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May 07, 2014
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Date:13WednesdayAugust 2014Lecture
The Nancy & Stephen Grand Israel National Center for Personalized Medicine - guest lecture - The molecular motor of the Sarcomere / The Fauna, A New View on Theory of Muscle Dynamics, Clinical Implications and Clinical Applications
More information Time 14:15 - 15:45Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Prof. Amir Landesberg
Faculty of Biomedical Engineering, Technion - Israel Institute of Technology, Haifa, IsraelOrganizer Department of Biomolecular SciencesContact -
Date:15FridayAugust 2014Cultural Events
Friday Culture: Following the Little Prince- Dr. Haim Shapira
More information Time 11:00 - 11:00Location Dolfi and Lola Ebner AuditoriumContact -
Date:20WednesdayAugust 2014Lecture
Multiscale simulations of colloidal nanostructures: self-assembly, ligand activity and molecular delivery
More information Time 11:00 - 12:00Title Joint Seminar: Organic Chemistry & Chemical PhysicsLocation Perlman Chemical Sciences BuildingLecturer Prof. Petr Kral
University of Illinois ChicagoOrganizer Department of Molecular Chemistry and Materials ScienceContact -
Date:27WednesdayAugust 2014Lecture
"Waiting for Joseph"- water management
More information Time 11:00 - 11:00Location Perlman Chemical Sciences BuildingLecturer Prof. Micha Tomkiewicz
Department of Physics, Brooklyn College of CUNYOrganizer Department of Molecular Chemistry and Materials ScienceContact -
Date:28ThursdayAugust 2014Lecture
Two-sided radial SLE and length-biased chordal SLE
More information Time 11:00 - 11:00Location Jacob Ziskind BuildingLecturer Laurie Field
University of ChicagoOrganizer Faculty of Mathematics and Computer ScienceContact -
Date:31SundayAugust 2014Lecture
Using Polymer Surface Confinement To Engineer Substrates for for Adult Stem Cell Differentiation
More information Time 11:00 - 11:00Location Perlman Chemical Sciences BuildingLecturer Prof. Miriam Rafailovich
Department of Materials Science- co-Director Program in Chemical and Molecular Engineering SUNY at Stony BrookOrganizer Department of Molecular Chemistry and Materials ScienceContact -
Date:02TuesdaySeptember 2014Lecture
"Ménage-à-trois: Single-atom Catalysis, Mass Spectrometry, and Computational Chemistry"
More information Time 11:00 - 12:00Title Joint Seminar:Organic Chemistry & Materials and InterfacesLocation Gerhard M.J. Schmidt Lecture HallLecturer Prof. Dr. Helmut Schwarz
Technische Universität BerlinOrganizer Department of Molecular Chemistry and Materials ScienceContact -
Date:04ThursdaySeptember 2014Lecture
Cellulose: a fascinating material with a promising future
More information Time 13:00 - 13:00Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Theo van de Ven
Sir William Mcdonald Chair in Chemistry, McGill University, Montreal, CanadaOrganizer Weizmann School of ScienceContact Abstract Show full text abstract about Research in cellulose is exploding exponentially, as researc...» Research in cellulose is exploding exponentially, as researchers look for renewable resources to replace chemicals and materials derived from fossil fuels. Cellulose is the most abundant biopolymer on earth and can be modified to make a large number of useful products, several of which will be discussed. Cellulose can be made into superabsorbent papers and gels, by introducing the appropriate amount of charge groups, usually carboxyl groups. Carboxylated fibers swell and can take up water more than hundred times their weight. They can be modified into an aqueous dope, from which one can spin textile fibers. The morphology of swollen fibers depends on the way the charges are introduced and reveals the underlying structure of the cell wall. By increasing the charge above 3 meq/g, the fibers break apart in nanocellulose and dissolved carboxylated cellulose (DCC). The nancellulose consist of cellulose nanofibers (CNF) and cellulose nanocrystals (CNC). The larger the charge, the larger the fraction of CNC. This CNC is different from conventional CNC, made by acid hydrolysis of cellulose fibers: it has DCC chains protruding from each end, which entangle when making films, resulting in transparent films much stronger than made from conventional CNC. They also have different cytotoxic properties: the higher the charge, the more they affect the metabolism of certain cells. The DCC end chains of CNC can by removed by hydrolysis, resulting in CNC with negatively charged ends. These particles can be crosslinked to make much longer chains, resembling CNF. Carboxyl groups in cellulose can be readily transformed in other functional groups, e.g. by a bioconjugation reaction. CNC films can be made superhydrophobic and paper can be made functional, making it hydrophobic, fluorescent or introducing sensors that can detect pathogens. -
Date:04ThursdaySeptember 2014Lecture
