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  • Date:08ראשוןדצמבר 201913שישידצמבר 2019

    XVIth International Symposium on Cholnergic Mechanisms

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    שעה
    08:00 - 08:00
    מיקום
    מרכז כנסים על-שם דויד לופאטי
    Kimmel Auditorium
    יושב ראש
    Israel Silman
    כנסים
  • Date:08ראשוןדצמבר 2019

    Representation, inference and design of multicellular systems

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    שעה
    13:15
    מיקום
    בניין הפיסיקה ע"ש עדנה וק.ב. וייסמן
    Drory Auditorium
    מרצה
    Harvard University
    מארגן
    מרכז לפיסיקה ביולוגית עש קלור
    צרו קשר
    תקצירShow full text abstract about The past decade has witnessed the emergence of single-cell t...»
    The past decade has witnessed the emergence of single-cell technologies that measure the expression level of genes at a single-cell resolution. These developments have revolutionized our understanding of the rich heterogeneity, structure, and dynamics of cellular populations, by probing the states of millions of cells, and their change under different conditions or over time. However, in standard experiments, information about the spatial context of cells, along with additional layers of information they encode about their location along dynamic processes (e.g. cell cycle or differentiation trajectories), is either lost or not explicitly accessible. This poses a fundamental problem for elucidating collective tissue function and mechanisms of cell-to-cell communication.
    In this talk I will present computational approaches for addressing these challenges, by learning interpretable representations of structure, context and design principles for multicellular systems from single-cell information. I will first describe how the locations of cells in their tissue of origin and the resulting spatial gene expression can be probabilistically inferred from single-cell information by a generalized optimal-transport optimization framework that can flexibly incorporate prior biological assumptions or knowledge derived from experiments. Inference in this case is based on an organization principle for spatial gene expression, namely a structural correspondence between distances of cells in expression and physical space, which we hypothesized and supported for different tissues. We used this framework to spatially reconstruct diverse tissues and organisms, including the fly embryo, mammalian intestinal epithelium and cerebellum, and further inferred spatially informative genes. Since cells encode multiple layers of information, in addition to their spatial context, I will also discuss several approaches for the disentanglement of single-cell gene expression into distinct biological processes, based on ideas rooted in random matrix theory and manifold learning. I will finally discuss how these results can be generalized to reveal principles underlying self-organization of cells into multicellular structures, setting the foundation for the computationally-directed design of cell-to-cell interactions optimized for specific tissue structure or function.
    Sunday, December 8, 2019 at 13:00
    Sandwiches at 12:45
    Drory Auditorium
    הרצאה
  • Date:08ראשוןדצמבר 2019

    A new anti-cancer treatment: Insulin regulation of the cytoskeleton

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    שעה
    15:00 - 16:00
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    Botnar Auditorium
    מרצה
    Yael Kuperman
    מארגן
    מדעי החיים
    Metabollic Research Forum
    צרו קשר
    הרצאה
  • Date:08ראשוןדצמבר 2019

    Seminar for thesis Defense - Zohar Erez

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    שעה
    15:30
    כותרת
    “Characterization of a novel molecular phage communication system”
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    מרצה
    Zohar Erez
    מארגן
    המחלקה לגנטיקה מולקולרית
    צרו קשר
    הרצאה
  • Date:09שנידצמבר 2019

    The temporal structure of the code of large neural populations

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    שעה
    10:30
    מיקום
    בניין לחקר המוח על-שם נלה וליאון בנוזיו
    מרצה
    Ehud Karpas (PhD Thesis Defense)
    Elad Schneidman Lab, Dept of Neurobiology, WIS
    מארגן
    המחלקה לנוירוביולוגיה
    צרו קשר
    פרטים נוספיםShow full text description of Students & Postdocs Seminar Benoziyo Brain Research ...»
    Students & Postdocs Seminar

    Benoziyo Brain Research Building Room 113

    For assistance with accessibility issues, please contact naomi.moses@weizmann.ac.il

    תקצירShow full text abstract about Studying the neural code deals with trying to understand how...»
    Studying the neural code deals with trying to understand how information is stored and processed in the brain, searching for basic principles of this "language". The study of population codes aims to understand how neural populations collectively encode information, and to map interactions between neurons. Previous studies explored the firing rates of single cells and how they evolve with time. Other studies have shown that neural populations are correlated and explored spatial activity patterns of large groups. In this work we combine these approaches, and study population activity of large groups of neurons, and how they evolve with time.

