:00
    מיקום
    בניין ע"ש מקס ולילאן קנדיוטי
    Seminar Room
    מרצה
    Prof. Jan-Willem Veening
    University of Lausanne
    מארגן
    המחלקה לבקרה ביולוגית
    צרו קשר
    הרצאה
  • Date:24שלישיאוקטובר 2017

    On discovery in (photo-) catalysis

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    שעה
    11:00 - 12:30
    מיקום
    בניין הלן ומילטון קימלמן
    Dov Elad Room
    מרצה
    Prof. Frank Glorius
    Organisch-Chemisches Institut der Westfälischen Wilhelms-Universität Münster, Germany
    מארגן
    המחלקה לכימיה אורגנית
    צרו קשר
    הרצאה
  • Date:24שלישיאוקטובר 2017

    Plant mitochondria group II introns splicing: A window into the evolution of the nuclear spliceosomal machineries

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    שעה
    11:30
    מיקום
    בניין לביוכימיה על שם נלה וליאון בנוזיו
    Auditorium
    מרצה
    Prof. Oren Ostersetzer-Biran
    Department of Plant and Environmental Sciences Alexander Silberman Institute of Life Sciences, Edmond Safra Campus The Hebrew University of Jerusalem Givat Ram, Jerusalem
    מארגן
    המחלקה למדעי הצמח והסביבה
    צרו קשר
    הרצאה
  • Date:25רביעיאוקטובר 2017

    Triple-stage mass spectrometry unravels the heterogeneity of endogenous protein complexes

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    שעה
    12:00 - 13:00
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצה
    Dr. Gili Ben-Nissan
    מארגן
    הפקולטה לביולוגיה
    צרו קשר
    הרצאה
  • Date:26חמישיאוקטובר 2017

    Physics Colloquium

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    שעה
    11:15 - 12:15
    מיקום
    בניין הפיסיקה ע"ש עדנה וק.ב. וייסמן
    Auditorium
    מרצה
    Prof. Jason Petta
    Princeton
    מארגן
    הפקולטה לפיסיקה
    צרו קשר
    פרטים נוספיםShow full text description of 11:00 Coffee, Tea and more ...»
    11:00 Coffee, Tea and more
    תקצירShow full text abstract about TBA ...»
    TBA
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  • Date:26חמישיאוקטובר 2017

    Pelletron meetings - by invitation only

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    שעה
    16:00 - 17:30
    צרו קשר
    הרצאה
  • Date:29ראשוןאוקטובר 2017

    Pre-SAAC Symposium

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    שעה
    08:30 - 13:30
    מיקום
    מרכז כנסים על-שם דויד לופאטי
    מארגן
    מדעי החיים
    הרצאה
  • Date:29ראשוןאוקטובר 2017

    Magnetic Resonance Seminar

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    שעה
    16:00
    כותרת
    Diffusion of Intracellular Metabolites: a Compartment Specific Probe for Microstructure and ‎Physiology
    מיקום
    בניין פרלמן למדעי הכימיה
    Shlomo Alexander Science Lounge
    מרצה
    Prof. Itamar Ronen
    Leiden University Medical Center
    מארגן
    המחלקה לפיסיקה כימית וביולוגית
    צרו קשר
    תקצירShow full text abstract about Intracellular metabolites that give rise to quantifiable MR ...»
    Intracellular metabolites that give rise to quantifiable MR resonances are excellent structural probes for the intracellular space, and are oftentimes specific, or preferential enough to a certain cell type to provide information that is also cell-type specific. In the brain, N-acetylaspartate (NAA) and glutamate (Glu) are predominantly neuronal/axonal in nature, whereas soluble choline compounds (tCho), myo-inositol (mI) and glutamine (Gln) are predominantly glial. The diffusion properties of these metabolites, examined by diffusion weighted MR spectroscopy (DWS) exclusively reflect properties of the intracellular milieu, thus reflecting properties such as cytosolic viscosity, macromolecular crowding, tortuosity of the intracellular space, the integrity of the cytoskeleton and other intracellular structures, and in some cases – intracellular sub-compartmentation and exchange.

    The presentation will introduce the basic methodological concepts of DWS and the particular challenges of acquiring robust DWS for accurate estimation of metabolite diffusion properties. Subsequently, the unique ability of DWS to characterize cell-type specific structural and physiological features will be demonstrated, followed by several applications of DWS to discern cell-type specific intracellular damage in disease, especially in multiple sclerosis (MS) and in neuropsychiatric systemic lupus erythematosus (NPSLE). Also discussed are the advantages and the challenges of performing DWS at ultrahigh field will follow, and the possibilities of combining DTI/DWI and DWS in a combined analysis framework aimed at better characterizing tissue microstructural properties in health and disease. The presentation will conclude with examples of the potential of DWS to monitor and quantify cellular energy metabolism, where enzymatic processes may affect the diffusion properties of metabolites involved in metabolism.
    הרצאה
  • Date:30שניאוקטובר 201702חמישינובמבר 2017

    International Board SAAC Review

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