March 08, 1991 - March 08, 2024

  • Date:28SundayFebruary 2021

    Modeling formation of caveolar superstructures

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    11:00 - 12:00
    Prof.Michael Koslov
    Department of Physiology and Pharmacology, TAU
    Department of Molecular Chemistry and Materials Science
    Soft Matter and Biomaterials
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    Caveolae, the flask-shaped pits covered by caveolin-cavin coats, are abundant features of the plasma membrane of many cells. Besides appearing as single membrane indentations, caveolae are organized as superstructures in the form of rosette-like clusters. Here we propose that clustering of caveolae is driven by forces originating from the elastic energy of membrane bending deformations and membrane tension. We substantiate this mechanism by computational modeling, which recovers the unique shapes observed for the most ubiquitous caveolar clusters consisting of two, three, four and five caveolae.