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Jodi Nunnari is a pioneer in the field of mitochondrial biology. She was the first to describe the organelle as a dynamic network in homeostatic balance and decipher the mechanisms of the machines responsible for mitochondrial division and fusion, which are critical determinants of overall mitochondrial shape and distribution. Nunnari’s laboratory at UC Davis is using system-based approaches to address how mitochondrial behavior is physiologically regulated within cells to shed light onto how mitochondrial dysfunction contributes to human disease.