August 20, 1988 - August 20, 2021

  • Date:17TuesdayApril 2018

    G-INCPM- Special Seminar - Prof. Yuval Dor, Dept. of Developmental Biology & Cancer Research, The Institute for Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem - "Non Invasive Detection of Tissue-Specific Cell Death"

    More information
    Time
    11:00 - 12:15
    Location
    Nancy and Stephen Grand Israel National Center for Personalized Medicine
    Auditorium
    Lecturer
    Prof. yuval Dor
    Dept. of Developmental Biology & Cancer Research, The Institute for Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem
    Organizer
    Department of Biomolecular Sciences
    Contact
    AbstractShow full text abstract about Cell-free circulating DNA (cfDNA), released from dying cells...»
    Cell-free circulating DNA (cfDNA), released from dying cells, is emerging as a diagnostic tool for monitoring cancer dynamics and graft failure. We developed a method of detecting tissue-specific cell death in humans, based on tissue-specific methylation patterns of DNA circulating in plasma. We interrogated tissue-specific methylome datasets to identify cell type-specific DNA methylation signatures, and established a method to detect these in mixed DNA samples and in cfDNA isolated from plasma. Using this new type of biomarker it is possible to detect the presence of cfDNA fragments derived from multiple tissues in healthy individuals and in pathologies including cancer, myocardial infarction, sepsis, neurodegeneration and more. In the long run we envision this approach opening a minimally-invasive window for monitoring and diagnosis of a broad spectrum of human pathologies, as well as better understanding of normal tissue dynamics.
    Lecture