September 25, 1988 - September 25, 2021

  • Date:14WednesdayMarch 2018

    G-INCPM-Special Seminar - Dr. Shalev Itzkovitz, Dept. of Molecular Cell Biology, Weizmann - "Spatial Transcriptomics of Mammalian Tissues"

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    Time
    11:00 - 12:30
    Location
    Nancy and Stephen Grand Israel National Center for Personalized Medicine
    Auditorium
    Lecturer
    Dr. Shalev Itzkovitz
    Dept.of Molecular Cell Biology, Weizmann
    Organizer
    Department of Biomolecular Sciences
    Contact
    AbstractShow full text abstract about Mammalian tissues are often composed of repeating anatomical...»
    Mammalian tissues are often composed of repeating anatomical units that are polarised by morphogens or directional blood flow. Thus single cells at different tissue coordinates operate in distinct microenvironment.
    This spatial diversity enables optimisation of tissue function by allocating different tasks to cells that reside in distinct tissue locations. To explore this spatial division of labor on a genome-wide scale we are combining single cell transcriptomics with in-situ measurements in intact tissues to enable inference of the sequenced cells’ original tissue locations. This approach enables reconstructing global spatial gene expression atlases. I will demonstrate these approaches on two stereotypical and highly structured organs - the liver and the intestinal epithelium.
    Lecture