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Dr. Haim Beidenkopf
Topological electronic phasesWeyl/Dirac topological semimetalsStrong/Weak/Crystalline/Higher-order topological insulatorsTopological superconductivity and Majorana modesTopological nano-devicesScanning tunneling microscopy and spectroscopyMolecular beam epitaxy
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Prof. Ed Bayer
Structural and functional aspects of the multi-enzyme cellulosome complex from cellulose-degrading bacteria.Collaboration with: Raphael Lamed, Tel Aviv University Yuval Shoham, Technion, Haifa Itzhak Mizrahi, Ben-Gurion University, Beer Sheva Oded Livnah, Hebrew University of Jerusalem Yitzhak Hadar, Hebrew University of Jerusalem Shi-You Ding, Michigan State University Nicole Koropatkin and Eric Martens, University of Michigan Rafael Bernardi, Auburn University Hermann Gaub, Ludwig Maximilian University Don C. Lamb, Ludwig Maximilian University Bryan White, University of Illinois Klaus Schulten, University of Illinois Bernard Henrissat, Marseille Mirjam Czjzek, Rostok, France Yingang Feng, Ya-Jun Liu and Qiu Cui, Qingdao, China Yannick Bomble, Martin Keller and Michael Himmel, NREL, Golden CO Victor De Lorenzo, Madrid Mariano Carrión-Vázquez, Spanish National Research Council Carlos Fonts, University of Lisbon Marek Cieplak, Polish Academy of Sciences Damien Thompson, University of Limerick Henri-Pierre Fierobe, CNRS, Marseille Harry Flint, University of Aberdeen Harry Gilbert, Newcastle University Gideon Davies, York University Dimitris Hatzinikolaou, University of AthensThe cohesin-dockerin couple - Protein-protein interactions that mediate recognition and specificity in cellulosome assembly.Cellulose-binding domains as models for protein-sugar interactions.Bioinformatics of cellulases and cellulosome componentsComparative genomics of cellulosome components.Structure determination of cellulosome components.Enzymology of cellulosomes for conversion of biomass to biofuelsDesigner cellulosomes - Selective engineering of chimaeric cellulosome constructs for nanotechnology.Avidin-biotin system - Mutated avidins and streptavidins
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Dr. Avraham Roi
The lab of host-pathogen genomics is interested in how individual encounters between host and pathogenic bacteria can ultimately define the outcome of infection. This is achieved by applying cross-disciplinary single-cell analysis platforms that collectively enable us to extensively profile and precisely monitor host-pathogen interactions within the context of in vivo infections.The work in the lab centers on salmonella infection of mouse macrophages as a tractable in vitro host-pathogen system. We use this model to develop state of the art high throughput genomic tools and interdisciplinary approaches, and then apply them to various in vivo infection models to address critical biological aspects of host-pathogen biology.Using comprehensive, quantitative, unbiased tools to analyse the molecular interactions that underlie distinct host-pathogen subpopulations and their impact on disease outcome.Using a powerful combination of cutting-edge single cell genetic and genomic approaches, we wish to address what forms the basis for successful immune clearance, from the level of individual infected cells to that of the whole organism, and why, in some cases, sterilization is incomplete?
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Dr. Ori Avinoam
Membrane remodeling during differentiation and fusion of vertebrate skeletal musclesCollaboration with:Spatial and temporal organization of the molecular machines driving cell-to-cell fusionMaintenance of Membrane homeostasis during cell fusionMechanisms of ER remodeling during cell fusionExocytosis of Large Secretory Vesicles (LSVs)Collaboration with: Prof. Benny ShiloSpatial and temporal organization of the molecular machines driving exocytosis of LSVs.The lipid and protein composition and function of the fusion porePre-organization of the vesicular membraneMaintenance of Membrane homeostasis during secretionThe fusion mechanism of extracellular vesicles and virusesCollaboration with:The fusion mechanism of extracellular vesiclesIdentification of Pan Coronavirus fusion inhibitorsDevelopment of correlative light and electron microcopy methods
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