    We studied the fine temporal structure of spiking patterns of groups of up to 100 simultaneously recorded units in the prefrontal cortex of monkeys performing a visual discrimination task. We characterized the population activity using 10 ms time bins and found that population activity patterns (codebooks) were strongly shaped by spatial correlations. Further, using a novel extension of models which describe spatio-temporal population activity patterns, we show that temporal sequences of population activity patterns have strong history-dependence. Together, the large impact of spatial and temporal correlations makes the observed sequences of activity patterns many orders of magnitude more likely to appear than predicted by models that ignore these correlations and rely only on the population rates.

    Surprisingly, despite these strong correlations, decoding behavior using models that were trained ignoring these correlations perform as well as decoders that were trained to capture these correlations. The difference in the role of correlations in population encoding and decoding suggests that one of the goals of the complex encoding scheme in the prefrontal cortex may be to create a code that can be read by simple downstream decoders that do not have to learn correlations.
    הרצאה
  • Date:09שנידצמבר 2019

    Principles of Protein Assembly in Cells

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    שעה
    11:00 - 12:15
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצה
    Dr. Emmanuel Levy
    Dept. of Structural Biology, WIS
    מארגן
    הפקולטה לכימיה
    צרו קשר
    סימפוזיונים
  • Date:09שנידצמבר 2019

    Foundations of Computer Science Colloquium

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    שעה
    11:15 - 13:00
    כותרת
    Clustering: How hard is it to classify data?
    מיקום
    בניין יעקב זיסקינד
    Room 155
    מרצה
    Karthik C.S
    Tel Aviv University
    מארגן
    הפקולטה למתמטיקה ומדעי המחשב
    Special Seminar, המחלקה למדעי המחשב ומתמטיקה שימושית
    Special Seminar, המחלקה למתמטיקה
    Special Seminar
    צרו קשר
    פרטים נוספיםShow full text description of Two popular objectives optimized in clustering algorithms ar...»
    Two popular objectives optimized in clustering algorithms are k-means and k-median. The k-means (resp. k-median) problem in the L_p-metric is specified by n points as input and the goal is to classify the input point-set into k clusters such that the k-means (resp. k-median) objective is minimized. The best-known inapproximability factor in literature for these NP-hard problems in L_p-metrics were well-below 1.01. In this talk, we take a significant step to improve the hardness of approximating these problems in various L_p-metrics.

    The talk is based on two joint works, one with Vincent Cohen-Addad and the other with Vincent Cohen-Addad and Euiwoong Lee.
    הרצאה
  • Date:09שנידצמבר 2019

    Trapped on the ribosome: exploring the chemical biology of translational control

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    שעה
    14:00 - 15:00
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצה
    Prof. Jack Taunton
    Dept. of Cellular and Molecular Pharmacology, University of California, San-Francisco
    מארגן
    המחלקה לביולוגיה מבנית
    צרו קשר
    הרצאה
  • Date:09שנידצמבר 2019

    A quantitative footprint of irreversibility in the absence of observable currents

