Get off at the Anava exit – Route 431 towards Rishon Lezion.
Take the second exit after getting onto 431: Ramla/Rehovot. Go up the ramp and make a left turn onto Route 40, towards Rehovot.
After several kilometers, you will see a Sonol station on the right side of the road. At the second traffic light after the Sonol station, make a right turn onto Menahem Begin Blvd. There is a sign at the turn indicating that you have entered Rehovot.
At the third traffic light on Menahem Begin make a left turn, onto Josephson. Make your first right turn, onto Carmel. After 15 meters you will hit a traffic circle (roundabout). The second turn off the circle is into the Davidson gate entrance of the Institute.
This gate is open 08:00-18:00, Sunday-Thursday.
If the gate is closed, you need to continue to the main gate. Continue in the traffic circle and return to Josephson, turning right (away from Menahem Begin).
Continue to the next traffic circle. You will essentially continue in the same direction (west) but the exit from the circle is slightly to the right of the road from which you came. You are now on Rehov Hanassi Harishon.
Continue on Hanassi Harishon through the next traffic circle, until you hit a No Enter. Make a left onto Bustenai and a right onto Ben Yehuda. Continue to the end of Ben Yehuda, making a right turn onto Rehov Herzl. At the 2nd traffic light, make a right turn into the main gate of the Institute.
From Tel Aviv
Exit Tel Aviv onto the Ayalon Darom (South).
Continue on the Ayalon going south, until Ayalon Darom merges into the Jeruasalem Tel-Aviv highway (follow signs to Jerusalem, Route 1).
Get off at the Ashdod exit. The sign will also say Tzomet Ganot, or Ganot Junction. You are now on the Tel Aviv Ashdod highway, which is Route 4.
Go past 2 exits (both are for Rishon L'Zion). After the second Rishon L'Zion exit, move into the right lane and and get off at the Gan Rave junction (Route 42). The exit will also list Rishon L'Zion again.
Stay in the left lane of the exit ramp, past the Rishon turnoff, which is to your right. Now you can move into the right lane, and merge with the traffic.
At the second junction, (Ein HaKore) bear right. The sign says Yavneh above, and Rehovot on ground level. At the next junction (Beit Oved), at the traffic light, (approximately 4 kilometers), make a left turn onto Route 4303.
At the 4th traffic light, enter the right turn lane toward Rehovot, onto Route 412, also called Rehov Weizmann.
At the 5th traffic light, make a left turn into the main gate of the Institute. (It's the 2nd traffic light after the overpass over the railroad tracks.)
Exit Haifa onto the Haifa Tel-Aviv highway, also known as Kvish Ha'hof, the Coastal Road (Route 2).
Continue to the large Glilot junction, Tzomet Glilot. From here you can choose between 2 routes:
Make a left turn, and shortly thereafter bear right onto the ramp leading onto the Ayalon Darom (South). Follow the instructions from Tel Aviv no. 2, above.
Make a left turn, and stay in the left lane. Continue straight on Route 5, in the left lane, under the underpass. After the underpass, move to the right lane. Take the ramp leading off Route 5, toward Ashdod (Route 4).
Stay on Route 4 until you pass both Rishon L'Zion exits and follow the instructions as listed from Tel Aviv no. 4, above.