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תוצאות חיפוש לאירועים

  • Date:09חמישיפברואר 2023

    Vision and AI

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    שעה
    12:15 - 13:15
    כותרת
    The implicit bias of SGD: A Minima stability analysis
    מיקום
    בניין יעקב זיסקינד
    Room 1
    מרצה
    Tomer Michaeli
    Technion
    מארגן
    המחלקה למדעי המחשב ומתמטיקה שימושית
    Seminar
    צרו קשר
    תקצירShow full text abstract about One of the puzzling phenomena in deep learning, is that neur...»
    One of the puzzling phenomena in deep learning, is that neural networks tend to generalize well even when they are highly overparameterized. Recent works linked this behavior with implicit biases of the algorithms used to train networks (like SGD). Here we analyze the implicit bias of SGD from the standpoint of minima stability, focusing on shallow ReLU networks trained with a quadratic loss. Specifically, it is known that SGD can stably converge only to minima that are flat enough w.r.t. its step size. Here we show that this property enforces the predictor function to become smoother as the step size increases, thus significantly regularizing the solution. Furthermore, we analyze the representation power of stable solutions. Particularly, we prove a depth-separation result: There exist functions that cannot be approximated by depth-2 networks corresponding to stable minima, no matter how small the step size is taken to be, but which can be implemented with depth-3 networks corresponding to stable minima. We show how our theoretical findings explain behaviors observed in practical settings.
    (Joint works with Rotem Mulayoff, Mor Shpigel Nacson, Greg Ongie, Daniel Soudry).
    הרצאה
  • Date:09חמישיפברואר 2023

    Machine Learning and Statistics Seminar

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    שעה
    12:15 - 13:15
    כותרת
    The implicit bias of SGD: A Minima stability analysis
    מיקום
    בניין יעקב זיסקינד
    Room 1
    מרצה
    Tomer Michaeli
    Technion
    מארגן
    המחלקה למדעי המחשב ומתמטיקה שימושית
    Seminar
    צרו קשר
    תקצירShow full text abstract about One of the puzzling phenomena in deep learning, is that neur...»
    One of the puzzling phenomena in deep learning, is that neural networks tend to generalize well even when they are highly overparameterized. Recent works linked this behavior with implicit biases of the algorithms used to train networks (like SGD). Here we analyze the implicit bias of SGD from the standpoint of minima stability, focusing on shallow ReLU networks trained with a quadratic loss. Specifically, it is known that SGD can stably converge only to minima that are flat enough w.r.t. its step size. Here we show that this property enforces the predictor function to become smoother as the step size increases, thus significantly regularizing the solution. Furthermore, we analyze the representation power of stable solutions. Particularly, we prove a depth-separation result: There exist functions that cannot be approximated by depth-2 networks corresponding to stable minima, no matter how small the step size is taken to be, but which can be implemented with depth-3 networks corresponding to stable minima. We show how our theoretical findings explain behaviors observed in practical settings.
    (Joint works with Rotem Mulayoff, Mor Shpigel Nacson, Greg Ongie, Daniel Soudry).
    הרצאה
  • Date:09חמישיפברואר 2023

    Genetic and Epigenetic Drivers of Melanoma Formation and Progression

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    שעה
    14:00 - 15:00
    מיקום
    בניין ע"ש מקס ולילאן קנדיוטי
    Auditorium
    מרצה
    Marcus Bosenberg, MD, PhD
    Anthony N. Brady Professor of Dermatology, Pathology, and Immunobiology Director, Yale Center for Immuno-Oncology Director, Yale SPORE in Skin Cancer Director, Center for Precision Cancer Modeling Co-Leader, Cancer Immunology Program Yale University
    מארגן
    המכון לחקר הטיפול בסרטן עש דואק
    Cancer Research Club
    צרו קשר
    פרטים נוספיםShow full text description of Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6K...»
    Meeting URL: https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09


    הרצאה
  • Date:12ראשוןפברואר 2023

    Understanding nutritional impact on bone development and quality

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    שעה
    15:00 - 16:00
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    Botnar Auditorium
    מרצה
    Prof. Efrat Monsonego Ornan
    Institute of Biochemistry and Nutrition The Faculty of Agriculture, Food and Environment The Hebrew University of Jerusalem
    מארגן
    מדעי החיים
    Metabollic Research Forum
    צרו קשר
    הרצאה
  • Date:13שניפברואר 202315רביעיפברואר 2023

