• Picture of Prof. Moty Heiblum

    Prof. Moty Heiblum

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    Exotic quantum states with quantum statistics different from elementary particles
    Non-abelian quantum states (e.g., hosting Majorana particles)
    Interference of electrons and fractional charges in the quantum Hall regime
    Thermal conductance of one-dimensional modes, revealing quantum behavior

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  • Picture of Prof. David Harel

    Prof. David Harel

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    Software and systems engineering, visual languages, biological modeling, olfaction.

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  • Picture of Prof. Haim Harari

    Prof. Haim Harari

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    Neutrino Physics (Particle Physics, cosmology, astrophysics implications)
    Patterns of quarks and leptons (masses, mixing, substructure)

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  • Picture of Prof. Gilad Haran

    Prof. Gilad Haran

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    Functional Dynamics of Proteins
    Collaboration with:  Amnon Horovitz, Weizmann, Rina Rosenzweig, Weizmann, Douglas Kojetin, Scripps Florida
    Membrane Organization and Dynamics
    Collaboration with:  Ronen Alon, Weizmann, Frank Brown, UCSB, Andres Alcover, Pasteur Institute
    Correlated motion in the membrane plan
    Super-resolution microscopy of the organization of receptors on the membrane of the T cell
    Interaction of surface plasmons with quantum emitters
    Collaboration with:  Ora Bitton, Weizmann, Lothar Houben, Weizmann, Lev Chuntonov, Technion, Javier Aizpurua, San Sebastian
    Strong coupling of plasmons and quantum dots

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  • Picture of Dr. Jacob (Yaqub) Hanna

    Dr. Jacob (Yaqub) Hanna

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    Deciphering Cellular Reprogramming
    Following a breakthrough that was made in 2006 (by Takahashi & Yamanaka), today we can reverse cellular differentiation, and generate induced pluripotent stem cells from somatic cells by epigenetic “reprogramming”. We investigate what are the dramatic molecular changes happening in the cell during reprogramming and how they are connected to similar in-vivo processes. We pointed out two chromatin regulators that play a role in this process, one is essential for reprogramming (Utx, Mansour et al 2012), and the other (Mbd3/NuRD, Rais et al 2013) is an obstacle, which upon its near-removal the reprogramming becomes dramatically faster and synchronized.
    Understanding Naïve and Primed Pluripotent States
    Being able to generate all cell types, mouse embryonic stem cells are a most valuable tool for research. They can be found in the developing mouse embryo in two distinct states: naïve – in the blastocyst, and primed – in the post-implantation epiblast. These two states are distinct in various aspects, most notable, only naïve cells can contribute efficiently to chimera. Naïve and primed cells can be sustained in-vitro, and are dependent on distinct signaling. In human, naïve stem cells were out of reach for a long time. We investigate the regulation of naïve and primed pluripotent stem cell in mouse and human. Specifically, we were able to maintain human stem cells in a “naive” state, with distinct molecular and functional properties, including enhanced ability to contribute to cross-species mouse chimeric embryos (Gafni et al, 2013). In addition, we found that mRNA methylation has a critical role in facilitating degradation of pluripotent genes, an essential step during the switch from naïve to primed states, both in-vitro and in-vivo (Geula et al, 2014). Our current studies involve elucidating molecular regulation of these states across different species, and define how their molecular architecture dictates their functional competence.
    Human-Mouse Cross-Species Chimerism
    Human stem cells that are sustained in naïve culture conditions, can be injected to mouse blastocyst and contribute to cross-species chimera (Gafni et al, 2013). We investigate these chimeric mice, which are valuable tool for human disease modeling in a whole-organism context.

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  • Picture of Dr. Itay Halevy

    Dr. Itay Halevy

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    The long-timescale co-evolution of biogeochemical cycles, the chemical and isotopic composition of the oceans and atmosphere, and climate on Earth and other planets.
    The geological, geochemical, and geobiological history of Earth, planets and satellites.
    Global biogeochemical cycles and their interaction with the climate system.
    Episodes of global climatic, biological or geochemical change, their causes and consequences, and their expression in the sedimentary rock record.
    Fractionation of stable isotopes during metabolic activity, its governing factors, and its expression in modern environments and in the sedimentary rock record.

