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Dr. Orly Laufman
Molecular and Cell Biology of RNA virusesRNA viruses including corona, zika and dengue are a major threat to human health. We study how RNA viruses interact with their host cells and transform them into viral manufactories.Our main model is enteroviruses - common viral pathogens that cause severe medical complications in humans, with no available therapeutic treatments.We investigate how enteroviruses remodel the structure and function of host organelles to generate an environment favorable to virus replication.Another key question we tackle is how enteroviruses, that express only a small number of proteins, take control of human cells with complex protein machineries. We study the different roles of viral proteins and the mechanisms they use to hijack host machineries.We aim to piece together the complete program of enterovirus replication. This could lead to the development of new antiviral therapeutics.
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Prof. Tsvee Lapidot
Metabolic regulation of Blood and Bone forming Stem Cells by Daily Light and Dark Cues (NE, TNF, Melatonin and PGE2).Regulation of Human and Murine Hematopoietic Stem Cell Migration and Development by Coagulation Cascades (both aPC/EPCR/Par1 anti inflammatory signals and Thrombin/PAR1 pro-inflammatory signals).Studying Molecular Cues guiding Human and murine Hematopoietic Stem Cells Homing and Bone Marrow (BM) recognition, retention and mobilization to the circulation.Metabolic regulation of BM Neutrophils activation and recruitment by Lactatae and GPR81 Signaling.Metabolic regulation of BM Neutrophils by Daily Light and Dark Cues.Energy sharing, Chemotherapy Resistance and Stress induced Mitochondira Transfer between Blood and Bone forming Stem Cells.AML AF9 Leukemic Stem Cells Metabolic interactions with BM Stromal Cells and Chemotherapy Resistance.Dynamic regulation of the Blood Bone Marrow Endothelial Barrier and Hematopoietic Stem Cell Niches.
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Prof. Doron Lancet
Bioinformatic tools for disease gene discovery, Origin of life on earthCollaboration with: Prof. Rafi Zidovetzki, University of California Riverside Prof. Philippe Schmitt-Kopplin, Helmholz Center Munich Prof. Daniel Segre, Boston UniversityGene and disease databases, Identification of disease-related mutations by next generation DNA sequencing (NGS), development of software tool for the analysis of NGS resultsComputer simulations of emergence, selection and evolution at the origin of life. Chemical kinetic modeals for mutually catalytic sets, Systems Chemistry
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Prof. Ilan Lampl
Mechanisms of tactile perception in the miceCollaboration with: Heinz Beck, Bonn Alex Binshtok, Hebrew University Nicholas Priebe, AustinConstruction of receptive field properties in the somatosensory cortexstudying functional connectivity in the barrel cortexMechanisms of adaptation in the cortexBalance excitation and inhibition in awake miceInterhemispheric correlationsMultimodal integrationNoise and synchrony in the mammalian cortexDynamic properties and mechanisms of ongoing activity in the cortexPatterns in neuronal activity in the cortex
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Prof. Meir Lahav
Solid State Chemistry in 2- and 3-dimensions. Pyroelectricity. Ice nucleation.Collaboration with: Prof Igor Lubomirsky Dr.David EhreOrganization of molecules at surfaces and interfaces;Chirality, Chemistry and the origin of lifePyroelectricity, Electrofreezing.
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Dr. Doron Kushnir
Problems within the field of high-energy astrophysics and gravitational waves astronomy. Especially supporting the ideas that:Supernova explosions of type Ia are due to direct collisions of white dwarf stars.Core-collapse supernovae are thermonuclear explosions.
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Prof. Leeor Kronik
Our group's research is focused on understanding unique properties and behavior of materials and interfaces, using first principles quantum mechanical calculations based mostly on density functional theory and many-body perturbation theory. The group is actively engaged in prediction and interpretation of novel experiments, as well as in the development of formalism and methodology. For much more detailed information, please click the homepage link below.
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Prof. Valery Krizhanovsky
The role of cellular senescence in aging and age-related diseasesCollaboration with: Uri AlonThe dynamics of senescent cells during agingThe role of senescent cells in lung fibrosis and chronic obstructive pulmonary diseaseThe role of senescent cells in Alzheimer's diseaseAnalysis of senescent cells heterogeneity on transcriptomic, proteomic and metabolomic levelsMechanisms of interaction of senescent cells with their microenvironmentInteraction of senescent cells with the immune systemCellular senescence in cancer development and treatmentCollaboration with: Ittai Ben-Porath, Hebrew UniversitySenescent cells in pre-malignant lesionsTherapy-induced senescence in cancerSenescence during embryonic developmentCollaboration with: Dr. Tal Biron-Shental, Meir HospitalSenescence in syncytiotrophoblast is disrupted during intra-uteral growth restriction (IUGR)
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