In Vivo Optical Imaging Publications

Selected Publications

• Shulman Z, Cohen SJ, Roediger B, Kalchenko V, Jain R, Grabovsky V, Klein E, Shinder V, Stoler-Barak L, Feigelson SW, Meshel T, Nurmi SM, Goldstein I, Hartley O, Gahmberg CG, Etzioni A, Weninger W, Ben-Baruch A, Alon R.
  Transendothelial migration of lymphocytes mediated by intraendothelial vesicle stores rather than by extracellular chemokine depots.
  Nat Immunol. 2011 Dec 4;13(1):67-76. PMID: 22138716
• Sapoznikov A, Pewzner-Jung Y, Kalchenko V, Krauthgamer R, Shachar I, Jung S.
  Perivascular clusters of dendritic cells provide critical survival signals to B cells in bone marrow niches.
  Nat Immunol. 2008 Apr;9(4):388-95. PMID: 18311142
• Cohen B, Ziv K, Plaks V, Israely T, Kalchenko V, Harmelin A, Benjamin LE, Neeman M.
  MRI detection of transcriptional regulation of gene expression in transgenic mice.
  Nat Med. 2007 Apr;13(4):498-503. PMID: 17351627
• Varol C, Landsman L, Fogg DK, Greenshtein L, Gildor B, Margalit R, Kalchenko V, Geissmann F, Jung S.
  Monocytes give rise to mucosal, but not splenic, conventional dendritic cells.
  J Exp Med. 2007 Jan 22;204(1):171-80. PMID: 17190836
• Kalchenko V, Shivtiel S, Malina V, Lapid K, Haramati S, Lapidot T, Brill A, Harmelin A.
  Use of lipophilic near-infrared dye in whole-body optical imaging of hematopoietic cell homing.
  J Biomed Opt. 2006 Sep-Oct;11(5):050507. PMID: 17092148
• Dadiani M, Kalchenko V, Yosepovich A, Margalit R, Hassid Y, Degani H, Seger D.
  Real-time imaging of lymphogenic metastasis in orthotopic human breast cancer.
  Cancer Res. 2006 Aug 15;66(16):8037-41. PMID: 16912179
• Kalchenko V, Israeli D, Kuznetsov Y, Meglinski I, Harmelin A.
  A simple approach for non-invasive transcranial optical vascular imaging (nTOVI).
  J Biophotonics. 2015 Nov;8(11-12):897-901. PMID: 25924020
• Kalchenko V, Israeli D, Kuznetsov Y, Harmelin A.
  Transcranial optical vascular imaging (TOVI) of cortical hemodynamics in mouse brain.
  Sci Rep. 2014 Jul 25;4:5839. PMID: 25059112

All Publications

2017

• Maronpot RR, Nyska A, Troth SP, Gabrielson K, Sysa-Shah P, Kalchenko V, Kuznetsov Y, Harmelin A, Schiffenbauer YS, Bonnel D, Stauber J, Ramot Y.
  Regulatory Forum Opinion Piece*: Imaging Applications in Toxicologic Pathology-Recommendations for Use in Regulated Nonclinical Toxicity Studies.
  Toxicol Pathol. 2017 Jun;45(4):444-471. PMID: 28641506
• Wolf Y, Boura-Halfon S, Cortese N, Haimon Z, Sar Shalom H, Kuperman Y, Kalchenko V, Brandis A, David E, Segal-Hayoun Y, Chappell-Maor L, Yaron A, Jung S.
  Brown-adipose-tissue macrophages control tissue innervation and homeostatic energy expenditure.
  Nat Immunol. 2017 Jun;18(6):665-674. PMID: 28459435
• Goldschmidt R, Kalchenko V, Scherz A.
  Real time laser speckle imaging monitoring vascular targeted photodynamic therapy
  Proceedings Volume 10047, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI; 100470M (2017); doi: 10.1117/12.2251971
  SPIE BiOS, 2017