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  • Picture of Prof. Shmuel Gurvitz

    Prof. Shmuel Gurvitz

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    Multi-dimensional tunnelling.
    Collaboration with:  Xin-Qi Li, D. Sokolovski
    Two-potential approach to tunneling problems
    Cluster decay
    Modified tunneling Hamiltonian
    Tunneling of the Bose-Einstein Condensate
    Time-dependent quantum transport in mesoscopic system.
    Collaboration with:  A. Aharony, O. Entin-Wohlman, Xin-Qi Li, Wei-Min Zhang
    Number and energy resolved master equations for quantum transport
    Relaxation and dephasing in persistent current
    Zeno effect and quantum description of classical apparatus
  • Picture of Prof. Eilam Gross

    Prof. Eilam Gross

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    Higgs Physics with the ATLAS detector at the LHC
    Collaboration with:  Students: Michael Pitt and Jonathan Shlomi
    Search for Charged Higgs Boson
    Search for Higgs Decay to Charm Quarks
    Chram Tag
    Strtiatics in High Energy Pjysics

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  • Picture of Prof. Atan Gross

    Prof. Atan Gross

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    How do changes in mitochondria function effect the initiation/progression of Parkinson's Disease?
    How do changes in mitochondria function effect the initiation/progression of Fibromyalgia?
    Establishing the role of mitochondrial carrier homolog 2 (MTCH2) in regulating the shape of mitochondria, metabolism and apoptosis
    Develop inhibitors for MTCH2 as potential therapies of diseases such as acute myeloid leukemia (AML) and obesity

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  • Picture of Prof. Yoram Groner

