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Prof. Avigdor Scherz
Quantification of atoms, groups and molecules electronegati using metal substituted bacteriochlorophylls and application to chemical reactivity.Resolving the forces which drive membrane protein assembly.The mechenism behind generation of reactive oxygen species (ROS) by illuminating novel bacteriochlorophyll derivatives and their application in photodynamic therapy (PDT) of tumors.
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Prof. Yardena Samuels
Synthetic lethal interaction network of melanomaIdentification of melanoma hub interactomesCRISPR screens to reveal driver gene interactions and drug resistance genesDecipher the immuno-genetic interactions between melanoma and T cellsHLA peptidome analysis of metastatic melanoma lesions
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Prof. Jacob Sagiv
Supramolecular Architecture at Interfaces (with R. Maoz)Supramolecular Surface Chemistry: Bottom-up Nanofabrication using Planned Self-Assembling Mono- and Multilayer Systems (with R. Maoz)Constructive Lithography: Contact Electrochemical Surface Patterning on Lateral Length Scales from Nanometer to Centimeter (with R. Maoz)
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Prof. Irit Sagi
Extracellular Matrix (ECM) remodeling: from biophysical principles to drug designECM remodeling by unique enzymes: investigating ECM proteolysis and cross-linking that provide chemical and mechanical stimuli regulating cellular behavior in health and disease.Drug Design: develop specific inhibitors to control the enzymatic activity of ECM remodeling enzymes, elucidating their function, mode of action, and therapeutic potential.Matrix Biology: the ECM and its remodeling enzymes in physiological and pathological conditions. Development of novel tools in the fields of systems biology, immunological tools, molecular and biochemical methods, and a wide range of imaging techniques to study ECM functional remodeling.
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Prof. Samuel Safran
Biological Physics - mesoscale theoryCollaboration with: Dennis Discher, Univ. Pennsylvania - DNA damage in migrating cells as a model of metastasis. Talila Volk, Weizmann Institute - muscle cells and nuclear deformation. Gary Karpen, Berekely - phase separation in the cellular nucleus: experiments; Frank Juilicher - MPI Dresden - phase separation theory. Prof. Zheng Gang Wang - CalTech - thoery of polymer interactions applied to chromosome ovelap. Tony Hyman - MPI Dresden - phase separation in cells.Soft matter physics - theoryCell cytoskeletal mechanics - theoryMesoscale chromatin organization - theoryCell shape and volume - theoryPhase separation and condensates in cells - theory
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Prof. Yinon Rudich
Health effects of atmospheric particulate matterCollaboration with: Prof. Ralf Zimmermann - Helmholtz Center Munich and University of Rostock, Germany Prof. Astrid Kiendler-Scharr - Hemholtz Ceter Juelich, GermanyIce nucleation by atmospheric particlesCollaboration with: Prof. Ido Braslvski - Hebrew UniversityThe transport of microorganisms in the atmosphere and their possible biogeochemical effects. Atmospheric microbiome.Optical properties of atmospheric organic aerosolsCollaboration with: Dr. Steve Brown - NOAA, Boulder CO Prof. Alexander Laskin - Purdue University
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