Cholinergic interneurons and state correlates in dorsomedial and dorsolateral striatum
More information Time 14:00 - 14:00Location Nella and Leon Benoziyo Building for Brain ResearchLecturer Prof. Geoffrey Schoenbaum, MD,PhD
Branch Chief, National Institute on Drug Abuse, NIHOrganizer Department of Brain SciencesContact -
Date:07SundaySeptember 2014Lecture
Relapse to drug use: behavioral and neuronal mechanisms
More information Time 12:30 - 12:30Location Nella and Leon Benoziyo Building for Brain ResearchLecturer Prof. Yavin Shaham
Branch Chief, Behavioral Neuroscience Branch, Intramural Research Program, NIDA-NIHOrganizer Department of Brain SciencesContact -
Date:08MondaySeptember 2014Lecture
Balanced Allocations: A Simple(r) Proof for the Heavily Loaded Case
More information Time 14:30 - 14:30Location Jacob Ziskind BuildingLecturer Udi Wieder
Microsoft Research Silicon ValleyOrganizer Faculty of Mathematics and Computer ScienceContact -
Date:11ThursdaySeptember 2014Lecture
Magnetic Resonance Seminar
More information Time 09:30 - 09:30Title Magic Angle Spinning NMR Spectroscopy of Protein AssembliesLocation Gerhard M.J. Schmidt Lecture HallLecturer Prof. Tatyana Polenova
University of DelawareOrganizer Department of Chemical and Biological PhysicsContact -
Date:12FridaySeptember 2014Cultural Events
Friday Culture:Thoughts at night- Dr Haim Shapira
More information Time 11:00 - 11:00Location Dolfi and Lola Ebner AuditoriumContact -
Date:12FridaySeptember 2014Cultural Events
About Miracles and Wonders
More information Time 13:00 - 13:00Title Children's TheaterLocation Michael Sela AuditoriumContact -
Date:13SaturdaySeptember 2014Cultural Events
Eli And Mariano
More information Time 21:00 - 21:00Title StandupLocation Michael Sela AuditoriumContact -
Date:15MondaySeptember 2014Cultural Events
The Lover
More information Time 20:30 - 20:30Title Habima TheatreLocation Michael Sela AuditoriumContact -
Date:16TuesdaySeptember 2014Lecture
Nucleosome repositioning links DNA (de)methylation and differential CTCF binding during stem cell development
More information Time 14:00 - 14:00Location Edna and K.B. Weissman Building of Physical SciencesLecturer Dr. Vladimir Teif
German Cancer Research Center (DKFZ)Organizer Department of Physics of Complex SystemsContact Abstract Show full text abstract about During differentiation of embryonic stem cells, chromatin re...» During differentiation of embryonic stem cells, chromatin reorganizes to establish cell type specific expression programs. Here, we have dissected the linkages between DNA methylation (5mC), hydroxymethylation (5hmC), nucleosome repositioning and binding of the transcription factor CTCF during this process. By integrating MNase-seq and ChIP-seq experiments in mouse embryonic stem cells (ESC) and their differentiated counterparts with biophysical modeling, we found that the interplay between these factors depends on their genomic context. The mostly unmethylated CpG islands have reduced nucleosome occupancy and are enriched in cell type-independent binding sites for CTCF. The few remaining methylated CpG dinucleotides are preferentially associated with nucleosomes. In contrast, outside of CpG islands most CpGs are methylated and the average methylation density oscillates so that it is highest in the linker region between nucleosomes. Outside CpG islands binding of TET1, an enzyme that converts 5mC to 5hmC, is associated with labile, MNase-sensitive nucleosomes. Such nucleosomes are poised for eviction in ESCs and become stably bound in differentiated cells where the TET1 and 5hmC levels go down. This process regulates a class of CTCF binding sites outside CpG islands that are occupied by CTCF in ESCs but loose the protein during differentiation. We rationalize this cell type dependent targeting of CTCF with a quantitative biophysical model of competitive binding with the histone octamer in dependence of the TET1, 5hmC and 5mC state.
Journal reference: http://genome.cshlp.org/content/early/2014/05/08/gr.164418.113
DKFZ press release: http://www.dkfz.de/en/presse/pressemitteilungen/2014/dkfz-pm-14-37-The-Long-and-Winding-Road-to-Gene-Regulation.php
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Date:16TuesdaySeptember 2014Lecture
Isolated hypersurface singularities and associated forms
More information Time 16:00 - 16:00Location Jacob Ziskind BuildingLecturer Alex Isaev
Australian National UniversityOrganizer Faculty of Mathematics and Computer ScienceContact -
Date:16TuesdaySeptember 2014Cultural Events
Machnisei Rachamim
More information Time 21:00 - 21:00Location Michael Sela AuditoriumContact -
Date:17WednesdaySeptember 2014Lecture
CRS your toolbox to sucssses - Mini Symposium of The Department of Chemical Resarch Support
More information Time 09:00 - 13:30Location Gerhard M.J. Schmidt Lecture HallOrganizer Department of Chemical Research SupportHomepage Contact