    New approaches to early embryogenesis & epigenetics

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    שעה
    08:00 - 08:00
    מיקום
    מרכז כנסים על-שם דויד לופאטי
    יושב ראש
    Yonatan Stelzer
    מארגן
    מרכז עש אהרון קציר , מכון הלן ומרטין קימל לחקר תאי הגזע
    דף בית
    צרו קשר
    כנסים
  • Date:13שניפברואר 2023

    TBD

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    שעה
    11:00 - 12:15
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצה
    Prof. Jacob Sagiv
    Molecular Chemistry and Materials Science Department
    מארגן
    הפקולטה לכימיה
    דף בית
    צרו קשר
    סימפוזיונים
  • Date:14שלישיפברואר 2023

    Photoinduced regioselective functionalization of arenes at proximal and distal sites

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    שעה
    11:00 - 12:00
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצה
    Prof. Debabrata Maiti
    Department of Chemistry & IDP in Climate Studies, IIT Bombay
    מארגן
    המחלקה לכימיה מולקולרית ולמדע חומרים
    צרו קשר
    תקצירShow full text abstract about Over years’ transition metal-catalyzed C-H activation has pr...»
    Over years’ transition metal-catalyzed C-H activation has propelled the field of organic synthesis for the construction of structurally complex and diverse molecules in resource-economical fashion. In this context, non-directed C-H activation has gained unprecedented attention for attaining region-specific C-H functionalizations in a step-economic mode. Unlike traditional Fujiwara-Moritani reaction, this approach relies on ligand assistance and thus uses arene as the limiting reagent. However, all existing non-directed C-H functionalizations utilize high thermal energy to induce the functional group which eventually put the regioselectivity at stake. In addition, use of super stoichiometric costly silver salts to regenerate the catalyst produces unwanted metal waste. In aid of developing a more sustainable and environmentally benign approach, we have established a photoredox catalytic system by a merger of palladium/organo-photocatalyst(PC) which forges highly regeiospecific C-H olefination of diverse arenes and heteroarenes. Visible light nullifies the requirement of silver salts and thermal energy in executing “region-resolved” Fujiwara-Moritani reaction.
    הרצאה
  • Date:15רביעיפברואר 2023

    Special Guest Seminar

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    שעה
    11:00 - 12:00
    מיקום
    בניין ע"ש מקס ולילאן קנדיוטי
    Auditorium
    מרצה
    Dr. Tomer Itkin
    Transcriptional Regulation of Hemato-Vascular Cell Fate Plasticity
    מארגן
    המחלקה לאימונולוגיה ורגנרציה ביולוגית
    צרו קשר
    הרצאה
  • Date:16חמישיפברואר 2023

    Molecular MRI of brain function

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    שעה
    09:30 - 10:30
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצה
    Prof. Alan Jasanoff
    McGovern Institute for Brain Research at MIT
    מארגן
    המכון לתהודה מגנטית עש הלן ומרטין קימל
    צרו קשר
    תקצירShow full text abstract about Understanding the neural bases of behavior and cognition req...»
    Understanding the neural bases of behavior and cognition requires determining how mechanistically distinct processing elements combine to carry out brain function at an integrated level. In this talk, I will introduce some of our laboratory’s efforts to address this goal using a combination of molecular sensors with noninvasive wide-field imaging. In the first part of the talk, I will discuss how workhorse optical neuroimaging approaches have inspired the design of molecular MRI probes for sensing physiological variables. Some of these probes detect light, providing a means for deep-tissue MRI-assisted optical imaging. I will next introduce an alternative molecular imaging concept inspired by widely used hemodynamic functional MRI techniques. By reengineering some of the proteins and peptides involved in neurovascular coupling, it is possible to create sensitive probes for a variety of neurobiological targets. I will illustrate how this strategy can be used to elucidate patterns of information flow and neurochemically specific functional connectivity in brain circuitry, with anticipated utility for deciphering mechanisms of learning and sensory processing in rodents and primates.

