Piezo2 in sensory neurons regulates systemic and adipose tissue metabolism , Passini F. S., Bornstein B., Rubin S., Kuperman Y., Krief S., Masschelein E., Mehlman T., Brandis A., Addadi Y., Shalom S. H. O., Richter E. A., Yardeni T., Tirosh A., De Bock K. & Zelzer E., 4, Cell Metabolism, 987-1000.e6, 37, 2025, https://doi.org/10.1016/j.cmet.2024.12.016
S100A8/S100A9 impairs energy expenditure and whole body metabolism , Neumann A., Efimova I., Shteinberg I., Tron R., Gaskin A., Erez N., Ben-Shlomo S., Levy N. A., Shteingard Y., Vogl T., Roth J., Kuperman Y., Zvibel I., Varol C. & Fishman S., 2, American Journal of Physiology - Endocrinology and Metabolism, E341-E354, 329, 2025, https://doi.org/10.1152/ajpendo.00076.2025
Mild chronic stress promotes female fertility via the ovarian CRF receptor , Gershon E., Issler O., Schroeder M., Kuperman Y., Nevo N., Lazar S., Elbaz M., Dekel N. & Chen A., , Cell Communication and Signaling, , 23, 2025, https://doi.org/10.1186/s12964-025-02371-0
Targeting CD38 immunometabolic checkpoint improves metabolic fitness and cognition in a mouse model of Alzheimers disease , Peralta Ramos J. M., Castellani G., Kviatcovsky D., Croese T., Tsitsou-Kampeli A., Burgaletto C., Abellanas M. A., Cahalon L., Phoebeluc Colaiuta S., Salame T. M., Kuperman Y., Savidor A., Itkin M., Malitsky S., Ovadia S., Ferrera S., Kalfon L., Kadmani S., Samra N., Paz R., Rokach L., Furlan R., Aharon-Peretz J., Falik-Zaccai T. C. & Schwartz M., , Nature Communications, , 16, 2025, https://doi.org/10.1038/s41467-025-58494-y
Urine Metabolomic Profiling and Machine Learning in Autism Spectrum Disorder Diagnosis: Toward Precision Treatment , Shazman S., Carmel J., Itkin M., Malitsky S., Shalan M., Soreq E., Elliott E., Lebow M. & Kuperman Y., 5, Metabolites, , 15, 2025, https://doi.org/10.3390/metabo15050332
Disruption of the developmental factor Otp in the adult forebrain reveals its diverse physiological functions , Tahor M., Kuperman Y., Nahum T., Tsoory M., Bejar B., Regev E., Blechman J., Biran J., Chen A. & Levkowitz G., , BioRxiv, , , 2025, https://doi.org/10.1101/2025.09.09.675064
Lowering mutant huntingtin by small molecules relieves Huntingtons disease symptoms and progression , Bahat A., Itzhaki E., Weiss B., Tolmasov M., Tsoory M., Kuperman Y., Brandis A., Shurrush K. A. & Dikstein R., 3, EMBO Molecular Medicine, 523-546, 16, 2024, https://doi.org/10.1038/s44321-023-00020-y
Prenatal-induced psychopathologies: All roads lead to microglia , Lebow M., Kuperman Y. & Chen A., , , 199-214, 5, 2023, https://doi.org/10.1016/B978-0-12-817558-3.00016-0
Store-operated Ca2+ entry regulatory factor alters murine metabolic state in an age-dependent manner via hypothalamic pathways , Gataulin D., Kuperman Y., Tsoory M., Biton I. E., Nataniel T., Palty R., Karbat I., Meshcheriakova A. & Reuveny E., 3, PNAS Nexus, , 2, 2023, https://doi.org/10.1093/pnasnexus/pgad068
Gut microbiota modulates weight gain in mice after discontinued smoke exposure , Fluhr L., Mor U., Kolodziejczyk A. A., Dori-Bachash M., Leshem A., Itav S., Cohen Y., Suez J., Zmora N., Moresi C., Ayalon N., Valdés-Mas R., Molina S., Hornstein S., Karbi H., Kviatcovsky D., Livne A., Bukimer A., Eliyahu-Miller S., Metz A., Brandis A., Mehlman T., Kuperman Y., Tsoory M., Stettner N., Harmelin A., Shapiro H. & Elinav E., 7890, Nature, 713-719+, 600, 2021, https://doi.org/10.1038/s41586-021-04194-8
