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January 01, 2013
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Date:23ThursdayNovember 2017Colloquia
The past of a quantum particle
More information Time 11:15 - 12:30Location Edna and K.B. Weissman Building of Physical SciencesLecturer Lev Vaidman
TAUOrganizer Faculty of PhysicsContact Abstract Show full text abstract about Textbooks of quantum mechanics lack the concept of the past ...» Textbooks of quantum mechanics lack the concept of the past of quantum systems. Few years ago I proposed to define the past of a quantum particle according the trace it leaves. While in many cases this definition provides a reasonable description, for a nested Mach-Zehnder interferometer it leads to a picture seemingly contradicting common sense: the particle leaves a trace in a place through which it could not pass. I will discuss recent theoretical and experimental studies of this controversial issue. -
Date:26SundayNovember 2017Lecture
Identification of Druggable and Redox vulnerabilities in a genetically defined cancer
More information Time 10:00 - 10:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Dr. Liron Bar-Peled
The Scripps Research Institute, Lallage Feazel Wall Fellow of the Damon Runyon Cancer Research FoundationOrganizer Department of Molecular GeneticsContact -
Date:26SundayNovember 2017Lecture
Terrestrial glints seen from deep space: cloud ice crystals detected from the 1st Lagrangian point
More information Time 11:00 - 11:00Location Sussman Family Building for Environmental SciencesLecturer Alex Kostinski
Michigan TechOrganizer Department of Earth and Planetary SciencesContact Abstract Show full text abstract about The deep space climate observatory (DSCOVR) spacecraft resid...» The deep space climate observatory (DSCOVR) spacecraft resides at the 1st Lagrangian point about one million miles from Earth, where roughly the solar pull balances the terrestrial one. A polychromatic imaging camera onboard delivers nearly hourly observations of the entire sun-lit face of the Earth. Many images contain surprisingly bright flashes of light over both ocean and land. We construct a yearlong time series of flash latitudes, scattering angles and oxygen absorption to demonstrate that the flashes over land are specular reflections off tiny cloud ice platelets. Such deep space detection of tropospheric ice can be used to constrain the likelihood of oriented crystals and their contribution to Earth albedo. These glints may help detecting starlight glints off faint companions in our search for habitable exoplanets.
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Date:26SundayNovember 2017Lecture
Molecular Genetics Departmental Seminars 2017-2018
More information Time 13:15 - 13:15Title “M1A: A rare mRNA modification impairing translation”Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Modi Safra Organizer Department of Molecular GeneticsContact -
Date:27MondayNovember 2017Colloquia
"Thinking outside the cell: Programmable DNA compartments"
More information Time 11:00 - 12:15Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Roy Bar-Ziv
Dept. of Chemical and Biological Physics, WISOrganizer Faculty of ChemistryContact -
Date:28TuesdayNovember 201730ThursdayNovember 2017Conference
NMRbox: A workshop on advanced processing in nuclear magnetic resonance
More information Time 08:00 - 08:00Location The David Lopatie Conference CentreChairperson Lucio Frydman -
Date:28TuesdayNovember 2017Lecture
Insights from deep mutational scanning experiments inform computational protein design
More information Time 10:00 - 10:30Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Shira Warszawski
Members - Dept. of Biomolecular Sciences-WISOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about Improving the binding affinity of protein-protein interactio...» Improving the binding affinity of protein-protein interaction is a major challenge in research, therapeutics and drug development. In antibodies, the process of somatic hypermutation and clonal selection leads the B cells to express high affinity binders. However, an undesirable side-effect is that affinity-enhancing mutations may reduce stability. We used deep mutational scanning to systematically map the mutational tolerance of an antibody variable fragment (Fv), finding that 20% of affinity-enhancing mutations occur at the interface between the light and heavy chains, away from the antigen binding site.
This interface mediates the interaction between the two chains that form the core of the antibody, and may therefore be responsible for both antibody stability and affinity. From the deep mutational scanning data, we learned general rules for stabilizing and improving the affinity of antibodies. Computational designed variants comprising 5-10 mutations in the light-heavy chain interface improve affinity by as much as an order of magnitude, and also improve thermal stability and aggregation resistance. Laborious cloning, selection, and sequence analysis can thus be averted through fully automated computational affinity and stability design.