    הרצאה
  • Date:16חמישיפברואר 2023

    Special Guest Seminar

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    שעה
    10:00 - 11:00
    כותרת
    Inter-organelle communication pathways revealed by imaging
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    Botnar Auditorium
    מרצה
    Prof. Jennifer Lippincott-Schwartz
    מארגן
    המחלקה לגנטיקה מולקולרית
    צרו קשר
    הרצאה
  • Date:16חמישיפברואר 2023

    Physics Colloquium

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    שעה
    11:15 - 12:30
    כותרת
    TBA..
    מיקום
    בניין הפיסיקה ע"ש עדנה וק.ב. וייסמן
    Auditorium
    מרצה
    Ran Levi
    TBA..
    מארגן
    הפקולטה לפיסיקה
    צרו קשר
    פרטים נוספיםShow full text description of 11:00 Coffee & refreshments...»
    11:00 Coffee & refreshments
    תקצירShow full text abstract about TBA.. ...»
    TBA..
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  • Date:16חמישיפברואר 2023

    Vision and AI

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    שעה
    12:15 - 13:15
    כותרת
    Perceive, reason, act
    מיקום
    בניין יעקב זיסקינד
    Room 1
    מרצה
    Gal Chechik
    BIU
    מארגן
    המחלקה למדעי המחשב ומתמטיקה שימושית
    Seminar
    צרו קשר
    פרטים נוספיםShow full text description of AI aims to build systems that interact with their environmen...»
    AI aims to build systems that interact with their environment, with people, and with other agents in the real world. This vision requires combining perception with reasoning and decision-making. It poses hard algorithmic challenges: from generalizing effectively from few or no samples to adapting to new domains to communicating in ways that are natural to people. I'll discuss our recent research thrusts for facing these challenges. These will include approaches to model the high-level structure of a visual scene
    הרצאה
  • Date:16חמישיפברואר 2023

    Sensitizing P-selectin-expressing brain malignancies to immune checkpoint modulators

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    שעה
    14:00 - 15:00
    מיקום
    בניין ע"ש מקס ולילאן קנדיוטי
    Auditorium
    מרצה
    Prof. Ronit Satchi-Fainaro, PhD
    Sackler Faculty of Medicine Head, Cancer Research and Nanomedicine Laboratory Director, Cancer Biology Research Center, Tel Aviv University Director, TAU Kahn 3D BioPrinting Initiative
    מארגן
    המכון לחקר הטיפול בסרטן עש דואק
    Cancer Research Club
    צרו קשר
    פרטים נוספיםShow full text description of https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2...»
    https://weizmann.zoom.us/j/5065402023?pwd=a3Z6KzRCU0xJaUFoM2Y5emZwZm1oZz09

    הרצאה
  • Date:19ראשוןפברואר 2023

    flow, deformation and, reaction in porous media: the Coupling of Flow and Elastic Expansion in Porous Media

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    שעה
    11:00
    מיקום
    בניין משפחת זוסמן
    M. Magaritz Seminar Room
    מרצה
    Yaniv Edery
    מארגן
    המחלקה למדעי כדור הארץ וכוכבי הלכת
    צרו קשר
    הרצאה
  • Date:19ראשוןפברואר 2023

    Soft Matter and Biomaterials Seminar

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    שעה
    11:00 - 12:00
    כותרת
    Nanotechnology for targeted drug and gene delivery: from basics to clinical applications
    מיקום
    בניין פרלמן למדעי הכימיה
    Room 404
    מרצה
    Prof. Avi Schroeder
    Dept. Chemical Engineering, Technion
    מארגן
    המחלקה לכימיה מולקולרית ולמדע חומרים
    צרו קשר
    תקצירShow full text abstract about Medicine is taking its first steps toward patient-specific c...»
    Medicine is taking its first steps toward patient-specific cancer care. Nanoparticles have many potential benefits for treating cancer, including the ability to transport complex molecular cargoes, including siRNA and protein, as well as targeting specific cell populations.
    The talk will explain the fundamentals of nanotechnology, from ‘barcoded nanoparticles’ that target sites of cancer where they perform a programmed therapeutic task. Specifically, liposomes diagnose the tumor and metastasis for their sensitivity to different medications, providing patient-specific drug activity information that can be used to improve the medication choice.
    The talk will also describe how liposomes can be used for degrading the pancreatic stroma to allow subsequent drug penetration into pancreatic adenocarcinoma and how nanoparticle’ biodistribution and anti-cancer efficacy are impacted by the patient’s sex and, more specifically, the menstrual cycle.
    The evolution of drug delivery systems into synthetic cells, programmed nanoparticles that have an autonomous capacity to synthesize diagnostic and therapeutic proteins inside the body, and their promise for treating cancer and immunotherapy, will be discussed.


