Stress-related emotional and behavioural impact following the first COVID-19 outbreak peak , Benjamin A., Kuperman Y., Eren N., Rotkopf R., Amitai M., Rossman H., Shilo S., Meir T., Keshet A., Nuttman-Shwartz O., Segal E. & Chen A., 11, Molecular Psychiatry, 6149-6158, 26, 2021, https://doi.org/10.1038/s41380-021-01219-6
Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation , Goldfarb Y., Givony T., Dobeš J., Kadouri N., Zalayat I., Peligero-Cruz C., Damari G., Dassa B., Ben-Dor S., Gruper Y., Oftedal B. E., Bratland E., Erichsen M. M., Berger A., Avin A., Nevo S., Haljasorg U., Kuperman Y., Ulman A., Porat Z., Haffner-Krausz R., Atasoy U., Leshkowitz D., Husebye E. S. & Abramson J., 11, Journal of Experimental Medicine, , 218, 2021, https://doi.org/10.1084/jem.20201076
Clock proteins and training modify exercise capacity in a daytime-dependent manner , Adamovich Y., Dandavate V., Ezagouri S., Manella G., Zwighaft Z., Sobel J., Kuperman Y., Golik M., Auerbach A., Itkin M., Malitsky S. & Asher G., 35, Proceedings of the National Academy of Sciences - PNAS, , 118, 2021, https://doi.org/10.1073/pnas.2101115118
Targeting purine synthesis in ASS1-expressing tumors enhances the response to immune checkpoint inhibitors , Keshet R., Lee J. S., Adler L., Iraqi M., Ariav Y., Lim L. Q. J., Lerner S., Rabinovich S., Oren R., Katzir R., Tishler H. W., Stettner N., Goldman O., Landesman H., Galai S., Kuperman Y., Kuznetsov Y., Brandis A., Mehlman T., Malitsky S., Itkin M., Koehler S. E., Zhao Y., Talsania K., Shen T., Peled N., Ulitsky I., Porgador A., Ruppin E. & Erez A., 9, Nature Cancer, 894-908, 1, 2020, https://doi.org/10.1038/s43018-020-0106-7
Diet Diurnally Regulates Small Intestinal Microbiome-Epithelial-Immune Homeostasis and Enteritis , Tuganbaev T., Mor U., Bashiardes S., Liwinski T., Nobs S. P., Leshem A., Dori-Bachash M., Thaiss C. A., Pinker E. Y., Ratiner K., Adlung L., Federici S., Kleimeyer C., Moresi C., Yamada T., Cohen Y., Zhang X., Massalha H., Massasa E., Koni P. A., Kuperman Y., Harmelin A., Gao N., Itzkovitz S., Honda K., Shapiro H. & Elinav E., 6, Cell, 1441-1459.e21, 182, 2020, https://doi.org/10.1016/j.cell.2020.08.027
Oxygen and Carbon Dioxide Rhythms Are Circadian Clock Controlled and Differentially Directed by Behavioral Signals , Adamovich Y., Ladeuix B., Sobel J., Manella G., Neufeld-Cohen A., Assadi M. H., Golik M., Kuperman Y., Tarasiuk A., Koeners M. P. & Asher G., 5, Cell Metabolism, 1092-1103.e3, 29, 2019, https://doi.org/10.1016/j.cmet.2019.01.007
Potential roles of gut microbiome and metabolites in modulating ALS in mice , Blacher E., Bashiardes S., Shapiro H., Rothschild D., Mor U., Dori-Bachash M., Kleimeyer C., Moresi C., Harnik Y., Zur M., Zabari M., Brik R. B., Kviatcovsky D., Zmora N., Cohen Y., Bar N., Levi I., Amar N., Mehlman T., Brandis A., Biton I., Kuperman Y., Tsoory M., Alfahel L., Harmelin A., Schwartz M., Israelson A., Arike L., Johansson M. E. V., Hansson G. C., Gotkine M., Segal E. & Elinav E., 7770, Nature, 474-480, 572, 2019, https://doi.org/10.1038/s41586-019-1443-5
GIP regulates inflammation and body weight by restraining myeloid-cell-derived S100A8/A9 , Mantelmacher F. D., Zvibel I., Cohen K., Epshtein A., Pasmanik-Chor M., Vogl T., Kuperman Y., Weiss S., Drucker D. J., Varol C. & Fishman S., 1, Nature metabolism, 58-69, 1, 2019, https://doi.org/10.1038/s42255-018-0001-z
