Pages
February 01, 2010
-
Date:08MondayApril 2013Lecture
Let the Data Drive: From MOPED to DELSA Global
More information Time 11:00 - 12:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Dr. Eugene Kolker
Director Bioinformatics & High-throughput Analysis Lab, Seattle Children’s Research InstituteHomepage Contact Abstract Show full text abstract about Large volumes of high-throughput mass spectrometry proteomic...» Large volumes of high-throughput mass spectrometry proteomics studies are being routinely conducted nowadays. They are ultimately aimed at better understanding biological processes by studying proteomes’ profiles. However, the size and complexity of proteomics data hinders efforts to easily share, integrate, query, and compare such profiles. I will overview our recent developments addressing these challenges, including the creation of MOPED (Model Organism Protein Expression Database, moped.proteinspire.org). MOPED focuses on answering four fundamental questions:
1. What proteins are identified and where (organisms, tissues, localizations, pathways)?
2. How much of each protein is identified (relative and absolute expression)?
3. How does the knowledge of your current experiment compare to existing information? and
4. How does this knowledge guide your next (experimental or computational) study?
Proteomics is certainly not the only field with data challenges. The Data-Enabled Life Sciences Alliance (DELSA Global, delsaglobal.org) grew out of a need for solutions that was recognized by many; its mission is to “Accelerate the impact of Data-Enabled Life Sciences on the pressing needs of the global society”. DELSA’s purpose is to build and advance a sustainable ecosystem of professional societies, funding agencies, foundations, companies, and citizens together with life science researchers and innovators in computing, infrastructure, and analysis. Key priorities for DELSA include enabling collaborative work, promoting reproducible research, and translating new discoveries into tools, resources, and products. I will introduce DELSA Global and its Endorsed Projects and Working Groups.
-
Date:08MondayApril 2013Lecture
From the cradle to the grave: protein folding and misfolding in health and disease
More information Time 13:00 - 13:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Prof. Judith Frydman
Stanford University, CA, USA Biology DepartmentOrganizer Department of Molecular GeneticsContact -
Date:08MondayApril 2013Lecture
Adaptive networks with preferred degree: from the mundane to the surprises
More information Time 14:15 - 14:15Location Edna and K.B. Weissman Building of Physical SciencesLecturer Royce Zia
Virginia Tech Department of PhysicsOrganizer Department of Physics of Complex SystemsContact Abstract Show full text abstract about Network studies have played a central role for understanding...» Network studies have played a central role for understanding many systems in nature - e.g., physical, biological, and social. So far, much of the focus has been static networks in isolation. Yet, many networks are dynamic, coupled to each other. We considered this issue, in the context of social networks. In particular, We introduce a simple model of adaptive networks, modeling a society in which an individual cuts/adds links based on whether he or she has more/less links than some "preferred number"($kappa$). For example, introverts/extroverts typically have small/large $kappa$'s. Evolving with detailed balance violating dynamics, the steady state distribution of this dynamic network is not known in general, though it displays reasonably understandable properties. I will begin with a brief summary of our findings for systems with a single $kappa$ (i.e., a homogeneous population), many of which are "mundane." Surprises arise when a system with just two $kappa$'s are simulated. I will present the details of a "society" consisting of extreme introverts and extroverts. In particular, we find a mapping to a 2-D Ising-like model, restoration of detailed balance, the exact steady state distribution, and an abrupt transition (in the total number of links, as the I-E composition crosses 50-50). Sharp contrasts between this phenomenon and typical phase transitions (e.g.,Lenz-Ising-Onsager) will be noted. Beyond this theoretically interesting limit of our system, we outline some potentially important applications, such as modeling the response to a spreading epidemic by a population with adaptive behavior. -