    Prof. Yoram Groner

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    Runx transcription factor 1 and 3 in development and disase
    Collaboration with:  The Proprioceptive System Masterminds Spinal Alignment: Insight into the Mechanism of Scoliosis. Blecher R, Krief S, Galili T, Biton IE, Stern T, Assaraf E, Levanon D, Appel E, Anekstein Y, Agar G, Groner Y, Zelzer E. Dev Cell. 2017 Aug 21;42(4):388-399.e3. doi: 10.1016/j.devcel.2017.07.022. PMID: 28829946 Similar articles Select item 28621410 2. The Leo Sachs' legacy: a pioneer's journey through hematopoiesis. Lotem J, Groner Y. Int J Dev Biol. 2017;61(3-4-5):127-136. doi: 10.1387/ijdb.160262yg. PMID: 28621410 Similar articles Select item 28299669 3. Runx3 in Immunity, Inflammation and Cancer. Lotem J, Levanon D, Negreanu V, Bauer O, Hantisteanu S, Dicken J, Groner Y. Adv Exp Med Biol. 2017;962:369-393. doi: 10.1007/978-981-10-3233-2_23. Review. PMID: 28299669 Similar articles Select item 28007784 4. An ensemble of regulatory elements controls Runx3 spatiotemporal expression in subsets of dorsal root ganglia proprioceptive neurons. Appel E, Weissmann S, Salzberg Y, Orlovsky K, Negreanu V, Tsoory M, Raanan C, Feldmesser E, Bernstein Y, Wolstein O, Levanon D, Groner Y. Genes Dev. 2016 Dec 1;30(23):2607-2622. doi: 10.1101/gad.291484.116. PMID: 28007784 Free PMC Article Similar articles Select item 26697350 5. Genomic-wide transcriptional profiling in primary myoblasts reveals Runx1-regulated genes in muscle regeneration. Umansky KB, Feldmesser E, Groner Y. Genom Data. 2015 Sep 1;6:120-2. doi: 10.1016/j.gdata.2015.08.030. eCollection 2015 Dec. PMID: 26697350 Free PMC Article Similar articles Select item 26414766 6. Runx3 specifies lineage commitment of innate lymphoid cells. Ebihara T, Song C, Ryu SH, Plougastel-Douglas B, Yang L, Levanon D, Groner Y, Bern MD, Stappenbeck TS, Colonna M, Egawa T, Yokoyama WM. Nat Immunol. 2015 Nov;16(11):1124-33. doi: 10.1038/ni.3272. Epub 2015 Sep 28. PMID: 26414766 Free PMC Article Similar articles Select item 26275053 7. Runx1 Transcription Factor Is Required for Myoblasts Proliferation during Muscle Regeneration. Umansky KB, Gruenbaum-Cohen Y, Tsoory M, Feldmesser E, Goldenberg D, Brenner O, Groner Y. PLoS Genet. 2015 Aug 14;11(8):e1005457. doi: 10.1371/journal.pgen.1005457. eCollection 2015 Aug. PMID: 26275053 Free PMC Article Similar articles Select item 25641675 8. Runx3 at the interface of immunity, inflammation and cancer. Lotem J, Levanon D, Negreanu V, Bauer O, Hantisteanu S, Dicken J, Groner Y. Biochim Biophys Acta. 2015 Apr;1855(2):131-43. doi: 10.1016/j.bbcan.2015.01.004. Epub 2015 Jan 30. Review. PMID: 25641675 Free Article Similar articles Select item 25605327 9. Loss of osteoblast Runx3 produces severe congenital osteopenia. Bauer O, Sharir A, Kimura A, Hantisteanu S, Takeda S, Groner Y. Mol Cell Biol. 2015 Apr;35(7):1097-109. doi: 10.1128/MCB.01106-14. Epub 2015 Jan 20. PMID: 25605327 Free PMC Article 10. Carcinogen-induced skin tumor development requires leukocytic expression of the transcription factor Runx3. Bauer O, Hantisteanu S, Lotem J, Groner Y. Cancer Prev Res (Phila). 2014 Sep;7(9):913-26. doi: 10.1158/1940-6207.CAPR-14-0098-T. Epub 2014 Jun 24. PMID: 24961879 Free Article Similar articles Select item 24469826 11. Pioneer of hematopoietic colony-stimulating factors: Leo Sachs (1924-2013). Sela M, Groner Y. Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1664-5. doi: 10.1073/pnas.1324228111. Epub 2014 Jan 27. No abstract available. PMID: 24469826 Free PMC Article Similar articles Select item 24421391 12. Transcription factor Runx3 regulates interleukin-15-dependent natural killer cell activation. Levanon D, Negreanu V, Lotem J, Bone KR, Brenner O, Leshkowitz D, Groner Y. Mol Cell Biol. 2014 Mar;34(6):1158-69. doi: 10.1128/MCB.01202-13. Epub 2014 Jan 13. PMID: 24421391 Free PMC Article Similar articles Select item 24236182 13. Runx3-mediated transcriptional program in cytotoxic lymphocytes. Lotem J, Levanon D, Negreanu V, Leshkowitz D, Friedlander G, Groner Y. PLoS One. 2013 Nov 13;8(11):e80467. doi: 10.1371/journal.pone.0080467. eCollection 2013. PMID: 24236182 Free PMC Article Similar articles Select item 24204843 14. Transcriptional reprogramming of CD11b+Esam(hi) dendritic cell identity and function by loss of Runx3. Dicken J, Mildner A, Leshkowitz D, Touw IP, Hantisteanu S, Jung S, Groner Y. PLoS One. 2013 Oct 15;8(10):e77490. doi: 10.1371/journal.pone.0077490. eCollection 2013. PMID: 24204843 Free PMC Article Similar articles Select item 24055056 15. Addiction of t(8;21) and inv(16) acute myeloid leukemia to native RUNX1. Ben-Ami O, Friedman