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Date:28TuesdayNovember 2017Lecture
Epigenetics in action: how transcription of mRNAs regulates their translation and stability
More information Time 10:30 - 11:00Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Dr. Boris Slobodin
Members - Dept. of Biomolecular Sciences-WISOrganizer Department of Biomolecular SciencesContact -
Date:28TuesdayNovember 2017Lecture
Control over photosynthetic energy transfer by rearrangements of its basic building blocks
More information Time 11:30 - 11:30Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Prof. Nir Keren
Dept. of Plant & Environmental Science, The Hebrew University of JerusalemOrganizer Department of Plant and Environmental SciencesContact -
Date:28TuesdayNovember 2017Lecture
"Nucleosome mobility and gene expression regulation: insights from single molecule studies"
More information Time 14:00 - 15:00Location Helen and Milton A. Kimmelman BuildingLecturer Prof. Ariel Kaplan
TechnionOrganizer Department of Chemical and Structural BiologyContact -
Date:28TuesdayNovember 2017Cultural Events
Jazz Show
More information Time 16:30 - 16:30Location Michael Sela AuditoriumOrganizer Faculty of Mathematics and Computer ScienceContact -
Date:29WednesdayNovember 2017Lecture
Population as Distributed Memory System
More information Time 11:00 - 11:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Dr. Ehud Lamm
The Cohn Institute for the History and Philosophy of Science and Ideas, Tel Aviv UniversityOrganizer Department of Molecular GeneticsContact Abstract Show full text abstract about We show how the distribution of skills or phenotypes in a po...» We show how the distribution of skills or phenotypes in a population acts as collective memory or "distributed information
store" serving individual so that individuals with varying innate abilities are able to
attain the mature fully skilled phenotype. We show how information moves "in" and "out" of genomes, relative to this memory system, elucidating how evolution determines where best to store information. This question applies to understanding diverse biological systems in which individuals acquire capacities from the population, including immunity, the microbiome, and social learning. Using Agent Based Modeling we investigate how properties of the
population and social aspects of the acquisition process affect the behavior of the system. We show
that the genetic properties of the population react predictably to changes in population properties that affect selection
pressures, without any group level selective processes. Specifically, parameter changes that make
acquisition slower lead to skills becoming increasingly innate while changes in parameters that improve
the results of acquisition (e.g., making acquisition reliant on abundant left-over tools) lead
to an increased reliance on acquisition, all while the average phenotype remains constant. The dynamics
we study contribute to understanding how individuals can evolve to become more or less reliant on
social learning and cultural information, how this depends on population properties (e.g., group
size), and how this manifests demographically. The more information stored externally, the stronger
the selection pressure on traits that support acquisition. Finally, we contrast our model and the Baldwin
Effect and relate out results to the study of the evolution of human social learning.
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Date:29WednesdayNovember 2017Lecture
In-cell NMR as a discovery tool: New biological functions for an old amyloid protein
More information Time 14:00 - 15:00Title Special Guest SeminarLocation Max and Lillian Candiotty BuildingLecturer Prof. Philipp Selenko
In-cell NMR Spectroscopy, Leibniz Institute of Molecular Pharmacology (FMP Berlin)Organizer Department of Immunology and Regenerative BiologyContact -
Date:30ThursdayNovember 2017Colloquia
Scaling up single-atom spin qubits in silicon
More information Time 11:15 - 12:30Location Edna and K.B. Weissman Building of Physical SciencesLecturer Andrea Morello
School of Electrical Engineering & Telecommunications Centre for Quantum Computation & Communication Technology UNSW Sydney, AustraliaOrganizer Faculty of PhysicsContact Abstract Show full text abstract about The modern information era is built on silicon nanoelectroni...» The modern information era is built on silicon nanoelectronic devices. The future quantum information era might be built on silicon too, if we succeed in controlling the interactions between individual spins hosted in silicon nanostructures.
Spins in silicon constitute excellent solid-state qubits, because of the weak spin-orbit coupling and the possibility to remove nuclear spins from the environment through 28Si isotopic enrichment. Substitutional 31P atoms in silicon behave approximately like hydrogen in vacuum, providing two spin 1/2 qubits -- the donor-bound electron and the 31P nucleus -- that can be coherently controlled [1,2], read out in single-shot [2,3], and are naturally coupled through the hyperfine interaction.
In isotopically-enriched 28Si, these single-atom qubits have demonstrated outstanding coherence times, up to 35 seconds for the nuclear spin [4], and 1-qubit gate fidelities well above 99.9% for both the electron and the nucleus [5]. The hyperfine coupling provides a built-in interaction to entangle the two qubits within one atom. The combined initialization, control and readout fidelities result in a violation of Bell’s inequality with S = 2.70, a record value for solid-state qubits [6].
Despite being identical atomic systems, 31P atoms can be addressed individually by locally modifying the hyperfine interaction through electrostatic gating [7]. Multi-qubit logic gates can be mediated either by the exchange interaction [8] or by electric dipole coupling [9].
Scaling up beyond a single atom presents formidable challenges, but provides a pathway to building quantum processors that are compatible with standard semiconductor fabrication, and retain a nanometric footprint, important for truly large-scale quantum computers.
