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Prof. Avri Ben-Ze'ev
Epithelial-mesenchymal transition (EMT), cancer stem cells (CSCs) and Wnt target genes in colon cancer metastasisMechanisms regulating L1CAM-mediated colon cancer invasion and metastasisThe interplay between the role of beta-catenin in cell adhesion and signaling during colon cancer development.The molecular basis and signaling roles of nerve cell adhesion receptors in colon cancer metastasisThe role of novel beta-catenin target genes in tumor development and metastasis
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Dr. Haim Beidenkopf
Topological electronic phasesWeyl/Dirac topological semimetalsStrong/Weak/Crystalline/Higher-order topological insulatorsTopological superconductivity and Majorana modesTopological nano-devicesScanning tunneling microscopy and spectroscopyMolecular beam epitaxy
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Prof. Ed Bayer
Structural and functional aspects of the multi-enzyme cellulosome complex from cellulose-degrading bacteria.Collaboration with: Raphael Lamed, Tel Aviv University Yuval Shoham, Technion, Haifa Itzhak Mizrahi, Ben-Gurion University, Beer Sheva Oded Livnah, Hebrew University of Jerusalem Yitzhak Hadar, Hebrew University of Jerusalem Shi-You Ding, Michigan State University Nicole Koropatkin and Eric Martens, University of Michigan Rafael Bernardi, Auburn University Hermann Gaub, Ludwig Maximilian University Don C. Lamb, Ludwig Maximilian University Bryan White, University of Illinois Klaus Schulten, University of Illinois Bernard Henrissat, Marseille Mirjam Czjzek, Rostok, France Yingang Feng, Ya-Jun Liu and Qiu Cui, Qingdao, China Yannick Bomble, Martin Keller and Michael Himmel, NREL, Golden CO Victor De Lorenzo, Madrid Mariano Carrión-Vázquez, Spanish National Research Council Carlos Fonts, University of Lisbon Marek Cieplak, Polish Academy of Sciences Damien Thompson, University of Limerick Henri-Pierre Fierobe, CNRS, Marseille Harry Flint, University of Aberdeen Harry Gilbert, Newcastle University Gideon Davies, York University Dimitris Hatzinikolaou, University of AthensThe cohesin-dockerin couple - Protein-protein interactions that mediate recognition and specificity in cellulosome assembly.Cellulose-binding domains as models for protein-sugar interactions.Bioinformatics of cellulases and cellulosome componentsComparative genomics of cellulosome components.Structure determination of cellulosome components.Enzymology of cellulosomes for conversion of biomass to biofuelsDesigner cellulosomes - Selective engineering of chimaeric cellulosome constructs for nanotechnology.Avidin-biotin system - Mutated avidins and streptavidins
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Dr. Avraham Roi
The lab of host-pathogen genomics is interested in how individual encounters between host and pathogenic bacteria can ultimately define the outcome of infection. This is achieved by applying cross-disciplinary single-cell analysis platforms that collectively enable us to extensively profile and precisely monitor host-pathogen interactions within the context of in vivo infections.The work in the lab centers on salmonella infection of mouse macrophages as a tractable in vitro host-pathogen system. We use this model to develop state of the art high throughput genomic tools and interdisciplinary approaches, and then apply them to various in vivo infection models to address critical biological aspects of host-pathogen biology.Using comprehensive, quantitative, unbiased tools to analyse the molecular interactions that underlie distinct host-pathogen subpopulations and their impact on disease outcome.Using a powerful combination of cutting-edge single cell genetic and genomic approaches, we wish to address what forms the basis for successful immune clearance, from the level of individual infected cells to that of the whole organism, and why, in some cases, sterilization is incomplete?
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