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  • Date:17רביעיאוקטובר 2018

    G-INCPM-Special Seminar - Prof. Rony Seger, Department of Biological Regulation, Weizmann Institute - "Targeting the nuclear translocation of MAPKs as a novel anti-inflammatory and anti cancer therapy"

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    שעה
    11:00 - 12:15
    מיקום
    המרכז הישראלי הלאומי לרפואה מותאמת אישית על-שם ננסי וסטיבן גרנד
    Auditorium
    מארגן
    המחלקה למדעים ביומולקולריים
    צרו קשר
    תקצירShow full text abstract about A hallmark of MAPK signaling is their nuclear translocation ...»
    A hallmark of MAPK signaling is their nuclear translocation upon stimulation, which is necessary for their physiological/pathological functions. We have identified two novel, distinct, regulated nuclear translocation mechanisms for ERK1/2 and JNK/p38, of which we made use of as a promising therapeutic approach. We developed a myristoylated, NTS-derived phosphomimetic peptide (EPE peptide), which blocked ERK1/2 nuclear translocation. In culture, the EPE peptide induced apoptosis of melanoma cells, inhibited the proliferation of other cancer cells but had no effect on immortalized cells. Combination of the EPE peptide and the MEK inhibitor had synergistic antitumor activity in mutated NRAS, BRAF and NF1 melanoma and Kras pancreatic cells. In xenograft models, the peptide was significantly more effective than BRAF inhibitors in preventing tumor recurrence of treatment-eradicated melanoma xenografts. We also developed p38-derived myristoylated peptide, termed PERY peptide, which inhibited the importin interaction with JNK1/2 and p38α/β and prevented their nuclear translocation. This peptide affected viability of several breast cancer-derived cell lines, and significantly reduced inflammation and intestinal damage in a mouse model of colitis. Moreover, the peptide inhibited inflammation-induced colorectal cancer in a AOM/DSS mouse model. Taken together, both the cancer and inflammatory models support the use of nuclear translocation of MAPKs as a novel drug target for signaling-related diseases.
    הרצאה
  • Date:17רביעיאוקטובר 2018

    G-INCPM-Special Seminar - Prof. Rony Seger, Department of Biological Regulation, Weizmann Institute - "Targeting the nuclear translocation of MAPKs as a novel anti-inflammatory and anti cancer therapy"

    More information
    שעה
    11:00 - 12:15
    מיקום
    המרכז הישראלי הלאומי לרפואה מותאמת אישית על-שם ננסי וסטיבן גרנד
    Auditorium
    מארגן
    המחלקה למדעים ביומולקולריים
    צרו קשר
    תקצירShow full text abstract about A hallmark of MAPK signaling is their nuclear translocation ...»
    A hallmark of MAPK signaling is their nuclear translocation upon stimulation, which is necessary for their physiological/pathological functions. We have identified two novel, distinct, regulated nuclear translocation mechanisms for ERK1/2 and JNK/p38, of which we made use of as a promising therapeutic approach. We developed a myristoylated, NTS-derived phosphomimetic peptide (EPE peptide), which blocked ERK1/2 nuclear translocation. In culture, the EPE peptide induced apoptosis of melanoma cells, inhibited the proliferation of other cancer cells but had no effect on immortalized cells. Combination of the EPE peptide and the MEK inhibitor had synergistic antitumor activity in mutated NRAS, BRAF and NF1 melanoma and Kras pancreatic cells. In xenograft models, the peptide was significantly more effective than BRAF inhibitors in preventing tumor recurrence of treatment-eradicated melanoma xenografts. We also developed p38-derived myristoylated peptide, termed PERY peptide, which inhibited the importin interaction with JNK1/2 and p38α/β and prevented their nuclear translocation. This peptide affected viability of several breast cancer-derived cell lines, and significantly reduced inflammation and intestinal damage in a mouse model of colitis. Moreover, the peptide inhibited inflammation-induced colorectal cancer in a AOM/DSS mouse model. Taken together, both the cancer and inflammatory models support the use of nuclear translocation of MAPKs as a novel drug target for signaling-related diseases.
    הרצאה
  • Date:17רביעיאוקטובר 2018

    G-INCPM-Special Seminar - Prof. Rony Seger, Department of Biological Regulation, Weizmann Institute - "Targeting the nuclear translocation of MAPKs as a novel anti-inflammatory and anti cancer therapy"