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    שעה
    14:15
    מיקום
    בניין הפיסיקה ע"ש עדנה וק.ב. וייסמן
    Room A
    מרצה
    Gili Bisker
    TAU
    מארגן
    המחלקה לפיסיקה של מערכות מורכבות
    Statistical Physics Seminar
    צרו קשר
    תקצירShow full text abstract about Time irreversibility is the hallmark of nonequilibrium dissi...»
    Time irreversibility is the hallmark of nonequilibrium dissipative processes. Detecting dissipation is essential for our basic understanding of the underlying physical mechanism, however, it remains a challenge in the absence of observable directed motion, flows, or fluxes. Additional difficulty arises in complex systems where many internal degrees of freedom are inaccessible to an external observer. In living systems, for example, the dissipation is directly related to the hydrolysis of fuel molecules such as adenosine triphosphate (ATP), whose consumption rate is difficult to directly measure in many experimental setups. In this talk, I will introduce a novel approach to detect time irreversibility and estimate the entropy production from time-series measurements, even in the absence of observable currents. This method can be implemented in scenarios where only partial information is available and thus provides a new tool for studying nonequilibrium phenomena.


    1. G. Bisker et al. Inferring broken detailed balance in the absence of observable currents,
    Nature Communications, 10(1), 1-10 (2019)
    2. G. Bisker et al. Hierarchical Bounds on Entropy Production Inferred from Partial
    Information, Journal of Statistical Mechanics: Theory and Experiment (9), 093210 (2017)
    הרצאה
  • Date:10שלישידצמבר 2019

    Molecular errors and evolvability

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    שעה
    11:00 - 12:00
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצה
    Prof. Joanna Masel
    Ecology and Evolutionary Biology, The University of Arizona, USA
    מארגן
    המחלקה לביולוגיה מבנית
    צרו קשר
    הרצאה
  • Date:10שלישידצמבר 2019

    Special Guest Seminar: Prof. Yair Reisner will lecture on "Hematopoietic and lung stem cell transplantation across major genetic barriers."

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    שעה
    11:00 - 12:00
    מיקום
    בניין וולפסון למחקר ביולוגי
    Auditorium
    מרצה
    Prof. Yair Reisner
    Head, Stem Cell Research; Dep. Stem Cell Transplantation & Cellular Therapy; MD Anderson Cancer Center; Houston, Texas.
    מארגן
    המחלקה לאימונולוגיה
    צרו קשר
    הרצאה
  • Date:10שלישידצמבר 2019

    Transposable elements as drivers of structural and functional variations in wheat genome

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    שעה
    11:30 - 12:30
    מיקום
    בניין לביוכימיה על שם נלה וליאון בנוזיו
    Auditorium
    מרצה
    Prof. Khalil Kashkush
    Dept. of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev
    מארגן
    המחלקה למדעי הצמח והסביבה
    דף בית
    צרו קשר
    פרטים נוספיםShow full text description of Hosts: Dr. Cathy Bessudo and Dr. Hadas Zehavi...»
    Hosts: Dr. Cathy Bessudo and Dr. Hadas Zehavi
    הרצאה
  • Date:10שלישידצמבר 2019

    Tracking proteins' conformations inside cells with Gd(III) spin labels

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    שעה
    14:00 - 15:00
    מיקום
    בניין הלן ומילטון קימלמן
    Dov Elad Room
    מרצה
    Prof. Daniella Goldfarb
    Department of Chemical and Biological Physics, WIS
    מארגן
    המחלקה לביולוגיה מבנית
    צרו קשר
    הרצאה
  • Date:11רביעידצמבר 2019

    Developmental Club Series 2019-20

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    שעה
    10:00
    כותרת
    Uncovering the basis of axonal guidance receptor multifunctionality
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    Botnar Auditorium
    מרצה
    Prof. Avraham Yaron
    מארגן
    המחלקה לגנטיקה מולקולרית
    Developmental Club
    צרו קשר
    הרצאה
  • Date:12חמישידצמבר 2019

    In vivo multimodality imaging of immune-vascular interactions in cardiovascular disease

