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Prof. Shmuel Pietrokovski
Developing computational methods for using and identifying protein motifs and applying them for the analysis of particular protein families.Developing advanced methods for comparing protein motifs.Applying protein motif comparisons for functional and structural predictions and to database annotation.Analysis of inteins ("protein splicing" elements) and homing endonucleases.Genetic variations in humans and different gene usage in women and menGene variations causing human disease, in particular infertility in men and various cancers.Different gene usage in women and men leading to differential selection between the sexes and allowing the accumulation of deleterious mutations.
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Prof. Gilad Perez
What gives masses to the particles? We believe that it is related to electroweak symmetry breaking which raises the hierarchy problem, the huge gap between the weak and Planck scales. The LHC experiments is addressing some of these questions and at the same time rising new ones. Recent cosmological-observation raised additional puzzles: What is the source of dark matter and energy? We explore experimental and theoretical methods to improve our knowledge regarding these issues. We also propose to use optical atomic clock spectroscopy to Search for Higgs-mediated interactions in atoms at table top experimentsInterpreting a 750 GeV Diphoton Resonance, By Rick S. Gupta, Sebastian Jager, Yevgeny Kats, Gilad Perez, Emmanuel Stamou. arXiv:1512.05332 [hep-ph].Is the Higgs Mechanism of Fermion Mass Generation a Fact? A Yukawa-less First-Two-Generation Model, By Diptimoy Ghosh, Rick Sandeepan Gupta, Gilad Perez. arXiv:1508.01501 [hep-ph].A Universe without weak interactions, By Roni Harnik, Graham D. Kribs, Gilad Perez. hep-ph/0604027. Phys.Rev. D74 (2006) 035006.Probing New Long-Range Interactions by Isotope Shift Spectroscopy By Julian C. Berengut et al.. arXiv:1704.05068 [hep-ph]. 10.1103/PhysRevLett.120.091801. Phys.Rev.Lett. 120 (2018) 091801.Probing Atomic Higgs-like Forces at the Precision Frontier By Cédric Delaunay, Roee Ozeri, Gilad Perez, Yotam Soreq. arXiv:1601.05087 [hep-ph]. 10.1103/PhysRevD.96.093001. Phys.Rev. D96 (2017) no.9, 093001.
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Prof. Rony Paz
Psychiatric disorders from pathologies in the amygdala-preftonal pathway (e.g. autism, anxiety-disorders, post-traumatic-stress-disorder (PTSD), epilepsy)Computational approaches to coding mechanisms in the brainMotivational and emotional modulation of memoryExtinction of memoryGeneralization and specificity of learningNeurobiology of learning and memoryNeuronal circuits and interactions between the amygdala and the prefrontal cortex
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Prof. Moshe Oren
Role of p53 in tumor-host interactions.Collaboration with: Prof. Michal Lotem, Hadassah Medical Center Prof. Yinon Ben-Neriah, Hebrew University Medical SchoolGain of function of mutant p53 in cancer.Collaboration with: Prof. Varda Rotter, Weizmann Institute; Prof. Vassilis Gorgoulis, Athens University Medical SchoolMolecular biology of p53.Regulation of the Hippo pathway and its deregulation in cancerCrosstalk between the p53 and Hippo pathways
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