2016

• Tsytsarev V, Pumbo E, Tang Q, Chen CW, Kalchenko V, Chen Y.
  Study of the cortical representation of whisker frequency selectivity using voltage-sensitive dye optical imaging.
  Intravital. 2016 Feb 18;5(1):e1142637. PMID: 28243518
• Marom A, Barak AF, Kramer MP, Lewinsky H, Binsky-Ehrenreich I, Cohen S, Tsitsou-Kampeli A, Kalchenko V, Kuznetsov Y, Mirkin V, Dezorella N, Shapiro M, Schwartzberg PL, Cohen Y, Shvidel L, Haran M, Becker-Herman S, Herishanu Y, Shachar I.
  CD84 mediates CLL-microenvironment interactions.
  Oncogene. 2017 Feb 2;36(5):628-638. PMID: 27452524
• Benhar I, Reemst K, Kalchenko V, Schwartz M.
  The retinal pigment epithelium as a gateway for monocyte trafficking into the eye.
  EMBO J. 2016 Jun 1;35(11):1219-35. PMID: 27107049
• Przygodzki T, Talar M, Blazejczyk A, Kalchenko V, Watala C.
  Quantification of the Blood Platelet Reactivity in the ADP-Induced Model of Non-Lethal Pulmonary Thromboembolism in Mice with the Use of Laser Doppler Flowmetry.
  PLoS One. 2016 Jan 11;11(1):e0146346. PMID: 26751810
• Rosenne S, Grinvald E, Shirman E, Neeman L, Dutta S, Bar-Elli O, Ben-Zvi R, Oksenberg E, Milko P, Kalchenko V, Weissman H, Oron D, Rybtchinski B.
  Self-Assembled Organic Nanocrystals with Strong Nonlinear Optical Response.
  Nano Lett. 2015 Nov 11;15(11):7232-7. PMID: 26447786

2015

• Kalchenko V, Israeli D, Kuznetsov Y, Meglinski I, Harmelin A.
  A simple approach for non-invasive transcranial optical vascular imaging (nTOVI).
  J Biophotonics. 2015 Nov;8(11-12):897-901. PMID: 25924020
• Bochner F, Fellus-Alyagor L, Kalchenko V, Shinar S, Neeman M.
  A Novel Intravital Imaging Window for Longitudinal Microscopy of the Mouse Ovary.
  Sci Rep. 2015 Jul 24;5:12446. PMID: 26207832

2014

• Kalchenko V, Kuznetsov Y, Preise D, Meglinski I, Harmelin A.
  Ear swelling test by using laser speckle imaging with a long exposure time.
  J Biomed Opt. 2014 Jun;19(6):060502. PMID: 24967913
• Kalchenko V, Israeli D, Kuznetsov Y, Harmelin A.
  Transcranial optical vascular imaging (TOVI) of cortical hemodynamics in mouse brain.
  Sci Rep. 2014 Jul 25;4:5839. PMID: 25059112

2013

• Milo I, Sapoznikov A, Kalchenko V, Tal O, Krauthgamer R, van Rooijen N, Dudziak D, Jung S, Shakhar G.
  Dynamic imaging reveals promiscuous crosspresentation of blood-borne antigens to naive CD8+ T cells in the bone marrow.
  Blood. 2013 Jul 11;122(2):193-208. PMID: 23637125
• Shechter R, Miller O, Yovel G, Rosenzweig N, London A, Ruckh J, Kim KW, Klein E, Kalchenko V, Bendel P, Lira SA, Jung S, Schwartz M.
  Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus.
  Immunity. 2013 Mar 21;38(3):555-69. PMID: 23477737

2012

• Kalchenko V, Kuznetsov Y, Meglinski I, Harmelin A.
  Label free in vivo laser speckle imaging of blood and lymph vessels.
  J Biomed Opt. 2012 May;17(5):050502. PMID: 22612117
• Marcovich AL, Brandis A, Daphna O, Feine I, Pinkas I, Goldschmidt R, Kalchenko V, Berkutzki T, Wagner HD, Salomon Y, Scherz A.
  Stiffening of rabbit corneas by the bacteriochlorophyll derivative WST11 using near infrared light.
  Invest Ophthalmol Vis Sci. 2012 Sep 19;53(10):6378-88. PMID: 22871842
• Avni R, Raz T, Biton IE, Kalchenko V, Garbow JR, Neeman M.
  Unique in utero identification of fetuses in multifetal mouse pregnancies by placental bidirectional arterial spin labeling MRI.
  Magn Reson Med. 2012 Aug;68(2):560-70. PMID: 22162003

