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July 01, 2013
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Date:01TuesdayOctober 2013Lecture
The role of hunger-promoting neurons in higher brain functions
More information Time 12:30 - 12:30Location Camelia Botnar BuildingLecturer Dr. Marcelo O. Dietrich
Section of Comparative Medicine, Yale UniversityOrganizer Department of Brain SciencesContact Abstract Show full text abstract about Hunger involves complex cognitive functions that rely on the...» Hunger involves complex cognitive functions that rely on the physiological need for energy. The profound impact that hunger has on complex behaviors indicates that neuronal circuitries that promote hunger should control higher brain functions. I will present evidence that activation of hunger-promoting AgRP neurons in the arcuate nucleus of the hypothalamus readily triggers changes in higher brain regions and behaviors, allocating a time-budget to consummatory responses (e.g., eating). In the absence of food, activation of these neurons leads to vast induction of repetitive behaviors, which can be prevented by using serotonin and dopamine reuptake inhibitors. Thus, we unmasked a hypothalamic neuronal population that regulates both homeostatic functions and complex behaviors.
More readings:
Hypothalamic control of energy balance: insights into the role of synaptic plasticity. Marcelo O Dietrich, Tamas L Horvath. Trends in Neurosciences ; 2013. DOI:10.1016/j.tins.2012.12.005
AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors. Marcelo O Dietrich, Jeremy Bober, Jozélia G Ferreira, Luis A Tellez, Yann S Mineur, Diogo O Souza, Xiao-Bing Gao, Marina R Picciotto, Ivan Araújo, Zhong-Wu Liu, Tamas L Horvath. Nature Neuroscience 2012; 15(8):1108-10
AgRP neurons: the foes of reproduction in leptin-deficient obese subjects. Marcelo O Dietrich, Tamas L Horvath. Proceedings of the National Academy of Sciences.2012; 109(8):2699-700
See also: http://www.researchgate.net/profile/Marcelo_Dietrich/publications/
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Date:01TuesdayOctober 2013Lecture
"Evolution and dynamics of protein complexes"
More information Time 14:00 - 15:00Location Helen and Milton A. Kimmelman BuildingLecturer Dr. Sarah Teichmann
European Bioinformatics Institute, Cambridge, UKOrganizer Department of Chemical and Structural BiologyContact -
Date:01TuesdayOctober 2013Cultural Events
A Duuble Scented Rose
More information Time 20:00 - 20:00Title Musical comedy in RussianLocation Michael Sela AuditoriumContact -
Date:02WednesdayOctober 2013Lecture
Identifying electrochemical processes in lithium-ion and lithium-oxygen batteries by solid state NMR spectroscopy
More information Time 11:00 - 11:00Location Perlman Chemical Sciences BuildingLecturer Prof. Michal Leskes
University of Cambridge, Department of Chemistry, Cambridge CB2 1EW, United KingdomOrganizer Department of Molecular Chemistry and Materials ScienceContact -
Date:03ThursdayOctober 2013Lecture
Biomaterials for tissue engineering
More information Time 11:00 - 11:00Location Perlman Chemical Sciences BuildingLecturer Prof. Jennifer Elisseeff
Dept. of Biomedical Engineering, John Hopkins UniversityOrganizer Department of Molecular Chemistry and Materials ScienceContact -
Date:03ThursdayOctober 2013Lecture
Exploring Genomics with the C1™ Single-Cell AutoPrep System
More information Time 14:00 - 15:00Title a new approach to single-cell gene expressionLocation Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Mark Lynch
Fluidigm EuropeOrganizer Department of Life Sciences Core FacilitiesContact Abstract Show full text abstract about For the first time, extract, reverse transcribe, preamplify,...» For the first time, extract, reverse transcribe, preamplify, and ultimately detect and analyze cell activity using just one technology:
Single-cell gene expression profiling emerged as a powerful method to reveal heterogeneity in cell populations and Fluidigm has developed a streamlined automated workflow based on microfluidic technology for capturing and analyzing single cells. It includes the C1Single-Cell Auto Prep System and the BioMark HD System for real-time PCR. The C1System, based on innovative microfluidic technology from Fluidigm allows prompt and reliable individual cells isolation and process for genomic analysis. For the first time, a researcher can isolate cells, extract RNA, and then reverse transcribe and preamplify mRNA transcripts automatically to detect and analyze cell activity. One technology reduces variability caused by multi-platform technical errors. Single-cell workflow facilitates expression assess of hundreds of genes in a few hours compared to experiments that would normally take days by traditional practices. Unique attributes of individual cells can be rapidly explored without the technical variability of a standard gene expression workflow. Single-cell genomic applications, includes single-cell mRNA sequencing, and provides a streamlined workflow for generating large volumes of data in cellular subpopulations.
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Date:03ThursdayOctober 2013Lecture
Danyel Biotech seminar: "Small amounts of sample material producing huge amounts of data: New protocols for preparing Illumina's deep sequencing libraries"
More information Time 15:00 - 15:45Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Dr. Florian Graedler
Sales Product Specialist, Illumina GermanyOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about This seminar will provide you with an overview on expanded a...» This seminar will provide you with an overview on expanded and improved portfolio of protocols developed recently by Illumina enabling new applications for next generation sequencing, a technique that becomes standard not only in research laboratories but also in diagnostics, agriculture and food testing, ultimately in everybody's life. -
Date:06SundayOctober 2013Lecture
TBD
More information Time 11:15 - 12:00Location Nella and Leon Benoziyo Physics BuildingLecturer Lukasz Wyrzykowski Organizer Nella and Leon Benoziyo Center for AstrophysicsContact -
Date:06SundayOctober 2013Lecture
Deletion of antigen specific CD8 T cells by activated CD8 T cells: Mechanism of action and potential role in Autoimmune Diabetes
More information Time 13:00 - 13:00Location Wolfson Building for Biological ResearchLecturer Dr. David Hagin
From Yair Reisner’s labOrganizer Faculty of BiologyContact -
Date:06SundayOctober 2013Lecture
High Throughput Assays at Single-Cell Resolution with Drop-Based Microfluidics
More information Time 13:15 - 13:15Location Dannie N. Heineman LaboratoryLecturer Dr. Assaf Rotem
Department of Physics and SEAS, Harvard UniversityOrganizer Clore Center for Biological PhysicsContact -
Date:06SundayOctober 2013Lecture
Role of Noncoding RNAs in Senescence-Associated Transcriptional Gene Silencing.