    References:
    1) Theranostic barcoded nanoparticles for personalized cancer medicine, Yaari et al. Nature Communications, 2016, 7, 13325
    2) Collagenase nanoparticles enhance the penetration of drugs into pancreatic tumors, Zinger et al., ACS Nano, 13 (10), 11008-11021, 2019
    3) Targeting neurons in the tumor microenvironment with bupivacaine nanoparticles reduces breast cancer progression and metastases, Science Advances, Kaduri et al., 7 (41), eabj5435, 2021
    4) Nanoparticles accumulate in the female reproductive system during ovulation affecting cancer treatment and fertility, Poley et al., ACS nano, 2022
    הרצאה
  • Date:22רביעיפברואר 2023

    Strong light-exciton interactions in 2D semiconductors

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    שעה
    11:00 - 12:00
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצה
    Prof. Itai Epstein
    School of electrical engineering, TAU
    מארגן
    המחלקה לכימיה מולקולרית ולמדע חומרים
    צרו קשר
    תקצירShow full text abstract about The remarkable properties of excitons in transition-metal-di...»
    The remarkable properties of excitons in transition-metal-dichalcogenides (TMDs), together with the ability to readily control their charge carriers, have attracted a significant amount of interest in recent years. Despite the atomic dimensions of the hosting 2D semiconductors, TMD excitons exhibit strong interaction with light, both in absorption and photoemission processes, and practically dominate the optical response of these 2D materials. In this talk, I will introduce several approaches for achieving extremely strong light-exciton interactions. First, by optical and electrical manipulation of TMD excitons inside a van der Waals heterostructure cavity [1], second, via the formation of highly-confined, in-plane exciton polaritons [2], and third, through the realization of valley-polarized hyperbolic exciton polaritons [3].
    These enhanced light–exciton interactions may provide a platform for studying excitonic phase-transitions, quantum nonlinearities and the enablement of new possibilities for 2D semiconductor-based optoelectronic devices.
    [1] I. Epstein et al, "Near-unity Light Absorption in a Monolayer WS2 Van der Waals Heterostructure Cavity", Nano letters 20 (5), 3545-3552 (2020).
    [2] I. Epstein et al, "Highly Confined In-plane Propagating Exciton-Polaritons on Monolayer Semiconductors", 2D Materials 7, 035031 (2020).
    [3] T. Eini, T. Asherov, Y. Mazor, and I. Epstein, "Valley-polarized Hyperbolic Exciton Polaritons in Multilayer 2D Semiconductors at Visible Frequencies", Phys. Rev. B 106, L201405 (2022).
    הרצאה
  • Date:26ראשוןפברואר 2023

    TBA

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    מיקום
    בניין משפחת זוסמן
    M. Magaritz Seminar Room
    מרצה
    Holly Michael
    מארגן
    המחלקה למדעי כדור הארץ וכוכבי הלכת
    צרו קשר
    הרצאה
  • Date:26ראשוןפברואר 202328שלישיפברואר 2023

    TBA

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    שעה
    08:00 - 08:00
    מיקום
    מרכז כנסים על-שם דויד לופאטי
    יושב ראש
    Anat Yarden
    צרו קשר
    כנסים
  • Date:26ראשוןפברואר 2023

    Scientific Council Meeting

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    שעה
    14:00 - 16:00
    מיקום
    מרכז כנסים על-שם דויד לופאטי
    Kimmel Auditorium
    צרו קשר
    אירועים אקדמיים
  • Date:27שניפברואר 2023

    Pseudo Natural Products – Chemical Evolution of Natural Product Structure

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    שעה
    11:00 - 12:15
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצה
    Prof. Herbert Waldmann
    Max Planck Institute of Molecular Physiology
    מארגן
    הפקולטה לכימיה
    דף בית
    צרו קשר
    תקצירShow full text abstract about Natural products have provided inspiration for chemical biol...»
    Natural products have provided inspiration for chemical biology and medicinal chemistry research. Their success raises the fundamental question whether the particular structural and biological properties of natural products can be translated to structurally less demanding compounds, readily accessible by chemical synthesis and yet still endowed with pronounced bioactivity.
    The lecture will describe a logic for the simplification of natural product structure by means of “Biology Oriented Synthesis” (BIOS) and its evolution into the “Pseudo Natural Product” (PNP) concept. Pseudo-natural products can be regarded as the human-made equivalent of natural product evolution, i.e. the chemical evolution of natural product structure. Application of natural product inspired compound collections designed and synthesized following these principles in cell-based phenotypic assays and subsequent identification of the cellular target proteins demonstrate that the BIOS and PNPs may enable innovation in both chemical biology and medicinal chemistry research.
    סימפוזיונים

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