A Mitochondrial VDAC1-Based Peptide Greatly Suppresses Steatosis and NASH-Associated Pathologies in a Mouse Model , Pittala S., Krelin Y., Kuperman Y. & Shoshan-Barmatz V., 10, Molecular Therapy, 1848-1862, 27, 2019, https://doi.org/10.1016/j.ymthe.2019.06.017
Protein tyrosine phosphatase alpha inhibits hypothalamic leptin receptor signaling and regulates body weight in vivo , Cohen-Sharir Y., Kuperman Y., Apelblat D., den Hertog J., Spiegel I., Knobler H. & Elson A., 4, FASEB Journal, 5101-5111, 33, 2019, https://doi.org/10.1096/fj.201800860RR
ASL Metabolically Regulates Tyrosine Hydroxylase in the Nucleus Locus Coeruleus , Lerner S., Eilam R., Kuperman Y., Tsoory M., Brandis A., Segal M., Chen A. & Erez A., 8, Cell Reports, 2144-2153.e7, 29, 2019, https://doi.org/10.1016/j.celrep.2019.10.043
Exposure to air pollution interacts with obesogenic nutrition to induce tissue-specific response patterns , Pardo M., Kuperman Y., Levin L., Rudich A., Haim Y., Schauer J. J., Chen A. & Rudich Y., , Environmental Pollution, 532-543, 239, 2018, https://doi.org/10.1016/j.envpol.2018.04.048
Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress , Ramot A., Jiang Z., Tian J., Nahum T., Kuperman Y., Justice N. & Chen A., 3, Nature Neuroscience, 385-388, 20, 2017, https://doi.org/10.1038/nn.4491
Brown-adipose-tissue macrophages control tissue innervation and homeostatic energy expenditure , Wolf Y., Boura-Halfon S., Cortese N., Haimon Z., Shalom H. S., Kuperman Y., Kalchenko V., Brandis A., David E., Segal-Hayoun Y., Chappell-Maor L., Yaron A. & Jung S., 6, Nature Immunology, 665-674, 18, 2017, https://doi.org/10.1038/ni.3746
Loss of forebrain MTCH2 decreases mitochondria motility and calcium handling and impairs hippocampal-dependent cognitive functions , Ruggiero A., Aloni E., Korkotian E., Zaltsman Y., Oni-Biton E., Kuperman Y., Tsoory M., Shachnai L., Levin-Zaidman S., Brenner O., Segal M. & Gross A., , Scientific Reports, , 7, 2017, https://doi.org/10.1038/srep44401
High-fat diet exacerbates cognitive rigidity and social deficiency in the BTBR mouse model of autism , Zilkha N., Kuperman Y. & Kimchi T., , Neuroscience, 142-154, 345, 2017, https://doi.org/10.1016/j.neuroscience.2016.01.070
Persistent microbiome alterations modulate the rate of post-dieting weight regain , Thaiss C. A., Itav S., Rothschild D., Meijer M. T., Levy M., Moresi C., Dohnalová L., Braverman S., Rozin S., Malitsky S., Dori-Bachash M., Kuperman Y., Biton I., Gertler A., Harmelin A., Shapiro H., Halpern Z., Aharoni A., Segal E. & Elinav E., 7634, Nature, 544-551, 540, 2016, https://doi.org/10.1038/nature20796
Loss of Muscle MTCH2 Increases Whole-Body Energy Utilization and Protects from Diet-Induced Obesity , Buzaglo-Azriel L., Kuperman Y., Tsoory M., Zaltsman Y., Shachnai L., Levin-Zaidman S., Bassat E., Michailovici I., Sarver A., Tzahor E., Haran M., Vernochet C. & Gross A., 7, Cell Reports, 1602-1610, 14, 2016, https://doi.org/10.1016/j.celrep.2016.01.046
Circadian control of oscillations in mitochondrial rate-limiting enzymes and nutrient utilization by PERIOD proteins , Neufeld - Cohen A., Robles M., Aviram R., Manella G., Adamovich Y., Ladeuix B., Nir D., Rousso Noori N. L., Kuperman Y., Golik M., Mann M. & Asher G., 12, Proceedings of the National Academy of Sciences of the United States of America, E1673-E1682, 113, 2016, https://doi.org/10.1073/pnas.1519650113
CRFR1 in AgRP Neurons Modulates Sympathetic Nervous System Activity to Adapt to Cold Stress and Fasting , Kuperman Y., Weiss M., Dine J., Staikin K., Golani O., Ramot A., Nahum T., Kuhne C., Shemesh Y., Wurst W., Harmelin A., Deussing J. M., Eder M. & Chen A., 6, Cell Metabolism, 1185-1199, 23, 2016, https://doi.org/10.1016/j.cmet.2016.04.017
Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics , Shemesh Y., Forkosh O., Mahn M., Anpilov S., Sztainberg Y., Manashirov S., Shlapobersky T., Elliott E., Tabouy L., Ezra G., Adler E. S., Ben-Efraim Y. J., Gil S., Kuperman Y., Haramati S., Dine J., Deussing J. M., Eder M., Schneidman E., Yizhar O. & Chen A., 11, Nature Neuroscience, 1489-1496, 19, 2016, https://doi.org/10.1038/nn.4346
Artificial Sweeteners Induce Glucose Intolerance by Altering the Gut Microbiota: Editorial comment , Suez J., Korem T., Zeevi D., Zilberman-Schapira G., Thaiss C. A., Maza O., Israeli D., Zmora N., Gilad S., Weinberger A., Kuperman Y., Harmelin A., Kolodkin-Gal I., Shapiro H., Halpern Z., Segal E. & Elinav E., 1, Obstetrical & Gynecological Survey, 31-32, 70, 2015, https://doi.org/10.1097/01.ogx.0000460711.58331.94
Increased anxiety in corticotropin-releasing factor type 2 receptor-null mice requires recent acute stress exposure and is associated with dysregulated serotonergic activity in limbic brain areas , Issler O., Carter R. N., Paul E. D., Kelly P. A., Olverman H. J., Neufeld-Cohen A., Kuperman Y., Lowry C. A., Seckl J. R., Chen A. & Jamieson P. M., 1, Biology of Mood and Anxiety Disorders, , 4, 2014, https://doi.org/10.1186/2045-5380-4-1
Artificial sweeteners induce glucose intolerance by altering the gut microbiota , Suez J., Korem T., Zeevi D., Zilberman-Schapira G., Thaiss C. A., Maza O., Israeli D., Zmora N., Gilad S., Weinberger A., Kuperman Y., Harmelin A., Kolodkin-Gal I., Shapiro H., Halpern Z., Segal E. & Elinav E., 7521, Nature, 181-186, 514, 2014, https://doi.org/10.1038/nature13793
Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis , Thaiss C. A., Zeevi D., Levy M., Zilberman-Schapira G., Suez J., Tengeler A. C., Abramson L., Katz M. N., Korem T., Zmora N., Kuperman Y., Biton I., Gilad S., Harmelin A., Shapiro H., Halpern Z., Segal E. & Elinav E., 3, Cell, 514-529, 159, 2014, https://doi.org/10.1016/j.cell.2014.09.048
Hypothalamic neuronal toll-like receptor 2 protects against age-induced obesity , Shechter R., London A., Kuperman Y., Ronen A., Rolls A., Chen A. & Schwartz M., , Scientific Reports, , 3, 2013, https://doi.org/10.1038/srep01254
Adipose tissue foam cells are present in human obesity , Shapiro H., Pecht T., Shaco-Levy R., Harman-Boehm I., Kirshtein B., Kuperman Y., Chen A., Blüher M., Shai I. & Rudich A., 3, Journal Of Clinical Endocrinology & Metabolism, 1173-1181, 98, 2013, https://doi.org/10.1210/jc.2012-2745
Ablation of very long acyl chain sphingolipids causes hepatic insulin resistance in mice due to altered detergent-resistant membranes , Park J. W., Park W. J., Kuperman Y., Boura-Halfon S., Pewzner-Jung Y. & Futerman A. H., 2, Hepatology, 525-532, 57, 2013, https://doi.org/10.1002/hep.26015
Postnatal ablation of POMC neurons induces an obese phenotype characterized by decreased food intake and enhanced anxiety-like behavior , Greenman Y., Kuperman Y., Drori Y., Asa S. L., Navon I., Forkosh O., Gil S., Stern N. & Chen A., 7, Molecular Endocrinology, 1091-1102, 27, 2013, https://doi.org/10.1210/me.2012-1344
Susceptibility to PTSD-like behavior is mediated by corticotropin-releasing factor receptor type 2 levels in the bed nucleus of the stria terminalis , Lebow M., Neufeld - Cohen -. C. A., Kuperman Y., Tsoory M., Gil S. & Chen A., 20, Journal of Neuroscience, 6906-6916, 32, 2012, https://doi.org/10.1523/JNEUROSCI.4012-11.2012