Date:08MondayApril 2013Lecture
The Space Complexity of Dynamic Approximate Set Membership
More information Time 14:30 - 14:30Location Jacob Ziskind BuildingLecturer Udi Wieder
Microsoft Research, Silicon ValleyOrganizer Faculty of Mathematics and Computer ScienceContact -
Date:08MondayApril 2013Lecture
Mutational and fitness landscapes of an RNA virus: implications for adaptation and pathogenesis
More information Time 14:30 - 14:30Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Prof. Raul Andino
Department of Microbiology and Immunology University of California, San FranciscoOrganizer Department of Molecular GeneticsContact -
Date:08MondayApril 2013Lecture
"Search for neutrinoless double beta decay with"Search for neutrinoless double beta decay with"Search for neutrinoless double beta decay with"Search for neutrinoless double beta decay with"Search for neutrinoless double beta decay with bolometers: the CUORE experiment"
More information Time 14:45 - 15:45Location Hebrew University, JerusalemLecturer Yuan Mei
Nuclear Science Division, Lawrence Berkeley National LabOrganizer Department of Particle Physics and AstrophysicsContact Abstract Show full text abstract about Neutrinoless double beta decay, a rare nuclear process, if f...» Neutrinoless double beta decay, a rare nuclear process, if found, would confirm the Majorana nature of neutrinos. Successful observation of neutrinoless double beta decay would require a detector with substantial amount of candidate isotope, as well as excellent energy resolution and extremely low background. The CUORE (Cryogenic Underground Observatory for Rare Events) experiment aims at addressing all these challenges with low temperature bolometers. CUORE is currently being constructed underground at Laboratori Nazionali del Gran Sasso (LNGS) in Italy. It packs 988 TeO2 crystals of 5x5x5 cm3 each, totaling 741 kg of detection mass, of which the candidate isotope Te-130 is 204 kg. The whole detector will be cooled down to a base temperature of 10 mK and the particle interaction signal will be read out from temperature rise of each crystal due to energy release. -
Date:08MondayApril 2013Lecture
"Search for neutron-rich hypernuclei: Lambda-6H and beyond"
More information Time 16:15 - 17:15Location Hebrew University, JerusalemLecturer Avraham Gal
The Hebrew UniversityOrganizer Department of Particle Physics and AstrophysicsContact Abstract Show full text abstract about In this talk I review recent experimental evidence presented...» In this talk I review recent experimental evidence presented by the FINUDA Collaboration in the e+e --> Phi --> K+K- DAFNE machine at Frascati, Italy, for a particle stable Lambda-6H, with one proton and four neutrons stabilized by a Lambda hyperon [1]. Ongoing few-body calculations of Lambda-6H as well as shell-model estimates for its stability will also be briefly reviewed. The Lambda-6H hypernucleus was highlighted by Akaishi [2] as a test ground for the significance of Lambda N Sigma N coupling in Lambda hypernuclei, spurred by the role it plays in s-shell hypernuclei and by the far-reaching consequences it might have for dense neutron-star matter with strangeness. The discovery of Lambda-6H has stirred renewed interest in charting domains of particle-stable neutron-rich Lambda hypernuclei, particularly for unbound nuclear cores.
Millener and I have studied within a shell-model approach several neutron rich Lambda hypernuclei in the nuclear p shell that could be formed in (pi-,K+) (ongoing experiment E10 at J-PARC, Japan) or in (K-,pi+) reactions on stable nuclear targets. The hypernuclear shell-model input was taken from a theoretically inspired successful fit of gamma-ray transitions in p-shell Lambda hypernuclei. Predictions for binding energies of Lambda-9He, Lambda-10Li, Lambda-12Be and Lambda-14B will be reviewed, concluding that none of the large effects conjectured by Akaishi to arise from Lambda N Sigma N coupling is borne out by our realistic shell-model calculations. -
Date:09TuesdayApril 201310WednesdayApril 2013Conference
Signal Transduction in Health and Disease
More information Time All dayLocation The David Lopatie Conference CentreChairperson Rony SegerContact -