    More information
    שעה
    11:00 - 12:15
    מיקום
    המרכז הישראלי הלאומי לרפואה מותאמת אישית על-שם ננסי וסטיבן גרנד
    Auditorium
    מארגן
    המחלקה למדעים ביומולקולריים
    צרו קשר
    תקצירShow full text abstract about A hallmark of MAPK signaling is their nuclear translocation ...»
    A hallmark of MAPK signaling is their nuclear translocation upon stimulation, which is necessary for their physiological/pathological functions. We have identified two novel, distinct, regulated nuclear translocation mechanisms for ERK1/2 and JNK/p38, of which we made use of as a promising therapeutic approach. We developed a myristoylated, NTS-derived phosphomimetic peptide (EPE peptide), which blocked ERK1/2 nuclear translocation. In culture, the EPE peptide induced apoptosis of melanoma cells, inhibited the proliferation of other cancer cells but had no effect on immortalized cells. Combination of the EPE peptide and the MEK inhibitor had synergistic antitumor activity in mutated NRAS, BRAF and NF1 melanoma and Kras pancreatic cells. In xenograft models, the peptide was significantly more effective than BRAF inhibitors in preventing tumor recurrence of treatment-eradicated melanoma xenografts. We also developed p38-derived myristoylated peptide, termed PERY peptide, which inhibited the importin interaction with JNK1/2 and p38α/β and prevented their nuclear translocation. This peptide affected viability of several breast cancer-derived cell lines, and significantly reduced inflammation and intestinal damage in a mouse model of colitis. Moreover, the peptide inhibited inflammation-induced colorectal cancer in a AOM/DSS mouse model. Taken together, both the cancer and inflammatory models support the use of nuclear translocation of MAPKs as a novel drug target for signaling-related diseases.
    הרצאה
  • Date:17רביעיאוקטובר 2018

    G-INCPM-Special Seminar - Prof. Rony Seger, Department of Biological Regulation, Weizmann Institute - "Targeting the nuclear translocation of MAPKs as a novel anti-inflammatory and anti cancer therapy"

    More information
    שעה
    11:00 - 12:15
    מיקום
    המרכז הישראלי הלאומי לרפואה מותאמת אישית על-שם ננסי וסטיבן גרנד
    Auditorium
    מארגן
    המחלקה למדעים ביומולקולריים
    צרו קשר
    תקצירShow full text abstract about A hallmark of MAPK signaling is their nuclear translocation ...»
    A hallmark of MAPK signaling is their nuclear translocation upon stimulation, which is necessary for their physiological/pathological functions. We have identified two novel, distinct, regulated nuclear translocation mechanisms for ERK1/2 and JNK/p38, of which we made use of as a promising therapeutic approach. We developed a myristoylated, NTS-derived phosphomimetic peptide (EPE peptide), which blocked ERK1/2 nuclear translocation. In culture, the EPE peptide induced apoptosis of melanoma cells, inhibited the proliferation of other cancer cells but had no effect on immortalized cells. Combination of the EPE peptide and the MEK inhibitor had synergistic antitumor activity in mutated NRAS, BRAF and NF1 melanoma and Kras pancreatic cells. In xenograft models, the peptide was significantly more effective than BRAF inhibitors in preventing tumor recurrence of treatment-eradicated melanoma xenografts. We also developed p38-derived myristoylated peptide, termed PERY peptide, which inhibited the importin interaction with JNK1/2 and p38α/β and prevented their nuclear translocation. This peptide affected viability of several breast cancer-derived cell lines, and significantly reduced inflammation and intestinal damage in a mouse model of colitis. Moreover, the peptide inhibited inflammation-induced colorectal cancer in a AOM/DSS mouse model. Taken together, both the cancer and inflammatory models support the use of nuclear translocation of MAPKs as a novel drug target for signaling-related diseases.
    הרצאה
  • Date:21ראשוןאוקטובר 2018

    Memorial Day for Yitzhak Rabin

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    שעה
    11:00 - 12:30
    צרו קשר
    הרצאה
  • Date:21ראשוןאוקטובר 2018