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    שעה
    10:00 - 11:00
    מיקום
    בניין פרלמן למדעי הכימיה
    Room 404
    מרצה
    Prof. Katrien Vandoorne
    Eindhoven University of Technology (The Netherlands), Department of Biomedical Engineering, Soft Tissue Engineering
    מארגן
    המחלקה לחומרים ופני שטח
    The Helen and Martin Kimmel Institute for Magnetic Resonance
    צרו קשר
    תקצירShow full text abstract about Cardiovascular disease is a result of genetic and environmen...»
    Cardiovascular disease is a result of genetic and environmental risk factors that together generate arterial and cardiac pathologies. Blood vessels connect multiple organ systems throughout the entire body allowing organs to interact via circulating messengers. Multimodality imaging achieves integration of these interfacing systems’ distinct processes, quantifying interactions that contribute to cardiovascular disease. Noninvasive multimodality imaging techniques are emerging tools that can further our understanding of this complex and dynamic interplay. Multichannel multimodality imaging including optics, CT, PET and MRI, are particularly promising because they can simultaneously sample multiple biomarkers. As the opportunities provided by imaging expand, mapping interconnected systems will help us decipher the complexity of cardiovascular disease and monitor novel therapeutic strategies.
    הרצאה
  • Date:12חמישידצמבר 2019

    Geometric Functional Analysis and Probability Seminar

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    שעה
    13:30 - 15:30
    כותרת
    Existence of persistence exponent for Gaussian stationary functions
    מיקום
    בניין יעקב זיסקינד
    Room 155
    מרצה
    Naomi Feldheim
    BIU
    מארגן
    הפקולטה למתמטיקה ומדעי המחשב
    Faculty of Mathematical Sciences Seminar, המחלקה למדעי המחשב ומתמטיקה שימושית
    Faculty of Mathematical Sciences Seminar, המחלקה למתמטיקה
    Faculty of Mathematical Sciences Seminar
    צרו קשר
    פרטים נוספיםShow full text description of Let Z(t) be a Gaussian stationary function on the real line,...»
    Let Z(t) be a Gaussian stationary function on the real line, and fix a level L
    הרצאה
  • Date:12חמישידצמבר 2019

    TAM Tyrosine Kinase Receptor Signaling in Cancer: Unexpected Roles in the Tumor microenvironment

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    שעה
    14:00 - 15:00
    מיקום
    בניין ע"ש מקס ולילאן קנדיוטי
    Auditorium
    מרצה
    Prof. Tal Burstyn-Cohen
    מארגן
    המחלקה לבקרה ביולוגית
    צרו קשר
    הרצאה
  • Date:15ראשוןדצמבר 201917שלישידצמבר 2019

    1st Israeli ISAC Flow Cytometry workshop

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    שעה
    כל היום
    מארגן
    המחלקה לתשתיות מחקר מדעי החיים
    צרו קשר
    פרטים נוספיםShow full text description of Weizmann Institute of Science, together with the Israeli Fl...»
    Weizmann Institute of Science, together with the Israeli
    Flow Cytometry Society and the ISAC Live Education
    Task Force, will host the 1st hands-on workshop for
    advanced applications in flow cytometry in Israel
    הרצאה
  • Date:15ראשוןדצמבר 201919חמישידצמבר 2019

    Selected Problems in Z-Pinch Physics

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    שעה
    08:00 - 08:00
    מיקום
    בניין הפיסיקה ע"ש עדנה וק.ב. וייסמן
    Drory Auditorium
    יושב ראש
    Tal Queller
    צרו קשר
    כנסים
  • Date:15ראשוןדצמבר 2019

    Evaporation from the ocean: A new Lagrangian model and its application to observations

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    שעה
    11:00
    מיקום
    בניין משפחת זוסמן
    M. Magaritz Seminar Room
    מרצה
    Natan Paldor
    The Hebrew University of Jerusalem
    מארגן
    המחלקה למדעי כדור הארץ וכוכבי הלכת
    צרו קשר
    הרצאה

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