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Prof. Ed Bayer
Structural and functional aspects of the multi-enzyme cellulosome complex from cellulose-degrading bacteria.The cohesin-dockerin couple - Protein-protein interactions that mediate recognition and specificity in cellulosome assembly.Cellulose-binding domains as models for protein-sugar interactions.Bioinformatics of cellulases and cellulosome componentsComparative genomics of cellulosome components.Structure determination of cellulosome components.Enzymology of cellulosomes for conversion of biomass to biofuelsDesigner cellulosomes - Selective engineering of chimaeric cellulosome constructs for nanotechnology.Avidin-biotin system - Mutated avidins and streptavidins
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Dr. Avraham Roi
The lab of host-pathogen genomics is interested in how individual encounters between host and pathogenic bacteria can ultimately define the outcome of infection. This is achieved by applying cross-disciplinary single-cell analysis platforms that collectively enable us to extensively profile and precisely monitor host-pathogen interactions within the context of in vivo infections.The work in the lab centers on salmonella infection of mouse macrophages as a tractable in vitro host-pathogen system. We use this model to develop state of the art high throughput genomic tools and interdisciplinary approaches, and then apply them to various in vivo infection models to address critical biological aspects of host-pathogen biology.Using comprehensive, quantitative, unbiased tools to analyse the molecular interactions that underlie distinct host-pathogen subpopulations and their impact on disease outcome.Using a powerful combination of cutting-edge single cell genetic and genomic approaches, we wish to address what forms the basis for successful immune clearance, from the level of individual infected cells to that of the whole organism, and why, in some cases, sterilization is incomplete?
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Dr. Ori Avinoam
The mechanisms of protein mediated membrane sculpting in health and diseaseSpatial and temporal organization of the molecular machines driving vesicle formation.Endocytosis and membrane trafficking in eukaryotes.Caveolae in muscle biogenesis, homeostasis and atrophy.Cell-to-cell fusionImaging Across ScalesCorrelative light and 3D electron microscopy at room temperature and in cryo.Advanced light microscopy techniques.
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Prof. Ruth Arnon
Pathological mechanism in the CNS of various multiple sclerosis animal models.Collaboration with: R. AharoniNeuroprotection, neurogenesis and remyelination consequences of Glatiramer Acetate treatment in EAE.Collaboration with: R. Aharoni; M. SelaMechanism of action of Copolymer 1 (Copaxone®), a therapeutic vaccine against multiple sclerosis.Collaboration with: M. Sela; R. AharoniInvolvement of peptides in animal models of Alzheimer disease and its ameliorationCollaboration with: R. Maron; M. Wilchek
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Prof. Michal Armoni
Teaching the foundations of computer science to young studentsTheoretical foundations of computer scienceBasic concepts in algorithm and program designFundamental ideas in computer science: Identifying the core ideas of the discipline, examining their teaching and learning processesReductive thinking: Reduction as a tool for problem solvingNondeterminism: a tool for abstractionReversingAbstraction
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