2011

• Shulman Z, Cohen SJ, Roediger B, Kalchenko V, Jain R, Grabovsky V, Klein E, Shinder V, Stoler-Barak L, Feigelson SW, Meshel T, Nurmi SM, Goldstein I, Hartley O, Gahmberg CG, Etzioni A, Weninger W, Ben-Baruch A, Alon R.
  Transendothelial migration of lymphocytes mediated by intraendothelial vesicle stores rather than by extracellular chemokine depots.
  Nat Immunol. 2011 Dec 4;13(1):67-76. PMID: 22138716
• Shivtiel S, Lapid K, Kalchenko V, Avigdor A, Goichberg P, Kalinkovich A, Nagler A, Kollet O, Lapidot T.
  CD45 regulates homing and engraftment of immature normal and leukemic human cells in transplanted immunodeficient mice.
  Exp Hematol. 2011 Dec;39(12):1161-1170.e1. PMID: 21911094
• Kalchenko V, Madar-Balakirski N, Meglinski I, Harmelin A.
  In vivo characterization of tumor and tumor vascular network using multi-modal imaging approach.
  J Biophotonics. 2011 Sep;4(9):645-9. PMID: 21714099
• London A, Itskovich E, Benhar I, Kalchenko V, Mack M, Jung S, Schwartz M.
  Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages.
  J Exp Med. 2011 Jan 17;208(1):23-39. PMID: 21220455
• Yivgi-Ohana N, Eifer M, Addadi Y, Neeman M, Gross A.
  Utilizing mitochondrial events as biomarkers for imaging apoptosis.
  Cell Death Dis. 2011 Jun 2;2:e166. PMID: 21633389
• Volovitz I, Marmor Y, Azulay M, Machlenkin A, Goldberger O, Mor F, Slavin S, Ram Z, Cohen IR, Eisenbach L.
  Split immunity: immune inhibition of rat gliomas by subcutaneous exposure to unmodified live tumor cells.
  J Immunol. 2011 Nov 15;187(10):5452-62. PMID: 21998458
• Marcus A, Waks T, Eshhar Z.
  Redirected tumor-specific allogeneic T cells for universal treatment of cancer.
  Blood. 2011 Jul 28;118(4):975-83. PMID: 21653325
• Kuznetsov YL, Kalchenko V, Meglinski I.
  Multimodal imaging of vascular network and blood microcirculation by optical diagnostic techniques.
  Quantum Electronics. 2011;41(4):308–313.
• Kalchenko V, Neeman M, Harmelin A.
  Whole-Body Imaging of Hematopoietic and Cancer Cells Using Near-Infrared Probes.
  In A.P. Demchenko (ed.). Advanced Fluorescence Reporters in Chemistry and Biology III: Applications in Sensing and Imaging.
  SS FLUOR, 2011 volume 113: 329-46.
• Appel E, Rabinkov A, Neeman M, Kohen F, Mirelman D.
  Conjugates of daidzein-alliinase as a targeted pro-drug enzyme system against ovarian carcinoma.
  J Drug Target. 2011 Jun;19(5):326-35. PMID: 20678009