Chronic activation of corticotropin-releasing factor type 2 receptors reveals a key role for 5-HT1A receptor responsiveness in mediating behavioral and serotonergic responses to stressful challenge , Neufeld-Cohen A., Kelly P. A., Paul E. D., Carter R. N., Skinner E., Olverman H. J., Vaughan J. M., Issler O., Kuperman Y., Lowry C. A., Vale W. W., Seckl J. R., Chen A. & Jamieson P. M., 6, Biological Psychiatry, 437-447, 72, 2012, https://doi.org/10.1016/j.biopsych.2012.05.005
An anxiolytic role for CRF receptor type 1 in the globus pallidus , Sztainberg Y., Kuperman Y., Justice N. & Chen A., 48, Journal of Neuroscience, 17416-17424, 31, 2011, https://doi.org/10.1523/JNEUROSCI.3087-11.2011
Urocortin 3 transgenic mice exhibit a metabolically favourable phenotype resisting obesity and hyperglycaemia on a high-fat diet , Jamieson P. M., Cleasby M. E., Kuperman Y., Morton N. M., Kelly P. A. T., Brownstein D. G., Mustard K. J., Vaughan J. M., Carter R. N., Hahn C. N., Hardie D. G., Seckl J. R., Chen A. & Vale W. W., 9, Diabetologia, 2392-2403, 54, 2011, https://doi.org/10.1007/s00125-011-2205-6
Protein tyrosine phosphatase epsilon affects body weight by downregulating leptin signaling in a phosphorylation-dependent manner , Rousso Noori N. L., Knobler H., Levy-Apter E., Kuperman Y., Neufeld - Cohen -. C. A., Keshet Y., Akepati V. R., Klinghoffer R. A., Chen A. & Elson A., 5, Cell Metabolism, 562-572, 13, 2011, https://doi.org/10.1016/j.cmet.2011.02.017
Prolonged and site-specific over-expression of corticotropin-releasing factor reveals differential roles for extended amygdala nuclei in emotional regulation , Regev L., Neufeld - Cohen -. C. A., Tsoory M., Kuperman Y., Getselter D., Gil S. & Chen A., 7, Molecular Psychiatry, 714-728, 16, 2011, https://doi.org/10.1038/mp.2010.64
Expression and regulation of corticotropin-releasing factor receptor type 2β in developing and mature mouse skeletal muscle , Kuperman Y., Issler O., Vaughan J., Bilezikjian L., Vale W. & Chen A., 1, Molecular Endocrinology, 157-169, 25, 2011, https://doi.org/10.1210/me.2010-0308
Perifornical urocortin-3 mediates the link between stress-induced anxiety and energy homeostasis , Kuperman Y., Issler O., Regev L., Musseri I., Navon I., Neufeld - Cohen -. C. A., Gil S. & Chen A., 18, Proceedings of the National Academy of Sciences of the United States of America, 8393-8398, 107, 2010, https://doi.org/10.1073/pnas.1003969107
A novel corticotropin-releasing factor receptor splice variant exhibits dominant negative activity: A putative link to stress-induced heart disease , Sztainberg Y., Kuperman Y., Issler O., Gil S., Vaughan J., Rivier J., Vale W. & Chen A., 7, FASEB Journal, 2186-2196, 23, 2009, https://doi.org/10.1096/fj.08-128066
Urocortins: emerging metabolic and energy homeostasis perspectives , Kuperman Y. & Chen A., 4, Trends in Endocrinology and Metabolism, 122-129, 19, 2008, https://doi.org/10.1016/j.tem.2007.12.002
Urocortin 2 modulates glucose utilization and insulin sensitivity in skeletal muscle , Chen A., Brar B., Choi C. S., Rousso D., Vaughan J., Kuperman Y., Kim S. N., Donaldson C., Smith S. M., Jamieson P., Li C., Nagy T. R., Shulman G. I., Lee K. & Vale W., 44, Proceedings of the National Academy of Sciences of the United States of America, 16580-16585, 103, 2006, https://doi.org/10.1073/pnas.0607337103