We, humans and animals, feel the outside world thanks to our 5 senses. We hear, we see, we smell, we touch, and we taste. The success of our lives often depends on how sharp our senses are. In a scientific environment, sensing and feeling is also important. In chemistry, in biology, in medicine, in forensics, as in other areas, feeling, recognising, is crucial. In the present seminar, I will show some examples of the use of chromophores such as porphyrins, emissive peptides, rhodamines, liquid crystals-based metal complexes, fluorescein and others, free or supported in polymers, paper, and gold, silver, platinum nanoparticles, or messoporous structured nanomaterials for hunting and capture of molecules, ions and biomarkers for Proteomics Applications.