2010

• Tei L, Mazooz G, Shellef Y, Avni R, Vandoorne K, Barge A, Kalchenko V, Dewhirst MW, Chaabane L, Miragoli L, Longo D, Neeman M, Aime S.
  Novel MRI and fluorescent probes responsive to the Factor XIII transglutaminase activity.
  Contrast Media Mol Imaging. 2010 Jul-Aug;5(4):213-22. PMID: 20812289
• Tzuman YC, Sapoznik S, Granot D, Nevo N, Neeman M.
  Peritoneal adhesion and angiogenesis in ovarian carcinoma are inversely regulated by hyaluronan: the role of gonadotropins.
  Neoplasia. 2010 Jan;12(1):51-60. PMID: 20072653
• Russek-Blum N, Nabel-Rosen H, Levkowitz G.
  Two-photon-based photoactivation in live zebrafish embryos.
  J Vis Exp. 2010 Dec 24;(46). pii: 1902. PMID: 21206475
• Ophir E, Eidelstein Y, Afik R, Bachar-Lustig E, Reisner Y.
  Induction of tolerance to bone marrow allografts by donor-derived host nonreactive ex vivo-induced central memory CD8 T cells.
  Blood. 2010 Mar 11;115(10):2095-104. PMID: 20042725
• Madar-Balakirski N, Tempel-Brami C, Kalchenko V, Brenner O, Varon D, Scherz A, Salomon Y.
  Permanent occlusion of feeding arteries and draining veins in solid mouse tumors by vascular targeted photodynamic therapy (VTP) with Tookad.
  PLoS One. 2010 Apr 22;5(4):e10282. PMID: 20421983
• Kalchenko V, Ziv K, Addadi Y, Madar-Balakirski N, Meglinski I, Neeman M, Harmelin A.
  Combined application of dynamic light scattering imaging and fluorescence intravital microscopy in vascular biology.
  Laser Physics Letters. 2010 Aug;7(8):603–6.
• Goldshaid L, Rubinstein E, Brandis A, Segal D, Leshem N, Brenner O, Kalchenko V, Eren D, Yecheskel T, Salitra Y, Salomon Y, Scherz A.
  Novel design principles enable specific targeting of imaging and therapeutic agents to necrotic domains in breast tumors.
  Breast Cancer Res. 2010;12(3):R29. PMID: 20497549
• Addadi Y, Moskovits N, Granot D, Lozano G, Carmi Y, Apte RN, Neeman M, Oren M.
  p53 status in stromal fibroblasts modulates tumor growth in an SDF1-dependent manner.
  Cancer Res. 2010 Dec 1;70(23):9650-8. PMID: 20952507

2009

• Cohen B, Addadi Y, Sapoznik S, Meir G, Kalchenko V, Harmelin A, Ben-Dor S, Neeman M.
  Transcriptional regulation of vascular endothelial growth factor C by oxidative and thermal stress is mediated by lens epithelium-derived growth factor/p75.
  Neoplasia. 2009 Sep;11(9):921-33. PMID: 19724686
• Migalovich HS, Kalchenko V, Nevo N, Meir G, Kohen F, Neeman M.
  Harnessing competing endocytic pathways for overcoming the tumor-blood barrier: magnetic resonance imaging and near-infrared imaging of bifunctional contrast media.
  Cancer Res. 2009 Jul 1;69(13):5610-7. PMID: 19509228
• Preise D, Oren R, Glinert I, Kalchenko V, Jung S, Scherz A, Salomon Y.
  Systemic antitumor protection by vascular-targeted photodynamic therapy involves cellular and humoral immunity.
  Cancer Immunol Immunother. 2009 Jan;58(1):71-84. PMID: 18488222
• Zangi L, Margalit R, Reich-Zeliger S, Bachar-Lustig E, Beilhack A, Negrin R, Reisner Y.
  Direct imaging of immune rejection and memory induction by allogeneic mesenchymal stromal cells.
  Stem Cells. 2009 Nov;27(11):2865-74. PMID: 19750539