    TBA

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    שעה
    11:00
    מיקום
    בניין משפחת זוסמן
    M. Magaritz Seminar Room
    מרצה
    Zvika Steiner
    University of Cambridge
    מארגן
    המחלקה למדעי כדור הארץ וכוכבי הלכת
    צרו קשר
    הרצאה
  • Date:22שניאוקטובר 2018

    title tbd

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    שעה
    11:00 - 12:15
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצה
    Prof. Michael Rosen
    UT Southwestern Medical Center
    מארגן
    הפקולטה לכימיה
    צרו קשר
    סימפוזיונים
  • Date:22שניאוקטובר 2018

    G-INCPM - Special Seminar - Dr. Wolfgang Mann, CEO, BlueCatBio GmbH, Germany - "Blue Washer: the most cost-effective tool to improve data quality (z') for adherent cellular assays"

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    שעה
    11:00 - 12:15
    מיקום
    המרכז הישראלי הלאומי לרפואה מותאמת אישית על-שם ננסי וסטיבן גרנד
    Auditorium
    מארגן
    המחלקה למדעים ביומולקולריים
    צרו קשר
    תקצירShow full text abstract about Since its introduction in 2015 the BlueWasher has rapidly be...»
    Since its introduction in 2015 the BlueWasher has rapidly become the de-facto standard for media change & cell wash in adherent cellular assays.
    The BlueWasher uses centrifugation instead of aspiration to remove liquids from all plate formats, including 1536w, eliminating background and variability at their (assay) sources. Highly reproducible residual volumes 10x lower than conventional plate washers enable imagers to produce cleaner images, raising z' 0.1-0.3 for typical adherent cellular assays. Higher z' means to miss fewer active compounds and reduce false positives to re-screen. BlueWasher immediately improves screening economics without complex assay or automation changes, delivering unparalleled ROI and direct boost to overall drug discovery productivity.
    A technical introduction into centrifugation based cell wash / media changed will be followed by a number of examples discussing improvement of data quality in HTS / HCS. Other bead based applications like nucleic acids extraction or protein binding assays will be presented as well.

    הרצאה
  • Date:22שניאוקטובר 2018

    TBA

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    שעה
    14:00 - 15:00
    כותרת
    Special Guest Seminar
    מיקום
    בניין ע"ש מקס ולילאן קנדיוטי
    Auditorium
    מרצה
    Prof. Kazuhiko Nakatani
    Institute of Scientific and Industrial Research, Osaka University, Japan
    מארגן
    המחלקה לבקרה ביולוגית
    צרו קשר
    הרצאה
  • Date:23שלישיאוקטובר 201825חמישיאוקטובר 2018

    Modern teaching methods and soft skills development in science

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    שעה
    08:00 - 08:00
    מיקום
    מרכז כנסים על-שם דויד לופאטי
    Kimmel Auditorium
    יושב ראש
    Ron Blonder
    צרו קשר
    כנסים
  • Date:23שלישיאוקטובר 2018

    The seeds of ice in clouds

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    שעה
    11:00
    מיקום
    בניין משפחת זוסמן
    M. Magaritz Seminar Room
    מרצה
    Prof. Ben Murray
    University of Leeds
    מארגן
    המחלקה למדעי כדור הארץ וכוכבי הלכת
    צרו קשר
    הרצאה
  • Date:23שלישיאוקטובר 2018

    Chemical Approaches to Study Oxidative Protein Folding

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    שעה
    14:00 - 15:00
    מיקום
    בניין הלן ומילטון קימלמן
    Dov Elad Room
    מרצה
    Dr. Norman Metanis
    מארגן
    המחלקה לביולוגיה מבנית
    צרו קשר
    הרצאה
  • Date:25חמישיאוקטובר 2018

    Hierarchical dynamics of visual inference

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    שעה
    12:30
    מיקום
    בניין לחקר המוח על-שם נלה וליאון בנוזיו
    מרצה
    Prof. Jochen Braun
    Institute of Biology Otto-von-Guericke Unversity, Magdeburg
    מארגן
    המחלקה לנוירוביולוגיה
    צרו קשר
    פרטים נוספיםShow full text description of Benoziyo Brain Research Building Room 113 Host: Prof. Dov...»
    Benoziyo Brain Research Building Room 113

