August 01-31, 2017
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Date:02WednesdayAugust 2017Lecture
Targetting Growth Factor Signalling to Reduce the Impact of Colon Cancer
More information Time 14:00 - 15:00Location Max and Lillian Candiotty Building
Seminar RoomLecturer Prof. Anthony Burgess
Laboratory Head at the Walter and Eliza Hall Institute, AustraliaOrganizer Department of Immunology and Regenerative BiologyContact -
Date:08TuesdayAugust 2017Lecture
Personalized Immunotherapy for Lung Cancer
More information Time 14:00 - 15:00Title Cancer Research Club SeminarLocation Max and Lillian Candiotty Building
Seminar RoomLecturer Prof. Roy S. Herbst
Director, Thoracic Oncology Research Program, Yale Comprehensive Cancer Center, Yale School of Medicine, USAOrganizer Department of Immunology and Regenerative BiologyContact Abstract Show full text abstract about Despite advances in the treatment of cancer, with novel mole...» Despite advances in the treatment of cancer, with novel molecularly targeted therapies and drug combinations, lung cancer continues to be one of the leading causes of cancer death worldwide. For this reason, significant efforts have been made to examine the interaction between cancer and the immune system. This has led to the discovery of the programmed death 1 (PD1) and ligand (PDL1) pathway, which was found to play a key role in immune evasion by cancer cells and the formation of a tumor microenvironment. Blockade of this pathway enables the ability of the innate immune system to activate their anticancer responses and to reverse the tumor microenvironment. Newly approved drugs, such as nivolumab and pembrolizumab, have mechanisms of action that inhibit PD1, while others like atezolizumab, block PDL1. Although, responses with these drugs have shown significant activity in some patients, only 20-30% of patients respond overall. In this talk, mechanistic studies to identify predictive markers of response will be discussed along with markers of resistance (both primary and acquired). In addition, novel combinations of immunotherapy with chemotherapy, targeted therapy and even chemotherapy will be explored. -
Date:09WednesdayAugust 2017Lecture
Beating the Thermodynamic Limit: Photo-Activation of n-Doping in Organic Semiconductors
More information Time 11:00 - 12:00Location Perlman Chemical Sciences Building
Room 404Lecturer Prof. Antoine Kahn
Dept. Electrical Engineering, Princeton UniversityOrganizer Department of Molecular Chemistry and Materials ScienceContact Details Show full text description of Doping is one of the keys to controlling the electronic and ...» Doping is one of the keys to controlling the electronic and electrical properties of organic semiconductors, lower contact resistance, enhance bulk conductivity and carrier mobility, and create higher performance devices. The talk starts with a rapid overview of doping mechanisms, of the reducing or oxidizing power of several n- and p-type molecular dopants, and of their impact on the conductivity of both vacuum- and solution-processed organic semiconductor films. We then turn to very low electron affinity materials (EA ~ 2.0-2.1 eV), which are central to electron transport layers in modern green and blue OLEDs, but are notably difficult to n-dope. We look at phenyldi(pyren-2-yl)phosphine oxide (POPy2) with an EA = 2.1 eV doped with the air-stable dimer of (pentamethylcyclopentadienyl)(1,3,5-trimethylbenzene)ruthenium ([RuCp*Mes]2) [1]. We demonstrate that photo-activation of the cleavable dimeric dopant results in kinetically stable and efficient n-doping of the host semiconductor, whose reduction potential is beyond the thermodynamic reach of the dimer’s effective reducing strength [2]. This stability arises from the photo-assisted cleavage of the dopant, which ultimately leads to the resulting monomeric cationic organometallic species for which the reverse reaction sequence is kinetically hindered on a time scale of at least thousands of hours. We show that the electron transport material doped in this manner is used to fabricate high-efficiency organic light-emitting diodes with significantly improved performance relative to un-doped devices. -
Date:09WednesdayAugust 2017Academic Events
Council of Professors
More information Time 15:00 - 17:00Location David Lopatie Conference Centre
Kimmel AuditoriumContact -
Date:12SaturdayAugust 2017Cultural Events
Astrith Baltsan - Jerusalem of Gold
More information Time 21:15Location Michael and Anna Wix AuditoriumContact Details Show full text description of Astrith Baltsa celbrate 50 Years of United Jerusalem. With...» Astrith Baltsa celbrate 50 Years of United Jerusalem.
With Keren Hadar and Thalamus Quartet.