2008

• Plaks V, Birnberg T, Berkutzki T, Sela S, BenYashar A, Kalchenko V, Mor G, Keshet E, Dekel N, Neeman M, Jung S.
  Uterine DCs are crucial for decidua formation during embryo implantation in mice.
  J Clin Invest. 2008 Dec;118(12):3954-65. PMID: 19033665
• Nadav L, Kalchenko V, Barak MM, Naparstek E, Geiger B, Katz BZ.
  Tumorigenic potential and disease manifestations of malignant B-cell variants differing in their fibronectin adhesiveness.
  Exp Hematol. 2008 Nov;36(11):1524-34. PMID: 18694619
• Fleshker S, Preise D, Kalchenko V, Scherz A, Salomon Y.
  rompt assessment of WST11-VTP outcome using luciferase transfected tumors enables second treatment and increase in overall therapeutic rate.
  Photochem Photobiol. 2008 Sep-Oct;84(5):1231-7. PMID: 18399928
• Somjen D, Katzburg S, Nevo N, Gayer B, Hodge RP, Renevey MD, Kalchenko V, Meshorer A, Stern N, Kohen F.
  A daidzein-daunomycin conjugate improves the therapeutic response in an animal model of ovarian carcinoma.
  J Steroid Biochem Mol Biol. 2008 May;110(1-2):144-9. PMID: 18482833
• Sapoznikov A, Pewzner-Jung Y, Kalchenko V, Krauthgamer R, Shachar I, Jung S.
  Perivascular clusters of dendritic cells provide critical survival signals to B cells in bone marrow niches.
  Nat Immunol. 2008 Apr;9(4):388-95. PMID: 18311142

2007

• Kalchenko V, Preise D, Bayewitch M, Fine I, Burd K, Harmelin A.
  In vivo dynamic light scattering microscopy of tumour blood vessels.
  J Microsc. 2007 Nov;228(Pt 2):118-22. PMID: 17970911
• Granot D, Addadi Y, Kalchenko V, Harmelin A, Kunz-Schughart LA, Neeman M.
  In vivo imaging of the systemic recruitment of fibroblasts to the angiogenic rim of ovarian carcinoma tumors.
  Cancer Res. 2007 Oct 1;67(19):9180-9. PMID: 17909023
• Kalchenko V, Brill A, Bayewitch M, Fine I, Zharov V, Galanzha E, Tuchin V, Harmelin A.
  In vivo dynamic light scattering imaging of blood coagulation.
  J Biomed Opt. 2007 Sep-Oct;12(5):052002. PMID: 17994888
• Cohen B, Ziv K, Plaks V, Israely T, Kalchenko V, Harmelin A, Benjamin LE, Neeman M.
  MRI detection of transcriptional regulation of gene expression in transgenic mice.
  Nat Med. 2007 Apr;13(4):498-503. PMID: 17351627
• Varol C, Landsman L, Fogg DK, Greenshtein L, Gildor B, Margalit R, Kalchenko V, Geissmann F, Jung S.
  Monocytes give rise to mucosal, but not splenic, conventional dendritic cells.
  J Exp Med. 2007 Jan 22;204(1):171-80. PMID: 17190836

2006

• Kalchenko V, Shivtiel S, Malina V, Lapid K, Haramati S, Lapidot T, Brill A, Harmelin A.
  Use of lipophilic near-infrared dye in whole-body optical imaging of hematopoietic cell homing.
  J Biomed Opt. 2006 Sep-Oct;11(5):050507. PMID: 17092148
• Dadiani M, Kalchenko V, Yosepovich A, Margalit R, Hassid Y, Degani H, Seger D.
  Real-time imaging of lymphogenic metastasis in orthotopic human breast cancer.
  Cancer Res. 2006 Aug 15;66(16):8037-41. PMID: 16912179
• Papo N, Seger D, Makovitzki A, Kalchenko V, Eshhar Z, Degani H, Shai Y.
  Inhibition of tumor growth and elimination of multiple metastases in human prostate and breast xenografts by systemic inoculation of a host defense-like lytic peptide.
  Cancer Res. 2006 May 15;66(10):5371-8. PMID: 16707464
• Plaks V, Kalchenko V, Dekel N, Neeman M.
  MRI analysis of angiogenesis during mouse embryo implantation.
  Magn Reson Med. 2006 May;55(5):1013-22. PMID: 16598729
• Shlomai A, Paran N, Shaul Y.
  PGC-1alpha controls hepatitis B virus through nutritional signals.
  Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):16003-8. PMID: 17043229