D, Leshkowitz D, Goldenberg D, Orlovsky K, Pencovich N, Lotem J, Tanay A, Groner Y. Cell Rep. 2013 Sep 26;4(6):1131-43. doi: 10.1016/j.celrep.2013.08.020. Epub 2013 Sep 19. PMID: 24055056 Free Article Similar articles Select item 23717578 16. Cell-autonomous function of Runx1 transcriptionally regulates mouse megakaryocytic maturation. Pencovich N, Jaschek R, Dicken J, Amit A, Lotem J, Tanay A, Groner Y. PLoS One. 2013 May 23;8(5):e64248. doi: 10.1371/journal.pone.0064248. Print 2013. PMID: 23717578 Free PMC Article Similar articles Select item 22903063 17. Positional differences of axon growth rates between sensory neurons encoded by Runx3. Lallemend F, Sterzenbach U, Hadjab-Lallemend S, Aquino JB, Castelo-Branco G, Sinha I, Villaescusa JC, Levanon D, Wang Y, Franck MC, Kharchenko O, Adameyko I, Linnarsson S, Groner Y, Turner E, Ernfors P. EMBO J. 2012 Sep 12;31(18):3718-29. doi: 10.1038/emboj.2012.228. Epub 2012 Aug 17. PMID: 22903063 Free PMC Article Similar articles Select item 22693452 18. The App-Runx1 region is critical for birth defects and electrocardiographic dysfunctions observed in a Down syndrome mouse model. Raveau M, Lignon JM, Nalesso V, Duchon A, Groner Y, Sharp AJ, Dembele D, Brault V, Hérault Y. PLoS Genet. 2012 May;8(5):e1002724. doi: 10.1371/journal.pgen.1002724. Epub 2012 May 31. PMID: 22693452 Free PMC Article Similar articles Select item 22370763 19. Roles of VWRPY motif-mediated gene repression by Runx proteins during T-cell development. Seo W, Tanaka H, Miyamoto C, Levanon D, Groner Y, Taniuchi I. Immunol Cell Biol. 2012 Sep;90(8):827-30. doi: 10.1038/icb.2012.6. Epub 2012 Feb 28. PMID: 22370763 Similar articles Select item 21786422 20. Absence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumour suppressor function. Levanon D, Bernstein Y, Negreanu V, Bone KR, Pozner A, Eilam R, Lotem J, Brenner O, Groner Y. EMBO Mol Med. 2011 Oct;3(10):593-604. doi: 10.1002/emmm.201100168. Epub 2011 Aug 8. PMID: 21786422 Free PMC Article Similar articles A Runx1-Smad6 rheostat controls Runx1 activity during embryonic hematopoiesis. Knezevic K, Bee T, Wilson NK, Janes ME, Kinston S, Polderdijk S, Kolb-Kokocinski A, Ottersbach K, Pencovich N, Groner Y, de Bruijn M, Göttgens B, Pimanda JE. Mol Cell Biol. 2011 Jul;31(14):2817-26. doi: 10.1128/MCB.01305-10. Epub 2011 May 16. PMID: 21576367 Free PMC Article Similar articles Select item 21536859 22. ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer. Thoms JA, Birger Y, Foster S, Knezevic K, Kirschenbaum Y, Chandrakanthan V, Jonquieres G, Spensberger D, Wong JW, Oram SH, Kinston SJ, Groner Y, Lock R, MacKenzie KL, Göttgens B, Izraeli S, Pimanda JE. Blood. 2011 Jun 30;117(26):7079-89. doi: 10.1182/blood-2010-12-317990. Epub 2011 May 2. PMID: 21536859 Free Article Similar articles Select item 20959602 23. Dynamic combinatorial interactions of RUNX1 and cooperating partners regulates megakaryocytic differentiation in cell line models. Pencovich N, Jaschek R, Tanay A, Groner Y. Blood. 2011 Jan 6;117(1):e1-14. doi: 10.1182/blood-2010-07-295113. Epub 2010 Oct 19. PMID: 20959602 Free Article Similar articles Select item 20615577 24. The novel RUNX3/p33 isoform is induced upon monocyte-derived dendritic cell maturation and downregulates IL-8 expression. Puig-Kröger A, Aguilera-Montilla N, Martínez-Nuñez R, Domínguez-Soto A, Sánchez-Cabo F, Martín-Gayo E, Zaballos A, Toribio ML, Groner Y, Ito Y, Dopazo A, Corcuera MT, Alonso Martín MJ, Vega MA, Corbí AL. Immunobiology. 2010 Sep-Oct;215(9-10):812-20. doi: 10.1016/j.imbio.2010.05.018. Epub 2010 Jun 20. PMID: 20615577 Similar articles Select item 20596738 25. In vivo effects of APP are not exacerbated by BACE2 co-overexpression: behavioural characterization of a double transgenic mouse model. Azkona G, Levannon D, Groner Y, Dierssen M. Amino Acids. 2010 Nov;39(5):1571-80. doi: 10.1007/s00726-010-0662-8. Epub 2010 Jul 2. PMID: 20596738 Similar articles Select item 20554226 26. Translation regulation of Runx3. Bone KR, Gruper Y, Goldenberg D, Levanon D, Groner Y. Blood Cells Mol Dis. 2010 Aug 15;45(2):112-6. doi: 10.1016/j.bcmd.2010.04.001. Epub 2010 Jun 2. PMID: 20554226 Similar articles Select item 19233693
    Dynamic combinatorial interactions of RUNX1 and cooperating partners during megakaryocytic differentiation
    Collaboration with:  Amos Tanay Department of Computer Science & Applied Mathematics
    Biological function of the RUNX transcription factors
    Positive and negative transcriptional regulation by Runx3
    The Human Leukemia Associated Transcription Factor RUNX1/AML1 and Down syndrome leukemia

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