Molecular and Cell Biology of RNA viruses
RNA viruses including corona, zika and dengue are a major threat to human health. We study how RNA viruses interact with their host cells and transform them into viral manufactories.
Our main model is enteroviruses - common viral pathogens that cause severe medical complications in humans, with no available therapeutic treatments.
We investigate how enteroviruses remodel the structure and function of host organelles to generate an environment favorable to virus replication.
Another key question we tackle is how enteroviruses, that express only a small number of proteins, take control of human cells with complex protein machineries. We study the different roles of viral proteins and the mechanisms they use to hijack host machineries.
We aim to piece together the complete program of enterovirus replication. This could lead to the development of new antiviral therapeutics.
