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March 17, 2016
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Date:05SundayFebruary 2017Lecture
Flow Cytometry and Single Cell Heterogeneity in the Mammalian Liver
More information Time 09:00 - 10:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Dr. Ayala Sharp Organizer Department of Life Sciences Core FacilitiesContact -
Date:05SundayFebruary 2017Lecture
The elusive nature of Earth magnetic field : paleomagnetic research from nano to global scale
More information Time 11:00 - 11:00Location Sussman Family Building for Environmental SciencesLecturer Ron Shaar
Hebrew University of JerusalemOrganizer Department of Earth and Planetary SciencesContact -
Date:05SundayFebruary 2017Lecture
The role of FABP4 in ER stress-triggered cell death
More information Time 13:00 - 13:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Rinat Livne
Menachem Rubinstein's group, Dept. of Molecular Genetics, WISOrganizer Department of Molecular GeneticsContact -
Date:06MondayFebruary 2017Colloquia
"Imaging wave function of few body systems: He dimers, trimers and the Efimov state of He3"
More information Time 11:00 - 12:15Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Reinhard Doerner
Institute for Nuclear Physics, Goethe University, FrankfurtOrganizer Faculty of ChemistryContact Abstract Show full text abstract about Two and three Helium atoms form very unusual and extreme qua...» Two and three Helium atoms form very unusual and extreme quantum systems. Their typical extend is ten to hundred times bigger than radius of the atoms, the wavefunction lives almost completely in the classically forbidden tunneling region and the binding energy of these systems is about 8 orders of magnitude smaller than that of a normal molecule.
We will show how coincidence detection of charged fragments and super strong laser fields can be used to image the wave functions of these Helium quantum giants and will show the first experimental images of an Efimov state. -
Date:06MondayFebruary 2017Lecture
Personalized Cancer Nano-Medicines
More information Time 14:00 - 15:00Title Special Guest SeminarLocation Max and Lillian Candiotty BuildingLecturer Prof. Avi Schroeder
Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Chemical Engineering Technion - Israel Institute of Technology, HaifaOrganizer Department of Immunology and Regenerative BiologyContact Abstract Show full text abstract about The field of medicine is taking its first steps towards pati...» The field of medicine is taking its first steps towards patient-specific care. Our research is aimed at tailoring treatments to address each person’s individualized needs and unique disease presentation. Specifically, we are developing nanoparticles that target disease sites, where they perform a programmed therapeutic task. These systems utilize molecular-machines and cellular recognition to improve efficacy and reduce side effects.
Nanoparticles have many potential benefits for treating cancer, including the ability to transport complex molecular cargoes, as well as targeting to specific cell populations.
The talk will describe principles for developing lipid nanoparticles that can be remotely triggered to release their payload in disease sites.
Two examples will be described: the first involves a nanoscale theranostic system for predicting the therapeutic potency of cancer medications. The system provides patient-specific drug activity data with single-cell resolution. The system makes use of barcoded nanoparticles to predict the therapeutic effect different drugs will have on the tumor microenvironment.
The second system makes use of enzymes, loaded into a biodegradable chip, to perform a programed therapeutic task – surgery with molecular precision. Collagenase is an enzyme that cleaves collagen, but not other tissues. This enzyme was loaded into the biodegradable chip and placed in the periodontal pocket. Once the collagenase releases from the chip, collagen fibers that connect between the teeth and the underlying bone are relaxed, thereby enabling enhanced orthodontic corrective motion and reducing pain. This new field is termed BioSurgery.
The clinical implications of these approaches will be discussed. -
Date:06MondayFebruary 2017Cultural Events
Trofoti - Children's Theater
More information Time 17:30 - 17:30Location Michael Sela AuditoriumContact -
Date:07TuesdayFebruary 2017Lecture
Breaking the dimer: NF-kB dimerization emerges as an excellent drug target
More information Time 10:00 - 10:30Location Wolfson Building for Biological ResearchLecturer Shaked Ashkenazi
Members - Dept. of Biomolecular Sciences-WISOrganizer Department of Biomolecular SciencesContact -
Date:07TuesdayFebruary 2017Lecture
QUANTUM FIELD THEORIES OF (N-1)-DIMENSIONAL EXTENDED OBJECTS IN 2N-DIMENSIONAL SPACE-TIME MANIFOLDS AS 2D QUANTUM FIELD THEORIES ON ``QUASI RIEMANN SURFACES'' OF INTEGRAL (N-1)-CURRENTS.
