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Prof. Dan Tawfik
Evolution and mechanism of enzymesMolecular evolution in man-made cell-like compartments.Directed evolution of tailor-made hydrolases (esterases, phosphoesterases, organophosphate hydrolases, and amidases) and DNA-modifying enzymes.Structure, mechanism and evolution of serum paraoxonases (PONs)The role of promiscuity and conformational plasticity in protein evolution.Directed evolution of DNA-methyltransferases and DNase inhibitorsThe stability effects of mutationsProtein evolvabilityChaperones and protein evolution
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Prof. Eldad Tzahor
Head muscle patterning and differentiationCharacterization of head muscle derived satellite cellsDissecting the myogenic programs in head muscle progenitorsInvolvement of p53 in cranial myogenesisCardiac and skeletal muscle progenitors during vertebrate embryogenesisStudying the crosstalk between BMP and FGF signaling pathways in cardiac progenitorsRegulation of Islet1 gene expression using novel imaging techniques in live embryosThe origin of the heart endocardium: Focus on the role of endothelial cells in cardiogenesis
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Prof. Jacob Sagiv
Supramolecular Architecture at Interfaces (with R. Maoz)Supramolecular Surface Chemistry: Bottom-up Nanofabrication using Planned Self-Assembling Mono- and Multilayer Systems (with R. Maoz)Constructive Lithography: Contact Electrochemical Surface Patterning on Lateral Length Scales from Nanometer to Centimeter (with R. Maoz)
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Prof. Igor Lubomirsky
Dielectric materialsProperties of Ultra-Thin Self-Supported Crystalline Oxide Films.Infrared focal plane array based on freestanding pyroelectric films.Oxygen ion transport in thin freestanding films.High temperature, electrochemical CO<sub>2</sub> reduction
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Prof. Joel Sussman
3D Structure Funciton Studies or proteins related to AutismCollaboration with: Israel Silman3D Structure Fucntions studies of ParaoxonaseCollaboration with: Dan Tawfik & Israel SilmanApplication of ultra rapid X-ray diffraction methods to study the enzymatic mechanism of AChE in real time.Collaboration with: Israel SilmanStructure based drug design studies on AChE and beta-secretase, including studies of complexes with transition state analogs; potential drugs for the treatment of Alzheimer's disease; and snake neurotoxins.Collaboration with: Israel SilmanX-ray structural analysis and molecular biology studies on proteins from the nervous system, including acetylcholinesterase (AChE), human, torpedo, drosophila, and krait; butyrylcholinesterase; neural cell adhesion proteins with sequence similarity to AChCollaboration with: Israel Silman3D Structure Funciton of proteins related to Gaucher DiseaseCollaboration with: Tony Futerman & Israel SilmanVisualization of 3D Protein Structures via new web based tool ProteopediaCollaboration with: Jaime Prilusky & Israel Silman
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Prof. Stephen Weiner
Structure - mechanical function relations in mineralized tissues (bones and teeth) using Optical Metrology.Collaboration with: Ron ShaharArchaeological science: revealing the microscopic archaeological recordCollaboration with: E. Boaretto, I Finkelstein, A. Maier, R. Shahack-GrossBiomineralization: mechanisms of mineral formation and growth in biology.Collaboration with: L. Addadi, Irit Sagi, Leeor Kronick
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