[1] J.J. Pla et al., Nature 489, 541 (2012)
[2] J.J. Pla et al., Nature 496, 334 (2013)
[3] A. Morello et al., Nature 467, 687 (2010)
[4] J.T. Muhonen et al., Nature Nanotech. 9, 986 (2014)
[5] J.T. Muhonen et al., J. Phys.: Condens. Matt. 27, 154205 (2015)
[6] J.P. Dehollain et al., Nature Nanotech. 11, 242 (2016)
[7] A. Laucht et al., Science Advances 1, e1500022 (2015)
[8] R. Kalra et al., Phys. Rev. X 4, 021044 (2014)
[9] G. Tosi et al., Nature Communications 8:450 (2017)
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Date:30ThursdayNovember 2017Lecture
Integrating genetic and epigenetic mechanisms of MAP kinase pathway targeted therapy resistance toward rational combination therapies
More information Time 14:00 - 15:00Title Cancer Research ClubLocation Max and Lillian Candiotty BuildingLecturer Prof. Keith T. Flaherty
Massachusetts General Hospital Cancer Center Harvard Medical School, USAOrganizer Department of Immunology and Regenerative BiologyContact Abstract Show full text abstract about Efforts to describe mechanisms of de novo and adaptive resis...» Efforts to describe mechanisms of de novo and adaptive resistance to BRAF and MEK inhibitors in melanoma have provided evidence of a convergent resistance phenotype defined by neural crest markers. Cells with this phenotype have been described as slowly cycling and invasive in comparison to isogenic cells with expressing melanocyte differentiation markers. Additionally, these neural crest-like cells utilize receptor tyrosine signaling to drive survival pathways and oxidative phosphorylation as their primary metabolic feature. These insights have provided new leads for therapeutic intervention to target these resistant cells. In parallel work, tumors that are not responsive to immune checkpoint antibodies have been found to have many of the same features: most notably loss of melanocyte lineage antigens and expression of neural crest markers. These data suggest that similar next-generation therapeutic strategies aimed at overcoming therapeutic resistance may be useful in combination with both MAPK pathway and immune checkpoint inhibitors. -
Date:30ThursdayNovember 2017Lecture
Pelletron meeting - by invitation only
More information Time 16:00 - 17:45Contact -
Date:03SundayDecember 2017Lecture
Aerosol-cloud-precipitation interaction in eastern China: observations and modelling analyses
More information Time 11:00 - 11:00Location Sussman Family Building for Environmental SciencesLecturer Prof Jianping Guo
State Key Laboratory of Severe Weather in the Chinese Academy of Meteorological ScienceOrganizer Department of Earth and Planetary SciencesContact -
Date:03SundayDecember 2017Colloquia
Neutron star mergers: gravitational waves and nucleosynthesis of heavy elements
More information Time 13:00 - 14:00Location Edna and K.B. Weissman Building of Physical SciencesLecturer Avishay Gal Yam, Eran Ofek, Prof. Eli Waxman, Prof. Doron Kushnir
WISOrganizer Faculty of PhysicsContact Abstract Show full text abstract about : In this special event, motivated by the 2017 Physics Nobel...» : In this special event, motivated by the 2017 Physics Nobel prize and the recent first
detection of a neutron star merger via both gravitational waves and electromagnetic radiation,
we will review the recent discovery and its implications.
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Date:03SundayDecember 2017Lecture
Molecular Genetics Departmental Seminars 2017-2018
More information Time 13:15 - 13:15Title “Uncovering Mbd3/NuRD function in reprogramming and early development”Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Nofar Mor Organizer Department of Molecular GeneticsContact -
Date:04MondayDecember 2017Lecture
The Atmosphere as a Dynamical System: a Happy Tale of Theory Matching Reality
More information Time 10:00 - 10:00Location Sussman Family Building for Environmental SciencesLecturer Gabriele Messori
Stockholm UniversityOrganizer Department of Earth and Planetary SciencesContact Abstract Show full text abstract about Atmospheric flows are characterized by chaotic dynamics and ...» Atmospheric flows are characterized by chaotic dynamics and recurring large-scale patterns. These two characteristics point to the existence of an atmospheric attractor defined by Lorenz as: “the collection of all states that the system can assume or approach again and again, as opposed to those that it will ultimately avoid”. While this dynamical systems perspective can seem horribly abstract, it has immediate applications to the study of large-scale atmospheric patterns and extreme weather events. I will first show that we can compute measures of the stability and complexity (dimension) of instantaneous atmospheric fields in a (relatively) easy way. Next, I hope to convince you that these two quantities are actually useful! Their extreme values correspond to specific large-scale atmospheric patterns, and match extreme weather occurrences. They can also be used to identify "maximum predictability" states of the atmosphere, where the flow at positive lags of up to one week is particularly stable and with a small number of degrees of freedom. Finally, there is a significant correlation between the time series of instantaneous stability and complexity of an atmospheric field and the mean spread at lead times of over two weeks of an operational ensemble weather forecast initialised from that state.
