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Dr. Liran Shlush
Clonal dynamics of aging hematopoiesis in humansCollaboration with: Amos Tanay Omar abdel Wahab Jon Dick Mark Minden Hofer Thomas Elisa Laurenti Paaladinesh Thavendiranathan Hartmut Geiger Benny Geiger Dennis Kim Müller-Tidow, Carsten Yinon Ben NeriaUnderstanding the functional effects of preleukaemic mutations on human haematopoietic stem cellsMicrohomology-mediated end joining (MMEJ) DNA repair in pre-leukemic hematopoietic stem cellsPrevention of myeloid malignancies among carriers of spliceosome mutationsAge-related clonal hematopoiesis and its link to age-related changes in the bone marrow microenvironmentMulti-dimensional analysis and the human aging blood system
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Prof. Yoram Shechter
Mechanism of insulin action: Post-binding events in insulin actionPost-receptor agents mimicking insulin.Effect of vanadium <I>in vivo</I> and <I>in vitro</I>.Role of protein tyrosine kinases and protein phosphotyrosine phosphatases in insulin effects.Inhibitors of tyrosine kinases.Chemical modifications of peptides and protein drugs.Novel technologies to prolong life time of peptide and protein drugs.
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Prof. Yosef Shaul
The molecular basis of virus-host cell interaction. How HBV modifies cell behavior.Collaboration with: Charles Rice the Rockefeller universityproteasomes as a target in cancer therapyproteasome composition, dynamics, function and regulation and various conditions.proteasomal degradation of intrinsically disordered proteins (IUP or IDP). the concept of degradation by default
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Prof. Michal Sharon
Studying large protein complexes involved in the protein degradation pathway using a novel mass spectrometry approach.Developing novel methodological approaches for structural mass spectrometryStructure-function relationship of the signalosome complexInvestigation of the 20S ubiquitin-independent degradation pathway
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Prof. Abraham Shanzer
Supramolecular chemistryBiomimetic ion binders, diagnostic tools in imaging technologies (fluorescent probes) and potential therapeutic agents. Synthesis, using classical and combinatorial chemistry methods and evaluation.Synthesis and properties of molecular based devices; molecular sensors, switches and logical gates for application in nanotechnology.Surface bound functional assemblies.
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