    Host: Prof. Dov Sagi dov.sagi@weizmann.ac.il tel: 3747
    For assistance with accessibility issues, please contact naomi.moses@weizmann.ac.il
    תקצירShow full text abstract about Visual input is noisy, variable, and ambiguous. Optimal inf...»
    Visual input is noisy, variable, and ambiguous. Optimal inference of physical causes is challenging even for a restricted set of causes (e.g., orientations and spatial frequencies). It is well understood (e.g., Veliz-Cuba et al., 2016) that stochastic dynamical systems can approximate optimal inference by continuously accumulating and evaluating visual evidence. I will argue that the dynamics of multi-stable perception is consistent with just such an inference mechanism. Its psychophysically observable characteristics fully constrain a hierarchical dynamics with three levels, the lowest of which may conceivably correspond to cortical columns or clusters of columns. Given suitable inputs, this hierarchical dynamics accumulates and evaluates noisy evidence to make nearly optimal categorical discriminations. Moreover, its dynamical features seem to afford functional benefits in a volatile world, such as balancing stability and sensitivity of inference.

    References:
    Cao, Pastukhov, Mattia, Braun (2016) Collective activity of many bistable assemblies reproduces characteristic dynamics of multistable perception. J. Neurosci., 36: 6957-72.

    Veliz-Cuba, Kilpatrick, Josic (2016) Stochastic models of evidence accumulation in changing environments. SIAM Review, 58: 264-289.

    הרצאה
  • Date:25חמישיאוקטובר 2018

    Development of placenta-derived (PLX) cell therapy- from bench- to bedside

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    שעה
    14:00 - 15:00
    כותרת
    Special Guest Lecture
    מיקום
    בניין ע"ש מקס ולילאן קנדיוטי
    Auditorium
    מרצה
    Dr. Racheli Ofir
    Vice President Research & Intellectual Property, {Pluristem, MATAM, Haifa
    מארגן
    המחלקה לבקרה ביולוגית
    צרו קשר
    תקצירShow full text abstract about PLacental expanded (PLX) cells are placenta-derived, mesench...»
    PLacental expanded (PLX) cells are placenta-derived, mesenchymal-like adherent stromal cells expanded using a bioreactor system which provides a three dimensional (3D) micro-environment enabling tightly controlled expansion. Accumulated data from multiple in vitro and in vivo experiments indicate that these cells act via a paracrine or endocrine manner to facilitate healing of damaged tissue.
    Pluristem’s two lead placenta-derived cell products, PLX-PAD and PLX-R18, are each in clinical development for several indications. PLX-Immune is in non-clinical development stages for Cancer. Data from non-clinical as well as clinical studies will be presented.
    הרצאה
  • Date:25חמישיאוקטובר 2018

    Pelletron meeting - by invitation only

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    שעה
    16:00 - 17:30
    צרו קשר
    הרצאה
  • Date:28ראשוןאוקטובר 201801חמישינובמבר 2018

    SAAC meeting

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    כותרת
    ישיבות הועדה המדעית האקדמית המייעצת, 2018
    צרו קשר
    מועצת המנהלים הבינלאומית
  • Date:28ראשוןאוקטובר 201802שישינובמבר 2018

    International Board SAAC Review

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    צרו קשר
    אירועים אקדמיים
  • Date:28ראשוןאוקטובר 2018

    The Ideal Solution to Interactively Analyze Microscopy Images

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    שעה
    10:30
    מיקום
    בניין ע"ש מקס ולילאן קנדיוטי
    Auditorium
    מרצה
    Georgia Golfis
    BITPLANE
    מארגן
    המחלקה לתשתיות מחקר מדעי החיים
    צרו קשר
    פרטים נוספיםShow full text description of General Presentation & live demo Imaris Training 28...»
    General Presentation & live demo

    Imaris Training 28-29 October 2018
    For training please register - ofra.golani@weizmann.ac.il
    הרצאה
  • Date:29שניאוקטובר 201801חמישינובמבר 2018

    International Board SAAC Review

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    צרו קשר
    פרטים נוספיםShow full text description of Review subjects - High Energy Theory and Experiment Organi...»
    Review subjects -
    High Energy Theory and Experiment
    Organic Chemistry and Material Science
    Developmental Biology and Regenerative Medicine
    אירועים אקדמיים
  • Date:31רביעיאוקטובר 2018

    Developmental Club Series 2018-2019

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    שעה
    10:00
    מיקום
    בניין קמיליה בוטנאר
    Botnar Auditorium
    מרצה
    Karina Yaniv
    מארגן
    המחלקה לגנטיקה מולקולרית
    Developmental Club
    צרו קשר
    הרצאה

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