More information Time 10:00 - 10:00Location Newe ShalomLecturer DANIEL FRIEDAN
REUTGERSOrganizer Department of Particle Physics and AstrophysicsContact Abstract Show full text abstract about Abstract: In my talk I will discuss some new features of ...»
Abstract: In my talk I will discuss some new features of conformal anomaly and entanglement entropy in the presence of boundaries. The talk is based on recent papers.This is a project to develop a wide expanse of new quantum field theories in 2n-dimensional space-time manifolds. For each 2d qft, there is to be a qft of extended objects in every 2n-dimensional space-time manifold M. The quantum fields live on ``quasi Riemann surfaces'', which are certain spaces of integral (n-1)-currents in M. The notion of integral current comes from Geometric Measure Theory. The quasi Riemann surfaces are complete metric spaces with analytic properties strictly analogous to Riemann surfaces. The new qfts are to be constructed on the quasi Riemann surfaces just as 2d qfts are constructed on ordinary Riemann surfaces. Local fields in space-time are obtained by restricting to small extended objects.
arXiv:1510.04566, arXiv:1601.06418 and arXiv:1604.07571
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Date:07TuesdayFebruary 2017Lecture
Antimicrobial Peptides: Mechanisms of Bacterial Biofilms Neutralization.
More information Time 10:30 - 11:00Location Wolfson Building for Biological ResearchLecturer Liav Tia Segev Zarko
Members - Dept. of Biomolecular Sciences-WISOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about Multidrug resistant bacteria are a growing phenomenon that c...» Multidrug resistant bacteria are a growing phenomenon that concerns the scientific community worldwide. Two extensively studied resistance mechanisms are biofilm colonization and bacterial outer membrane remodeling. An attractive alternative to conventional antibiotics are antimicrobial peptides (AMPs), innate immune system molecules serving as a first line of defense in fighting invading pathogens. We show that AMPs can either inhibit or reduce biofilm formation and degrade established ones via several bactericidal and non- bactericidal mechanisms. Alternatively, AMPs can promote bacterial lipopolysaccharide (LPS) remodeling and potentially affect biofilm colonization. Our findings suggest that bacteria that are unable to remodel LPS compensate for it by adopting a biofilm lifestyle.
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Date:07TuesdayFebruary 2017Lecture
Controls and functions of non-structural carbon reserves in trees
More information Time 11:00 - 11:45Location Ullmann Building of Life SciencesLecturer Dr. Guenter Hoch
Department of Environmental Sciences - Botany, University of Basel, SwitzerlandOrganizer Department of Plant and Environmental SciencesContact -
Date:07TuesdayFebruary 2017Lecture
TACHYONIC ANTIBRANES AND THE LANDSCAPE
More information Time 11:15 - 11:15Location Newe ShalomLecturer IOSIF BENA
SACLAYOrganizer Department of Particle Physics and AstrophysicsContact Abstract Show full text abstract about Abstract:: ntibranes in backgrounds that have charge dissolv...» Abstract:: ntibranes in backgrounds that have charge dissolved in fluxes are a key ingredient in constructing a landscape (Multiverse) of deSitter vacua in String Theory, and also of constructing microstate solutions corresponding to non-supersymmetric near-extremal black holes. There are several regimes of parameters in which one can study the physics of these antibranes, and I will show that in the regime of parameters where their gravitational backreaction is important, antibranes have a naked singularity that cannot be resolved either by brane polarization or by cloaking with a black hole horizon, and that signals a tachyonic instability. I will also present recent evidence that the theory on the wordvolume of anti-D3 branes is finite to all loops. I will conclude by discussing the implications of these results for the Multiverse paradigm and for the Fuzzball proposal. -
Date:07TuesdayFebruary 2017Lecture
Store it, use it or lose it; Carbon reserve dynamics in stressed trees
More information Time 12:15 - 13:00Location Ullmann Building of Life SciencesLecturer Prof. Simon Landhausser
Department of Renewable Resources, University of Alberta, Edmonton, CanadaOrganizer Department of Plant and Environmental SciencesContact -
Date:07TuesdayFebruary 2017Lecture
Why Sensory Deprivation and High Plasticity may lead to Hallucinations and Synaesthesia:A Computational Perspective
