Zoom Link:
https://weizmann.zoom.us/j/92668474661?pwd=d01aQVZkWnhiT0NRQlFkVE5XeWRjdz09
Caveolae, the flask-shaped pits covered by caveolin-cavin coats, are abundant features of the plasma membrane of many cells. Besides appearing as single membrane indentations, caveolae are organized as superstructures in the form of rosette-like clusters. Here we propose that clustering of caveolae is driven by forces originating from the elastic energy of membrane bending deformations and membrane tension. We substantiate this mechanism by computational modeling, which recovers the unique shapes observed for the most ubiquitous caveolar clusters consisting of two, three, four and five caveolae.
