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Dr. Avraham Roi
The lab of host-pathogen genomics is interested in how individual encounters between host and pathogenic bacteria can ultimately define the outcome of infection. This is achieved by applying cross-disciplinary single-cell analysis platforms that collectively enable us to extensively profile and precisely monitor host-pathogen interactions within the context of in vivo infections.The work in the lab centers on salmonella infection of mouse macrophages as a tractable in vitro host-pathogen system. We use this model to develop state of the art high throughput genomic tools and interdisciplinary approaches, and then apply them to various in vivo infection models to address critical biological aspects of host-pathogen biology.Using comprehensive, quantitative, unbiased tools to analyse the molecular interactions that underlie distinct host-pathogen subpopulations and their impact on disease outcome.Using a powerful combination of cutting-edge single cell genetic and genomic approaches, we wish to address what forms the basis for successful immune clearance, from the level of individual infected cells to that of the whole organism, and why, in some cases, sterilization is incomplete?
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Dr. Ori Avinoam
The mechanisms of protein mediated membrane sculpting in health and diseaseSpatial and temporal organization of the molecular machines driving vesicle formation.Endocytosis and membrane trafficking in eukaryotes.Caveolae in muscle biogenesis, homeostasis and atrophy.Cell-to-cell fusionImaging Across ScalesCorrelative light and 3D electron microscopy at room temperature and in cryo.Advanced light microscopy techniques.
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Dr. Rotem Arnon-Friedman
Quantum cryptographyDevice-independent quantum cryptographyQuantum key distributionCertification protocolsQuantum-proof randomness extractorsEntanglement theoryNon-localityEntanglement certificationEntanglement as a resource for quantum cryptography
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Prof. Ruth Arnon
Pathological mechanism in the CNS of various multiple sclerosis animal models.Collaboration with: R. AharoniNeuroprotection, neurogenesis and remyelination consequences of Glatiramer Acetate treatment in EAE.Collaboration with: R. Aharoni; M. SelaMechanism of action of Copolymer 1 (Copaxone®), a therapeutic vaccine against multiple sclerosis.Collaboration with: M. Sela; R. AharoniInvolvement of peptides in animal models of Alzheimer disease and its ameliorationCollaboration with: R. Maron; M. Wilchek
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Prof. Michal Armoni
Teaching the foundations of computer science to young studentsTheoretical foundations of computer scienceBasic concepts in algorithm and program designFundamental ideas in computer science: Identifying the core ideas of the discipline, examining their teaching and learning processesReductive thinking: Reduction as a tool for problem solvingNondeterminism: a tool for abstractionReversingAbstraction
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Prof. Abraham Arcavi
Research on cognitive characteristics of non academically oriented math students.Collaboration with: Dr. Ronnie KarsentyDesign of curriculum materials as a research based activityCollaboration with: Dr. Sue MagidsonLong-term design of a new curriculum for grades 10, 11 and 12 for non-academically oriented students.Collaboration with: Dr. Nurit Hadas
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Dr. Yaron Antebi
Developing a systems-level framework to characterize signal integration at the single cell level.Defining the role of perception and integration of complex stimuli in determining cellular fate.Analyzing multi-ligand information processing in the BMP/TGFβ pathway and its effect on mesenchymal stem cell differentiation.Studying signal processing capabilities of additional pathways (e.g. JAK/STAT, Wnt, FGF)
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