More information Time 12:30 - 12:30Location Gerhard M.J. Schmidt Lecture HallLecturer Dr. Oren Shriki
Dept of Cognitive and Brain Sciences Ben-Gurion UniversityOrganizer Department of Brain SciencesContact Abstract Show full text abstract about Recurrent connections are abundant in cortical circuitry but...» Recurrent connections are abundant in cortical circuitry but their functional role has been the subject of intense debates. The talk will present a computational approach to investigate the role of recurrent connections in the context of sensory processing. Specifically, I will describe a neural network model in which the recurrent connections evolve according to concrete learning rules that optimize the information representation of the network. Interestingly, these networks tend to operate near a "critical" point in their dynamics, namely close to a phase of "hallucinations", in which non-trivial spontaneous patterns of activity evolve even without structured input. Various scenarios, such as attenuation of the external inputs or increased plasticity, can lead the network to cross the border into the hallucinatory phase. The theory will be illustrated through applications to a model of a visual hypercolumn, a model of tinnitus and a model of synaesthesia.
References:
Shriki O. and Yellin D., Optimal Information Representation and Criticality in an Adaptive Sensory Recurrent Neural Network. PLoS Computational Biology 12(2): e1004698. doi:10.1371/journal.pcbi.1004698, 2016
Shriki O., Sadeh Y. and Ward J., The Emergence of Synaesthesia in a Neuronal Network Model via Changes in Perceptual Sensitivity and Plasticity. PLoS Computational Biology 12(7): e1004959. doi:10.1371/journal.pcbi.1004959, 2016.
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Date:07TuesdayFebruary 2017Lecture
S-DUALITY IN MATHCAL{N} = 1 ORIENTIFOLD SCFTS
More information Time 12:30 - 12:30Location Newe ShalomLecturer INAKI GARCIA-ETXEBARRIA
MPIOrganizer Department of Particle Physics and AstrophysicsContact Abstract Show full text abstract about Abstract: I will present a general solution to the problem o...» Abstract: I will present a general solution to the problem of determining all S-dual descriptions for a specific (but very rich) class of N=1 SCFTs. These SCFTs are indexed by decorated toric diagrams, and can be engineered in string theory by probing orientifolds of isolated toric singularities with D3 branes. The S-dual phases are described by quiver gauge theories coupled to specific types of conformal matter which I will describe explicitly. -
Date:07TuesdayFebruary 2017Lecture
AMO Journal Club
More information Time 13:15 - 14:30Location Edna and K.B. Weissman Building of Physical SciencesOrganizer Department of Physics of Complex SystemsContact Abstract Show full text abstract about Speakers: Gal Orenstein, Arnaud Courvoisier ...» Speakers: Gal Orenstein, Arnaud Courvoisier -
Date:07TuesdayFebruary 2017Lecture
“Mapping binding landscapes through computation and experiment”
More information Time 14:00 - 15:00Location Helen and Milton A. Kimmelman BuildingLecturer Dr. Julia Shifman
Department of Biological Chemistry Hebrew UniversityOrganizer Department of Chemical and Structural BiologyContact -
Date:07TuesdayFebruary 2017Lecture
Molecular Neuroscience Forum Seminar
More information Time 15:00 - 16:00Title Molecular mechanisms controlling synapse stability and plasticityLocation Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Jan Pielage
Technical University of KaiserslauternOrganizer Department of Biomolecular SciencesHomepage Contact -
Date:08WednesdayFebruary 2017Lecture
G-INCPM-Special Seminar - Prof. Paul Brennan, Associate Professor of Medicinal Chemistry, Principal Investigator, SGC & Target Discovery Institute, Head of Chemistry, Alzheimer's Research, UK Oxford Drug Discovery Institute - "Discovery & Use of Chemical Probes for Target Discovery & Validation"
More information Time 11:00 - 12:15Location Nancy and Stephen Grand Israel National Center for Personalized MedicineLecturer Prof. Paul Brennan
