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Prof. Maya Schuldiner
Uncovering tethers, functions and regulators of membrane contact sites in yeastMitochondria-ER contact sitesPeroxisome-Lipid Droplet contact sitesNucleus-Mitochondria contact sitesThe proteome of contact sitesTargeting and translocation to OrganellesUncovering a role for the Ssh1, the alternative, translocon in yeastDeciphering targeting of proteins to mitochondriaTargeting of membrane proteins to peroxisomesTargeting of low-hydrophobicity SS proteins to the ERTargeting of proteins to the surface of the ERUncovering new peroxisomal proteins and their functionsCollaboration with: Dr. Einat ZalckvarMetabolite transport across the peroxisome membranePeroxisome contact sitesPeroxisome quality controlPeroxisome targetingNew peroxisomal enzymes and their functionsPexophagyPeroxisomes in metabolismNovel methodologies for systematic exploration of yeast organelle protein functionsCreation of versatile yeast librariesHigh throughput electron microscopy techniquesTranslocation sensors
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Dr. Rita Schmidt
Developing new tools for human MRI, especially at ultra-high field 7T MRI scanner, aiming to better understand the human brain functionDeveloping new methods to improve the spatial and temporal resolution in functional brain MRIDeveloping new contrast methods for functional MRI to study brain functionAdvancing dedicated MR pulse sequences to achieve fast and ultrafast high quality MR imaging and spectroscopic imagingBoosting the accessible MR signal in localized functional brain trials
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Prof. Avigdor Scherz
Quantification of atoms, groups and molecules electronegati using metal substituted bacteriochlorophylls and application to chemical reactivity.Resolving the forces which drive membrane protein assembly.The mechenism behind generation of reactive oxygen species (ROS) by illuminating novel bacteriochlorophyll derivatives and their application in photodynamic therapy (PDT) of tumors.
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Prof. Yardena Samuels
Synthetic lethal interaction network of melanomaIdentification of melanoma hub interactomesCRISPR screens to reveal driver gene interactions and drug resistance genesDecipher the immuno-genetic interactions between melanoma and T cellsHLA peptidome analysis of metastatic melanoma lesions
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Prof. Jacob Sagiv
Supramolecular Architecture at Interfaces (with R. Maoz)Supramolecular Surface Chemistry: Bottom-up Nanofabrication using Planned Self-Assembling Mono- and Multilayer Systems (with R. Maoz)Constructive Lithography: Contact Electrochemical Surface Patterning on Lateral Length Scales from Nanometer to Centimeter (with R. Maoz)
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Prof. Irit Sagi
Extracellular Matrix (ECM) remodeling: from biophysical principles to drug designECM remodeling by unique enzymes: investigating ECM proteolysis and cross-linking that provide chemical and mechanical stimuli regulating cellular behavior in health and disease.Drug Design: develop specific inhibitors to control the enzymatic activity of ECM remodeling enzymes, elucidating their function, mode of action, and therapeutic potential.Matrix Biology: the ECM and its remodeling enzymes in physiological and pathological conditions. Development of novel tools in the fields of systems biology, immunological tools, molecular and biochemical methods, and a wide range of imaging techniques to study ECM functional remodeling.
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