January 06, 1996 - January 06, 2029

  • Date:19MondayMay 2025

    Mechanisms of axonal degeneration following traumatic brain injury

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    Time
    11:00 - 12:30
    Location
    Benoziyo Bldg. for Biological Sciences
    Seminar Rm. 290 -Floor 2
    LecturerProf. Wilma Friedman
    Special Guest Joint Seminar Dept. of Biomolecular Sciences & Dept. of  Molecular Neuroscience
    AbstractShow full text abstract about Traumatic brain injury to the cortex elicits the loss of neu...»
    Traumatic brain injury to the cortex elicits the loss of neurons at the site of damage, but also evokes changes in the tissue environment of axon terminals that project to the site of injury from distal locations.  We previously demonstrated that basal forebrain cholinergic neurons (BFCNs) undergo retrograde degeneration following cortical TBI that is mediated by the p75 neurotrophin receptor (p75NTR).  We have investigated mechanisms governing p75NTR-mediated retrograde degeneration as well as the behavioral consequences of the loss of BFCNs following TBI.  Mice lacking the p75NTR in cholinergic neurons showed sparing of these neurons following TBI, and preservation of cognitive function.
    Lecture