Associate Professor of Medicinal Chemistry, Principal Investigator, SGC & Target Discovery Institute, Head of Chemistry, Alzheimer's Research, UK Oxford Drug Discovery InstituteOrganizer Faculty of BiochemistryContact Abstract Show full text abstract about Epigenetics is the study of heritable changes in phenotype t...» Epigenetics is the study of heritable changes in phenotype that are not encoded in an organism’s DNA. Epigenetic effects due to persistent changes in gene transcription have been linked to chemical modification of DNA and the proteins that package and regulate DNA in the nucleus, histones. One of the major post-translational modifications of histones is acetylation of lysine residues prevalent in histone tails. The principal readers of histone acetyl lysine marks are bromodomains (BRDs), which are a diverse family of over sixty evolutionary conserved protein-interaction modules. Proteins that contain BRDs have been implicated in the development of a large variety of diseases, including cancer and inflammation. In order to decipher the complex biology of bromodomains and provide evidence linking specific bromodomain targets to disease, we are discovering selective, cell active small molecule inhibitors of bromodomains. -
Date:08WednesdayFebruary 2017Lecture
G-INCPM-Special Seminar - Prof. Paul Brennan, Associate Professor of Medicinal Chemistry, Principal Investigator, SGC & Target Discovery Institute, Head of Chemistry, Alzheimer's Research UK Oxford Drug Discovery Institute
More information Time 11:00 - 12:15Location Nancy and Stephen Grand Israel National Center for Personalized MedicineLecturer Prof. Paul Brennan Organizer Faculty of BiochemistryContact Abstract Show full text abstract about Epigenetics is the study of heritable changes in phenotype t...» Epigenetics is the study of heritable changes in phenotype that are not encoded in an organism’s DNA. Epigenetic effects due to persistent changes in gene transcription have been linked to chemical modification of DNA and the proteins that package and regulate DNA in the nucleus, histones. One of the major post-translational modifications of histones is acetylation of lysine residues prevalent in histone tails. The principal readers of histone acetyl lysine marks are bromodomains (BRDs), which are a diverse family of over sixty evolutionary conserved protein-interaction modules. Proteins that contain BRDs have been implicated in the development of a large variety of diseases, including cancer and inflammation. In order to decipher the complex biology of bromodomains and provide evidence linking specific bromodomain targets to disease, we are discovering selective, cell active small molecule inhibitors of bromodomains.
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Date:08WednesdayFebruary 2017Lecture
Machine Learning and Statistics Seminar
More information Time 11:15 - 12:15Title Large-scale and Non-approximate Kernel Methods Using Random FeaturesLocation Jacob Ziskind BuildingLecturer Haim Avron
Tel Aviv UniversityOrganizer Faculty of Mathematics and Computer ScienceContact Abstract Show full text abstract about Kernel methods constitute a mathematically elegant framework...» Kernel methods constitute a mathematically elegant framework for general-purpose infinite-dimensional non-parametric statistical inference. By providing a principled framework to extend classical linear statistical techniques to non-parametric modeling, their applications span the entire spectrum of statistical learning. However, training procedures naturally derived via this framework scale poorly and with limited opportunities for parallelization. This poor scalability poses a significant barrier for the use of kernel methods in big data applications. As such, with the growth in data across a multitude of applications, scaling up kernel methods has acquired renewed and somewhat urgent significance.
Random feature maps, such as random Fourier features, have recently emerged as a powerful technique for speeding up and scaling the training of kernel-based methods. However, random feature maps only provide crude approximations to the kernel function, so delivering state-of-the-art results requires huge amount of random features. Nevertheless, in some cases, even when the number of random features is driven to be as large as the training size, full recovery of the generalization performance of the exact kernel method is not attained. In the talk I will show how random feature maps can be used to efficiently perform non-approximate kernel ridge regression, and thus there is no need to compromise between quality and running time. The core idea is to use random feature maps to form preconditioners to be used in solving kernel ridge regression to high accuracy. I will describe theoretical conditions on when this yields an effective preconditioner, and empirically evaluate the method and show it is highly effective for datasets of up to one million training examples.
