mRNA based vaccines prevent COVID-19 infections, putting them at the forefront of the current global fight against the COVID-19 pandemic. The scientific and clinical development of mRNA medicines, which began in ernest only ~10 years ago, has the potential to not only change the landscape of infectious disease vaccines but to also impact the treatment of cancer, genetic metabolic, autoimmune, and cardiovascular diseases. This talk will review the translational medicine approach to the research and development of both infectious disease vaccines, as exemplified by COVID-19 vaccine Moderna, as well as other applications of mRNA medicines currently in clinical development.
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