More information Time 14:30 - 14:30Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Dr. Oliver Bischof
Group Leader CNRS-CR1 Institut PasteurOrganizer Faculty of BiologyContact -
Date:06SundayOctober 2013Cultural Events
Seeing Through”, a tribute to the music of Shmulik Kraus
More information Time 20:30 - 20:30Title with Alma Zohar, Tal Gordon, Dudi Levi, Daniel Solomon, Iggy Dayan (from Mashina) and Avi Belleli (from Tractor’s Revenge)Location Michael Sela AuditoriumContact -
Date:07MondayOctober 201309WednesdayOctober 2013Academic Events
Minerva Annual Meeting 2013
More information Time All dayTitle Minerva committee interviews of scientists who submitted full proposals in all faculties.Homepage Contact Abstract Show full text abstract about If you require further information please contact Chaya Moyk...» If you require further information please contact Chaya Moykopf (4048) -
Date:07MondayOctober 2013Cultural Events
Uncle Chaim
More information Time 17:30 - 17:30Title Children's TheaterLocation Michael Sela AuditoriumContact -
Date:08TuesdayOctober 2013Lecture
"Signaling by bacterial chemoreceptors: A dynamic story?"
More information Time 10:00 - 11:00Location Wolfson Building for Biological ResearchLecturer Prof. John S. Parkinson
Dept. of Biology - University of UtahOrganizer Department of Biomolecular SciencesContact -
Date:08TuesdayOctober 2013Lecture
“Asymmetric Catalysis in Complex Molecular Environments”
More information Time 11:00 - 11:00Title Organic Chemistry - Departmental SeminarLocation Helen and Milton A. Kimmelman BuildingLecturer Prof. Scott Miller
Department of Chemistry Yale UniversityOrganizer Department of Molecular Chemistry and Materials ScienceContact -
Date:08TuesdayOctober 2013Lecture
Special guest seminar: "Celiac disease: A model disorder linking adaptive and innate immunity"
More information Time 11:30 - 12:30Location Wolfson Building for Biological ResearchLecturer Detlef Schuppan, M.D., Ph.D.
Professor of Medicine Harvard Medical School/University of Mainz Med. SchoolOrganizer Department of Systems ImmunologyContact -
Date:08TuesdayOctober 2013Lecture
Magnetic Resonance Seminar
More information Time 12:00 - 12:00Title Quantum nonlinear optics with Rydberg polaritonsLocation Perlman Chemical Sciences BuildingLecturer Prof. Ofer Firstenberg
Harvard UniversityOrganizer Department of Chemical and Biological PhysicsContact Abstract Show full text abstract about Realizing and engineering optical non-linearity at the level...» Realizing and engineering optical non-linearity at the level of single photons is a goal of scientific and technological significance. We obtain strong interaction between propagating photons by coherently coupling them to Rydberg atoms in a cold gas. While slowly traversing the medium, the "Rydberg polaritons” interact via the Van-der-Waals force, owing to their large electric dipole-moment. We are able to vary the dynamics of the
two-photon wavefunction from dispersive (Schrodinger-like) to dissipative (diffusion-like) and observe strong bunching, anti-bunching, and a conditional phase-shifts of 1 radian for two individual photons.
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Date:08TuesdayOctober 2013Lecture
On Beauty, Precision, Electronics and Quantum Mechanics
More information Time 12:00 - 13:00Title Physics Now lectureLocation Dolfi and Lola Ebner AuditoriumLecturer Prof. Ady Stern
Condensed Matter Physics DepartmentOrganizer Communications and Spokesperson DepartmentContact -
Date:08TuesdayOctober 2013Lecture
Predicting deliberate decisions and the onset of conscious intention
More information Time 13:15 - 13:15Location Gerhard M.J. Schmidt Lecture HallLecturer Dr. Uri Maoz
Div. of Biology, California Institute of Technology, Pasadena, CAOrganizer Department of Brain SciencesContact Abstract Show full text abstract about Human behavior was shown to be predictable from neural activ...» Human behavior was shown to be predictable from neural activity before subjects reported having decided on the contents or onset of their actions. This was suggested to challenges the role of consciousness intentions in decision making, and through it have far reaching implications for the notions of free will and moral responsibility. However, these studies focused on non-ecological, arbitrary decisions – like raising the left or right hand for no reason or purpose and with no consequences – which are not typically held to be the hallmarks of freedom, not to mention assigning blame or praise. We wanted to understand to what degree this ability generalizes to deliberate actions, so we analyzed intracranial, human brain activity in a competitive environment – a matching-pennies game. We were increasingly better able to predict such actions with time before movement onset, retrospectively and even online and in real time. We further discovered specific neural differences between deliberate and arbitrary decision making using EEG. And we also found bias activity in monkey DLPFC and striatum that may help explain the early predictions in arbitrary decisions. I will sketch some features of a model of action selection that is congruent with the above findings.