September 21, 1988 - September 21, 2021

  • Date:20ThursdaySeptember 2018

    Proteomic analysis of breast cancer heterogeneity

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    Time
    14:00 - 15:00
    Title
    Special Guest Seminar
    Location
    Max and Lillian Candiotty Building
    Auditorium
    Lecturer
    Dr. Tamar Geiger
    Department of Human Molecular Genetics and Biochemistry Sackler Faculty of Medicine Tel Aviv University
    Organizer
    Department of Biological Regulation
    Contact
    AbstractShow full text abstract about For more information and assistance with Accessibility issue...»
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    please contact
    Rina Tzoref, Seminars Coordinator: li.tzoref@weizmann.ac.il
    Batya Greenman: batya.greenman@weizmann.ac.il
    Host
    Prof. Yosef Yarden
    08 934 4015
    yosef.yarden@weizmann.ac.il
    Breast cancer is a heterogeneous group of diseases, traditionally distinguished based on the
    expression levels of three key receptors: Estrogen receptor, progesterone receptor and Her2.
    However extensive mRNA expression studies, and genomic studies show higher complexity of
    classification and can further subdivide the tumors. In our work, we apply mass spectrometry-based
    proteomics analysis and challenge the existing classification. Furthermore, we analyze the internal
    tumor heterogeneity by dividing the tumors according to their histopathological parameters, and
    identify the diversity of proteomic profiles within single tumors. Altogether, the proteomic approach
    was able to unravel hidden layers within this complex disease.
    Lecture