Date:09TuesdayApril 2013Lecture
Axon pruning is actively regulated by microtubules destabilizing protein, Kinesin Superfamily Protein 2A (KIF2A)
More information Time 10:00 - 10:30Location Wolfson Building for Biological ResearchLecturer Maya Maor
WIS-Department of Biological ChemistryOrganizer Department of Biomolecular SciencesContact -
Date:09TuesdayApril 2013Lecture
"The HIV-1 fusion protein exerts complex immunosuppressive effects"
More information Time 10:30 - 11:00Location Wolfson Building for Biological ResearchLecturer Avi Ashkenazi
WIS-Department of Biological ChemistryOrganizer Department of Biomolecular SciencesContact -
Date:09TuesdayApril 2013Lecture
An estimate for the Morse index of a Stokes wave
More information Time 11:00 - 11:00Location Jacob Ziskind BuildingLecturer Eugene Shargorodsky
King's College LondonOrganizer Faculty of Mathematics and Computer ScienceContact -
Date:09TuesdayApril 2013Lecture
"Tomato glandular trichomes: cellular chemical factories with strong metabolic diversity"
More information Time 11:15 - 11:15Location Ullmann Building of Life SciencesLecturer Prof. Robert L. Last
Department of Biochemistry and Molecular Biology, Michigan State University, USA http://www.bmb.msu.edu/faculty/last.htmlOrganizer Department of Plant and Environmental SciencesContact -
Date:09TuesdayApril 2013Lecture
Posttranscriptional control of inflammation
More information Time 13:30 - 13:30Location Wolfson Building for Biological ResearchLecturer Osamu Takeuchi, M.D., Ph.D.
Laboratory of Infection and Prevention Institute for Virus Research Kyoto UniversityOrganizer Department of Systems ImmunologyContact -
Date:09TuesdayApril 2013Lecture
"N-terminal domains in two-domain proteins are biased to be shorter and predicted to fold faster than their C-terminal counterparts"
More information Time 14:00 - 15:00Location Helen and Milton A. Kimmelman BuildingLecturer Prof. Ron Unger
Faculty of Life sciences, Bar Ilan UniversityOrganizer Department of Chemical and Structural BiologyContact -
Date:09TuesdayApril 2013Lecture
Localization of Functions in the Human Brain:Combined Neuroimaging, Intracranial EEG, and Electrical Brain Stimulation
More information Time 16:00 - 16:00Location Nella and Leon Benoziyo Building for Brain ResearchLecturer Prof. Josef Parvizi
Neurology and Neurological Sciences, Stanford UniversityOrganizer Department of Brain SciencesContact Abstract Show full text abstract about Throughout the history of neuroscience, from the Chinese to ...» Throughout the history of neuroscience, from the Chinese to the Egyptians and Romans, it was a key problem to find the seat of human experience. Once it was discovered that the brain is the sole proprietor of the human mind, a second flurry of scientific discourse focused on defining the localization of cognitive functions in the vast mantle of the brain. In my talk, after a brief historical overview, I will discuss the notion of localization of function in the brain in light of recent data from intracranial electrophysiological recordings during real life settings and electrical stimulation of the brain in conscious human subjects.
-
Date:09TuesdayApril 2013Cultural Events
Mana
More information Time 20:30 - 20:30Title presented by the Vertigo Dance CompanyLocation Michael Sela AuditoriumContact -
Date:10WednesdayApril 2013Lecture
Slit/Robo signaling: does it promote attraction, retraction, or arrest of muscle migration
More information Time 10:00 - 10:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Prof. Talila Volk
Dept. of Molecular Genetics, WISContact -
Date:10WednesdayApril 2013Lecture
TBD
More information Time 11:00 - 12:00Location Nella and Leon Benoziyo Physics BuildingLecturer Anastasia Fialkov Organizer Nella and Leon Benoziyo Center for AstrophysicsContact -
Date:10WednesdayApril 2013Lecture
Anisotropy, geometric structure and frustration effects in molecule-based nanomagnets
More information Time 11:00 - 11:00Location Perlman Chemical Sciences BuildingLecturer Prof. G. Kamieniarz
Faculty of Physics, A. Mickiewicz University, Poznań, PolandOrganizer Department of Molecular Chemistry and Materials ScienceContact -
Date:10WednesdayApril 2013Lecture
POPULAR LECTURES -IN HEBREW
More information Time 12:00 - 12:00Location Dolfi and Lola Ebner AuditoriumContact