Bach , Handel, Monteverdi -
Date:15TuesdayAugust 2017Lecture
Genome wide identification of genes mediating cancer resistance
More information Time 14:00 - 15:00Location Max and Lillian Candiotty Building
Seminar RoomLecturer Prof.Eytan Ruppin
Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, and Blavatnik School of Computer Science University of Maryland, College Park, MD, USAOrganizer Department of Immunology and Regenerative BiologyContact Abstract Show full text abstract about Most patients with advanced cancer eventually acquire resist...» Most patients with advanced cancer eventually acquire resistance to targeted therapies, spurring extensive efforts to identify molecular events mediating therapy resistance. Many of these events involve synthetic rescue (SR) interactions, where the reduction in cancer cell viability caused by targeted gene inactivation is rescued by the adaptive alteration of another gene (the rescuer). Here we perform a genome-wide identification of SR-mediated resistance determinants by analyzing the tumor transcriptomics and survival data of 10,000 cancer patients. Predicted SR interactions are validated versus publicly available resistance data and new experimental screens that we have conducted. We show that the SR interactions successfully predict cancer patients’ response and emerging resistance and that the targeting of predicted rescuer genes re-sensitizes resistant cancer cells. These results provide novel rationale-based combinatorial approaches for proactively overcoming therapy resistance. Finally, going beyond targeted therapy, we show that the SR analysis can successfully predict molecular alterations conferring resistance to immunotherapy in melanoma patients.
[Work led by Avinash Das and Joo Sang Lee in my lab, in collaboration with the labs of Silvio Gutkind (UCSD), Cyril Benes (MGH), Keith Flaherty & Genevieve Boland (MGH) and Meenhard Herlyn (Wistar).] -
Date:17ThursdayAugust 2017Lecture
Functional dissection of decision-related activity in the primate dorsal stream
More information Time 12:30Location Nella and Leon Benoziyo Building for Brain ResearchLecturer Dr. Leor Katz
University of Texas at AustinOrganizer Department of Brain SciencesContact Details Show full text description of Room 113 Benoziyo Brain Research Building Host: Prof. R...» Room 113
Benoziyo Brain Research Building
Host: Prof. Rony Paz rony.paz@weizmann.ac.il tel: 6236
For assistance with accessibility issues, please contact naomi.moses@weizmann.ac.il
Abstract Show full text abstract about The study of perceptual decision-making is key to understand...» The study of perceptual decision-making is key to understanding complex cognitive behavior. Two decades of recordings in primate parietal cortex suggest that neurons in the lateral intraparietal (LIP) cortex integrate sensory evidence from upstream neurons (presumably MT) in favor of making a decision. However, the causal role of LIP in decision-making had not been tested directly.
In this talk, I will present recent experiments that tested whether area LIP—which exhibits strong decision-related activity—is causally related to perceptual decision-making. In contrast to the generally accepted model, we found that inactivation in area LIP had no measurable impact on decision-making behavior (despite having exerted effects in a control task). This finding suggests that strong decision-related activity does not guarantee a causal role in decision-making. To better understand the MT-LIP circuit we then applied a Generalized Linear Model (GLM) to simultaneously recorded MT and LIP neurons. We found that much of MT & LIP responses may be interpreted in simple sensorimotor terms, as opposed to appealing to nuanced cognitive phenomena. These results shift our understanding of decision-related activity in the primate brain and motivate new approaches to further dissecting the circuit.
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Date:29TuesdayAugust 2017Lecture
AMO Special Seminar
More information Time 13:15 - 14:30Title Quantum Simulation of Lattice Gauge Theories: from Analog to DigitalLocation Edna and K.B. Weissman Building of Physical SciencesLecturer Dr. Erez Zohar, Max-Planck-Institut für Quantenoptik, GermanyOrganizer Department of Physics of Complex Systems
Optics and Atomic Physics SeminarContact Abstract Show full text abstract about Gauge theories are not only important and fundamental in mod...» Gauge theories are not only important and fundamental in modern physics, they also present some hard, challenging puzzled waiting to be solved.
In the recent years, quantum information, optics and atomic physics have proposed two new approaches for studying such theories: tensor networks studies and quantum simulation.
In my talk I will discuss the latter, present some analog quantum simulation schemes using ultracold atoms, and focus on a recent, digital formulation of lattice gauge theories that decomposes four-body interactions from two-body ones, allowing for digital quantum simulation schemes with atomic systems. -
Date:31ThursdayAugust 2017Lecture
Next Generation (Chip Based) Gene Synthesis: The Coming Revolution in Pharmaceutical, Food and Environment
More information Time 11:00 - 12:00Location Wolfson Building for Biological Research
AuditoriumLecturer Prof. Joseph M. Jacobson
Massachusetts Institute of Technology, USAOrganizer Life SciencesHomepage Contact